• 17.Ishigam M, Uchiyama M, Kondo T, Iwabuchi H, Inoue S, Takasaki W, Ikeda T, Komai T, Ito K, Sugiyama Y. Inhibition of in vitro metabolism of simvastatin by itraconazole in humans and prediction of in vivo drug-drug interactions. (webmd.com)
  • Generic is a drug that has proven pharmaceutical, biological, and therapeutic equivalence to the brand name drug. (medsoffering.com)
  • Gugulipid shows a similar therapeutic effect to many cholesterol-lowering drugs without any apparent risk of liver damage. (meschinohealth.com)
  • Twenty years later, milk thistle was acknowledged as a therapeutic agent against all types of toxic exposure. (thepeopleschemist.com)
  • Hypolipidemic agents , or antihyperlipidemic agents , are a diverse group of pharmaceuticals that are used in the treatment of hyperlipidemias . (wikidoc.org)
  • Zocor is a medication that may be described as a hypolipidemic (pharmaceutical of a diverse kind that that treats hyperlipidemias) or lipid - lowering drug (LLD)/agents). (triquitips.ru)
  • However, a strong variation has been noticed among the different agents: analyses of all published studies suggest a very limited role of pravastatin and simvastatin in modifying LDL size and their subclasses, while fluvastatin and atorvastatin seem to be much more effective agents. (unipa.it)
  • Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
  • Although the incidence of drug-induced skeletal muscle toxicity is very low (0.1-0.2%) with monotherapy, it may increase following concomitant drug therapy with the immunosuppressant, cyclosporine A (CsA), and possibly with certain other hypolipidemic agents. (aspetjournals.org)
  • Bile acids and cholesterol homeostasis, regulation and related diseases Drug transporters, toxicology and delivery Biological and pharmaceutical therapy development. (uri.edu)
  • Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
  • Drugs currently used in therapy to treat hyperlipidemia, have several drawbacks. (springeropen.com)
  • Medicinal chemists worldwide are routinely engaged in the discovery and development of newer molecules which can act differently and more effectively than the drugs presently employed in therapy. (springeropen.com)
  • Statins are potent inhibitors of hydroxy-methyl-glutaryl-coenzyme A reductase, the rate-limiting enzyme in hepatic cholesterol synthesis and are the main drugs of choice for the treatment of elevated plasma LDL cholesterol concentrations. (unipa.it)
  • Lipid-lowering drugs - HMG-CoA reductase inhibitor. (pharmru.com)
  • 16.Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. (webmd.com)
  • Remarkably, Gugulipid is a very safe drug relative to most cholesterol-lowering drugs used in modern medicine (especially when compared to the commonly used statin drugs, which inhibit the HMG-CoA Reductase enzyme in the liver, and can lead to liver damage). (meschinohealth.com)
  • The mild, self-limited ALT elevations are likely due to a toxic intermediate of drug metabolism and the reversal of these elevations due to adaptation. (nih.gov)
  • Yang D, Yang J, Shi D, Deng R and Yan B (2012) Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of cholesteryl ester hydrolase ces1 and bile salt export pump. (uri.edu)
  • Other FXR ligands include natural products and investigational drugs. (nature.com)
  • Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
  • Stroke 21:12131391 line esterase inhibitors are competitive (reversible) blocking (j_-och3ch agents. (themauimiracle.org)
  • They are called lipid-lowering drugs (LLD) or agents. (wikidoc.org)
  • A clinical trial is being conducted to see the benefit of a known lipid-lowering drug such as pitavastatin in patients with advanced prostate cancer who are being treated with the new anti-androgens. (who.int)
  • Hypolipidemic treatment is able to alter LDL subclass distribution and statins are currently the most widely used lipid-lowering agents. (unipa.it)
  • A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. (drugcentral.org)
  • Gugulipid was granted approval in India for marketing as a lipid-lowering drug in June 1986. (meschinohealth.com)
  • Thus, results of the experimental study reveal that the leaf of Nelumbo nucifera has potent hypoglycemic and hypolipidemic properties. (scirp.org)
  • Hypersensitivity to simvastatin and other ingredients, as well as other statin drugs in series history. (pharmru.com)
  • It's generally accepted that cumin oil is a hypoglycemic agent. (healthline.com)
  • He heard about Gymnema from an Asian Indian friend with diabetes and would like your advice about which of these supplements or herbals and spices to use, and in what daily dosages, before starting a new hypoglycemic agent. (medscape.com)
  • In general, doctors prescribe this drug combination for people with very high triglyceride levels that do not respond positively to dietary changes, for people with type 2 diabetes and high triglycerides and for people with hereditary high cholesterol. (wise-geek.com)
  • They suggest that a combination of rapamycin and another drug to offset that increase in insulin resistance might provide the benefits of this medication without the unwanted side effect. (med-chemist.com)
  • Therefore, it is now inevitable to move forward for a sophisticated oral drug that will be therapeutically effective as hypoglycemic side by side hypolipidemic agents at low cost particularly both for the developing and under-developed countries. (scirp.org)
  • Stroke can reduce the possibility of reaching therapeutically appropriate brain levels of neuroprotective drug. (patentpc.com)
  • We used a cell-based human FXR β-lactamase ( Bla ) reporter gene assay to profile the Tox21 10K compound collection of environmental chemicals and drugs. (nature.com)
  • the main cause of the different interactions of these drugs. (who.int)
  • Hypolipidemic agents drug interactions: approach to establish and assess its clinical significance. (who.int)
  • Cumin is considered to have hypolipidemic properties. (healthline.com)
  • Results of pharmacokinetic studies in rats treated with various HMGRIs +/- CsA indicated that coadministration of CsA alters the disposition of these compounds, resulting in increased systemic exposure (e.g., increased area under the plasma drug concentration vs. time curve-AUC) and consequent (up to 13-fold) increases in skeletal muscle drug levels. (aspetjournals.org)
  • metabolised by the 3A4 isoform of cytochrome P450 (CYP3A4), and some drugs can substantially increase the plasma levels of these statins. (who.int)
  • The best theoretical drug should decrease serum lipoprotein cholesterol levels, increase biliary cholesterol secretion and fecal elimination and favoring at the same time gallbladder emptying to prevent gallstone formation. (nih.gov)
  • Coadministration with these agents may cause increases in simvastatin levels and potentiate its hepatic or muscle toxicity. (nih.gov)
  • Impairment of BSEP expression by xenobiotics such as diabetic drug troglitazone and endobiotics such as estrogens leads to an increase in intrahepatic as well as systemic bile acid levels, a hallmark for intrahepatic cholestasis. (uri.edu)
  • Fibrates are a class of drugs called hypolipidemic agents, because their main use is to lower blood triglyceride levels. (wise-geek.com)
  • This is because, in addition to lowering triglycerides and LDL cholesterol, these drugs can increase levels of so-called "good" high-density lipoprotein ( HDL ) cholesterol and even can improve the symptoms of insulin resistance. (wise-geek.com)
  • Reduction in levels of LDL cholesterol is achieved because these drugs reduce the rate at which low-density lipoproteins are produced in the liver. (wise-geek.com)
  • Other agents that increase NO levels independently of ecNOS may also be used. (patentpc.com)
  • It may be impossible to give a drug in sufficient doses to raise the blood levels enough to have a beneficial effect on the brain. (patentpc.com)
  • Local responses to acid (a ph of the subjects and may lead to different levels of protective 36 chapter 4 anzi.Infeciive agents 335 ing l3 of the. (themauimiracle.org)
  • A hypolipidemic is a substance that helps your body control high levels of fats that hurt your heart and cholesterol levels. (healthline.com)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
  • Simple coumarins and analogues are a large class of compounds that have attracted their interest for a long time due to their biological activities: they have shown to be useful as antitumoural, anti-HIV agents and as CNS-active compounds. (benthamscience.com)
  • both gfr and developing countries offer their lives in an autoclave): Steam procedure is one of its hypolipidemic effect is that entecavir be taken into 7.3.5 additional formulation demands when the precipitant drug. (themauimiracle.org)
  • Despite the growing interest in FXR ligands in drug discovery, little is known with regard to the roles of FXR in mediating or protecting xenobiotic-induced toxicity. (nature.com)
  • Unlike other cholesterol-lowering drugs, the administration of Gugulipid has not revealed any significant side effects, liver damage or toxicity, in human or animal studies to date. (meschinohealth.com)
  • FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury. (webmd.com)
  • available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-com munication-new-restrictions-contraindications-and-dose-limitations-zocor June 8, 2011. (webmd.com)
  • Information is also highlighted concerning the development of new synthetic strategies that could help in drug design and in the work on SAR or QSAR. (benthamscience.com)
  • Increased NO production may facilitate administration of drugs not easily absorbed to the brain and/or reduce serum concentrations necessary for desired physiological effects. (patentpc.com)
  • This is especially true if the drug being administered to the brain causes side effects that are harmful or undesirable to the rest of the body. (patentpc.com)
  • In addition, there are two natural agents that have proven cholesterol and triglyceride lowering effects that can be used to complement a diet and lifestyle plan aimed at lowering these two cardiovascular risk factors. (meschinohealth.com)
  • Drug Metab Dispos 1999 Feb;27(2):173-9. (webmd.com)
  • The study was carried out to evaluate the hypolipidemic and hypoglycemic effect of Nelumbo nucifera leaf powder. (scirp.org)
  • Koenig said additional studies are needed to gauge the long-term impact of the drug, the optimal dosage and whether the facial cream should be a combined with an oral treatment. (med-chemist.com)
  • Prior to treatment, patients should appoint Ovenkorom standard hypolipidemic diet, which must be maintained throughout the course of treatment. (pharmru.com)
  • Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. (webmd.com)
  • Patients suffering from strokes may benefit from an increase in blood flow and increased delivery of anti-stroke or neuroprotective drugs. (patentpc.com)
  • It is therefore highly desirable to be able to improve cerebral blood flow and drug delivery, particularly under stroke conditions. (patentpc.com)
  • It is metabolized into isoniazid, an anti-tuberculosis agent, and so is contraindicated in patients with tuberculosis. (wikipedia.org)
  • Patients with PCa will be treated with one of these 4 active drugs for their disease: a.4. (who.int)
  • Eighty percent of patients getting the study drug experienced a significant improvement compared to 25 percent of those getting the mixture with no rapamycin,' she said. (med-chemist.com)
  • Although most patients with STEMI can undergo percutaneous coronary intervention (PCI) and take the drugs recommended by the guidelines to relieve their symptoms, it cannot rescue the apoptotic and necrotic cardiomyocytes [ 5 ]. (biomedcentral.com)
  • Progress in Drug Research. (wikipedia.org)
  • Dr Singletary's primary research interests are in molecular carcinogenesis and cancer chemoprevention, specifically identifying and determining the mechanism of action of phytochemicals in fruits, vegetables, and spices as cancer protective agents. (lww.com)
  • We have periodically reviewed some such novel molecular targets for antihyperlipidaemic drug research (Jain et al. (springeropen.com)
  • Clinically, the choice of an agent will depend on the patient's cholesterol profile , cardiovascular risk , and the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications. (wikidoc.org)
  • For the hypolipidemic activity investigation, the selected animals are normally fed high fat diet to originate hyperlipidemia inside those animals. (scirp.org)
  • It has been used for many years for this purpose in India, where it is has received prescription drug status, due to its high level of efficacy, as determined in human clinical trials. (meschinohealth.com)
  • Analytical chemists have increasingly turned their attention to drug discovery and drug analysis and to solve fundamental questions of biological significance in physiology and genetics. (benthamscience.com)
  • Bile acid sequestrants may cause gastrointestinal problems, and may also reduce the absorption of other drugs and vitamins from the gut. (wikidoc.org)
  • This indicated its probable site of action to be at the surface of the GIT (something similar to the bile acid sequestering agents). (springeropen.com)
  • Even so, fibrate medications sometimes are prescribed as monotherapy, which simply means the drug is prescribed as the only cholesterol-lowering medication. (wise-geek.com)
  • 15) _______ are drugs which when administered favors erythropoiesis i.e. synthesis of red blood cells and increase the oxygen carrying capacity of the blood. (msbtenews.com)
  • In addition, fibrate drugs increase the rate at which these lipoproteins are removed from the blood. (wise-geek.com)
  • Increased cerebral blood flow means that drugs are also carried into the brain. (patentpc.com)
  • This beneficial role can be detrimental if the drug cannot cross the blood-brain border. (patentpc.com)
  • Reduced cerebral blood flow could be a factor in the uptake and penetration of lipophilic drugs such as MK-801 into brain tissue. (patentpc.com)
  • The uptake of these drugs is severely affected by ischemia and reduced blood flow. (patentpc.com)
  • Ginger [root/rhizome of the plant]- Zingiber officinale is one of the most commonly used dietary condiments and widely used in traditional folk medicine, science for a long time and is considered a potential chemo preventive agent [ 1 ]. (zenonco.io)
  • It has been demonstrated that the plant-based exudate gums such as gum Acacia [ 4 ] and gum kondagogu [ 5 ] can be utilized as reducing and stabilizing agents for the silver nanoparticle biosynthesis. (springeropen.com)
  • Diabetes was defined by the presence of fasting plasma glucose 126 mg/dl or the use of oral hypoglycemic agents or insulin. (bvsalud.org)
  • In the present study we have attempted to check the role of isolated saponins from Asparagus filicinus for its hypolipidemic activity. (ijpsr.com)
  • in the present study the role of saponin for hypolipidemic activity has been evaluated. (ijpsr.com)
  • A facile and ecofriendly green method has been developed for the synthesis of silver nanoparticles from silver nitrate using gum ghatti ( Anogeissus latifolia ) as a reducing and stabilizing agent. (springeropen.com)
  • The oil extracted from cumin seeds has been used as an effective larvicide and antiseptic agent. (healthline.com)
  • It's so effective that researchers hope cumin might be an effective replacement for people who cannot afford expensive prescription drugs to treat their IBS. (healthline.com)
  • 6]-gingerol has been shown to be a highly effective agent against skin cancer in the two-stage initiation-promoting mouse skin model in in-vivo as an anticancer agent [ 13 ]. (zenonco.io)
  • Thus, newer molecular targets related to hyperlipidemia are routinely exploited in the pursuit for discovering better, effective and safer drugs (Jain et al. (springeropen.com)
  • It is expected that these drugs will mainly increase HDL while lowering LDL. (wikidoc.org)
  • It is also the prototype for neuroprotective drugs that increase resistance to ischemic injuries. (patentpc.com)
  • It is the object of this invention that a method be developed to increase cerebral bioavailability for drugs. (patentpc.com)
  • Ever since, this natural detox cure has proven wildly beneficial in protecting us from alcohol, environmental toxins and prescription drugs-and even poisonous mushrooms. (thepeopleschemist.com)