Drugs for diseases neglected diseases. Medical search. Frequent questions

Under Dr Pécoul's vision and leadership, DND i delivered 12 new treatments for neglected diseases such as sleeping sickness, leishmaniasis, or for young children and infants with HIV. (dndi.org)
We anticipate that this methodology will be broadly applicable for the synthesis of potential drugs for the treatment malaria, Chagas' disease, leishmaniasis and African sleeping sickness. (ubc.ca)
Drug repurposing and nanoparticles: New strategies against leishmaniasis 12. (researchandmarkets.com)
NMTrypI addresses sleeping sickness, leishmaniasis, and Chagas disease. (europa.eu)
Leishmaniasis, a neglected tropical disease that is caused by protozoan parasites from the genus Leishmania, is not well understood. (healthinternetwork.org)
Visceral Leishmaniasis, which can affect the liver and spleen, is the most severe type of this disease. (healthinternetwork.org)
Antimonial drugs are the most commonly used treatment for leishmaniasis. (healthinternetwork.org)
Professionals and experts agree that leishmaniasis, a neglected tropical illness, needs more resources and attention to be managed. (healthinternetwork.org)
According to the authors, governments need to invest more in research into leishmaniasis and create new tools for diagnosing and treating the disease. (healthinternetwork.org)
Leishmaniasis, a neglected and serious tropical disease, affects many millions around the globe. (healthinternetwork.org)
These data demonstrated that non-dihydropyridine-CCBs present antiprotozoal activity and could be useful candidates for future in vivo efficacy studies against Leishmaniasis and Chagas' disease. (hindawi.com)
Leishmaniasis is a neglected infectious disease caused by several different species of protozoan parasites of the genus Leishmania . (hindawi.com)
Cutaneous leishmaniasis (CL), the most common form of leishmaniasis, has always been neglected as a major public health problem due to its non-fatality. (frontiersin.org)
The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. (lu.se)
Many of the analogues prepared were shown to be more potent in vitro than pulchrol and the current drugs used to treat Leishmaniasis and the Chagas disease (Miltefosine and Benznidazole respectively). (lu.se)

PLOS Neglected Tropical Diseases is the top Open Access tropical medicine journal, featuring an International Editorial Board and increased support for developing country authors. (plos.org)
PLoS Neglected Tropical Diseases, 2017, 11(5):e0005585. (fao.org)
PLoS Neglected Tropical Diseases, 2015, 9(7):e0003921. (fao.org)
PLoS Neglected Tropical Diseases, 2015, 9(6):e0003785. (fao.org)
A study in PLOS Neglected Tropical Diseases published in the journal PLOS said that improving access and diagnosis is key to decreasing the disease's burden. (healthinternetwork.org)

Chagas' disease is the leading cause of heart failure in Latin America. (ubc.ca)
Cruzain, the major cysteine protease of the causative organism Trypanosoma cruzi , is an optimal biological target for Chagas disease. (ubc.ca)
Diseases still present in Chile - such as Chagas disease, with around 120,000 people carrying the parasite in our country - or Hantavirus, which since 1996 to date has infected around 1,300 people in Chile, with a lethality of up to 40% - do not receive enough investment for research and development, and treatments remain old, ineffective, toxic, or simply non-existent. (dndi.org)
Is the Subject Area "Chagas disease" applicable to this article? (plos.org)
Nanomedicines against Chagas disease 10. (researchandmarkets.com)
Medscape 's Portuguese edition spoke with André Siqueira, MD, PhD, an infectious disease specialist and researcher at the Laboratory of Acute Febrile Diseases at the Oswaldo Cruz Foundation's Evandro Chagas National Institute of Infectious Diseases. (medscape.com)
We focus on eliminating African sleeping sickness, Chagas disease as well as taeniasis. (bayer.com)
We will continue supporting WHO in fighting African sleeping sickness and Chagas disease. (bayer.com)
As the only manufacturer of the treatments Nifurtimox and Suramin, recognized by the WHO as essential medicines, our initial focus has been on fighting the diseases these medicines treat like Chagas disease and African sleeping sickness (HAT). (bayer.com)

Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria. (cdc.gov)
Scientists warned the regulator that more than 70% of the $3bn global budget allocated for neglected disease R&D was allocated to HIV/AIDS, malaria, and tuberculosis, leaving little for other diseases. (pharmaceutical-technology.com)
Prompt diagnosis and treatment of malaria can prevent severe disease or death and limit ongoing transmission to local Anopheles mosquitoes and other persons. (medscape.com)
Preventing mosquito bites and controlling mosquitoes at home can prevent mosquitoborne diseases, including malaria. (medscape.com)
Other treatments (anti-malaria drugs) proved to be inadequate. (medscape.com)
The 4 major drug classes used to treat malaria include quinoline-related compounds, antifolates, artemisinin derivatives, and antimicrobials. (medscape.com)
This is the prophylactic drug of choice for sensitive malaria. (medscape.com)
When it is administered for treatment of P falciparum malaria, this drug must be used as part of combination therapy (eg, typically with quinine or quinidine). (medscape.com)
Clindamycin is part of combination therapy for drug-resistant malaria (eg, typically with quinine or quinidine). (medscape.com)
It is used for the prophylaxis or treatment of drug-resistant malaria. (medscape.com)
Research for such communicable diseases as tuberculosis and malaria has ground to a halt. (doctorswithoutborders.org)
Title : CDC's neglected tropical diseases program Corporate Authors(s) : Center for Global Health (U.S.), Division of Parasitic Diseases and Malaria. (cdc.gov)

The Neglected Tropical Diseases (NTDs) programme of the World Health Organization (WHO) country office is committed to managing and reducing the burden of NTDs. (who.int)
We work to raise community awareness of NTDs and promote social mobilization to support prevention, control and elimination of these diseases. (who.int)
The World Health Organization classifies a group of 20 conditions as neglected tropical diseases (NTDs). (dndi.org)
In its 'Road map for neglected tropical diseases 2021-2030', the World Health Organization outlined its targets for control and elimination of neglected tropical diseases (NTDs) and research needed to achieve them. (bvsalud.org)
WHO guidelines and country policies show that drugs may be recommended for control and elimination for NTDs for which they are not SRA approved (i.e. for 'off-label' use) if efficacy and safety data for the relevant NTD are considered sufficient by WHO and country authorities. (bvsalud.org)
Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). (researchandmarkets.com)
According to the World Health Organization (WHO), neglected tropical diseases (NTDs) are a group of diseases that disproportionately affect low-income populations. (ifhhro.org)
3,4] Data collected by the WHO show that although nearly one billion people are affected by NTDs because they have few economic resources and are often politically and economically marginalized, the international community has not allocated sufficient funds to eliminate these diseases. (ifhhro.org)
Together with the World Health Organization (WHO) and other partners, we are working towards the goal of sustainable elimination of some of the most devastating Neglected Tropical Diseases (NTDs) as public health problems in some of the most underserved regions of the world by 2030. (bayer.com)
NTDs are preventable and treatable diseases that place a heavy burden on the world's poorest populations. (bayer.com)
That is why we partner with the WHO and other organizations to eliminate NTDs through better understanding of disease burdens, socio-cultural contexts and the varied obstacles to healthcare access. (bayer.com)

Cysteine protease inhibitors have significant potential for use as therapeutics for parasitic diseases. (ubc.ca)

The organization was set up by key research and health institutions, notably from the public sector in neglected-disease-endemic countries - the Oswaldo Cruz Foundation from Brazil, the Indian Council of Medical Research, the Kenya Medical Research Institute, the Ministry of Health of Malaysia and France's Pasteur Institute, with seed funding from Médecins Sans Frontières' (MSF) 1999 Nobel Peace Prize. (wikipedia.org)
Dr Pizarro takes the helm from Dr Pécoul as the organization continues to expand the leadership role of the Global South and shift more medical research activities to neglected diseases-endemic countries. (dndi.org)
Mass drug administration entails annual distribution of diethylcarbamazine in combination with albendazole for a minimum of five years in an endemic area. (bmj.com)
The infectious diseases burden imposed by the parasites of Trypanosomatidae family represents a huge problem on people's lives in countries where these diseases are endemic. (europa.eu)
The partners are SMEs (5) and academics (8) in Europe and in disease-endemic countries (Italy, Greece, Portugal, Sudan, and Brazil). (europa.eu)

Empowering Women and Improving Female Reproductive Health through Control of Neglected Tropical Diseases. (cdc.gov)
Hotez PJ, Fenwick A, Savioli L, Molyneux D. Rescuing the bottom billion through control of neglected tropical diseases Cdc-pdf External . (cdc.gov)
Programmes, partnerships, and governance for elimination and control of neglected tropical diseases. (cdc.gov)
Prospects for the control of neglected tropical diseases by mass drug administration. (cdc.gov)
One of the speakers was Raman Velayudhan, PhD, the unit head of the WHO's Global Program on the Control of Neglected Tropical Diseases for coordinating the dengue and arbovirus initiatives. (medscape.com)

The WHO Special Programme for Research and Training in Tropical Diseases (TDR) acts as a permanent observer to the initiative. (wikipedia.org)
Examples of PDPs include the International AIDS Vaccine Initiative, MMV, the Global Alliance for TB Drug Development (TB Alliance), and DNDi. (wikipedia.org)
Dr Luis Pizarro, a Chilean-French medical doctor and global health expert, became the new Executive Director of the international non-profit medical research organization Drugs for Neglected Diseases initiative (DND i ). (dndi.org)
Drugs for Neglected Diseases initiative is a not-for-profit research organization that develops new treatments for neglected patients. (cinfo.ch)
One promising path is exploitation of the worldwide experience with 'off-label' treatment of diseases with insufficient treatment options as pursued by the ' CURE ID ' initiative. (bvsalud.org)
Beyond actually delivering new drugs to the patients who need them, we also expect that the NITD will become a model initiative contributing to a solution for the access-to-medicine problem in poor countries. (the-scientist.com)

The third sustainable development goal calls for elimination of neglected tropical diseases, including filariasis, by 2020. (bmj.com)
220 897 dengue fever cases, and 25 064 Rift Valley fever cases among arboviruses or vector-borne diseases reported in 2020. (who.int)
By the end of 2020, progress towards the 2030 targets had stalled and the neglected tropical disease road map targets for 2020 were not achieved. (who.int)
Performance and operational feasibility of two diagnostic tests for cryptosporidiosis in children (CRYPTO-POC): a clinical, prospective, diagnostic accuracy study, The Lancet Infectious Diseases (2020). (medicalxpress.com)

Support the health authorities to conduct mass drug administration campaigns with increased national coverage for (i) schistosomiasis, including more than 75% of treatment coverage for school-aged children, to eliminate the disease as a public health problem by 2025 and (ii) soil-transmitted helminthiasis, including deworming coverage for at least 75% of eligible school-aged children by 2021 and preschool children by 2026. (who.int)
The Health Assembly subsequently adopted the new neglected tropical disease road map (2021-2030). (who.int)

Centers for Disease Control and Prevention. (cdc.gov)
I will describe the build-up, operation, and international collaboration of the platform, with the ambition to share learnings and best practice with academic drug discovery centers globally. (selectbiosciences.com)
Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)
I'm Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)

These diseases affect some of the poorest and most marginalised populations in the world. (bmj.com)
Our work focuses on the medical needs of marginalized and difficult to reach populations living in developing countries, whose needs are often neglected. (doctorswithoutborders.org)
Addressing the many diseases that afflict the world's poorest populations, often in remote areas of the world, is not an easy task. (bayer.com)
The area has high rates of diarrhea and malnutrition and is therefore globally representative of the populations that are hardest affected by the disease. (medicalxpress.com)
The reinforcement principle is focused on the protection of populations at risk of filovirus diseases, and it is intended to promote the development of filovirus vaccines. (who.int)

As people with neglected diseases do not represent a lucrative market for pharmaceutical companies, incentives to invest in research and development are lacking for these diseases. (wikipedia.org)

These organisations would also welcome increased financial support for neglected tropical disease product development and testing, and an expansion of FDA's orphan grants programme," he said. (pharmaceutical-technology.com)
This programme comprises two key strategies: mass drug administration to prevent infection, and management of morbidity and prevention of disability. (bmj.com)
The integrated framework builds on progress made in the last two decades in the control, elimination and/or eradication of tropical and vector-borne diseases and addresses major programme deficiencies that drive the persistently high burden of these diseases and the lost momentum towards the 2030 targets. (who.int)

For example, the 3P Project (3), developed by MSF in collaboration with other organisations, would employ an open collaborative R&D framework and a combination of push, pull and pool mechanisms to promote the timely development of more effective treatments for drug-resistant tuberculosis (DR-TB). (bmj.com)
The NITD, a wholly owned Novartis affiliate supported by Singapore's Economic Development Board, is now focusing on discovering novel ways to prevent and treat tuberculosis and dengue fever-two neglected diseases prevalent in the developing world. (the-scientist.com)
Initially, the NITD will focus on two major tropical diseases: dengue fever and tuberculosis. (the-scientist.com)

Lymphatic filariasis is a tropical disease that affects about 70 million people worldwide. (bmj.com)
What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. (medscape.com)
Chikungunya, a tropical disease in poorer countries, is now becoming a major global health issue given the worldwide distribution of its mosquito vector ( Aedes albopictus and, to a less extent, Aedes aegypti ). (medscape.com)
A demo dataset is available from the ChEMBL - Neglected Tropical Disease archive at https://chembl.gitbook.io/chembl-ntd/downloads/deposited-set-2-novartis-gnf-whole-cell-dataset-20th-may-2010 . (nature.com)
As a center of knowledge and education in tropical disease drug discovery, the NITD will help people in the developing world learn how to continue to address these problems in their own countries. (the-scientist.com)

Existing treatments for this disease have low efficacy and unacceptable side effects. (ubc.ca)
Here, we are providing an overview of clinical research in the past 10 years evaluating the anti-infective efficacy of oral small-molecule drugs for NTD(s) for which they are neither SRA approved, nor included in current WHO strategies nor, considering the research sponsors, likely to be registered with a SRA for that NTD, if found to be effective and safe. (bvsalud.org)
Problems associated with existing drugs include inefficient delivery, insufficient efficacy, excessive toxicity and increasing resistance. (europa.eu)
The major objectives of this 3-year project are: i) development of drug leads which may be used in combination with a known or an investigational drugs, by using a common drug discovery platform established by experts in their respective fields, ii) development of pharmacodynamic biomarkers enabling the proteomic profiling of compound efficacy and early identification of drug resistance. (europa.eu)

To address the crisis in access to critical drugs for communicable diseases including HIV/AIDS but also such neglected diseases as Sleeping Sickness, Kala Azar and others, MSF has launched the Access to Essential Medicines Campaign. (doctorswithoutborders.org)

Sensitivity analysis of infectious disease models: methods, advances and their application. (cdc.gov)

Dr. Julia Schaletzky , Executive Director of the UCB Drug Discovery center and the Center for Emerging and Neglected Diseases, is the UCB campus lead and a member of the UC DDC executive committee. (berkeley.edu)

The high genetic variability of influenza A viruses poses a continual challenge to seasonal and pandemic vaccine development, leaving antiviral drugs as the first line of defense against antigenically different strains or new subtypes. (frontiersin.org)
Because there are no vaccine or antiviral drugs currently available for these patients, NITD will focus on discovering antiviral therapies for dengue virus-induced disease. (the-scientist.com)
There is no vaccine and current drugs for cryptosporidiosis are suboptimal, but new drugs are in development. (medicalxpress.com)

Though generally seen as a problem of the developed world, a recent article in the Lancet infectious Diseases (vol 9, page 130) found "… that its neglected status as a developing world pathogen does not equate with low rates of disease. (ubc.ca)
These findings are now published in a large article in the renowned medical journal The Lancet Infectious Diseases , with an accompanying commentary article. (medicalxpress.com)

Amendments to the PRV legislation are vital to ensuring it delivers benefits to neglected patients, yet even if fixed, the PRV mechanism alone is not enough to address unmet medical needs in the area of neglected diseases. (bmj.com)
UC DDC provides UC researchers with funding, mentorship, and resources to advance the creation of drugs that address important unmet medical needs. (berkeley.edu)

One publication reported that only 1.1% of new drugs were approved specifically for neglected diseases over a period of 25 years (1975 to 1999) despite the fact that these diseases represented 11.4% of the global burden. (wikipedia.org)
Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR. The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination. (cdc.gov)
Hotez PJ, Kamath A. Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden. (cdc.gov)
Measuring the burden of neglected tropical diseases: the global burden of disease framework. (cdc.gov)
In spite of representing more than 10% of the global disease burden, over the past decade, less than 3.8% of new drugs approved across the world were indicated for neglected diseases (2). (bmj.com)
India alone harbours 40% of the world's burden of disease. (bmj.com)
Annual epidemics represent an important disease burden and cause an estimated 250,000-500,000 deaths worldwide, and occasional pandemics are associated with increased morbidity and mortality ( 1 , 2 ). (frontiersin.org)
Tropical and vector-borne diseases contribute significantly to the global burden of communicable diseases. (who.int)

Human African trypanosomiasis in the Democratic Republic of the Congo: disease distribution and risk. (fao.org)

Since then, DND i has developed and delivered 12 new treatments for six deadly neglected diseases. (dndi.org)
DND i has already developed 12 affordable, available, and community-adapted treatments for six deadly diseases, such as hepatitis C that affects around 35,000 people in Chile. (dndi.org)

2018). CDC's neglected tropical diseases program. (cdc.gov)

More than a billion people - more than a seventh of the world's population - are infected with one of the 20 diseases listed by the World Health Organization (WHO) as neglected tropical diseases. (wikipedia.org)

We are already seeing the rise of climate-sensitive diseases like dengue, and the ongoing COVID-19 pandemic has shown how the fruits of medical innovation continue to be denied to the majority of the world's population. (dndi.org)
There's no specific treatment for any of those three arboviral diseases, [ meaning Zika, dengue, and chikungunya]. (medscape.com)
The disease is highly symptomatic and characterized by a Dengue-like episode (fever and rash) and a unique incapacity to walk, accompanied by myalgia and neurological symptoms. (medscape.com)

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. (elsevierpure.com)
Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. (elsevierpure.com)
But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. (elsevierpure.com)
These results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications. (elsevierpure.com)
combined, they provide a state-of-the-art pipeline for drug discovery. (berkeley.edu)
The consortium is governed by experts in drug discovery and development who serve as site lead representatives for their respective UC campuses. (berkeley.edu)
I'm very excited that we now can offer a much bigger range of resources through the UC-wide Drug Discovery Consortium. (berkeley.edu)
Dr. Schaletzky plans to also actively involve students in the effort and is currently setting up a "Drug Discovery Makerspace" in her center to provide highly relevant training for students interested in biotechnology. (berkeley.edu)
We further validate the potential of this culture system for high-throughput screening to prime and accelerate anti- P. vivax drug discovery efforts. (nature.com)
In the last decade, high-throughput screens based on cultured P. falciparum or on those of the hepatic stages of the rodent parasites P. berghei or P. yoelii , as reviewed in Hovlid and Winzeler 14 , have enriched the drug discovery pipeline with a wealth of promising novel lead compounds. (nature.com)
Given the regular and onerous use of P. cynomolgi in macaques for biological and drug discovery programmes, it was surprising that these early observations were not exploited further. (nature.com)
Atta-ur-Rahman, M. Iqbal Choudhary , " Anti-Angiogenesis Drug Discovery and Development ", Bentham Science Publishers (2011). (benthamscience.com)
Our findings show that JAEGER is a viable approach for finding novel active compounds for drug discovery. (nature.com)
Winkler, D. A. Use of artificial intelligence and machine learning for discovery of drugs for neglected tropical diseases. (nature.com)
We have established eight drug-discovery projects and our aim is to bring at least two compounds to clinical trials by 2008, and broadly make available two novel compounds by 2013. (the-scientist.com)
The NITD is the first establishment of its kind to focus solely on drug discovery for these infectious diseases using modern pharmaceutical research tools. (the-scientist.com)
This presentation will introduce the newly created Alzheimer's Research UK Drug Discovery Institutes and then illustrate how new inhibitors of the bromodomain of the BRPF family are being used to explore the fundamental biology and possible disease association of these proteins. (selectbiosciences.com)
CEO Chris Molloy explains how the Medicines Discovery Catapult will support fast-to-patient drug discovery in the UK and invites discussion with the audience in this interactive session. (selectbiosciences.com)
SciLifeLab DDD is a newly established national Swedish infrastructure for academic drug discovery. (selectbiosciences.com)

Integrated Implementation of Programs Targeting Neglected Tropical Diseases through Preventive Chemotherapy: Proving the Feasibility at National Scale. (cdc.gov)
Current strategies to control this disease are mainly based on chemotherapy. (hindawi.com)
Despite being available for the last 100 years, the chemotherapy is based on the use of few drugs, including the antimonial derivatives. (hindawi.com)
Monitoring drug coverage for preventive chemotherapy. (who.int)

Product development partnerships (PDPs), also called public-private partnerships (PPPs) aim to implement and accelerate research and development (R&D) into health tools (diagnostics, vaccines, drugs) for diseases that are neglected, by enabling new collaborations between private industry, academia, and the public sector. (wikipedia.org)
Informatics for neglected diseases collaborations. (cdc.gov)

A medical doctor by training, Dr Pizarro became the first CEO of Solthis from 2007 until 2019, an international health organization dedicated to increasing access to care for HIV, maternal health, and other infectious diseases in West Africa. (dndi.org)
To address this situation, when the international humanitarian organization Médecins Sans Frontières received the Nobel Peace Prize in 1999, it allocated the funds received to conduct a study that resulted in the creation of a collaborative, non-profit model for the research and development of new drugs for neglected diseases. (dndi.org)

Alternatives to profit-driven drug development emerged in the early 2000s to meet the needs of these neglected patients. (wikipedia.org)
To overcome the lack of commercial research into drug development, PDPs can apply "delinkage" principles that aim to separate the cost of research and development from the price of products. (wikipedia.org)
More than ever, there is a need for patient-centric not-for-profit drug development models like DNDi. (dndi.org)
It succeeded in establishing strong working partnerships with academia, public research institutions, and global pharmaceutical companies that historically had little interest in neglected diseases, showing that an alternative model for drug development, focused on patients' needs and not on profit, can deliver. (dndi.org)
Yet only a fraction of global pharmaceutical research and development focuses on diseases that affect poor and vulnerable communities. (cinfo.ch)
Trouiller P, Olliaro P, Torreele E, Orbinski J, Laing R, Ford N. Drug development for neglected diseases: a deficient market and a public-health policy failure. (cdc.gov)
Thus, a critical need exists for drug development. (ubc.ca)
As a medical humanitarian organisation that has been working to diagnose and treat people suffering from neglected diseases for almost 30 years (1), Médecins Sans Frontières (MSF) understands only too well that the dearth of research & development (R&D) for new tools to treat these diseases is directly attributable to a lack of funding and effective incentives. (bmj.com)
Our country has a fundamental role to play in leading the development of new treatments and tools that will enable us to advance in the NTD agenda and eliminate or control diseases that significantly affect Latin America. (dndi.org)
Our review of small-molecule anti-infective drugs recently approved by a stringent regulatory authority (SRA) or in at least Phase 2 clinical development for regulatory approval showed that this pipeline cannot deliver all new treatments needed. (bvsalud.org)
The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. (nature.com)
Furthermore, effective measures that could lead to its elimination would require the development of novel drugs to eliminate the hypnozoite, the dormant liver form responsible for relapses that also characterise P. vivax infections, as well as strategies to thwart transmission. (nature.com)
This book covers different therapeutic targets for angiogenesis interventions with emphasis on clinical development of antiangiogenic drugs that target antiangiogenic cascade in different forms of cancers like breast cancer, multiple myeloma, renal carcinoma, gastrointestinal, prostate and lung cancer. (benthamscience.com)
These diseases impair physical and cognitive development, contribute to mother and child illness and death, make it difficult to farm or earn a living, and limit productivity in the workplace. (bayer.com)
Finally, the cure principle intends to foster the development of post-exposure therapies that would help to reduce disease mortality as well as to reduce virus transmission. (who.int)
These infections have been classified as neglected diseases, and still require the development of safer and more efficient alternatives to their current treatments. (lu.se)

We help carry out mass drug administration campaigns to treat and prevent schistosomiasis and soil-transmitted helminthiases among high-risk groups. (who.int)
Implemented mass drug administration campaigns for school-aged children and adults for schistosomiasis and soil transmitted helminths since 2017. (who.int)
Schistosomiasis--drug therapy. (who.int)

Acting in the public interest, DNDi fills existing R&D gaps for essential drugs for these diseases by initiating and coordinating drug R&D projects in collaboration with the international research community, the public sector, the pharmaceutical industry and other relevant partners. (cinfo.ch)
Because there are no major economic markets for drugs to treat neglected tropical diseases in the US, Europe or Japan, major pharmaceutical companies are less likely to conduct their own R&D into these health issues. (pharmaceutical-technology.com)
This text book is a guide for pharmaceutical academics (students and teachers) as well as industry professionals learning about drug delivery and formulation. (benthamscience.com)

Many, and especially the industry, argue that the worst affected countries do not have the infrastructure or medical expertise to adequately administer the complex regimen of HIV/AIDs drugs. (doctorswithoutborders.org)
Even without ARVT, there is a lot of work to be done around the treatment of opportunistic diseases of Aids, such as cryptococcal meningitis, a common systemic fungal infection that can be deadly to people whose immune systems have been crippled by HIV. (doctorswithoutborders.org)
Clinically relevant medical condition other than HAT that, in the Investigator's opinion, may jeopardize patient safety or interfere with participation in the study, including but not limited to significant liver or cardiovascular disease, documented or suspected active infection (including AIDS), CNS trauma or seizure disorders, coma or altered consciousness. (who.int)

We are investigating iron uptake systems in Staphylococcus aureus , a significant opportunistic Gram positive pathogen with a high prevalence of multiple drug resistance such as MRSA. (ubc.ca)
Aberrant use and poor quality of trypanocides: a risk for drug resistance in Gurage zone, south western Ethiopia. (fao.org)
Cattle breeding, trypanosomosis prevalence and drug resistance in Northern Togo. (fao.org)
As resistance against drugs targeting viral proteins emerges rapidly, we assessed the antiviral activity of already approved drugs that target cellular proteins involved in the viral life cycle and were orally bioavailable. (frontiersin.org)
Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda. (cdc.gov)

It is based on the premise that repeated mass drug administration will reduce the microfilaria density in the community and thus halt transmission and new infections. (bmj.com)
Since March 2013, human infections with a previously undescribed H7N9 virus were observed, which also circulates in domestic birds without causing severe disease ( 8 ). (frontiersin.org)
Two classes of approved drugs against influenza A virus infections have been available for years: adamantane-based M2 ion channel blockers, which prevent acidification of the endosome and therefore release of the viral particles into the cytosol ( 10 ), and neuraminidase inhibitors, which prevent the release of newly formed viral particles from infected cells ( 11 ). (frontiersin.org)

Nanoformulations of old and new antimalarial drugs 11. (researchandmarkets.com)
Beware of counterfeit antimalarial drugs being taken by patients that may have been purchased overseas or via the internet. (medscape.com)

Evidence of the lack of new drugs for diseases that cause high mortality and morbidity among people living in poor areas has been published in the scientific literature. (wikipedia.org)

DNDi was created in 2003 to develop new treatments for neglected diseases. (wikipedia.org)
DNDi has built a large drug pipeline for neglected diseases with both improvements on existing drugs and entirely new chemical entities. (wikipedia.org)

Socioeconomic aspects of neglected tropical diseases. (cdc.gov)

Upon infection, susceptible (S) individuals develop primary disease (I1) at a rate proportional to the transmission rate and the total number of infectious individuals (I1 + I2). (cdc.gov)
As it is a silent disease, the vast majority (25,000 people in our country) are unaware that they are infected and, unfortunately, a significant number develop chronic infection. (dndi.org)
therefore, 1 or more classes of drugs often are given at the same time to combat malarial infection synergistically. (medscape.com)
Treatment regimens are dependent on the geographic location of infection, the likely Plasmodium species, and the severity of disease presentation. (medscape.com)
Antipyretics, such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), are indicated to reduce the level of discomfort caused by the infection and to reduce fever. (medscape.com)

Elephantiasis, Filarial--drug therapy. (who.int)

Push to cure hepatitis B, a neglected disease (4/10). (kff.org)

Despite the major progress achieved in medicine during the past 50 years, many tropical diseases affecting the poorest are still neglected. (wikipedia.org)

Yaws is the most prevalent infectious, nonvenereal treponemal disease and is caused by Treponema pallidum pertenue . (medscape.com)

Hotez PJ, Pecoul B. "Manifesto" for Advancing the Control and Elimination of Neglected Tropical Diseases. (cdc.gov)
Our mission is to reduce human suffering and death through the prevention, control, elimination and eradication of neglected tropical diseases using evidence-informed interventions. (who.int)
The pipeline for drugs for control and elimination of neglected tropical diseases: 2. (bvsalud.org)

Addressing an urgent need to develop better, more affordable vaccines and drugs for diseases that are devastating in lower income countries. (dundee.ac.uk)

Although neglected tropical diseases can be fatal, there is a lack of modern, safe and effective medications to treat these illnesses. (wikipedia.org)
The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. (flutrackers.com)
Between 1975 and 1997 out of 1,223 new drugs developed only 13 (1%) were to treat tropical diseases. (doctorswithoutborders.org)
Novartis and its stakeholders believe, however, that these diseases should not be neglected any longer, even if the pharmaceuticals used to treat them will not make a profit in the foreseeable future. (the-scientist.com)

It can bring about significant inflammation and, in some people, severe acute disease. (medscape.com)

Thus, antiviral drugs are an essential component of pandemic response scenarios and play an important role in reducing disease severity during seasonal influenza epidemics. (frontiersin.org)

We performed repeated simulations across a range of disease transmission assumptions (, n = 3) and treatment assumptions, varying both the coverage and number of mass treatment rounds undertaken (Table 1). (cdc.gov)
In addition, we calculated Partial-Rank Correlation Coefficients for all model parameters (disease and treatment), which calculates the correlation of each variable with the probability that eradication is achieved if all other parameters are kept fixed, as previously described ( 7 ). (cdc.gov)
Partial rank correlation coefficients of disease and treatment parameters with the probability of achieving yaws eradication. (cdc.gov)
Our vision is to save lives and improve the health of people living with neglected diseases by using an alternative model to develop medicines for these diseases and by ensuring equitable access to treatment. (cinfo.ch)
MSF calls on the US Congress to amend the PRV mechanism to close loopholes and ensure that benefits reach patients suffering from neglected diseases, and to consider additional mechanisms to incentivise R&D for neglected diseases that ensure all patients needing treatment are able to access the resulting products. (bmj.com)
Lipid nanoparticles for the treatment of neglected tropical diseases 17. (researchandmarkets.com)
Dextromethorphan treatment of ferrets infected with a pandemic H1N1 strain led to a reduction in clinical disease severity, but no effect on viral titer was observed. (frontiersin.org)
In addition to identifying dextromethorphan as a potential influenza treatment option, our study illustrates the feasibility of a bioinformatics-driven rational approach for repurposing approved drugs against infectious diseases. (frontiersin.org)
Pharmacological chaperones (PCs) are low-molecular weight chemical molecules used in patients for the treatment of some rare diseases caused primarily by protein instability. (upc.edu)
The most common treatment involves the use of antimonial drugs. (healthinternetwork.org)

Accordingly, most not-for-profit organisations and academic institutions would welcome additional guidance from the FDA and national regulatory authorities in countries where these diseases and conditions are part of the landscape. (pharmaceutical-technology.com)
To date, 115 countries have reported cases of the disease, which can cause chronic disabilities and have a major impact on quality of life. (medscape.com)
Our long-term aim is to help reduce the risk of these and other tropical diseases, and ultimately, to improve the prosperity of developing countries. (the-scientist.com)
Since the emergence of Ebola virus disease (EVD) in West Africa in 2013 the world has seen a constant surge of EVD outbreaks in Central and Western African countries. (who.int)

We discover, develop, and deliver new treatments for neglected patients around the world that are affordable and patient-friendly - and have already saved millions of lives. (cinfo.ch)
Patients receiving these drugs should be assessed for QT prolongation at baseline and carefully monitored if this is present. (medscape.com)
Patients with normal QT intervals on electrocardiogram (ECG) may not be at a significantly increased risk for drug-induced dysrhythmia, but caution is advised, particularly if the patient is taking multiple drug regimens or if they are on other drugs affecting the QT interval. (medscape.com)
And there's plenty of room for improvement as Pfizer has priced the drug worldwide beyond the reach of most patients. (doctorswithoutborders.org)
Many infectious diseases occur in the developing world and affect millions of patients who have not benefited from the biomedical science revolution. (the-scientist.com)

Research priorities for neglected infectious diseases in Latin America and the Caribbean region External PloS Negl Trop Dis. (cdc.gov)
Strategic emphases for tropical diseases research: a TDR perspective. (cdc.gov)
Our research focuses on the identification and characterization of candidate drug targets through the molecular genetic and genomic dissection of virulence mechanisms. (ubc.ca)
The first issue is ensuring there is adequate research efforts around neglected diseases. (doctorswithoutborders.org)

Leishmaniasis15

PLOS Neglected Tropical5

Chagas9

Malaria12

NTDs11

Parasitic1

Endemic5

Control of neglected tropical5

Initiative6

20204

20212

Centers4

Populations5

People with neglected diseases1

Programme3

Tuberculosis3

Tropical disease5

Efficacy4

Sleeping sickness1

Infectious disease1

Center for Emerging1

Vaccine3

Lancet2

Unmet medical needs2

Burden8

Human African trypano1

Treatments for six deadly2

20181

World Health Organ1

Dengue3

Discovery19

Chemotherapy4

Collaborations2

Organization2

Development16

Schistosomiasis3

Pharmaceutical3

AIDS3

Resistance5

Infections3

Antimalarial2

Mortality1

DNDi2

Socioeconomic1

Infection5

Filarial1

Hepatitis1

Poorest1

Prevalent1

Elimination3

Addressing1

Treat4

Severe1

Antiviral drugs1

Treatment10

Countries4

Patients5

Research4