Drugs drug resistance bacterial. Medical search. Frequent questions

Baptista M , Depardieu F , Reynolds P , Courvalin P , Arthur M . Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci. (cdc.gov)
Courvalin P . Genotypic approach to the study of bacterial resistance to antibiotics. (cdc.gov)
CDC supports judicious use of antibiotics and antifungals in people and animals, including the important work that the U.S. Food and Drug Administration (FDA) and U.S. Department of Agriculture (USDA) are doing to improve antibiotic use in veterinary medicine and agriculture. (cdc.gov)
In this analysis for example, the index displayed how physicians were able to use other drugs for treating resistant strains of E. coli infections, and how very few options remained for treating Acinetobacter, a super bug, which is more and more resistant to all available antibiotics. (medicalnewstoday.com)
If we do nothing, resistance will continue to develop and our most valuable antibiotics ultimately will fail. (medicalnewstoday.com)
17). Resistance to most commonly available antibiotics was moderate to very high among Gram-positive and Gram-negative isolates. (who.int)
To make things worse, many pharmaceutical companies have lost interest in pursuing the expensive research and development needed to develop novel antibiotics because rapid resistance leads to a failure to recuperate their investments," Bromhead said. (nzherald.co.nz)
Protein-based entities that attach to bacterial cells and infect them, phages only target the bacteria they are meant to kill, eliminating any disruption of the greater microbiome that can occur with some antibiotics. (nzherald.co.nz)
Infections are treated with antibiotics, though they are becoming more difficult to treat as the bacteria develop resistance to the drugs, according to the CDC. (livescience.com)
According to the National Center for Biotechnology Information (NCBI) 2013 estimate, conjunctivitis impacted around 6 million persons in the U.S. Bacterial conjunctivitis takes about a week to cure, and fluoroquinolones are the most commonly used antibiotics for treating bacterial conjunctivitis. (medgadget.com)
This may result in the prescribing of strong drugs such as corticosteroids and antibiotics at high doses. (medgadget.com)
Antibiotics that require bacterial division will be less effective, as biofilm-forming bacteria are usually in a quiescent state. (vin.com)
Antibiotic resistance, where disease-causing bacteria evolve resistance to drugs that usually kill them, is a rising problem globally, meaning new antibiotics need to be found. (innovationtoronto.com)
A team led by professor Alain Filloux at Imperial College London, and Despoina Mavridou at The University of Texas at Austin has identified a potential drug target that could be an ideal candidate for the development of novel antibiotics. (innovationtoronto.com)
Most ubiquitous essential processes are already being inhibited by existing drugs, while specialized antibiotics usually inhibit only one bacterial species. (innovationtoronto.com)
The history of antibiotics is cyclical: Drugs are developed, but bacterial evolution can soon render them ineffective in treating infections. (pewtrusts.org)
Despite antibiotics' vital role in cancer care, companies have abandoned their development in favor of more profitable drugs. (pewtrusts.org)
ISABEL GORDO Bacteria exposed to antibiotics rapidly acquire mutations that allow them to develop resistance to the drugs, and this process is fairly well understood. (the-scientist.com)
therefore, the current study was designed to assess the efficacy of certain antibiotics, toothpaste, and medicinal plant extracts ( Ajuga bracteosa and Curcuma longa ) versus the bacterial pathogens isolated from the human oral cavity. (scielo.br)
The data obtained through this study revealed that antibiotics were more effective for oral bacterial pathogens than toothpaste and plant extracts which showed moderate and low activity, respectively. (scielo.br)
This is potentially much more dangerous than resistance to antibiotics," warned study lead author Craig MacLean, a professor of Evolution and Microbiology at Oxford. (alipac.us)
The use of antibiotics has long been a contentious issue, with many experts warning that the widespread use of these drugs in livestock contributes to the rise of antibiotic-resistant bacteria. (alipac.us)
The pressing need for new antibiotics has sparked a growing interest in AMPs as potential solutions, including drugs based on human AMPs. (alipac.us)

If compensatory mutations are indeed widespread, pathogens can reach both high level of resistance and high fitness. (elifesciences.org)
The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved. (wikipedia.org)
The objective of the current ering new classes of antimicrobials and the increasing study was, therefore, to assess the bacteriologic pro- emergence and reemergence of resistant pathogens, file, resistance pattern, and patient's outcome in Lan- mortality from infectious disease is increasing [1]. (who.int)
Most bacterial pathogens responsible for such infections are enclosed by polysaccharide capsules that protect them from phagocytosis and complement- mediated killing, ensuring their persistence on the respiratory mucosa and survival in the bloodstream and deep body tissues. (cdc.gov)
However, until now no estimates have covered all locations and a broad range of pathogens and drug combinations, according to the researchers. (hindustantimes.com)
The new Global Research on Antimicrobial Resistance (GRAM) report estimates deaths linked to 23 pathogens and 88 pathogen-drug combinations in 204 countries and territories in 2019. (hindustantimes.com)
Among all the bacterial species, Staphylococcus aureus (29.62%) and Proteus mirabilis (22.2%) were found to be more prevalent oral pathogens. (scielo.br)
The main pathogens isolated from the nosocomial infections were significantly more resistant to the first-line recommended drug. (biomedcentral.com)

It can be used by hospitals to track their own resistance levels and to measure their own success of interventions, such as antibiotic stewardship and infection control programs. (medicalnewstoday.com)
MRSA is a serious bacterial skin infection. (medicalnewstoday.com)
This report presents recommendations of the Hospital Infection Control Practices Advisory Committee for preventing and controlling the spread of vancomycin resistance, with a special focus on VRE. (cdc.gov)
It is likely that patterns of microbial infection and antibiotic resistance in ICU patients differ widely from one hospital or country to another and are often facilitated by the increasing use of invasive techniques, immunosuppressive drugs and inappropriate antibiotic therapy [1,4-7]. (who.int)
The objective of this study was to investigate the incidence of microbial infection in association with antibiotic resistance among patients consecutively admitted to the adult ICU in the Jordan University Hospital in Amman over a one-year period. (who.int)
Shigellosis is an acute enteric infection that is an important cause of domestically acquired and travel-associated bacterial diarrhea in the United States. (cdc.gov)
The Canadian HIV Strain and Drug Resistance Surveillance Program (SDR program) monitors and assesses HIV strains and the transmission of HIV drug resistance among individuals with newly diagnosed and not yet treated HIV infection in Canada. (canada.ca)
Primary drug resistance is resistance observed in treatment-naive individuals with newly diagnosed HIV infection, in whom resistance is presumably due to the transmission of a drug-resistant variant of HIV-1. (canada.ca)
Although newer classes of drugs are available, the most commonly used drugs approved for the treatment of HIV infection fall into three classes: nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). (canada.ca)
Disease burden was estimated in two ways: deaths caused directly by AMR (ie deaths that would not have occurred had the infections been drug-susceptible and therefore more treatable), and deaths associated with AMR (ie where a drug-resistant infection was implicated in deaths, but resistance itself may or may not have been the direct cause). (hindustantimes.com)
The growth of ophthalmic bacterial infection boosted the demand for antibacterial medications for treating it. (medgadget.com)
The chronic inflammation makes each bout of infection harder to treat and repeated antimicrobial use may select for resistance. (vin.com)
Several important viral diseases, like measles and COVID-19, and the bacterial infection tuberculosis are important examples of illnesses that spread directly from human to human through the inhalation of droplets and/or aerosols that carry the infectious agents. (birmingham.ac.uk)
When choosing drug treatments, the acquisition site of infection and the local epidemiological situation should be taken into account. (biomedcentral.com)
Your provider may order a bacteria culture test if you have symptoms of a bacterial infection . (medlineplus.gov)
If harmful bacteria are found in your sample, it usually means you have a bacterial infection. (medlineplus.gov)

Globally, in 2018 about half a million TB infections were rifampicin-resistant, of which 78% were multi-drug resistant (MDR)-TB ( World Health Organization [WHO], 2019a ). (frontiersin.org)
Herniation can sometimes occur in acute bacterial meningitis and other CNS infections as the consequence of severe cerebral edema or acute hydrocephalus. (medscape.com)
Candida auris is a newly emerging drug-resistant fungus that has led to infections in healthcare facilities across the world. (medicalnewstoday.com)
This increase poses important problems, including a) the lack of available antimicrobial therapy for VRE infections, because most VRE are also resistant to drugs previously used to treat such infections (e.g., aminoglycosides and ampicillin), and b) the possibility that the vancomycin-resistant genes present in VRE can be transferred to other gram-positive microorganisms (e.g. (cdc.gov)
Vancomycin resistance in enterococci has coincided with the increasing incidence of high-level enterococcal resistance to penicillin and aminoglycosides, thus presenting a challenge for physicians who treat patients who have infections caused by these microorganisms (1,4). (cdc.gov)
Des infections microbiennes ont été observées chez 30% (155/519) de l'ensemble des malades admis au service de soins intensifs pour adultes de l'Hôpital universitaire de Jordanie à Amman en 1993. (who.int)
Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
Bacteriophages, or phages as they are more simply known, are used today in Russia, Georgia and Poland to fight bacterial infections. (nzherald.co.nz)
At least 1.2 million people died in 2019 as a direct result of antibiotic-resistant bacterial infections, according to a study published in the medical journal Lancet. (hindustantimes.com)
Hundreds of thousands of deaths now occur due to previously treatable infections as they have become resistant to drugs. (hindustantimes.com)
In effect, hundreds of thousands of deaths now occur due to common, previously treatable infections such as lower respiratory and bloodstream infections as the bacteria that cause them have become resistant to drugs. (hindustantimes.com)
Drug resistance in lower respiratory infections - such as pneumonia - had the greatest impact on AMR disease burden, causing more than 400,000 deaths and associated with more than 1.5 million deaths. (hindustantimes.com)
Drug resistance in bloodstream infections - which can lead to the life-threatening condition sepsis - caused around 370,000 deaths and was associated with nearly 1.5 million deaths. (hindustantimes.com)
Drug resistance in intra-abdominal infections - commonly caused by appendicitis - led directly to around 210,000 deaths and was associated with around 800,000. (hindustantimes.com)
Repurposing of Drugs to Fight Persistent Infections-Antibacterial Compounds Against Non-growing Bacteria. (asm.org)
Ceftin is available as a generic drug and is prescribed to treat infections with susceptible bacteria including skin and middle ear infections, tonsillitis , throat infections, laryngitis , bronchitis , pneumonia , urinary tract infections, and gonorrhea . (rxlist.com)
The new drug target, identified in Pseudomonas aeruginosa , is also crucial for the survival of other pathogenic bacteria, including those that cause meningitis, urinary tract infections and staph infections - meaning any antibiotic targeting it could have a range of uses. (innovationtoronto.com)
Used to help diagnose bacterial or fungal infections in your respiratory tract, such as bacterial pneumonia , tuberculosis , bronchiectasis , and histoplasmosis . (medlineplus.gov)
Used to detect bacterial infections in your digestive system, including food poisoning . (medlineplus.gov)

Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. (elifesciences.org)

We present our study on the efficacy and phenotypic impact of compensatory evolution in Escherichia coli strains carrying multiple resistance mutations. (elifesciences.org)
Malaria in 2012 has become a resurgent threat in South East Asia and sub-Saharan Africa, and drug-resistant strains of Plasmodium falciparum are posing massive problems for health authorities. (wikipedia.org)
XDR Shigella strains can spread antimicrobial resistance genes to other enteric bacteria. (cdc.gov)
The emergence of drug resistance in treated populations (antiretroviral treatment-experienced patients) and transmission of drug- resistant strains to newly infected individuals are important public health concerns in the prevention and control of HIV. (canada.ca)
CEFTIN tablets are indicated for the treatment of pediatric patients (who can swallow tablets whole) with acute bacterial otitis media caused by susceptible strains of Streptococcus pneumoniae , Haemophilus influenzae (including β-lactamase-producing strains), Moraxella catarrhalis (including β-lactamase-producing strains), or Streptococcus pyogenes . (rxlist.com)
CEFTIN for oral suspension is indicated for the treatment of pediatric patients aged 3 months to 12 years with acute bacterial otitis media caused by susceptible strains of Streptococcus pneumoniae , Haemophilus influenzae (including β-lactamase-producing strains), Moraxella catarrhalis (including β-lactamase-producing strains), or Streptococcus pyogenes . (rxlist.com)
From the patients' ascitic fluids, 334 pathogenic strains, including 178 Gram-negative bacterial strains, 138 Gram-positive bacterial strains and 18 other microbial strains were isolated. (biomedcentral.com)
The strains isolated from the patients with nosocomial SBP displayed higher drug resistance than those isolated from patients with community-acquired SBP. (biomedcentral.com)
In the study, E. coli strains carrying a resistance gene called MCR-1 were exposed to AMPs known to play significant roles in innate immunity across chickens, pigs and humans. (alipac.us)

BDQ resistance is especially associated with mutations in atpE and Rv0678 genes. (frontiersin.org)
A rapid process of sharing resistance exists among single-celled organisms, and is termed horizontal gene transfer in which there is a direct exchange of genes, particularly in the biofilm state. (wikipedia.org)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
data are preliminary and based on broth microdilution susceptibility testing and/or presence of resistance genes and mutations found in whole genome sequences of bacterial DNA. (cdc.gov)
Phenotypic tests assess growth of a virus containing the genes of interest in the presence of drugs against which resistance is being determined. (canada.ca)
They then studied one of the new toxin genes, known as Tse8, to find out how it was able to harm bacterial competitors. (innovationtoronto.com)
The excessive use of colistin in livestock farming during the 1980s contributed to the emergence and spread of E. coli bacteria carrying colistin resistance genes, leading to subsequent restrictions on the drug's agricultural use. (alipac.us)
Sometimes molecular methods can be used to detect specific resistance genes. (msdmanuals.com)

Tuberculosis (TB) is one of the major causes of death related to antimicrobial resistance worldwide because of the spread of Mycobacterium tuberculosis multi- and extensively drug resistant (multi-drug resistant (MDR) and extensively drug-resistant (XDR), respectively) clinical isolates. (frontiersin.org)
Multiple bacterial isolates from a single patient with the same resistance patterns were considered as one isolate for studying minimum inhibitory concentration (MIC) using Micro Scan, Type TN dried panel (Baxter Health Care Corporation, West Sacramento, California, USA). (who.int)
In-vitro Antibacterial Activity of a Fosfomycin-Trimethoprim-Sulfamethoxazole Combination Against a Bacterial Collection of Multidrug-Resistant Clinical Isolates. (asm.org)
Establishment of Loop Mediated Isothermal Amplification Assay for the Surveillance of Multi-drug Resistance Markers in P.vivax Clinical Isolates and Chloroquine Transporter Markers in P.falciparum Clinical Isolates. (asm.org)

However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of resistance may proceed too slowly to be of practical importance. (elifesciences.org)
The extent of resistance loss was found to be generally antibiotic-specific, driven by mutations that reduce both resistance level and fitness costs of antibiotic-resistance mutations. (elifesciences.org)
We conclude that phenotypic reversion to the antibiotic-sensitive state can be mediated by the acquisition of additional mutations, while maintaining the original resistance mutations. (elifesciences.org)
However, in other cases, such deleterious side effects of resistance mutations are undetectable, and resistance can even confer benefits in specific, antibiotic-free environmental settings ( Maharjan and Ferenci, 2017 ). (elifesciences.org)
It is frequently assumed that such compensatory mutations mitigate the fitness costs of resistance mutations without affecting the level of resistance. (elifesciences.org)
As the range of targets for compensation is much broader, compensatory mutations are more likely than the reversion of resistance mutations. (elifesciences.org)
Unfortunately, BDQ quickly acquired two main mechanisms of resistance, consisting in mutations in either atpE gene, encoding the target, or in Rv0678 , coding for the repressor of the MmpS5-MmpL5 efflux pump. (frontiersin.org)
Finally, we also constructed a data sheet including the mutations associated with BDQ resistance that could be useful for the early detection of BDQ-resistance in MDR/XDR patients with the purpose of a better management of antibiotic resistance in clinical settings. (frontiersin.org)
The most common mutations linked to low-level of BDQ resistance are present in Rv0678 gene coding for the M. tuberculosis repressor of MmpS5-MmpL5 efflux system. (frontiersin.org)
Drug resistance largely results from changes (mutations) in the genetic material that code for these enzymes, rendering ART less effective. (canada.ca)
Most mutations do not result in the development of drug resistance, as they are lethal, reduce fitness, or even if not affecting viral growth, occur at sites that are not targeted by ART. (canada.ca)
However, under conditions in which treatment does not completely inhibit viral replication, a virus with drug-resistant mutations may begin to thrive, resulting in treatment failure. (canada.ca)
By comparing the generated sequences with databases containing resistance-conferring mutations, the presence or absence of drug resistance can be determined. (canada.ca)

When an organism is resistant to more than one drug, it is said to be multidrug-resistant. (wikipedia.org)

Development of a Rabbit Model of Nosocomial Pneumonia to Combat Emergence of Resistance. (asm.org)
A Randomized, Double-Blind, Placebo Controlled Multicenter Study to Evaluate the Efficacy and Safety of CAL02 Administered Intravenously in Addition to Standard of Care in Subjects With Severe Community Acquired Bacterial Pneumonia (SCABP). (asm.org)

This can be seen in cancerous tumors where some cells may develop resistance to the drugs used in chemotherapy. (wikipedia.org)

Acute bacterial meningitis is a medical emergency, and delays in instituting effective antimicrobial therapy result in increased morbidity and mortality. (medscape.com)

To fight MDR and XDR tuberculosis, three new antitubercular drugs, bedaquiline (BDQ), delamanid, and pretomanid were approved for use in clinical setting. (frontiersin.org)
According to the World Health Organization (WHO) report, in 2018, tuberculosis (TB), caused by Mycobacterium tuberculosis , was one of the major causes of death related to antimicrobial resistance ( World Health Organization [WHO], 2019a ). (frontiersin.org)

The susceptibility and resistance breakpoints are based on tissue levels following systemic dosing. (vin.com)
Susceptibility Testing Susceptibility tests determine a microbe's vulnerability to antimicrobial drugs by exposing a standardized concentration of organism to specific concentrations of antimicrobial drugs. (msdmanuals.com)

The emergence of multi-drug resistance types is expected to drive the global bacterial conjunctivitis drugs market growth over the forecast period. (medgadget.com)

Biochemical and Biophysical Characterization of Klebsiella pneumoniae FabI, a Target for Antibacterial Drug Discovery. (asm.org)
CEFTIN is a semisynthetic, cephalosporin antibacterial drug for oral administration. (rxlist.com)

Biofilms may also enhance the development of antimicrobial resistance - a gradual decrease in antimicrobial concentration means that some bacteria could be exposed to a mutant selection window. (vin.com)
From the 1950s onwards, the development of antimicrobial drugs and vaccines have been powerful additions to our arsenal against infectious diseases. (birmingham.ac.uk)

Antibiotic and antifungals use in food animals can help treat, control, and prevent bacterial diseases in animals. (cdc.gov)
At the same time, rapidly developing resistance of microbes to anti- infective drugs is undermining treatment of bacterial, viral and parasitic diseases, weakening the weapons against them. (who.int)
tracking epidemic and emerging diseases and anti-infective drug resistance, and locating communicable diseases geographically within countries, regionally and globally. (who.int)

Drug, toxin, or chemical resistance is a consequence of evolution and is a response to pressures imposed on any living organism. (wikipedia.org)
This epidemiologic setting substantially differs from that of large families in that the latter include children of different ages and therefore, at any given time, only a fraction of siblings belong to the age group at enhanced risk for bacterial colonization and invasion, which limits the chances to acquire and transmit the organism. (cdc.gov)

Much of the U.S. progress in combating antimicrobial resistance was lost in 2020, in large part, due to the effects of the COVID-19 pandemic. (cdc.gov)

The researchers explain how the index can be applied to evaluate trends in resistance linked to two disease-causing microorganisms, namely Escherichia coli and Acinetobacter baumannii. (medicalnewstoday.com)

Bacterial meningitis must be the first and foremost consideration in the differential diagnosis of patients with headache, neck stiffness, fever, and altered mental status. (medscape.com)
The diagnosis of bacterial meningitis is made by culture of the CSF sample. (medscape.com)

In short, the lack of concerted effort by governments and the pharmaceutical industry, together with the innate capacity of microbes to develop resistance at a rate that outpaces development of new drugs, suggests that existing strategies for developing viable, long-term anti-microbial therapies are ultimately doomed to failure. (wikipedia.org)

However, they readily acquire multi-drug resistance (see below). (vin.com)

Available data suggest that the prevalence of primary drug resistance in Canada is similar to that observed in other developed countries where highly active antiretroviral treatment is widely used. (canada.ca)
The increasing prevalence of bacterial conjunctivitis necessitates the development of new medications, such as vancomycin ophthalmic ointment, which are in the clinical testing pipeline and a few are awaiting approval. (medgadget.com)

Oral Pharmacokinetics and Efficacy of BWC0977, a Novel Bacterial Topoisomerase Inhibitor. (asm.org)
Antibiotic sensitivity data can be used to predict the efficacy of systemic drugs, although penetration to the ear tissues is often low and high doses are needed. (vin.com)

Spontaneous bacterial peritonitis (SBP) is a serious complication and common cause of death in patients with liver cirrhosis. (biomedcentral.com)

Such strategies implicitly presume that resistance leads to reduced bacterial fitness in an antibiotic-free environment, and therefore these resistant populations should be rapidly outcompeted by antibiotic-sensitive variants. (elifesciences.org)

The four main mechanisms by which microorganisms exhibit resistance to antimicrobials are: Drug inactivation or modification: e.g., enzymatic deactivation of Penicillin G in some penicillin-resistant bacteria through the production of β-lactamases. (wikipedia.org)

Both types of drug resistance limit strategies for antiretroviral therapy (ART), have important implications for HIV-related morbidity and mortality, and may result in increased health care costs. (canada.ca)

to antimicrobial drugs. (msdmanuals.com)

Unnecessary antibiotic use leads disease-causing bacteria to chemically develop and grow resistant to drugs. (medgadget.com)
Colistin, derived from a bacterial AMP, is chemically similar to certain AMPs produced in the human immune system. (alipac.us)

NNRTIs), a single mutation may be associated with a high level of resistance to drugs from that same class. (canada.ca)

Without alternative strategies, the acquisition of drug resistance by pathogenic microorganisms looms as possibly one of the most significant public health threats facing humanity in the 21st century. (wikipedia.org)

The actual increase in the incidence of VRE in U.S. hospitals might be greater than reported because the fully automated methods used in many clinical laboratories cannot consistently detect vancomycin resistance, especially moderate vancomycin resistance (as manifested in the VanB phenotype) (9-11). (cdc.gov)

The likely sensitivity of Malassezia and staphylococci can be predicted using knowledge of local resistance patterns and previous treatment. (vin.com)

Bacterial conjunctivitis spreads due to inadequate hygiene, compromised immune systems, ocular illnesses such as blepharitis and dry eye, and infected cosmetics. (medgadget.com)

The most commonly used drugs used in ART target the reverse transcriptase (RT) and protease enzymes. (canada.ca)

Scientists have now looked at the evolution of bacterial resistance toward live agents: cells of the immune system. (the-scientist.com)
MacLean noted that the danger lies in the potential evolution of bacterial resistance to AMP-based drugs. (alipac.us)

A total of 130 samples were collected from Khyber Teaching Hospital Peshawar, Pakistan, among those 27 species isolated, and eight bacterial species were identified from the samples. (scielo.br)
The human mouth serves as the best habitat for numerous bacterial species due to its alkaline condition, favourable to most bacteria and fungi. (scielo.br)

Among these cases, 6.2% were estimated to have extensively drug-resistant (XDR)-TB ( World Health Organization [WHO], 2019a ). (frontiersin.org)
A Parallel Threat of Extensively Drug-Resistant Typhoid Fever in Pediatric Cohort During COVID-19 Pandemic. (asm.org)

Because the drug is so specific, any mutation in these molecules will interfere with or negate its destructive effect, resulting in antibiotic resistance. (wikipedia.org)

Burden of Antimicrobial Resistance in Hospitalized Patients with Cancer: A Multicenter Analysis. (asm.org)

Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. (wikipedia.org)
Mapping the geography of antibiotic use and summarizing their effectiveness with a Drug Resistance Index bring us one step closer to the solutions we urgently need in order to curtail this public health crisis. (medicalnewstoday.com)

Bacterial culture and sensitivity testing can help identify organisms that are hard to differentiate on cytology (e.g., streptococci, enterococci, E. coli , Klebsiella , Proteus and coryneforms). (vin.com)
This work on the development of E. coli macrophage resistance and virulence is important," wrote James Shapiro , a professor of microbiology at the University of Chicago who was not involved in the work, in an e-mail to The Scientist . (the-scientist.com)

Moubareck C , Bourgeois N , Courvalin P , Doucet-Populaire F . Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice. (cdc.gov)

Wait until Abx Tx complete to administer live bacterial vaccine. (medscape.com)
Drug interactions with Ceftin include vaccines (for example, typhoid vaccine) and probenecid. (rxlist.com)

This study was conducted to compare the microbiological characteristics, drug resistance, and treatment outcomes for nosocomial SBP and community-acquired SBP. (biomedcentral.com)

The rising number of cases of bacterial conjunctivitis demands effective medication, which fuels the global bacterial conjunctivitis drugs market growth over the forecast period. (medgadget.com)
Our Ceftin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)

This Epi Update provides a summary of primary HIV drug resistance in Canada and in other developed countries and includes an overview of data from the Canadian Strain and Drug Resistance Surveillance (SDR) program, a collaboration between the provinces and the Public Health Agency of Canada (the Surveillance and Risk Assessment Division and the National HIV and Retrovirology Laboratories). (canada.ca)

Magnet S , Courvalin P , Lambert T . Activation of the cryptic aac ( 6 ´)- Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion. (cdc.gov)
Unless the drug used makes sexual reproduction or cell-division or horizontal gene transfer impossible in the entire target population, resistance to the drug will inevitably follow. (wikipedia.org)
On average, the gene increased resistance to human and animal AMPs by 62 percent. (alipac.us)

We have demonstrated that drug-resistance frequently declines within 480 generations during exposure to an antibiotic-free environment. (elifesciences.org)
Exploring the Effect of Sub-MIC Antibiotic Exposure on Bacterial Hetero-resistance at Single Cell Level. (asm.org)

Anatomy8

Organisms22

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Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes76

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Antibiotics23

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Strains9

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Multidrug-resistant1

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Susceptibility2

Emergence1

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20201

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