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  • therapeutic
  • Additionally, if one drug is a administered as a prodrug, as is the case with certain anticancer therapeutic agents, and a PXR agonist is then coadministered, the resulting increased biotransformation of the prodrug would probably produce profound and unwanted toxic side effects. (aspetjournals.org)
  • Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. (aiocm.org)
  • Traces of therapeutic activities in China date from the Shang dynasty (14th-11th centuries BCE). (wikipedia.org)
  • Dosage
  • The reader is advised to consult with a physician or other medical professional and to check product information (including packaging inserts) for changes and new information regarding dosage, precautions, and contra indication before administering any drug, herb, supplement, compound, therapy or treatment discussed herein. (cancerconnect.com)
  • Metabolism
  • Mechanisms include (a) decreased uptake of drug, (b) reduced intracellular drug concentration by efflux pumps, (c) altered cell cycle checkpoints, (d) altered drug targets, (e) increased metabolism of drug and (f) induced emergency response genes to impair apoptotic pathway. (aiocm.org)
  • Therapy
  • The cork tree is native to the Amur River watershed in northeastern China and far western Russia, and its extract is widely available as an herbal supplement, so if it is successful as a cancer therapy it could potentially offer a price advantage for patients as well. (healthcanal.com)
  • To manage the condition, most health care professionals turn to drug therapy. (naturalnews.com)
  • PXR-mediated herb-drug interactions can have undesirable effects in patients receiving combination therapy. (aspetjournals.org)
  • These data are of particular importance due to the fact that this herbal remedy is currently marketed as an adjunct therapy that reduces the side effects of conventional chemotherapy and is available without a prescription. (aspetjournals.org)
  • Future studies should be conducted to determine the extent to which coadministration of this Chinese herbal remedy alters the pharmacokinetic and pharmacodynamic properties of conventional anticancer therapy. (aspetjournals.org)
  • The (ca. 730) dietary therapy book Shiliao bencao 食療本草 ("Nutritional Materia Medica") prescribes daily consumption of cannabis in the following case: "those who wish to see demons should take it (with certain other drugs) for up to a hundred days. (wikipedia.org)
  • Plant
  • Pharmacological activity of the plant species varies depending on processing (dried or steamed) and location of cultivation (eg, Japan versus China). (drugs.com)
  • Nyssa sinensis (Chinese tupelo) is a species of flowering plant in the family Cornaceae (or Nyssaceae), native to China and Vietnam. (wikipedia.org)
  • Early Chinese classics have many references to using the plant for clothing, fiber, and food, but none to its psychotropic properties. (wikipedia.org)
  • Herbals were often illustrated to assist plant identification. (wikipedia.org)
  • supplement
  • According to this law, the dietary supplement manufacturer is responsible for ensuring that a dietary supplement is safe before it is marketed, but does not need to provide such information to the US Food and Drug Administration unless it is contains an ingredient not sold in the US prior to 1994. (cancerconnect.com)
  • Amrita Bindu--a salt-spice-herbal health food supplement for the prevention of nitrosamine induced d. (biomedsearch.com)
  • mechanism
  • A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. (aiocm.org)
  • Proposed drug efflux mechanism for ABC transporters. (aiocm.org)
  • Substrate drugs can bind to Pgp through multiple binding sites, thereby allowing flexibility in the mechanism of transport [11, (aiocm.org)
  • OBJECTIVE: To explore the clinical effect and possible mechanism of Shengxueling (SXL), a Chinese medical preparation mainly consisting of ginseng saponins, in treating refractory idiopathic thrombocytopenic purpura (ITP). (biomedsearch.com)
  • cells
  • Although it protects cells from toxic insults, it also represents the molecular basis for an important class of drug-drug interactions. (aspetjournals.org)
  • Multi-drug resistance (MDR) in cancer chemotherapy refers to the ability of cancer cells to survive from treatment of a wide range of drugs . (aiocm.org)
  • In addition to the MDR induced by drugs in early exposure, the MDR cancer cells may subsequently develop cross-resistance to several unexposed and structurally unrelated chemotherapeutic agents . (aiocm.org)
  • Cancer cells can develop resistance to multiple drugs by various mechanisms as depicted. (aiocm.org)
  • ABCG2 is localized in the apical region in cells and transports many cytotoxic drugs, detoxified metabolites, toxins and carcinogens . (aiocm.org)
  • northeastern
  • R. glutinosa is a perennial herb that grows wild in northern and northeastern China, particularly in Hunan province. (drugs.com)
  • include
  • The concept does not include synthesized compounds manufactured in China. (nih.gov)
  • Mechanisms of MDR include decreased uptake of drugs, alterations in cellular pathways and increased active efflux of drugs [3-(Figure ​(Figure1).1). (aiocm.org)
  • treatment
  • The rats were then given a treatment of either budesonide or the herbal mixture - or both. (naturalnews.com)
  • citation needed] In 1993, a series of end-stage renal disease cases was reported from Belgium associated with a weight loss treatment, where Stephania tetrandra in a herbal preparation was suspected of being substituted with Aristolochia fangchi. (wikipedia.org)
  • Taiwan
  • Chinese: 高雄醫學大學), originally known as Kaohsiung Medical College, is a private university located in Sanmin District, Kaohsiung, Taiwan. (wikipedia.org)
  • Ting-Chao Chou (born 1938 in Taiwan, Chinese name: 周廷潮) is a Chinese American theoretical biologist, pharmacologist, cancer researcher and inventor. (wikipedia.org)
  • His brief essay On Praising Lotus Flower (愛蓮說) was recited by many hundred millions of school children since it was selected in the standard high school textbook in both mainland China and Taiwan. (wikipedia.org)
  • Under the Japan's rule of Taiwan 1895-1945, the Chou family established a private family school teaching Chinese characters and classics. (wikipedia.org)
  • oncology
  • A leader in developing new drugs to treat cancer, the CTRC Institute for Drug Development (IDD) conducts one of the largest oncology Phase I clinical drug programs in the world, and participates in development of cancer drugs approved by the U.S. Food & Drug Administration. (healthcanal.com)
  • cancer
  • P-glycoprotein (Pgp), multidrug-resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP/ABCG2) is frequently observed in cancer cell lines selected with chemotherapeutic drugs and critical to clinical drug resistance . (aiocm.org)
  • Mechanisms of MDR towards cancer chemotherapeutic drugs. (aiocm.org)