• We next investigated whether the inhibition of FASN by using a specific FASN inhibitor, cerulenin, can influence growth and EMT/metastatic potential of A549CisR and H157CisR cells. (oncotarget.com)
  • Further experiments showed that NPD6433 and cerulenin, another fatty acid synthase inhibitor, were able to kill numerous yeast species in the culture. (scitechdaily.com)
  • Cerulenin, a fatty acid synthase (FASN) natural inhibitor, and Atorvastatin, a competitive inhibitor of the mevalonate pathway, have been used to test the cytotoxic effects on PDAC CSCs. (atlasofscience.org)
  • Through screening the RIKEN natural product depository (NPDepo) and identifying a specific compound, NPD6433, that inhibits fatty acid synthase, they found this approach reduced fatalities in infected laboratory worms by about 50% and may offer a promising alternative to current treatments that are becoming less effective due to increasing drug resistance. (scitechdaily.com)
  • Finally, blocking lipogenesis with fatty acid synthase inhibitors (cerulenin and C75) and siRNA-mediated silencing of SREBP1 and ATP citrate lyase (ACL) significantly attenuated GSK3 inhibition-induced senescence. (koreamed.org)
  • Since the 1970s, Ōmura has discovered more than 480 new compounds, of which 25 kinds of drugs and reagents are in use. (wikipedia.org)
  • Furthermore, compounds having a unique structure and biological activity discovered by Omura are drawing attention in drug discovery research, and new anticancer drugs and the like have been created. (wikipedia.org)
  • To address this notion, known natural Epoxide compounds, Cerulenin and Fosfomycin were examined for QSI activity for the agr and fsr systems in addition to in silico and SAR studies. (springeropen.com)
  • No significant tumor regression was detected at the end of cerulenin treatment, but IHC staining showed higher expression of EMT/metastasis markers in H157CisR cell-derived tumors than H157P cell-derived tumors, and showed dramatic reduction of these markers in tumor tissues of cerulenin-treated mice, confirming the in vitro results. (oncotarget.com)
  • QSI marking cyclic peptide-mediated QS in Gram-positive bacteria is an effective tool to overcome the crisis of antibiotic-dependent chemotherapy due to the emergence of drug resistance strain, e.g., methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin resistant Enterococci (VRE). (springeropen.com)
  • Methicillin-resistant S. aureus (MRSA) and vancomycin-resistant Enterococci (VRE) are among the most dangerous drug-resistant bacteria. (springeropen.com)
  • The World Health Organization (WHO) expressed grave worry in 2017 about the progress of new antibiotics against diseases caused by multi-drug resistant (MDR) pathogens, including VRE and MRSA. (springeropen.com)
  • Drug-resistant fungi are a growing problem, and leads for the development of new drugs offer hope against these evolving pathogens," says Yoko Yashiroda, lead RIKEN CSRS author of the study. (scitechdaily.com)
  • Previously, it has been shown that saké yeast strains resistant to the antifungal cerulenin produce significantly lower levels of VA. In this study, we used a classical mutagenesis method to isolate a series of cerulenin-resistant strains, derived from a commercial diploid wine yeast. (oregonstate.edu)
  • When integrated into the genome of a haploid wine strain, the mutated YAP1 alleles partially reproduced the low-VA production phenotype of the diploid cerulenin-resistant strains, suggesting that YAP1 might play a role in (regulating) acetic acid production during fermentation. (oregonstate.edu)
  • Reproducing the Brethren: Grain Provisioning of Norwich Cathedral Priory, c. keeping in the Other organization: psychiatry and einem in the Writings of Smaragdus of St. Intertextuality in the fungi of St. Polluting the Sacred: drug and cloud in English Daily Life c. (xn--drpverein-rahe-vpb.de)
  • Campbell later acquired these bacteria and developed the derived drug ivermectin that was first commercialised for veterinary use in 1981 later put to human use against Onchocerciasis in 1987-88 with the name Mectizan, and is today used against river blindness, lymphatic filariasis, scabies and other parasitic infections. (wikipedia.org)
  • It is believed that the large molecular size of ivermectin prevents it from crossing the blood/aqueous humour barrier, and renders the drug an important treatment of helminthically-derived blindness. (wikipedia.org)
  • Platinum-based drugs, particularly cis-diammine-dichloroplatinum (II) (cisplatin, DDP), are used in the treatment of many cancers, including lung cancer. (oncotarget.com)
  • Conventional molecular target drugs can selectively inhibit gene mutations which activate prolifiration of cancer cells, but many patients in which gene mutations cannot be detected are not targets of the molecular target drugs. (justia.com)
  • Groves FD, Zhang L, Chang YS, Ross PF, Casper H, Norred WP, You buy, Fraumeni JF Jr. Fusarium rates in response and growth drugs in a MCF-7 contamination for predictive surface in Shandong Province, China. (xn--drpverein-rahe-vpb.de)
  • Social-economic factors predict state differences in opioid… Media accounts of the opioid overdose epidemic emphasize the role of prescription drugs and, to a lesser extent, declining economic and social conditions. (atlasofscience.org)
  • At present, as new drug targets for anti-TB agents, the high-resolution structures of gene products encoded by virulence genes are now available, and structure-based inhibitor design is now underway, with the prospect of generating new classes of drugs that are potently active against MTB. (medscape.com)
  • beta-ketoacyl carrier protein synthase as a drug target, implications from the crystal structure of a complex with the inhibitor cerulenin. (berkeley.edu)
  • 11. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. (nih.gov)
  • Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis. (nih.gov)
  • In view of the interaction of the drug with hepatic cytochrome P-450, we studied the effects of CsA on bile acid synthesis, in which several cytochrome P-450-dependent enzymes are involved [10]. (docksci.com)
  • Furthermore, compounds having a unique structure and biological activity discovered by Omura are drawing attention in drug discovery research, and new anticancer drugs and the like have been created. (wikipedia.org)
  • In isolated rat liver mitochondria, 26-hydroxylation of cholesterol was potently inhibited by the drug (concn. (docksci.com)
  • 13. Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling. (nih.gov)
  • After briefly exploring webmd, i have not widely identified any specific harmful drug interactions between isoprenaline and octamoxin. (sbolot.org)
  • Northern blot analyses indicated that CgPDR1 regulated both constitutive and drug-induced expression of CgCDR1, a multidrug transporter gene. (nih.gov)
  • Cyclosporin A (CsA) is one of the most effective immunosuppressive drugs available and is widely used in organ transplantation [1,2]. (docksci.com)
  • Approved drugs associated with a target. (nih.gov)
  • Masoprocol was associated with fewer adverse effects now than teriflunomide, including adverse effects are leading to drug discontinuance. (sbolot.org)
  • Opposite effects of stimulant and antipsychotic drugs on striatal fast-spiking interneurons. (harvard.edu)
  • This graph shows the total number of publications written about "Cerulenin" by people in this website by year, and whether "Cerulenin" was a major or minor topic of these publications. (rush.edu)
  • There are a number of constraints that have deterred companies from making efforts to develop new anti-TB drugs. (medscape.com)
  • This problem should be tackled via the development of such new anti-TB drugs with the global cooperation of medical researchers, pharmaceutical companies and public agencies. (medscape.com)
  • In order to combat intractable TB, especially MDR- and XDR-TB, the development of new classes of drugs exhibiting potent anti-MTB activity without crossresistance to the existing anti-tuberculous drugs is urgently required. (medscape.com)