• To prevent the recurrence of tumors after surgery, conventional therapies such as chemotherapy fail to differentiate sufficiently between healthy and cancerous cells. (genengnews.com)
  • It has been used in chemotherapy to help treat malignant mesothelioma, a cancer that is highly resistant to standard cancer drugs. (survivingmesothelioma.com)
  • The standard chemotherapy approach to mesothelioma is a combination of pemetrexed (Alimta) and a platinum-based drug such as cisplatin. (survivingmesothelioma.com)
  • A team of medical researchers in Italy have achieved what they are calling "excellent" tumor control and survival results in malignant pleural mesothelioma patients using a combination of surgery, chemotherapy, and radiotherapy. (survivingmesothelioma.com)
  • The study may support a regimen to produce complete remission with front-line therapy, without the increased risks associated with systemic chemotherapy or a stem cell transplant. (mdanderson.org)
  • As first-line chemotherapy for patients with peritoneal mesothelioma, the combination of pemetrexed plus gemcitabine is active and can be an option for patients who cannot take cisplatin. (medscape.com)
  • This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therapy (ACT) in four shehias (smallest administration unit) that had been identified as hotspots through Zanzibar's malaria case notification surveillance system. (biomedcentral.com)
  • For the treatment of falciparum malaria, WHO is recommending the use of a type of drug called artemisinin-based combination therapy, or ACTs. (cdc.gov)
  • Combination therapy has gained momentum in oncology in recent years, with various studies demonstrating higher response rates with combinations of drugs compared to monotherapies, and the FDA recently approving therapeutic combination regimens that demonstrated superior safety and efficacy to monotherapies. (wikipedia.org)
  • The company unveiled on Tuesday positive data from Phase I and Phase II studies for three different triple combination regimens for CF patients with certain types of gene mutations with one F508del mutation and one minimal function mutation (F508del/Min). (drugdiscoverytrends.com)
  • [ 1 ] Combination drug regimens are considered the standard of care for treatment of HIV infection and for prevention of perinatal HIV transmission. (medscape.com)
  • Results from a three year double-blinded trial which compared antiretroviral therapies show that the combination regimens of tenofovir DF and stavudine, are equally effective, though tenofovir DF has more favorable outcomes with respect to cholesterol levels and the nervous system. (news-medical.net)
  • Among the advantages of multitarget drugs vs drug combinations are the more predictable pharmacokinetic (PK) and pharmacodynamic (PD) relationship of the components of a single medicine, the possibility that one motif might improve the bioavailability of the second entity, the greater efficacy against advanced-stage diseases, the lower toxicities, the simultaneous presence of the chemical entities in multiple tissues, and the improved patient compliance [ 2 ]. (biomedcentral.com)
  • As a pediatric endocrinologist, I can tell you we're seeing more and more Type 2 diabetes in kids and adolescents, and it seems to be a more aggressive form than adult onset diabetes, so we do need better therapies to achieve even greater efficacy and degree of weight loss," said Andrea Haqq , a professor in the University of Alberta's Faculty of Medicine & Dentistry . (eurekalert.org)
  • Further studies should also focus on how differences in biological sex affect drug efficacy and safety. (eurekalert.org)
  • Accordingly, they illuminated new uses for IDO1 inhibitors to enhance the antitumor efficacy of hypoxia/metabolic stress-inducing drugs in cancer and other diseases. (mainlinehealth.org)
  • Combination drug studies using IDO inhibitors to safely enhance the efficacy of cancer cell-targeted therapeutics, including RAS/RAF pathway inhibitors, PI3K/mTOR pathway inhibitors and hypoxia-inducing agents. (mainlinehealth.org)
  • An important step is to monitor the efficacy of this drug. (cdc.gov)
  • The support we provide can include financial support, training in how to do efficacy monitoring, providing quality assured drug, and reviewing the data. (cdc.gov)
  • Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options. (medindia.net)
  • Monotherapy, or the use of a single therapy, can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. (wikipedia.org)
  • The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. (rxreasoner.com)
  • Approved and experimental epigenetic drugs are undergoing clinical trials in combination with other therapeutic agents via fused or linked pharmacophores in order to benefit from synergistic effects of polypharmacology. (biomedcentral.com)
  • Another current trend in therapy is drug repurposing or the re-discovery of a new therapeutic area for a drug used traditionally to treat a given pathology, either through the ability to modulate an additional target or by the involvement of the primary target in multiple pathologies. (biomedcentral.com)
  • With the invention and development of laser technology, photo-based therapeutic modalities such as photodynamic therapy (PDT) and photothermal therapy (PTT) have become prospective minimally invasive approaches for cancer treatment [ 1 - 5 ]. (thno.org)
  • Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. (nature.com)
  • These new uses broaden the number of therapeutic combinations and applications for IDO inhibitors that would not otherwise be obvious. (mainlinehealth.org)
  • We describe the clinical courses and detail treatments of 20 critically ill patients with invasive mechanical ventilation, which may be valuable for determining future therapies and intensive care of critically ill patients with COVID-19. (fortunejournals.com)
  • In a recent study about solid cancers, Martin Nowak, Bert Vogelstein, and colleagues showed that in most clinical cases, combination therapies are needed to avoid the evolution of resistance to targeted drugs. (wikipedia.org)
  • In addition, the regulatory requirements are more complex when the agents are used in combination, since the safety profile of each drug needs to be demonstrated before clinical trials, and this can be further delayed due to regulatory and IP issues, in particular if the two drugs are being developed by different companies [ 1 ]. (biomedcentral.com)
  • It is possible that the addition of a third agent may be tolerated clinically in such a dosing regimen and provide the opportunity to overcome, or ameliorate, the major clinical problem of resistance to targeted therapies," they concluded. (pharmaceutical-journal.com)
  • Re-treated patients who fail to achieve undetectable HCV-RNA at Week 12 of therapy, or whose HCV-RNA remains detectable after 24 weeks of therapy, are highly unlikely to achieve SVR and discontinuation of therapy should be considered [see Clinical Studies (14.1) ]. (drugs.com)
  • The duration of treatment should be individualized to the patient depending on baseline disease characteristics, response to therapy, and tolerability of the regimen [see Indications and Usage (1.1) , Adverse Reactions (6.1) , and Clinical Studies (14) ]. (drugs.com)
  • We therefore conclude that the GNS@CaCO 3 /ICG holds great promise for clinical applications in anti-tumor therapy with tumor imaging or drug tracing. (thno.org)
  • image: Andrea Haqq (right) is bringing her clinical experience working with patients to an international collaboration aimed at identifying personalized drug combinations to better treat people with obesity and Type 2 diabetes. (eurekalert.org)
  • Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
  • In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
  • The technology expands the potential clinical scope of use for this drug class. (mainlinehealth.org)
  • While two clinical trials of SCID-X1 gene therapy have shown success, some infants developed leukaemia as a result of the integrating virus used for gene delivery, a risk previously estimated as insignificant. (edu.au)
  • My project also includes an ethics component to investigate risk and uncertainty in clinical gene therapy, which allows me to draw on my undergraduate training in science and law. (edu.au)
  • Although considerable information is accumulating on the relationship between genetic variation and drug metabolism and adverse effects, precious little evidence exists for their added value in clinical practice. (cdc.gov)
  • Currently, cisplatin as a single drug has been used as the standard drug for phase III clinical trials. (medscape.com)
  • artemisinin-based combination therapies, long-lasting insecticide-treated bednets, and rapid diagnostic tests, and progress in the development of new drugs and vaccines is encouraging. (who.int)
  • Pharmaceutical' combination therapy may be achieved by prescribing/administering separate drugs, or, where available, dosage forms that contain more than one active ingredient (such as fixed-dose combinations). (wikipedia.org)
  • Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. (biomedcentral.com)
  • Mass drug administration for malaria was well accepted by communities at high risk of malaria in Zanzibar, with high participation and completion rates. (biomedcentral.com)
  • One potential strategy for targeted interventions in a malaria elimination setting is focal mass drug administration (MDA) in high-risk populations. (biomedcentral.com)
  • A drug derived from the eggs of leopard frogs may offer new hope for people with intractable malignant mesothelioma - especially if the drug is administered in combination with a malaria drug called dihydroartemisinin (DHA). (survivingmesothelioma.com)
  • Although DHA, the second drug in the experimental combination, is designed to treat malaria , it has also been shown to exhibit antitumor and antivirus activities. (survivingmesothelioma.com)
  • The report also includes a summary on the status of drug resistance for TB, HIV and malaria. (who.int)
  • Health Organization, about drug resistant malaria treatment in Vietnam. (cdc.gov)
  • However, monotherapies may also be used because of unwanted side effects or dangerous drug interactions. (wikipedia.org)
  • Interactions between Chinese herbal medicinal products and orthodox drugs / Kelvin Chang and Lily Cheung. (who.int)
  • These multiple ligands should in principle have a lower risk of drug-drug interactions and drug resistance compared to cocktails or multicomponent drugs. (biomedcentral.com)
  • Called lipin, the gene may provide a new target for therapies to control obesity, diabetes and other weight-related disorders. (news-medical.net)
  • Canadian and German researchers are teaming up to identify new drug combinations to treat people with obesity and Type 2 diabetes. (eurekalert.org)
  • treatment options for mesothelioma patients, including a recently-approved combination drug therapy. (nolo.com)
  • Keep in mind that doctors who specialize in the treatment of mesothelioma patients typically use a combination of the therapies described below (called a "multimodal" approach). (nolo.com)
  • Conclusion: We conducted multidisciplinary treatments using a single protocol, including antiviral drugs, methylprednisolone and daily proning, for critically ill COVID-19 patients who required invasive mechanical ventilation. (fortunejournals.com)
  • Also, the researchers explored the safety and tolerability of VX-659 as a component of a triple combination for two weeks in 12 patients with CF that were ages 18 and older with one F508del mutation and one minimal function mutation (3 in placebo and 9 in VX-659 120 mg), according to the announcement. (drugdiscoverytrends.com)
  • Low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in a group of patients with HIV lipodystrophy, a condition involving the redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection. (news-medical.net)
  • Nutritional therapy for HIV-infected patients is shifting focus. (news-medical.net)
  • Use of an oral antidiabetes medication produced significant improvement in a group of patients with HIV lipodsytrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)
  • Discontinuation of therapy should be considered in patients who do not achieve at least a 2 log 10 drop or loss of hepatitis C virus (HCV)-RNA at 12 weeks, or if HCV-RNA remains detectable after 24 weeks of therapy. (drugs.com)
  • The treatment duration for patients who previously failed therapy is 48 weeks, regardless of HCV genotype. (drugs.com)
  • The recommended dose of REBETOL when used in combination with PegIntron in pediatric patients ages 3-17 years is 15 mg/kg/day in two divided doses (see Table 2 ). (drugs.com)
  • There have been a number of systematic reviews of the effectiveness of antihypertensive therapy, but most have focused on overall effectiveness [ 1 , 2 ] or effectiveness in special groups such as elderly patients. (cmaj.ca)
  • Sometimes, patients with higher blood pressure need combination treatment -- even initially -- to bring it to a normal range. (webmd.com)
  • The researchers conclude that combining the drugs has several advantages, including higher effectiveness in at least some patients and fewer side-effects. (eurekalert.org)
  • Even a five per cent weight loss is considered clinically meaningful, and patients in some of the combination drug trials are achieving 10 or 15 per cent, said Haqq, who is a member of the Alberta Diabetes Institute and the Women and Children's Health Research Institute . (eurekalert.org)
  • A combination of ponatinib and blinatumomab was found to be safe and highly effective in patients with newly diagnosed or relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
  • This trial shows that the combination of ponatinib and blinatumomab produces high rates of complete molecular response, which reduces the chances that patients will relapse and increases the likelihood that they will be disease-free. (mdanderson.org)
  • This treatment combination is very attractive since it minimizes the risk of treatment-related complications for the patient, especially for older patients who have existing medical comorbidities and typically have a poor prognosis. (mdanderson.org)
  • Antibody-drug conjugates (ADCs) are revolutionizing care for patients with certain advanced solid tumors. (medscape.com)
  • Given the growing number of patients receiving ADCs and the expanding indications for their use, understanding the toxicity profiles of these drugs, and developing strategies to mitigate and manage these side effects have become paramount, Paolo Tarantino, MD, of the Dana-Farber Cancer Institute in Boston, and colleagues explained in a recent review exploring ADC toxicities and efforts to improve patient safety. (medscape.com)
  • Sur les 655 patients fébriles, 35,9 % ont été recensés comme étant atteints de paludisme en se fondant sur les résultats de laboratoire de l'hôpital. (who.int)
  • Fingerstick self-glucose monitoring is recommended for all patients receiving insulin or sulfonylureas, those starting or changing therapy, and those who have not met treatment goals or who have intercurrent illness. (medscape.com)
  • Insulin therapy is indicated in symptomatic patients with persistent hyperglycemia, the presence of an HbA 1c of more than 9%, or ketoacidosis. (medscape.com)
  • Liraglutide, a glucagonlike peptide-1 (GLP-1) agonist, is the first noninsulin drug approved to treat type 2 diabetes in pediatric patients since metformin was approved for pediatric use in 2000. (medscape.com)
  • Abacavir hypersensitivity reaction affects 5 to 8% of patients and can be observed during the first 6 weeks of antiretroviral therapy. (cdc.gov)
  • [ 21 , 22 ] In a study of 25 patients with resectable malignant pleural mesothelioma, a 1-week course of high-dose hemithoracic intensity-modulated radiation therapy (IMRT) before extrapleural pneumonectomy proved feasible and prolonged survival. (medscape.com)
  • Single-agent pemetrexed therapy showed a response rate of 10.5%, a median time to progressive disease of 6 months, and a median survival time of 14 months in chemo-naive patients. (medscape.com)
  • This drug was chosen partly because genetic analysis of the parasites in the study showed that the parasites from all 46 patients had a single copy of the gene Pfmdr1 , confirming that all parasites were sensitive to mefloquine. (cdc.gov)
  • They found that treating cells with a MEK-PI3K-inhibitor combination led to a synergistic effect in cell growth inhibition. (pharmaceutical-journal.com)
  • However, adding a low concentration of navitoclax, a BCL2-family inhibitor, to the MEK-PI3K regimen in previously untreated cells resulted in improved synergistic interaction between the therapies and blocked the acquisition of resistance. (pharmaceutical-journal.com)
  • Other combinations may include an ACE inhibitor with a thiazide diuretic. (webmd.com)
  • Similarly, trastuzumab emtansine (Kadcyla), enfortumab vedotin (Padcev), mirvetuximab soravtansine (Elahere), and tisotumab vedotin (Tivdak), which have a microtubule inhibitor as the payload, come with similar toxicities to the microtubule-inhibiting drugs. (medscape.com)
  • Disparities in combination drug therapy use in older adults with coronary heart disease: a cross-sectional time-series in a nationally representative US sample. (umassmed.edu)
  • Combination ART is more effective than a single-drug regimen in reducing perinatal transmission. (medscape.com)
  • or didanosine [ddI] and d4T) for most HIV exposures and an expanded regimen that includes the addition of a third drug for HIV exposures that pose an increased risk for transmission. (cdc.gov)
  • The report concludes, "The Onc/DHA combination therapy may have the potential to become a novel regimen for NSCLC and mesothelioma. (survivingmesothelioma.com)
  • In a phase III study, Vogelzang et al showed the superior benefits of a regimen using pemetrexed in combination with cisplatin over administration of cisplatin alone. (medscape.com)
  • Recent precision medicine approaches have focused on targeting multiple biomarkers found in individual tumors by using combinations of drugs. (wikipedia.org)
  • Dr. Artzi asserted that the patch can also serve as a neoadjuvant, a therapy designed to shrink tumors prior to their resection. (genengnews.com)
  • Antiretroviral therapy (ART) during pregnancy should focus on the reduction of perinatal transmission and the treatment of maternal human immunodeficiency virus (HIV) disease. (medscape.com)
  • Regardless of HIV viral load and CD4 count, all HIV-infected pregnant people should be offered antiretroviral therapy (ART) to reduce perinatal transmission. (medscape.com)
  • Combination antiretroviral therapy is the most effective pharmacotherapy for HIV treatment. (cdc.gov)
  • One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously. (wikipedia.org)
  • Once it is slapped on a tumor, it delivers a combination of drug, gene, and light-based therapy. (genengnews.com)
  • By delivering therapy locally, releasing tiny amounts of drug to a tumor site, the new patch can avoid the side effects that often accompany systemic treatments. (genengnews.com)
  • Also, with systemically administered treatments, only a small portion of the drug reaches the tumor site itself, meaning that the primary tumor is not treated as effectively as it should be. (genengnews.com)
  • Indeed, even when the tumor was not removed, the triple-combination therapy alone was enough to destroy it. (genengnews.com)
  • In this study, the calcium carbonate worked not only a drug keeper to entrap ICG on the surface of GNSs in the form of a stable aggregate which was protected from blood clearance, but also as the a pH-responder to achieve highly effective tumor-triggered drug release locally. (thno.org)
  • Meanwhile, the distinct pH-triggered drug release performance of GNS@CaCO 3 /ICG implemented the tumor-targeted NIR fluorescence imaging. (thno.org)
  • In addition, we monitored the bio-distribution and excretion pathway of GNS@CaCO 3 /ICG based on the NIR fluorescence from ICG and two-photon fluorescence and photoacoustic signal from GNSs, and the results proved that GNS@CaCO 3 /ICG had a great ability for tumor-specific and tumor-triggered drug release. (thno.org)
  • A newly-published Chinese report suggests that the combination has anti-tumor effects on non-small cell lung cancer and malignant mesothelioma not seen with conventional cancer drugs. (survivingmesothelioma.com)
  • the combination of Onconase and DHA disrupted the cancer cells' ability to form blood vessels that feed a growing tumor. (survivingmesothelioma.com)
  • The addition of separate adapter molecules (AMs) specific for tumor antigens and CAR-immune cells targeting these AMs allows a more precise and temporally limited therapy. (nature.com)
  • Thereby, several antigens can be targeted at once and the therapy can be adapted in case antigen-loss tumor variants appear. (nature.com)
  • One well-known example of on-target, off-tumor toxicity is ADC-related cardiotoxicity, which can occur with HER2-targeted drugs that use trastuzumab . (medscape.com)
  • Researchers treated a panel of 47 human colorectal cancer cell lines with combinations of MEK- PI3K- and ERK-inhibitors. (pharmaceutical-journal.com)
  • Preclinical proof of concept for this drug class in combination with RAS/RAF, PI3K/mTOR and hypoxia-inducing targeted therapeutics. (mainlinehealth.org)
  • The combination of prednisolone and the antithrombotic drug dipyridamole was profiled using in vitro and in vivo models of anti-inflammatory activity and glucocorticoid-induced adverse effects to demonstrate a dissociated activity profile. (biomedcentral.com)
  • To benefit from those effects, it is required that the multitarget drug exhibit balanced in vitro and in vivo activities to match potency for the corresponding targets, as well as optimized PK and safety profiles. (biomedcentral.com)
  • Treating colorectal cancer with a trio of targeted drugs reduces the acquisition of drug resistance, in vitro research published in Oncogene shows (25 March 2019) [1] . (pharmaceutical-journal.com)
  • The application of GNS@CaCO 3 /ICG for in vitro and in vivo therapy achieved the combined antitumor effects upon the NIR irradiation, which was superior to the single PDT or PTT. (thno.org)
  • To test the impact of the combination, the research team applied it to NSCLC and mesothelioma cells in the laboratory (in vitro). (survivingmesothelioma.com)
  • In June 2019, the US Food and Drug Administration (FDA) approved liraglutide for children aged 10 years or older with type 2 diabetes mellitus. (medscape.com)
  • Different stimulus including pH, light and temperature have been used for controlled drug release to prevent drug inactivation and minimize side-effects. (thno.org)
  • Sometimes, using lower doses of one or more drugs in combination can minimize side effects. (webmd.com)
  • After finding that triple-combination therapy may help to prevent resistance acquisition in colorectal cancer cells, the researchers said that future studies should look into questions of timing, dosage and tolerability. (pharmaceutical-journal.com)
  • The researchers said the findings indicated that triple-combination therapy may help to prevent resistance acquisition, rather than overcoming pre-existing resistance. (pharmaceutical-journal.com)
  • There is no syndrome that causes increased belly fat and decreased facial and limb fat among HIV-positive men who take antiretroviral drugs, according to a study by researchers at the San Francisco VA Medical Center and the University of California, San Francisco. (news-medical.net)
  • The article detailed how the researchers used a prophylactic hydrogel patch to deliver a combination of gene, drug, and phototherapy in a colon cancer mouse model. (genengnews.com)
  • The researchers recently published a paper that examines the potential of several drugs that control incretins. (eurekalert.org)
  • In addition to drug combinations, the researchers are looking for non-pharmacological solutions, such as how adding fibre to a person's diet can slow weight gain and improve the effectiveness of existing diabetes medications. (eurekalert.org)
  • Presumptive HIV treatment with combination ART including 6 weeks of zidovudine should be administered to infants born to people who did not receive antepartum care or did not have a sustained viral response during pregnancy. (medscape.com)
  • Should not be administered in combination with zidovudine (poor antiretroviral effect). (cdc.gov)
  • Four drug classes were evaluated in the trials: thiazides (21 trials), beta-adrenergic blockers (5), calcium-channel blockers (4) and angiotensin-converting-enzyme (ACE) inhibitors (1). (cmaj.ca)
  • The same cannot be said for high-dose thiazide therapy, beta-blockers, calcium-channel blockers or ACE inhibitors. (cmaj.ca)
  • However in the last years, immunotherapies using immune-checkpoint inhibitors (ICI), as well as cellular therapies, have moved into the limelight as promising alternative treatments. (nature.com)
  • Thus, there is a need for drug adjuvants to leverage the immunomodulatory effects of targeted drugs where IDO inhibitors are well-positioned. (mainlinehealth.org)
  • LIMR's technology illuminates the use of IDO/TDO inhibitors in new types of combination cancer therapy that were not previously rationalized. (mainlinehealth.org)
  • New uses of IDO inhibitors in combination drug therapy: PCT patent application. (mainlinehealth.org)
  • Examine trends and disparities in use of and expenditures for three new classes of diabetes drugs (glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase 4 inhibitors, and sodium-glucose cotransporter-2 inhibitors) by race, ethnicity, insurance coverage, education, and income. (commonwealthfund.org)
  • The results obtained with radiation therapy have been disappointing. (medscape.com)
  • However, investigators evaluating the feasibility of the Surgery for Mesothelioma After Radiation Therapy (SMART) approach for resectable malignant pleural mesothelioma reported that preoperative radiation therapy may improve survival. (medscape.com)
  • Disparities in use between Black and white adults emerged soon after the drugs' introduction, controlling for trends by insurance status, income, and education. (commonwealthfund.org)
  • Similar disparities by insurance coverage also emerged shortly after the drugs became available and continue today. (commonwealthfund.org)
  • Disparities in spending are small in magnitude but increasing as use of these drugs grows. (commonwealthfund.org)
  • While there is no cure for malignant mesothelioma, a number of treatment methods-especially when used in combination-can be effective in managing the disease and prolonging life. (nolo.com)
  • Combination therapy may seem costlier than monotherapy in the short term, but when it is used appropriately, it causes significant savings: lower treatment failure rate, lower case-fatality ratios, fewer side-effects than monotherapy, slower development of resistance, and thus less money needed for the development of new drugs. (wikipedia.org)
  • After 8 weeks of oral dosing in mice, treatment with the combination did not alter prednisolone-induced reduction in osteocalcin and mid-femur bone density, which are markers of steroid-induced osteoporosis. (biomedcentral.com)
  • Epigenetic drug discovery is a rapidly advancing field, and drugs targeting epigenetic enzymes are in the clinic for the treatment of hematological cancers. (biomedcentral.com)
  • Increasing the body's production of growth hormone may be an effective treatment for HIV lipodystrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)
  • Selected were randomized controlled trials of at least 1 year's duration that provided morbidity or mortality data and that compared 1 of 6 possible first-line antihypertensive therapies either with another 1 of the 6 drug therapies (drug-drug comparison) or with no treatment, including placebo (drug-no treatment comparison). (cmaj.ca)
  • The following outcomes were pooled according to trial design (drug-drug or drug-no treatment comparison) and the drug therapy: death, stroke, coronary artery disease, total cardiovascular events, withdrawal due to adverse effect, and decrease in systolic and diastolic blood pressure. (cmaj.ca)
  • In both the drug-drug and the drug-no treatment comparison trials, thiazides were significantly better at reducing systolic blood pressure than the other drug classes. (cmaj.ca)
  • Low-dose thiazide therapy can be prescribed as the first-line treatment of hypertension with confidence that the risk of death, coronary artery disease and stroke will be reduced. (cmaj.ca)
  • These results imply that the anti-angiogenesis effects may make important contributions to the in vivo antitumor effects of the Onc/DHA combination treatment," writes study author Dr. Ruling Shen with the School of Life Science and Technology at Tongji University. (survivingmesothelioma.com)
  • If one medicine can't lower your blood pressure, your doctor may try combination treatment for hypertension. (webmd.com)
  • Studies show that many people get better control of blood pressure with combination treatment than with one drug. (webmd.com)
  • When is combination treatment for high blood pressure necessary? (webmd.com)
  • Combination treatment means another class of blood pressure medication is added to the first drug to increase effectiveness. (webmd.com)
  • Also, combination treatment may cost less. (webmd.com)
  • Your doctor will prescribe combination treatment cautiously. (webmd.com)
  • How will I know if the combination treatment works? (webmd.com)
  • The available evidence about the effectiveness of specific first-line antihypertensive drugs in lowering blood pressure and preventing adverse outcomes has not been systematically quantified in a manner that would assist clinicians in choosing a first-line drug. (cmaj.ca)
  • Only 2 reviews have attempted to distinguish between the effectiveness of antihypertensive therapies used as first-line agents. (cmaj.ca)
  • Pharmacogenomics is the study of genetic variation as a factor in drug response, affecting both safety and effectiveness. (cdc.gov)
  • Multidrug therapy against leprosy : development and implementation over the past 25 years / [editor]: H. Sansarricq. (who.int)
  • In 5 drug-drug trials comparing thiazides with beta-blockers, the former were associated with a significantly lower rate of withdrawal due to adverse effects (relative risk [RR] 0.69, 95% confidence interval [CI] 0.63-0.76). (cmaj.ca)
  • In the trials that had an untreated control group, low-dose thiazide therapy was associated with a significant reduction in the risk of death (RR 0.89, 95% CI 0.81-0.99), stroke (RR 0.66, 95% CI 0.56-0.79), coronary artery disease (RR 0.71, 95% CI 0.60-0.84) and cardiovascular events (RR 0.68, 95% CI 0.62-0.75). (cmaj.ca)
  • 1 , 8 ] Collins and associates [1] reviewed drug-drug comparison trials, but only 2 of the 3 trials included were appropriate to make that comparison. (cmaj.ca)
  • The review by Psaty and colleagues [8] had a number of deficiencies: drug-drug comparison trials were not included, trials were misclassified to drug therapy groups, and data on the effects of lowering blood pressure were not included. (cmaj.ca)
  • Various systems biology methods must be used to discover combination therapies to overcome drug resistance in select cancer types. (wikipedia.org)
  • Antiretroviral drugs reduce perinatal transmission by several methods, accounting for the recommendation for a combination antepartum, intrapartum, and infant ART. (medscape.com)
  • One of the main components of managing a patient with hypertension is deciding which drug to prescribe for first-line therapy. (cmaj.ca)
  • High-dose thiazide therapy, beta-blocker therapy and calcium-channel blocker therapy did not significantly reduce the risk of death or coronary artery disease. (cmaj.ca)
  • VX-659 was tested in a randomized, double-blind, placebo-controlled study where investigators evaluated the safety and tolerability of single and multiple ascending doses of VX-659 alone as well as in triple combination with tezacaftor and ivacaftor in healthy volunteers. (drugdiscoverytrends.com)
  • Atezolizumab-bevacizumab drug combination can yield positive outcomes in terms of extended survival and the elimination of liver cancer. (medindia.net)
  • That level of complexity is one of the primary impediments to the growth of combination therapy in oncology. (wikipedia.org)
  • T has recently highlighted combination therapy as a top research priority in oncology. (wikipedia.org)
  • My PhD project is to determine if the cellular protein dynamin II (dynII) is a potential anti-cancer drug target. (edu.au)
  • When used in a drug combination, the diuretic has fewer side effects. (webmd.com)
  • Combination therapy with two or more antibiotics are often used in an effort to treat multi-drug resistant Gram-negative bacteria. (wikipedia.org)
  • Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
  • Drug treatments designed to combat the HIV virus have improved, decreasing some nutritional problems, while bringing others to light. (news-medical.net)
  • The goal is to develop personalized prescriptions that are more effective than single drugs and that can potentially replace more invasive treatments such as bariatric surgery, especially for children. (eurekalert.org)
  • Typically, the term refers to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression). (wikipedia.org)
  • Efforts are underway to use chemoinformatics to help understand drug effects from a signal transduction network perspective [ 3 ], to confidently predict new molecular targets for known drugs, and to explain polypharmacology. (biomedcentral.com)
  • Their local, triple-combination approach to cancer therapy, the MIT scientists concluded, can be adapted to other cancer cell types and to molecular targets associated with disease progression. (genengnews.com)
  • Emerging results suggest that many molecular targeted therapies developed as precision medicines for cancer indirectly exert immunostimulatory effects. (mainlinehealth.org)
  • And though the amounts of drug delivered may be said to be "tiny," they are, effectively, more concentrated. (genengnews.com)
  • There may be less frequent doctor visits as the drug combination effectively manages the hypertension. (webmd.com)
  • Furthermore, they find that the simultaneous administration of multiple targeted drugs minimizes the chance of relapse when no single mutation confers cross-resistance to both drugs. (wikipedia.org)
  • Combination therapy or polytherapy is therapy that uses more than one medication or modality. (wikipedia.org)
  • Dr. Artzi and her colleagues described their work in an article that appeared July 25 in the journal Nature Materials, in an article entitled, "Local Triple-Combination Therapy Results in Tumour Regression and Prevents Recurrence in a Colon Cancer Model. (genengnews.com)
  • Another wrinkle, which makes adverse events harder to predict, is "drugs with similar targets or similar payloads don't always have identical toxicity," Bardia said. (medscape.com)
  • PDT uses photosensitizers exposed to a laser tuned to a specific wavelength to produce highly reactive oxygen species, especially singlet oxygen ( 1 O 2 ), finally leading to the death of malignant cells [ 6 - 8 ], while photothermal therapy causes hyperthemia in tissues when absorbing energy from a laser [ 9 - 10 ]. (thno.org)
  • The primary challenge of the photo-based anti-cancer therapy is to define a method that ensures the specific killing effect of malignant tissues, while minimizing the side-effect to normal tissues or organs. (thno.org)
  • The combination synergistically suppresses release of proinflammatory mediators, including tumour necrosis factor-α, IL-6, chemokine (C-C motif) ligand 5 (RANTES), matrix metalloproteinase-9, and others, from human peripheral blood mononuclear cells and mouse macrophages. (biomedcentral.com)
  • However, with 300 FDA-approved cancer drugs on the market, there almost 45,000 possible two-drug combinations and almost 4.5 million three-drug combinations for to choose from. (wikipedia.org)
  • However, the use of cocktails or multicomponent drugs to address several targets simultaneously is also popular to treat multifactorial diseases such as cancer and neurological disorders. (biomedcentral.com)
  • This is a combination of drugs that aim to destroy cancer cells. (medicalnewstoday.com)
  • Single drug or a combination of different drugs to kill cancer cells. (medicinenet.com)
  • The current trend in cancer therapy is the addition of immunomodulators that leverage immune attacks in the context of traditional standards of care. (mainlinehealth.org)
  • The large global market for cancer drugs is expected to increase from $85B in 2016 to $155.6B by 2025, according to the research and consulting firm Transparency Market Research. (mainlinehealth.org)
  • There are many medications that are used in combination to help control high blood pressure. (webmd.com)
  • The intended applications of pharmacogenomics research include identifying responders and non-responders to medications, avoiding adverse events, optimizing drug dose and avoiding unnecessary healthcare costs. (cdc.gov)
  • In addition, ligands are being discovered which, as single chemical entities, are able to modulate multiple epigenetic targets simultaneously (multitarget epigenetic drugs). (biomedcentral.com)
  • Polypharmacology refers to the ability of drugs to interact simultaneously and specifically with multiple targets (multitarget drugs). (biomedcentral.com)
  • Control medicines for asthma are drugs you take to control your asthma symptoms. (medlineplus.gov)
  • Normally, you use these medicines only when you are using an inhaled steroid drug and you still have symptoms. (medlineplus.gov)
  • If you have asthma, your doctor will avoid using drugs that could cause asthma -like symptoms. (webmd.com)
  • Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. (biomedcentral.com)