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  • combination
  • Thus, we can conclude that curcumin can be used as MDR modulator as well as chemosensitizer in combination with cytarabine, standard chemotherapeutic drug, to reduce the cytotoxicity profile as IC 50 value decreases when treated in combination. (eurekaselect.com)
  • 1,2 To minimize such undesirable effects, the clinical concept of balanced or multimodal analgesia proposes to use a combination of analgesics to provide better pain relief and to minimize the side effects of each drug. (asahq.org)
  • Thus, to test the proposed hypothesis, rats were treated with ketamine or morphine alone or with the combination of both drugs, and then submitted to the capsaicin orofacial test. (asahq.org)
  • In our article, we tested at protein and mRNA levels the effects of the combination of tamoxifen and trastuzumab on both estrogen receptor and HER2/neu proteins, providing a possible mechanism to explain the nature of the interaction of these two drugs on breast cancer cell lines. (aacrjournals.org)
  • CONCLUSIONS: Gambogic acid plus docetaxel produced a synergistic anti-tumor effect in gastrointestinal cancer cells, suggesting that the drug combination may offer a novel treatment option for patients with gastric and colorectal cancers. (biomedsearch.com)
  • ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. (wikipedia.org)
  • To condition the rats, he used a combination[clarification needed] of saccharin-laced water (the conditioned stimulus) and the drug Cytoxan, which unconditionally induces nausea and taste aversion and suppression of immune function. (wikipedia.org)
  • Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa. (wikipedia.org)
  • It is usually taken in combination with atovaquone, another antimalarial drug. (wikipedia.org)
  • Proguanil displays synergism when used in combination with the antimalarial atovaquone. (wikipedia.org)
  • Synergistic
  • As research better explains the biochemistry of drug use, fewer ADRs are Type B and more are Type A. Common mechanisms are: Abnormal pharmacokinetics due to genetic factors comorbid disease states Synergistic effects between either a drug and a disease two drugs Various diseases, especially those that cause renal or hepatic insufficiency, may alter drug metabolism. (wikipedia.org)
  • Apoptosis
  • Additionally, mRNA expression of drug-associated genes, i.e., β-tublin III and tau, and the apoptosis-related gene survivin, were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). (biomedsearch.com)
  • dopamine
  • It has been used to study the role of neurotensin in the regulation of dopamine receptor activity and glutamate signalling in the brain, and in animal studies SR-142948 blocked the effects of stimulant drugs, including MDMA. (wikipedia.org)
  • effects
  • Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. (curehunter.com)
  • This is because remifentanil will be rapidly eliminated from the blood plasma on termination of the remifentanil infusion, hence the effects of the drug will quickly dissipate even after very long infusions. (wikipedia.org)
  • This drug is contraindicated in case of having: Blockage of the gallbladder or a sphincter of Oddi problem Problems with alcohol abuse Pancreatitis Liver problems Chronic or severe constipation Common adverse effects are constipation and nausea, but rates of discontinuation due to constipation were low for both eluxadoline and placebo. (wikipedia.org)
  • Other animal research suggests that long term drug-induced antidepressants effects modulate the expression of genes mediated by clock genes, possibly by regulating the expression of a second set of genes (i.e. clock-controlled genes). (wikipedia.org)
  • 3. Zanaflex (Tizanidine) demonstrates anti-hypertensive effects and should be avoided in patients taking Isradipine due to the possibility of synergism between both medications. (wikipedia.org)
  • interaction
  • It is important that preclinical studies of drug combinations present in full detail the interaction analytic approach ( 3 ). (aacrjournals.org)
  • We have tested three different drug administration schedules of tamoxifen and trastuzumab in our analysis of the interaction of these two drugs. (aacrjournals.org)
  • clinical
  • Clinical interest in synergism dates back to the early 1950s when practitioners noted that patients with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. (wikipedia.org)
  • This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs. (wikipedia.org)
  • generates
  • Mouse organoid drug screening identifies that itraconazole generates spheroid collapse and loss of dormancy. (rupress.org)
  • Effect
  • Their article concludes that there is a synergism between tamoxifen and trastuzumab, which occurs without any effect on HER2/neu levels or signaling activity. (aacrjournals.org)
  • When injected secretly, it does not have any effect, whereas standard pain drugs have an effect, even if they are administered without the subject's awareness. (wikipedia.org)
  • gastrointestinal
  • Lorglumide (CR-1409) is a drug which inhibits gastrointestinal motility and reduces gastric secretions, acting as a cholecystokinin antagonist, with fairly high selectivity for the CCKA subtype. (wikipedia.org)
  • Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. (wikipedia.org)
  • pharmaceutical
  • Modern medicine makes use of many plant-derived compounds as the basis for evidence-based pharmaceutical drugs. (wikipedia.org)
  • Consequently, this allows saving time and cost and resources as well as increasing efficiency an effectiveness in medical, pharmaceutical research and new drug development. (wikipedia.org)
  • Acute
  • But still, we were interested to show that even quetiapine is one of the drugs that can cause acute pancreatitis [2- and same is shown in the Table 1 and Figure 1 . (lww.com)
  • Here we are interested in adding with previous references that quetiapine could also be one of the reasons for this acute pancreatitis and the mechanism behind the involvement is the drug synergism. (lww.com)
  • occurs
  • 2008), indicating that its addition occurs early in the drug production and sales process rather than at the street sales or street use level. (thefreelibrary.com)
  • early
  • Over a hundred of the 224 drugs mentioned in the Huangdi Neijing, an early Chinese medical text, are herbs. (wikipedia.org)
  • As such, early publications of amphenone B, and some subsequent publications, refer to the drug by the incorrect structure. (wikipedia.org)
  • cause
  • An adverse drug event (ADE) refers to any injury occurring at the time a drug is used, whether or not it is identified as a cause of the injury. (wikipedia.org)
  • The cause of hyperglycemia appears to alter the response to hypoglycemic drugs. (wikipedia.org)