• Establishing new non-toxic excipients that can be used to create novel drug products is most welcome! (acs.org)
• In addition to its active ingredient, several important components contribute to the overall stability of a drug product including excipients, formulation, and packaging. (pharmtech.com)
• His research interests include new excipients and advanced techniques that are able to develop novel drug delivery systems, particularly electrospinning and electrospun medicated nanofibers. (benthamscience.com)
• An orodispersible tablet form would thus be advantageous, as salbutamol sulphate is water-soluble drug and its formulation into an orodispersible tablet form would render it to disintegrate rapidly and thereby result in rapid absorption without any lag time 3 . (ispub.com)
• Drug solubilisation capacities of the micellar solutions were determined using griseofulvin as a poorly water-soluble model drug. (dmu.ac.uk)
• Antibody-drug conjugates are powerful new treatment options for lymphomas and solid tumours, and immunomodulatory antibodies have also recently achieved remarkable clinical success. (ebscohost.com)
• The article reports that Oxford BioTherapeutics won the exclusive global rights to ImmunoGen's maytansinoid antibody drug conjugates (ADC) technology and some Xenomouse antibodies produced by Amgen. (ebscohost.com)
• The article presents information on a clinical research study to be released by Celldex Therapeutics Inc. This study is related to CDX-011, an antibody drug conjugate (ADC) that contains a human monoclonal antibody, in patients with advanced breast cancer. (ebscohost.com)
• The article discusses the pivotal study called METRIC by biopharmaceutical company Celldex Therapeutics Inc. as a result of the positive data gathered from its Phase II trial of antibody-drug conjugate (ADC) glembatumumab vedotin (CDX-011) in patients with metastatic, triple-negative breast. (ebscohost.com)
• The article informs about the phase IIb trial of CDX-011 antibody drug conjugate by Celldex Therapeutics Inc. in patients expressing glycoprotein NMB (GPNMB) and pretreated breast cancer. (ebscohost.com)
• Enzymatic conjugation using branched linkers for constructing homogeneous antibody-drug conjugates with high potency. (nature.com)
• ADVENTRX Pharmaceuticals is a specialty pharmaceutical company whose product candidates are being developed to improve the performance of existing anti-cancer drugs by addressing limitations associated principally with their safety and use. (drugs.com)
• Stability testing of bio/pharmaceutical products evaluates how environmental factors affect an API or finished drug product and are essential to established drug handling and storage conditions, as well as shelf life. (pharmtech.com)
• Experts at contract analytical laboratories shared insight on testing of drug-product attributes with Pharmaceutical Technology , including testing at different stages of development, special considerations for different dosage forms, special considerations for transport tests and temperature excursions, the benefits of risk-based approaches, and new instruments and test methods. (pharmtech.com)
• Stability testing provides evidence of the safety, efficacy, and quality of a pharmaceutical drug product over time. (pharmtech.com)
• Sigmoid Pharma CEO, Dr. Ivan Coulter, details the company's oral pharmaceutical formulation technology, LEDDS (liquid/emulsion drug delivery system), at Dublin City University's Invent Centre. (pharmamanufacturing.com)
• The essential information source for professionals involved in the formulation, development, manufacturing and supply of drugs and medicines in the pharmaceutical and biopharmaceutical industry. (epmmagazine.com)
• Thisprogram probably contains the most extensive source of pharmaceutical stability dataextant. (drugstorepdfsearch.com)
• Drug Stability Test Chamber finds its use in the pharmaceutical industry, medicine, biotechnology, food industry, electronics and all related fields including life sciences. (didacscientific.com)
• As the optimal choice for pharmaceutical companies to test drug stability, it is suitable for the accelerated tests, long-term experiments, high-temperature tests of drugs and new drugs in pharmaceutical companies. (didacscientific.com)
• HR 749 Lower Drug Cost Through Competition Act Introduced January 30, 2017 by Kurt Schrader (D-OR) To increase competition in the pharmaceutical industry. (opensecrets.org)
• HR 5808 Medicaid Pharmaceutical Home Act of 2018 Introduced May 15, 2018 by Gus Bilirakis (R-FL) To amend title XIX of the Social Security Act to require States to operate drug management programs for at-risk beneficiaries, and for other purposes. (opensecrets.org)
• Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive interest of researchers from pharmaceutical and chemical sciences and of drug regulatory agencies. (nih.gov)
• But many of these polymers don't stabilize protein drugs outside the body. (acs.org)
• The micelle shown in Figure 1 illustrates how a hydrophobic drug is surrounded by the hydrophobic blocks of the polymers inside a micelle, while the hydrophilic PEG blocks are exposed to hydrophilic solvent. (sigmaaldrich.com)
• In this study we explore the preparation of core-crosslinked micelles of linear-dendritic methoxy-poly(ethylene glycol) (MPEG)-co-poly(ester-sulfide) (PES) polymers to improve the stability of such polymeric micelle systems against premature disintegration and drug release. (dmu.ac.uk)
• Most polymers used for nanoparticle drug delivery systems are natural, biocompatible, and biodegradable, which helps prevent contamination in the CNS. (wikipedia.org)
• However, under strong directional selection, mutations that confer novel phenotypes but compromise structural stability of proteins may be permissible. (biochemj.org)
• During the evolution of antibiotic resistance, mutations that confer drug resistance often have pleiotropic effects on the structure and function of antibiotic-target proteins, usually essential metabolic enzymes. (biochemj.org)
• Our data demonstrate that defects in double-strand break repair lead to an increase in genome instability, while drug resistance arises more rapidly in C. albicans strains lacking mismatch repair proteins or proteins central to double-strand break repair. (asm.org)
• Malignant melanoma is a difficult cancer to treat due to the rapid development of resistance to drugs targeting single proteins. (aacrjournals.org)
• Proteins and Wave Functions: What are the most important reactions in drug synthesis and stability? (blogspot.ch)
• With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. (wiley.com)
• Different mRNA transcripts may encode functionally distinct proteins or contribute to variability of mRNA stability or protein translation efficiency. (aspetjournals.org)
• The polymer is directly soluble in water up to 10 % w/v. Dissolution of this polymer into water improves the capacity of the solution to dissolve drugs directly. (sigmaaldrich.com)
• One of these include orodispersible tablet technology which offers the advantages of both solids and liquids such as quick disintegration and dissolution of tablets, no residue in mouth, requires no water intake, provides a pleasant mouth feel and even allows high drug loading 2 . (ispub.com)
• Intrinsic dissolution testing showed increased dissolution rate of both drugs in the coamorphous form as well as a synchronized release for the 1:1 coamorphous blend. (ku.dk)
• When interpreting toxicological results there are a lot of different aspects to consider, such as: were the analytical methods used appropriate and with acceptable accuracy, what specimen was analyzed and how was it collected and stored before the analysis, what concentration of a drug can be considered normal or "therapeutic" and which concentration is fatal. (diva-portal.org)
• According to World Health Organization (WHO), plants are the major sources for the drugs to be prescribed globally and constitute around 25 % and currently 121 compounds with therapeutic potential are actively used. (ijpsonline.com)
• ADC chemical linkers connect therapeutic antibodies and highly potent antitumor drug molecules. (nature.com)
• Therapeutic Drug Monitoring. (lww.com)
• The SiNPs-based nanocarriers displayed pronounced therapeutic efficiency on drug-resistant breast cancer cells. (springer.com)
• 35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX, indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer cells. (springer.com)
• These drugs cross the BBB and deliver pharmaceuticals to the brain for therapeutic treatment of neurological disorders. (wikipedia.org)
• Princeton, NJ - January 18, 2012 - Soligenix, Inc. (OTCBB: SNGX) (Soligenix or the Company), a development stage biopharmaceutical company, announced today results from long-term stability studies of its proprietary DNI (dominant negative inhibitor) anthrax rPA (recombinant protective antigen) subunit protein vaccine, known as SGX204. (drugs.com)
• Long-term stability of DNI rPA was also demonstrated after refrigerated storage for more than 7 years. (drugs.com)
• We believe that the combination of long-term stability over several years with stability at such elevated temperatures has the potential to confer a distinct advantage over other anthrax vaccine technologies currently in development. (drugs.com)
• Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction. (ijpc.com)
• While both drugs remained non-crystalline during the study using mesoporous silica, polymer-based HME formulations showed recrystallization after one week. (fraunhofer.de)
• Researchers from the UK and Denmark have developed a new method to predict the physical stability of drug candidates, which could help with the development of new and more effective medicines for patients. (cam.ac.uk)
• Physical stability was examined at 277.15 and 298.15 K under dry conditions (phosphorus pentoxide) and analyzed with X-ray powder diffraction (XRPD). (ku.dk)
• Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis. (ijpc.com)
• A novel, reproducible, precise, accurate and dependable high-performance thin-layer chromatographic technique was developed and authenticated as per International Conference on Harmonization guiding principle for quantitative evaluation of forskolin as a bulk drug and in a nanosuspension. (ijpsonline.com)
• A simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method for analysis of capsaicin in the bulk drug has been developed and validated. (elsevier.com)
• Flumazenil concentrations were measured by a stability-indicating high- performance liquid chromatographic assay at baseline and 2, 4, 8, 12, and 24 hours after mixing. (elsevier.com)
• Genome changes, such as aneuploidy, translocations, loss of heterozygosity, or point mutations, are often observed in clinical isolates that have become resistant to antifungal drugs. (asm.org)
• Other studies demonstrated that gross chromosome rearrangements, such as chromosome gain or loss or isochromosome formation ( 14 , 25 ), occur in clinical isolates that have become drug resistant. (asm.org)
• The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles. (sigmaaldrich.com)
• One of the challenges in treating patients with heart failure (HF) is achieving clinical stability and reducing the hospital readmission rate. (clinicaltrials.gov)
• This report aims to describe a randomized clinical trial protocol designed to assess the effectiveness of the AAD and of nonpharmacologic management in improving clinical stability and reducing the readmission rate at 90 days in patients with HF. (clinicaltrials.gov)
• The endpoints examined in previous randomized clinical trials comparing aspart and lispro were not directed specifically at assessing the effect of insulin type on glycemic stability. (clinicaltrials.gov)
• this discrepancy may account for the failure of these trials to demonstrate the difference in the stability of insulin aspart and lispro that has been noted in clinical practice. (clinicaltrials.gov)
• This was a huge breakthrough in the nanoparticle drug delivery field, and it helped advance research and development toward clinical trials of nanoparticle delivery systems. (wikipedia.org)
• Now, researchers have developed a polymer that could stabilize protein drugs both before and after injection. (acs.org)
• In the new study, they wanted to test the glycopolymer's ability to stabilize protein drugs in and out of the body. (acs.org)
• This is a promising alternative to PEG," the staple polymer conjugated to protein drugs, says Theresa M. Reineke of the University of Minnesota. (acs.org)
• Statistical analysis also revealed a correlation between the degree of protein binding of the different drugs and percentage of vitreous/femoral blood concentrations. (diva-portal.org)
• Structural stability is a major constraint on the evolution of protein sequences. (biochemj.org)
• The lack of data is of particular significance with protein-based drugs where action is determined by their complex structure. (openrepository.com)
• Three types of OMVs were compared for their stability, containing either one (monovalent) or three different PorA subtypes (trivalent), the latter with and without class 4 outer membrane protein (OMO, RmpM).Aqueous formulations were stored freeze-dried (4 degreesC), frozen (-70 degreesC) and in liquid form at 4, 37 and 56 degreesC. (leidenuniv.nl)
• One parameter that has so far not been included in early stability predictions is the temperature at which protein unfolding becomes irreversible (Tnr). (coriolis-pharma.com)
• Experience mother: delayed-release antibiotic charge attrition may start you on heat stability of doxycycline a tablet lowered efficacy or a doxycycline sun. (txlyd.com)
• Fig. 1 EVCit ensures high ADC stability and efficacy in mouse models (figures from our paper with modifications). (nature.com)
• The aim of this study was to assess the stability of some well-known drugs of abuse methamphetamine (MA), 11-nor-9-carboxy-Δ9- tetrahydrocannabinol (THC-COOH), benzoylecgonine (BE), and morphine (MOR) in urine samples kept at room temperature by adding a salt mixture (sodium citrate, sodium ascorbate, borax). (ingentaconnect.com)
• Alprostadil was the least stable of the drug components at room temperature and under refrigeration. (ijpc.com)
• Twenty-seven essential drugs were stored in a rural site and a urban one where temperature and hygrometry were recorded daily. (ajtmh.org)
• where $$\Delta H_m$$ and $$T_m$$ are the enthalpy of fusion and melting temperature for the pure drug respectively, $$R$$ is the gas constant, $$\lambda$$ is the molar volume ratio of the polymer to the drug, $$\chi$$ is the Flory-Huggins interaction parameter. (pssrc.org)
• T\) is the temperature at which the measurement is made and $$\nu_{\text{drug}}$$ is the volume fraction of the drug in the polymer. (pssrc.org)
• Using the recrystallization method, the temperature ($$T$$) is the variable under control and can be regarded as free of error whereas the volume fraction of the drug ($$\nu_{\text{drug}}$$) is subject to error. (pssrc.org)
• By using a scientific method, it creates a long-time stable temperature, humidity conditions required for evaluation of drug failure. (didacscientific.com)
• In a novel approach of predicting the glass transition temperature, the 1:1 drug ratio was inserted as an individual component in the Gordon-Taylor equation with the excess drug representing the second compound. (ku.dk)
• During drug-product development, the primary attributes assessed during stability studies focus on the physical and chemical limits. (pharmtech.com)
• Recently, however, it is commonly used as a model hydrophobic drug for studies involving controlled release and tracking of localized delivery. (sigmaaldrich.com)
• Although encouraging recent studies showed promising results with Zelboraf, a selective V600E B-Raf kinase inhibitor, development of drug resistance remains a problem ( 2 ). (aacrjournals.org)
• These findings mirror bench studies showing that the relative stability differences between aspart and lispro in pump infusion systems becomes more apparent over time. (clinicaltrials.gov)
• Drug release studies indicated that a more sustained release of griseofulvin was achieved for the core-crosslinked micelles compared to the non-crosslinked micelles, attributable to greater stability of the crosslinked core structure. (dmu.ac.uk)
• With the aid of nanoparticle delivery systems, however, studies have shown that some drugs can now cross the BBB, and even exhibit lower toxicity and decrease adverse effects throughout the body. (wikipedia.org)
• We assessed the stability of isoniazid, rifampicin, clarithromycin, linezolid and amikacin in Middlebrook 7H9 medium and that of clarithromycin, amikacin and cefoxitin in the cation-adjusted Mueller Hinton broth. (eur.nl)
• In the subsequent presentations, practical aspects of stability testing for drug substances and throughout drug development are discussed. (gmp-compliance.org)
• Must the development stability programme meet ICH Q1A? (gmp-compliance.org)
• Thus, a unique clinically viable nanoparticle-based drug has been developed containing leelamine for the treatment of melanoma that acts by inhibiting the activity of major signaling pathways regulating the development of this disease. (aacrjournals.org)
• Thus, detecting such stability problems in a candidate early avoids high development costs and can reduce the development time of a drug product. (coriolis-pharma.com)
• While using these parameters certainly reduces unnecessary development efforts, stability predictions are not always accurate and there is a large interest in adding more predictive parameters to the portfolio. (coriolis-pharma.com)
• That's brought FDA a mix of criticisms ranging from those who finance drug development to patients and their families waiting for approvals. (foodsafetynews.com)
• The development of effective and safe vehicles to deliver small interfering RNA (siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics, which has emerged as a powerful platform to treat drug-resistant cancer cells. (springer.com)
• The expression of CYP3A4 changes during liver development and may be affected by the administration of some drugs. (aspetjournals.org)
• We conclude that the 3′-end processing of CYP3A4 contributes to the quantitative regulation of CYP3A4 gene expression through alternative polyadenylation, which may serve as a regulatory mechanism explaining changes of CYP3A4 expression and activity during hepatocyte differentiation and liver development and in response to drug induction. (aspetjournals.org)
• However, little is known about alternative transcription and RNA processing of CYP3A4 and its implication on regulation of CYP3A4 expression during liver development and drug administration. (aspetjournals.org)
• While development of anti-cancer drugs for humans is the main game for PharmAust , the canine market is also valuable in its own right. (businessnews.com.au)
• To allow increased loading without systemic toxicity, we used liposomes, which are biocompatible microscopic lipid vesicles with a bilayer membrane structure that have been used to deliver hydrophilic, amphiphilic, and hydrophobic drugs. (pnas.org)
• Therefore, the hydrophilic/hydrophobic balance of these materials was controlled by chemical modification and their stability/hydrolysis has been studied. (redorbit.com)
• One example of cationic liposomes uses bolaamphiphiles, which contain hydrophilic groups surrounding a hydrophobic chain to strengthen the boundary of the nano-vesicle containing the drug. (wikipedia.org)
• Several new technologies for oral delivery have recently been available to address the problems of physicochemical and pharmacokinetic characteristic of drugs, while improving patient compliance. (ispub.com)
• It must be noted that the duration of the cholesterol-lowering effect of statins is substantially longer than the duration of the pharmacokinetic half-life of these drugs. (news-medical.net)
• Kaewbumrung, S., Panichayupakaranant, P.: Antibacterial activity of plumbagin derivative-rich Plumbago indica root extracts and chemical stability. (springer.com)
• Many different delivery methods exist to transport these drugs into the body, such as peroral, intranasal, intravenous, and intracranial. (wikipedia.org)
• The objective of the current study was to develop a validated stability-indicating assay method (SIAM) for risperidone after subjecting it to forced decomposition under hydrolysis, oxidation, photolysis, and thermal stress conditions. (hindawi.com)
• Our study shows that the binding of graphene-drug complex is favorable when the drug molecules and finite graphene sheets become comparable in sizes. (hindawi.com)
• Naturally, medical linings are cure needed over the doxycycline of stability heat additional study to ensure that inflammation is controlled. (txlyd.com)
• A three-drug injection mixture of alprostadil 12.5 µg/mL, papaverine hydrochloride 4.5 mg/mL and phentolamine mesylate 0.125 mg/mL in bacteriostatic 0.9% sodium chloride injection was evaluated for stability at 23°C, 4°C, -20°C and -70°C. The injection remained clear and colorless in all samples throughout the study. (ijpc.com)
• Our study demonstrates that trade-offs between structural stability and function can influence innate drug resistance as well as the potential for mutationally acquired drug resistance of an enzyme. (biochemj.org)
• To evaluate the stability of essential drugs stored in realistic tropical conditions, we have carried out a two-year prospective study in western Burkina Faso. (ajtmh.org)
• Samples of each drug were taken for further analysis to the World Health Organization Collaborative Center for the Study of Stability of Drugs in Nantes, France every three months. (ajtmh.org)
• The divided study, on prednisolone tablet stability the plasma nitrobenzene, developed particular relative population and was withdrawn from the acetophenone. (huebner-baustoffe.de)
• The purpose of this study is to describe the use of alcohol, drugs and cigarettes in patients at a psychosis unit over a 1 1/2 year period after them having taken part in a screening investigation including a feed-back of the results to personnel. (ebscohost.com)
• First-episode drug-induced psychosis: a medium term follow up study reveals a high-risk group. (ebscohost.com)
• A study carried out by Simone Tassani, first author of the paper, Miguel Ángel González Ballester, ICREA research professor and Jérôme Noailly, members of BCN MedTech of the Department of Information and Communication Technologies (DTIC) at UPF, with the participation of Josep M. Font-Llagunes, a researcher at the UPC, has shown that muscle tension significantly reduces subjects' stability. (news-medical.net)
• The goal of the study was to investigate the effect in humans of voluntary muscle contraction and relaxation on the stability of the standing posture to find out if muscle tension has an impact on stability and to estimate this impact using minimally invasive procedures. (news-medical.net)
• In this study, a coamorphous drug/drug combination between the two nonsteroidal anti-inflammatory drugs, naproxen and ¿-indomethacin, was prepared and investigated. (ku.dk)
• The purpose of this study was to examine expression of alternative CYP3A4 mRNA transcripts in hepatocytes in response to developmental signals and drugs. (aspetjournals.org)
• The goal of this project is to develop a method to provide stability data in a standard electronic format so that it may be viewed as it appears on paper or electronic paper by regulatory agencies and industry. (hl7.org)
• Therefore, understanding the regulatory mechanisms of CYP3A4 expression in response to developmental and environmental signals is critically important for drug therapy. (aspetjournals.org)
• 9th most commonly prescribed drug between 2002 - 2009 (U.S.). ClinCalc ranks Alprazolam as 23rd most commonly prescribed drug in 2014 (U.S. (ems1.com)
• A Baghdad-sanctioned umbrella organization of an estimated 50 mainly Shiite militias, including some backed by Iran, engaged in illicit activities in recent months that undermine security and stability in Iraq, the office of the inspector general (OIG) at the U.S. Department of Defense (DOD) stressed this week. (breitbart.com)
• The PMF, also known as Hashd al Shaabi, is involved in the region's drug trade and other illicit activities, the OIG suggested, noting: "Iran also conducts other illicit activity in Iraq that undermines security and stability. (breitbart.com)
• The method can be used for identification and quantitative analysis of capsaicin in the bulk drug. (elsevier.com)
• The DARTS method for drug target identification. (pnas.org)
• Background: It has long been recognized that ensuring analyte stability is of crucial importance in the use of any quantitative bioanalytical method. (ingentaconnect.com)
• A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. (google.co.uk)
• Part of the difficulty in finding cures for these central nervous system (CNS) disorders is that there is yet no truly efficient delivery method for drugs to cross the BBB. (wikipedia.org)
• The microbiological assay revealed decreases in drug concentration of ≥75% (rifampicin, clarithromycin, cefoxitin) and 60% (linezolid) after 14 days. (eur.nl)
• The 12-month stability data are consistent with the stability data collected at 6 and 9 months and will support the Company's submission of a New Drug Application (NDA) for Exelbine, which the Company expects to take place in the fourth quarter of this year. (drugs.com)
• This could be three to 12 months of stability data. (pharmtech.com)
• This could be 12-24+ months of stability data. (pharmtech.com)
• One crucial question in interpretation of postmortem toxicology results is to find reliable data on the significance of different drug concentrations. (diva-portal.org)
• We initially evaluated open source descriptors and model building algorithms using a training set of approximately 50,000 molecules and a test set of approximately 25,000 molecules with human liver microsomal metabolic stability data. (aspetjournals.org)
• This section first discusses various theoretical equations used to describe the solid-state stability of drugs and introduces an empirical equation that can often describe the data adequately. (drugtimes.org)
• In response, all of the data from the SLEP representing 122 drug products generated by the was reviewed and analyzed. (drugstorepdfsearch.com)
• There is a lack of stability data for in-use parenteral drugs. (openrepository.com)
• Furthermore, evidence of stability at day 119 gave increased confidence for the data from earlier time points. (openrepository.com)
• Choy GS, Egging P, White B. Stability data for ambulatory infusion pump reservoirs. (nhia.org)
• The crux of the controversy is data suggesting that use of ACE inhibitors and ARBs may increase expression of ACE2, which leads to the hypothesis that these drugs may increase patient susceptibility to the virus. (medscape.com)
• SAN DIEGO, Sept. 14 /PRNewswire/ -- ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX) today announced the results of stability tests performed on samples of ANX-530 (vinorelbine injectable emulsion), or Exelbine™, manufactured at the Company's intended commercial manufacturing site. (drugs.com)
• Product: like doxycycline dosage samples, doxycycline may cause doxycycline to doxycycline of stability heat the developing tootake if this genitalium is taken during help. (txlyd.com)
• Requirement for very low quantity of mobile phase along with ease in preparation of samples for calibration plot are other advantages of HPTLC analysis of drugs. (ijpsonline.com)
• Therefore, samples at the 1:2 and 2:1 ratios showed recrystallization of the excess drug upon storage whereas the 1:1 ratio samples remained amorphous. (ku.dk)
• In line with these considerations, two poor glass formers, haloperidol and carbamazepine, were formulated as polymer-based solid dispersion via HME and with mesoporous silica, and their stability was compared under accelerated conditions. (fraunhofer.de)
• Flumazenil (1.0 mg) was mixed with each of the other drugs in polyvinyl chloride minibags containing 50 mL of 5% dextrose injection to achieve concentrations commonly used when the drugs are administered by continuous i.v. infusion. (elsevier.com)
• Flumazenil was visually compatible and chemically stable when admixed with 5% dextrose injection and selected drugs. (elsevier.com)
• Mechanistically, MKK7 acts through the kinases JNK1 and JNK2, and this signaling pathway directly couples oncogenic and genotoxic stress to the stability of p53, which is required for cell cycle arrest and suppression of epithelial cancers. (nature.com)
• The crystal structures, dimer stabilities, and kinetics have been analyzed for wild-type human immunodeficiency virus type 1 (HIV-1) protease (PR) and resistant mutants PR(L24I), PR(I50V), and PR(G73S) to gain insight into the molecular basis of drug resistance. (nih.gov)