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  • efficacy
  • Experience mother: delayed-release antibiotic charge attrition may start you on heat stability of doxycycline a tablet lowered efficacy or a doxycycline sun. (txlyd.com)
  • A head-to-head comparison of HydraSpace™-containing DAR4 ADCs to marketed drugs, derived from the same antibody and toxic payload components, indicated a significant improvement in both the efficacy and safety of several vivo models, corroborated by in-depth pharmacokinetic analysis. (mdpi.com)
  • It can simultaneously evaluate the toxic potential of a drug on cells from multiple organs and evaluate drug stability, distribution, metabolite formation, and efficacy. (wikipedia.org)
  • The labeled expiration date is a manufacturer's promise for a time until which the drug will have full efficacy and be safe as manufactured. (wikipedia.org)
  • However, it is difficult for anyone including researchers and physicians to find information to verify how much any given drug will degrade in efficacy or become unsafe over time. (wikipedia.org)
  • To ensure efficacy, safety quality and validity of marketed drugs and to promote proper, rational and efficient use. (wikipedia.org)
  • The program seeks to promote appraisal of evidence in terms of proven efficacy and safety from controlled clinical trial data, and adequate consideration of quality, cost and choice of competitor drugs by choosing the item that has been most thoroughly investigated, has favorable pharmacokinetic properties and is reliably produced locally. (wikipedia.org)
  • isoniazid
  • We assessed the stability of isoniazid, rifampicin, clarithromycin, linezolid and amikacin in Middlebrook 7H9 medium and that of clarithromycin, amikacin and cefoxitin in the cation-adjusted Mueller Hinton broth. (eur.nl)
  • Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C. Furonazide was prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product. (wikipedia.org)
  • toxicity
  • The drug has relatively low toxicity. (wikipedia.org)
  • The IdMOC system has numerous applications in drug development, such as the evaluation of drug metabolism and toxicity. (wikipedia.org)
  • In vitro toxicity screening using hepatocytes in conjunction with other primary cells such as cardiomyocytes (cardiotoxicity model), kidney proximal tubule epithelial cells (nephrotoxicity model), astrocytes (neurotoxicity model), endothelial cells (vascular toxicity model), and airway epithelial cells (pulmonary toxicity model) is invaluable to the drug design and discovery process. (wikipedia.org)
  • Cytochrome P450 Drug metabolism Pharmacology Toxicology Li AP, Bode C, Sakai Y. A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. (wikipedia.org)
  • Also, the drugs can often be used at lower doses, reducing toxicity. (wikipedia.org)
  • therapeutic
  • When interpreting toxicological results there are a lot of different aspects to consider, such as: were the analytical methods used appropriate and with acceptable accuracy, what specimen was analyzed and how was it collected and stored before the analysis, what concentration of a drug can be considered normal or "therapeutic" and which concentration is fatal. (diva-portal.org)
  • Taken together, HydraSpace™ technology based on a polar sulfamide spacer provides significant improvement in manufacturability, stability, and ADC design, and is a powerful platform to enable next-generation ADCs with enhanced therapeutic index. (mdpi.com)
  • PEGylation (often styled pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated (pegylated). (wikipedia.org)
  • The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system (reduced immunogenicity and antigenicity), and increase the hydrodynamic size (size in solution) of the agent which prolongs its circulatory time by reducing renal clearance. (wikipedia.org)
  • By encapsulating the drug compound in the nanostructures, injectable depots are able to deliver therapeutic levels of drug substance over extended periods from a single injection. (wikipedia.org)
  • assay
  • The microbiological assay revealed decreases in drug concentration of ≥75% (rifampicin, clarithromycin, cefoxitin) and 60% (linezolid) after 14 days. (eur.nl)
  • The objective of the current study was to develop a validated stability-indicating assay method (SIAM) for risperidone after subjecting it to forced decomposition under hydrolysis, oxidation, photolysis, and thermal stress conditions. (hindawi.com)
  • Degradation products resulting from the stress studies did not interfere with the detection of Risperidone, and the assay is thus stability indicating. (hindawi.com)
  • Since products continually change over time, the characteristics of any drug are not unchanging but instead estimated with assay measurements to be within the specification required by the government regulator where the drug is sold. (wikipedia.org)
  • long-term stab
  • Princeton, NJ - January 18, 2012 - Soligenix, Inc. (OTCBB: SNGX) (Soligenix or the Company), a development stage biopharmaceutical company, announced today results from long-term stability studies of its proprietary DNI (dominant negative inhibitor) anthrax rPA (recombinant protective antigen) subunit protein vaccine, known as SGX204. (drugs.com)
  • Long-term stability of DNI rPA was also demonstrated after refrigerated storage for more than 7 years. (drugs.com)
  • We believe that the combination of long-term stability over several years with stability at such elevated temperatures has the potential to confer a distinct advantage over other anthrax vaccine technologies currently in development. (drugs.com)
  • SLEP
  • The SLEP datasupports the assertion that many drug products, if properly stored, can be extended pastthe expiration date. (drugstorepdfsearch.com)
  • In response, all of the data from the SLEP representing 122 drug products generated by the was reviewed and analyzed. (drugstorepdfsearch.com)
  • The Shelf Life Extension Program (SLEP) is a joint program of the United States Department of Defense and the Food and Drug Administration which aims to reduce the cost to the military of maintaining stockpiles of certain pharmaceuticals by researching the expiration of drugs. (wikipedia.org)
  • Under SLEP, medications are tested for safety and stability for extended periods of time in controlled storage conditions. (wikipedia.org)
  • To reduce the cost to the military of maintaining stockpiles of certain pharmaceuticals, the United States Department of Defense and the Food and Drug Administration operate a joint initiative known as the Shelf Life Protection Program (SLEP), which evaluates the long-term effectiveness of medications stockpiled by the DoD and other government agencies. (wikipedia.org)
  • protein
  • Statistical analysis also revealed a correlation between the degree of protein binding of the different drugs and percentage of vitreous/femoral blood concentrations. (diva-portal.org)
  • Structural stability is a major constraint on the evolution of protein sequences. (biochemj.org)
  • ADAGEN (pegademase bovine) manufactured by Enzon Pharmaceuticals, Inc., US was the first PEGylated protein approved by the U.S. Food and Drug Administration (FDA) in March 1990, to enter the market. (wikipedia.org)
  • attrition
  • Despite tremendous efforts in the field of targeted cancer therapy with antibody-drug conjugates (ADCs), attrition rates have been high. (mdpi.com)
  • molecules
  • In this work graphene sheets with various sizes and graphene oxide functionalized with polyethylene glycol (GO-PEG) are utilized as nanocarriers to load anticancer drug molecules including CE6, DOX, MTX, and SN38. (hindawi.com)
  • Our study shows that the binding of graphene-drug complex is favorable when the drug molecules and finite graphene sheets become comparable in sizes. (hindawi.com)
  • The boundaries of finite sized graphene sheets restrict the movement of drug molecules. (hindawi.com)
  • The double-side loading often slows down the diffusion of drug molecules compared with the single-side loading. (hindawi.com)
  • The structures also allow for the use of controlled release and prevention of degradation of fragile short half live molecules, a serious issue for amino-acid based drugs. (wikipedia.org)
  • Considerations
  • The shape is chosen to strike a balance between cost, hydrostatic considerations (accommodation, load carrying and stability), hydrodynamics (speed, power requirements, and motion and behavior in a seaway) and special considerations for the ship's role, such as the rounded bow of an icebreaker or the flat bottom of a landing craft. (wikipedia.org)
  • metabolic
  • Camurus' in-house product portfolio targets healthcare needs in areas of growth-hormone disorders, cancer, oncology supportive care, metabolic disease, and drug addiction. (wikipedia.org)
  • tuberculosis
  • The emergence of drug-resistant tuberculosis and disease caused by nontuberculous mycobacteria has increased the need for accurate drug susceptibility testing of mycobacteria. (eur.nl)
  • resistance
  • Our study demonstrates that trade-offs between structural stability and function can influence innate drug resistance as well as the potential for mutationally acquired drug resistance of an enzyme. (biochemj.org)
  • Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization, as there have been signs that malarial parasites are developing resistance to the drug. (wikipedia.org)
  • The World Health Organization (WHO) is pressuring manufacturers to stop making the uncompounded drug available to the medical community at large, aware of the catastrophe that would result if the malaria parasite developed resistance to artemisinins. (wikipedia.org)
  • injectable
  • SAN DIEGO, Sept. 14 /PRNewswire/ -- ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX) today announced the results of stability tests performed on samples of ANX-530 (vinorelbine injectable emulsion), or Exelbine™, manufactured at the Company's intended commercial manufacturing site. (drugs.com)
  • behavior
  • As well as producing training programs and publications, the group is undertaking research in a number of member countries, focused primarily on changing behavior to improve drug use. (wikipedia.org)
  • High
  • Positive stability was demonstrated when DNI rPA was subjected to temperatures as high as 70?C for one month. (drugs.com)
  • IdMOC can also be used for routine and high throughput screening of drugs with desirable ADME or ADME-Tox properties. (wikipedia.org)
  • FVA-9 Blaue Maus II (Blue Mouse II) In 1933 the FVA students turned their attention to a lightweight soaring glider designed to have good aerodynamic, stability and control properties, as well as a high L/D ratio at a reasonably high speed to allow flight between thermals. (wikipedia.org)
  • Everything was shaped to reduce drag and increase stability at high speed. (wikipedia.org)
  • The company provides innovative nanoscale drug-delivery systems for development of high-value therapeutics. (wikipedia.org)
  • Artemisinin and its endoperoxides derivatives have been used for the treatment of P. falciparum related infections but low bioavailability, poor pharmacokinetic properties and high cost of the drugs are a major drawback of their use. (wikipedia.org)
  • Artemisinins can be used alone, but this leads to a high rate of recrudescence (return of parasites) and other drugs are required to clear the body of all parasites and prevent recurrence. (wikipedia.org)
  • expiration
  • Based on testing and stability assessment, 88% of the lots wereextended at least 1 year beyond their original expiration date for an average extension of66 months, but the additional stability period was highly variable. (drugstorepdfsearch.com)
  • Drug expiration is the date after which a drug might not be suitable for use as manufactured. (wikipedia.org)
  • Standard advice from drug manufacturers and some health organizations is to dispose of drugs after the expiration date printed on the packaging. (wikipedia.org)
  • However, the published expiration date is not an absolute indication that a drug has spoiled. (wikipedia.org)
  • Medical authorities find it difficult to discuss when consumers can safely use drugs after the printed expiration date because it is hard to get clear information. (wikipedia.org)
  • Manufacturers print expiration dates on drug bottle labels. (wikipedia.org)
  • The labeled expiration date is not an indication of when a drug has become ineffective or unsafe to use. (wikipedia.org)
  • Many drugs are effective for years after their expiration dates. (wikipedia.org)
  • Drug manufacturers never support the use of drugs after the expiration date because that could make them liable if something went wrong. (wikipedia.org)
  • The expiration date printed on drug packaging will differ from the true expiration date of the drug. (wikipedia.org)
  • Before the true expiration of a drug, its active ingredient will retain its potency. (wikipedia.org)
  • Also before expiration, no components of the drug will degrade to become harmful. (wikipedia.org)
  • After a manufacturer has decided what true expiration date it has set, then it will decide another date to make public and advertise on the packaging of the drug. (wikipedia.org)
  • The printed expiration date will always be sooner than the true expiration date, because the drug should always be effective and safe before the labeled expiration date if kept properly. (wikipedia.org)
  • If that medication could be used by other people before its expiration, then sometimes, interested parties discuss drug recycling to transfer ownership of the drugs away from the party which will not use them to the party which needs them. (wikipedia.org)
  • In such discussions, anyone considering the transfer of drugs will also consider if drugs could be used before their expiration. (wikipedia.org)
  • severe
  • The more represented bacteriologic dosages included all erectile adapters, the heat stability of doxycycline severe youre adult meanswill, blondei and doctor hyclate use effects, and dag pustules. (txlyd.com)
  • In the decades before 2003 the Iraqi arena was clean of drugs: "one of the very few regional states that could claim that drug abuse was not a problem in society," security consultant Mustafa Al-Ani expressed years ago, citing "strict laws" and "severe punishment" by the Baath regime as the reason for this. (middleeastmonitor.com)
  • crucial
  • One crucial question in interpretation of postmortem toxicology results is to find reliable data on the significance of different drug concentrations. (diva-portal.org)
  • Surprisingly, though crucial for the stability of EcDHFR, significant sequence variation is found at this site among bacterial dihydrofolate reductases (DHFRs). (biochemj.org)
  • payload
  • Different ADC formats are explored in terms of drug-to-antibody ratios (DAR2, DAR4) and we describe the generation of a DAR4 ADC by site-specific attachment of a bivalent linker-payload construct to a single conjugation site in the antibody. (mdpi.com)
  • study
  • Naturally, medical linings are cure needed over the doxycycline of stability heat additional study to ensure that inflammation is controlled. (txlyd.com)
  • 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) is a chemical compound used to study the chemistry of the oxidation of drugs. (wikipedia.org)
  • increase
  • A sander increase genotype was performed at the heat stability of doxycycline shedding of each patient to insurance assess the lyme farif. (txlyd.com)
  • Statics on the problem might be inconclusive but the protracted nature of drug abuse confirms predictions made by the UN Office on Drugs and Crime in late 2003 that drug trafficking would increase. (middleeastmonitor.com)
  • Resources
  • A US State Department report from 2013 rued Iraq's leadership for failure to "devote significant resources to drug cases," but unverified images and Twitter posts allege that Iraq's special forces were dispatched last weekend to southern Iraq to combat the drug trade in southern Iraq. (middleeastmonitor.com)
  • medications
  • Just, a presc good jedan of the book with those medications will however become immune by using an nmr voldoende based on heat stability of doxycycline the belt of response expression characteristics. (txlyd.com)
  • Essential
  • To achieve these objectives in Indonesia, the following changes were implemented: A national list of essential drugs was established and implemented in all public sector institutions. (wikipedia.org)
  • District hospitals and health centers have to procure their drugs based on the essential drugs list. (wikipedia.org)
  • data
  • The 12-month stability data are consistent with the stability data collected at 6 and 9 months and will support the Company's submission of a New Drug Application (NDA) for Exelbine, which the Company expects to take place in the fourth quarter of this year. (drugs.com)
  • dosage
  • Product: like doxycycline dosage samples, doxycycline may cause doxycycline to doxycycline of stability heat the developing tootake if this genitalium is taken during help. (txlyd.com)
  • actively
  • Many developing nations have developed national drug policies, a concept that has been actively promoted by the WHO. (wikipedia.org)
  • Results
  • We are very excited about these extraordinary stability results," stated Robert N. Brey, PhD, Chief Scientific Officer of Soligenix. (drugs.com)
  • potential
  • Graphene, a two-dimensional nanomaterial with unique biomedical properties, has attracted great attention due to its potential applications in graphene-based drug delivery systems (DDS). (hindawi.com)
  • induction
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is used. (wikipedia.org)
  • immune
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • development
  • CAM2032 is a new drug being developed for long-term treatment of prostate cancer, with development also initiated for endometriosis. (wikipedia.org)
  • storage
  • We also investigated the possible influence of potassium fluoride on the concentrations of the 46 drugs in vitreous humor after storage for one year. (diva-portal.org)
  • products
  • Captisol, a chemically modified cyclodextrin, is proven to improve the solubility and stability of drugs and is currently used in six marketed products. (epmmagazine.com)
  • The drug products were categorized into five groups based onincidence of initial extension failures and termination failures (extended lot eventuallyfailed upon re-testing). (drugstorepdfsearch.com)
  • Due to the lot-to-lot variability, the stability and quality of extendeddrug products can only be assured by periodic testing and systematic evaluationof each lot. (drugstorepdfsearch.com)
  • major
  • Drug gangs are notably active in Iraq's shrine cities of Karbala and Najaf, where there have been major seizures in the last 13 years. (middleeastmonitor.com)
  • A major teaching hospital has developed a program on rational drug use, developing a hospital formulary, guidelines for rational diagnosis and treatment guidelines for the rational use of antibiotics. (wikipedia.org)
  • effects
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • The drugs differ in their mechanism and side-effects. (wikipedia.org)
  • anti-cancer drugs
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. (wikipedia.org)