Drug resistant temporal lobe epilepsy. Medical search. Frequent questions

Temporal lobe epilepsy is the most common focal onset epilepsy, and 80% of temporal lobe epilepsy is mesial (medial) temporal lobe epilepsy, temporal lobe epilepsy arising from the inner (medial) part of the temporal lobe that may involve the hippocampus, parahippocampal gyrus or amygdala. (wikipedia.org)
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy characterized by recurrent seizures originating in the hippocampus and with sprouting of mossy fiber axons that contribute to new recurrent synaptic excitability in the dentate gyrus (DG). (bioworld.com)
We observed that seizures localized to mesial temporal subregions (hippocampus, amygdala, anterior cingulate) have a higher predilection for ANT recruitment, and the recruitment was faster (ranged 5-12 secs) and preceded clinical onset for seizures that impaired consciousness. (biorxiv.org)
The activation of dentate granule cells in the hippocampus plays a key role in alterations that occur during the development of post-traumatic epilepsy. (neurosciencenews.com)
2023 ) Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. (academictree.org)
In the great majority of patients with temporal lobe epilepsy, the focus lies in the hippocampus, a much-studied, seahorse-shaped midbrain structure that's crucial to spatial navigation and to encoding new experiences into long-term memory. (sciencedaily.com)
in temporal lobe epilepsy (tle) with evidence of hippocampal sclerosis (tle-mts) volumetric gray (gm) and white (wm) matter abnormalities are not restricted to the hippocampus but also are found in extrahippocampal structures. (brain-knowledge-engine.org)
Reorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway. (brain-knowledge-engine.org)
we used the mouse pilocarpine model of temporal lobe epilepsy (tle), and injected iontophoretically the anterograde tracer phaseolus vulgaris leucoagglutinin (pha-l) into gliotic ca3, medial septum and the nucleus of diagonal band of broca, median raphe, and lateral supramammillary nuclei, or the retrograde tracer cholera toxin b subunit (ctb) into gliotic ca3 area of hippocampus . (brain-knowledge-engine.org)
our results suggest that complex mdr expression changes not only in the hippocampus but in the gph may play a role in aed pharmacoresistance in intractable epilepsy patients with mesial temporal lobe epilepsy (mtle) by altering the permeability of aeds across the blood-brain barrier (bbb). (brain-knowledge-engine.org)
Abstract Introduction: Human hippocampal tissue resected from pharmacoresistant epilepsy patients was investigated to study the effect of the antiepileptic drug CBZ (carbamazepine) and was compared to similar experiments in the hippocampus of control rats. (pdffox.com)
Alterations of the microvascular network in the sclerotic hippocampus of patients with temporal lobe epilepsy. (brain-knowledge-engine.org)

Temporal lobe epilepsy (TLE) was defined in 1985 by the International League Against Epilepsy (ILAE) as a condition characterized by recurrent, unprovoked seizures originating from the medial or lateral temporal lobe. (medscape.com)
Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. (medscape.com)
Under the International League Against Epilepsy (ILAE) 2017 classification of the epilepsies, focal onset epilepsy occurs from seizures arising from a biological neural network within a single cerebral hemisphere. (wikipedia.org)
At the time of the first meeting of the International League Against Epilepsy (ILAE) in 1909, surgical treatment for epilepsy had been accepted as an alternative therapy for over two decades, but was rarely practiced, considered a last resort for carefully selected patients. (cureepilepsy.org)
In 2010, the International League Against Epilepsy (ILAE) released a consensus statement defining DRE as the "…failure to achieve sustained seizure freedom with adequate trials of at least two appropriately chosen and used AED regimens (whether administered as monotherapies or in combination). (neurosurgicalatlas.com)
in this study, we investigated mrna and protein expression levels of the three vglut subtypes in hippocampal tissue of patients suffering from temporal lobe epilepsy (tle) with hippocampal sclerosis (hs), international league against epilepsy type 1 (ilae type 1) compared to autopsy controls, using quantitative polymerase chain reaction and semi-quantitative western blotting. (brain-knowledge-engine.org)

SAN FRANCISCO, April 24, 2023 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapies for the treatment of neurological disorders, announced the presentation of updated clinical data from its ongoing Phase I/II clinical trial of a single dose of NRTX-1001 in people with drug-resistant mesial temporal lobe epilepsy (MTLE). (ucbventures.com)
Klitgaard and Kauppinen recently co-authored a "critical review" on RNA therapies for epilepsy published in Epilepsia online on September 13, 2023. (medscape.com)
Epilepsy currents 2023 9 23 (4): 257-258. (cdc.gov)
Epilepsy & behavior : E&B 2023 9 147 109432. (cdc.gov)

In the field of neurology, temporal lobe epilepsy is an enduring brain disorder that causes unprovoked seizures from the temporal lobe. (wikipedia.org)

Very few papers on epilepsy surgery were presented at ILAE meetings or published in Epilepsia during the first half of the 20th century. (cureepilepsy.org)
Epilepsy surgery was accepted as standard of care for drug-resistant focal epilepsy and was well-represented at international ILAE congresses and in Epilepsia. (cureepilepsy.org)
AED) strategies, five surgical procedures, and Epilepsy (ILAE) Commission Report from 1997 one nondrug, nonsurgical intervention. (cdc.gov)

Temporal lobe epilepsy is the most common type of focal onset epilepsy among adults. (wikipedia.org)
A dystonic posture on one side of the body commonly indicates seizure onset from the opposite side of the brain e.g. right arm dystonic posture arising from a left temporal lobe seizure. (wikipedia.org)
PURPOSE: To design a non-patient-specific system to detect the electrical onset of seizures in patients with temporal lobe epilepsy.METHODS: We used EEG data from 29 seizures of 18 temporal lobe epilepsy patients who underwent multiday video-scalp EEG monitoring as part of their presurgical evaluations. (amrita.edu)
In contrast, inactivating these cells, known to neuroscientists as mossy cells, facilitates the spread throughout the brain of the electrical hyperactivity initially localized at a seizure's onset, causing the full-blown behavioral symptoms of temporal lobe epilepsy. (sciencedaily.com)
Temporal lobe epilepsy (TLE) is one of the most common forms of epilepsy, accounting for approximately 60% of all cases of epilepsy with a focal onset. (kimiyahealing.co.uk)
Furthermore, those who are referred receive surgery an average of 20 years after onset of epilepsy, often too late to avoid irreversible disability. (cureepilepsy.org)
The effects of DMF in preventing the onset of epilepsy and modifying the disease were investigated in the kainic acid-induced status epilepticus model of temporal lobe epilepsy in rats. (biomedcentral.com)

Medtronic is currently involved in a pivotal SLATE (Stereotactic Laser Ablation for Temporal Lobe Epilepsy) study in the United States to support an expanded FDA indication for the treatment of epilepsy in patients with drug-resistant mesial temporal lobe epilepsy (MTLE), the most common form of partial or localization related epilepsy. (medgadget.com)
The data support the development of Neurona Therapeutics' regenerative cell therapy candidate, NRTX-1001, which is being evaluated in an ongoing Phase I/II clinical trial of a one-time dose in people with drug-resistant MTLE (NCT05135091). (cureepilepsy.org)
Objective: Laser interstitial thermal therapy (LITT) is a novel minimally invasive alternative to open mesial temporal resection in drug-resistant mesial temporal lobe epilepsy (MTLE). (lfranca.uk)
surgery is regarded as a common treatment option for patients with mesial temporal lobe epilepsy (mtle) as a result of hippocampal sclerosis (hs). (brain-knowledge-engine.org)
Mesio temporal lobe epilepsy (MTLE) is one of the most prominent forms of focal drug resistant epilepsy. (synapcell.com)
The MTLE Mouse model is a chemically induced model of mesial temporal lobe epilepsy. (synapcell.com)
A first step to validate the first application on the market for drug resistant focal epilepsies is proposed with the MTLE mouse model. (synapcell.com)
A screening protocol was developed with the MTLE mouse model and is used to test a library of 6 compounds over 3 weeks in order to identify the most promising drugs based on their effect on hippocampal paroxysmal discharges. (synapcell.com)

Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis. (brain-knowledge-engine.org)
22 The prototypical example of a surgically-remediable epilepsy syndrome is temporal lobe epilepsy associated with mesial temporal sclerosis (MTS). (neurosurgicalatlas.com)

Experimental activation of a small set of nerve cells in the brain prevents convulsive seizures in a mouse model of temporal lobe epilepsy, the most common form of epilepsy among human adults. (sciencedaily.com)
Experimental activation of a small set of nerve cells in the brain prevents convulsive seizures in a mouse model of temporal lobe epilepsy, the most common form of epilepsy among human adults, according to a study by researchers at the Stanford University School of Medicine. (sciencedaily.com)
To answer the question, Soltesz, who holds the James R. Doty Professorship of Neurosurgery and Neurosciences, and his colleagues turned to a mouse model of temporal lobe epilepsy. (sciencedaily.com)
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. (brain-knowledge-engine.org)
Activation of Fos during spontaneous hippocampal seizures in a model of temporal lobe epilepsy. (brain-knowledge-engine.org)
Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy. (brain-knowledge-engine.org)
The purpose of this study was to evaluate the effects of anakinra, lamotrigine, and their combination on epileptogenesis using the rat lithium-pilocarpine model of temporal lobe epilepsy. (bvsalud.org)
to elucidate seizure-associated disturbances in the norepinephrine-dependent modulation of hippocampal output, we investigated the functional consequences of the \xce\xb2-ar-dependent synaptic plasticity at ca1-subiculum synapses for the transfer of hippocampal output to the para hippocampal region in the pilocarpine model of temporal lobe epilepsy . (brain-knowledge-engine.org)

30% of people with epilepsy continue to have seizures. (lu.se)
Â The aim of epilepsy surgery is to improve the quality of life of people with epilepsy. (ejournals.ca)
Factors influencing on QoL in people with epilepsy. (ejournals.ca)
When medications fail, as they do in about one-third of people with epilepsy, surgery to remove affected brain tissue without compromising function is a drastic step, but offers a potential cure. (nih.gov)
But in some people with epilepsy, glutamate seems to build up outside of brain cells, triggering continuous overstimulation and potential seizures. (nih.gov)
In contrast to the people with epilepsy, GluCEST scans of 11 healthy volunteers didn't show any consistent differences in glutamate levels on one side of the brain versus the other. (nih.gov)
Although the new study represents a very small number of patients, it suggests that GluCEST might stand to improve patient care and quality of life in people with epilepsy who now have very limited treatment options. (nih.gov)
The researchers say they've reported their early findings in hopes that they can be validated in more people with epilepsy by researchers at other medical centers. (nih.gov)
We employed these earlier people with epilepsy published in 2000 showed search dates to ensure that we captured data on that compared to U.S. Census Bureau norms, standard drug treatments, which are likely to be respondents received less education, were less in relatively older literature. (cdc.gov)

Gating of hippocampal output by \\xce\\xb2-adrenergic receptor activation in the pilocarpine model of epilepsy. (brain-knowledge-engine.org)

The less common lateral temporal lobe or neocortical temporal lobe seizures arise from the outer (lateral) temporal lobe. (wikipedia.org)
Lateral temporal lobe seizures arising from the temporal-parietal lobe junction may cause complex visual hallucinations. (wikipedia.org)
In comparison to mesial temporal lobe seizures, lateral temporal lobe seizures are briefer duration seizures, occur with earlier loss of awareness, and are more likely become a focal to bilateral tonic-clonic seizure. (wikipedia.org)

71 Psychiatric disorders are more common among those with epilepsy, and the highest prevalence occurs among those with temporal lobe epilepsy. (wikipedia.org)
2010. The 3',5'-cyclic adenosine monophosphate (cAMP) cascade is a major signal transduction system in brain and may be involved in psychiatric illnesses such as mood disorders and drug addiction. (grantome.com)
Hill, D. Psychiatric disorders of epilepsy . (symptoma.com)

Seizure symptoms and behavior distinguish seizures arising from the medial temporal lobe from seizures arising from the lateral (neocortical) temporal lobe. (wikipedia.org)
Researchers say there is no reliable scientific evidence to support the claim that listening to Mozart's Sonata KV448 can provide relief from symptoms of epilepsy as previously claimed. (neurosciencenews.com)
Phobic and agoraphobic symptoms are common in those with epilepsy and result in a poorer quality of life. (neurosciencenews.com)
The temporal lobe is responsible for functions such as memory, emotion, and language, so seizures that originate in this area of the brain can lead to a range of symptoms, including altered consciousness, memory loss, and changes in mood or behavior. (kimiyahealing.co.uk)
Symptoms of temporal lobe seizures may vary depending on the individual and the severity of the seizures. (kimiyahealing.co.uk)
Temporal lobe epilepsy (TLE) can present with a range of symptoms, which can vary from person to person. (kimiyahealing.co.uk)
IRF2BPL has recently been described as a novel cause of neurodevelopmental disorders with multi-systemic regression, epilepsy, cerebellar symptoms, dysphagia, dystonia, and pyramidal signs. (researchid.co)
Interestingly," he said, "these experiments also showed a disappearance of symptoms for epilepsy that outlasted drug exposure suggesting significant disease-modifying properties with a curative potential for epilepsy. (medscape.com)

validation in human drug-resistant epileptic tissue resected from patients. (lu.se)
Epilepsy is defined as a brain disorder characterized by an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition. (medscape.com)
Medical management with anti-epileptic drugs (AEDs) is the first-line intervention for patients with epilepsy. (neurosurgicalatlas.com)
Though anti- epileptic drugs (AED) are the most common means of treating TLE, undesirable side effects associated with them limit their usage. (journalcra.com)
This kind of study would shed light on the cellular and molecular basis underlying anti-epileptic and cognition enhancing effects of enriched rehabilitation for treating drug resistant TLE in young as well as aged subjects. (journalcra.com)
1] Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy . (nih.gov)
Does epileptic activity impair sleep-related memory consolidation in epilepsy? (anphylab.com)
Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric Patients. (cdc.gov)

[ 1 ] Temporal lobe epilepsy is a common type of epilepsy that is sometimes difficult to diagnose, but once diagnosed it can be effectively treated with medications. (medscape.com)
Temporal lobe epilepsy is a type of epilepsy that is characterized by seizures that originate in the temporal lobe of the brain. (kimiyahealing.co.uk)
While the findings are preliminary and must be confirmed by larger studies, researchers are hopeful that GluCEST, which takes about 30 minutes, may open the door to new ways of treating this type of epilepsy. (nih.gov)

Continuous EEG monitoring after status epilepticus revealed an accelerated and exacerbated epilepsy phenotype whereby spontaneous seizures began sooner, occurred more frequently and were of longer duration in miR-22-deficient mice. (researchsquare.com)
Expression of various miRNAs is dysregulated in experimental models of status epilepticus and in resected brain tissue from patients with drug-resistant temporal lobe epilepsy [ 11-13 ]. (researchsquare.com)

Rhythm Pharmaceuticals Inc. has presented preclinical data on its new drug candidate, RM-718, a next-generation melanocortin MC4 receptor (MC4R) agonist for weekly administration with a potential development path for hypothalamic obesity. (bioworld.com)
In epilepsy, several gene therapy alternatives are at late preclinical stage, and their advance towards clinical trials is expected in the nearest future. (lu.se)
Taken together, these innovative approaches will lead to discovery of novel gene therapy targets and modalities, facilitating preclinical investigations, which in the long-run will benefit drug-resistant population of patients with epilepsy. (lu.se)
Preclinical studies have highlighted the potential of RNA therapies for treatment of epilepsy. (medscape.com)
At NEUmiRNA Therapeutics, we have successfully designed potent and selective RNA drugs for a novel disease target that enable unprecedented elimination of the drug resistance and chronic epilepsy in a preclinical model mimicking temporal lobe epilepsy ," Klitgaard told Medscape Medical News . (medscape.com)

Epilepsy and Behavior, 50 , 162-170. (mpg.de)
Epilepsy & behavior : E&B. vol 38. (brain-knowledge-engine.org)
Besides unpredictable seizure attacks, co-morbidities like cognitive impairment, anxiety, depression and disturbed social behavior are severe in elderly subjects inflicted with epilepsy. (journalcra.com)
Epilepsy and Behavior. (arizona.edu)

The annual cost of epilepsy in Europe is estimated at 15 B€. The major unmet need is defined as inability to control seizures in drug-resistant population. (lu.se)
Though current antiseizure medications (ASMs) can control seizures in two thirds of patients, drug-resistant epilepsy remains a major challenge for the remaining one third, as does the lack of disease-modifying therapies. (medscape.com)

The current therapies for drug-resistant epilepsy are only partially effective and have serious drawbacks. (ca.gov)
In this proposal, we will investigate a new generation of precise gene therapies based on targeting novel optogenetic and chemogenetic tools to strengthen seizure-suppressant effect and improve seizure freedom outcome in drug-resistant models of epilepsy. (lu.se)
Henrik Klitgaard, PhD, and Sakari Kauppinen, PhD, scientific co-founders of NEUmiRNA Therapeutics, note that the success of messenger RNA (mRNA) vaccines to counter the COVID-19 pandemic has fueled interest in exploring the potential of RNA-based therapies as a new modality in epilepsy with improved therapeutic properties. (medscape.com)

Here, we describe therapeutic strategies for modulating disease-associated RNA molecules and highlight the potential of RNA therapeutics for the treatment of different patient populations such as sporadic, drug-resistant epilepsy, and childhood monogenic epilepsies. (cureepilepsy.org)
And finally, yesterday, Neurona Therapeutics announced the dosing of their initial patient in their Phase 1/2 clinical trial to treat drug-resistant mesial temporal lobe epilepsy . (clearpointneuro.com)
But RNA-based therapeutics offer new hope and experts predict they could fill these gaps and revolutionize epilepsy treatment. (medscape.com)

The QoL of older adults with epilepsy: A systematic review. (ejournals.ca)
Prevalence and predictors of vitamin D deficiency among adults with epilepsy: A cross-sectional study. (cdc.gov)

In fact, 90% of patients with temporal interictal epileptiform abnormalities on their electroencephalograms (EEGs) have a history of seizures. (medscape.com)
Patients undergoing testing for epilepsy often experience significant distress when their medication is reduced to provoke seizures. (neurosciencenews.com)
This experimental therapy, called NRTX-1001, has the potential to offer drug-resistant temporal lobe epilepsy patients a non-destructive cure for their seizures. (neurosciencenews.com)
Using EEG technology, researchers were able to detect pathological brain activity associated with seizures up to thirty minutes before a seizure occurred in patients with temporal lobe epilepsy. (neurosciencenews.com)
And it points to an entirely new entry point for developing drugs that could bring therapeutic relief to people with chronic, drug-resistant epilepsy, a debilitating condition that not only circumscribes patients' lifestyles and occupational options but predisposes them to depression, anxiety and early death. (sciencedaily.com)
Your medically-refractory focal epilepsy patients may benefit from Visualase™ MRI-guided laser ablation. (medtronic.com)
the memory deficits in patients with temporal lobe epilepsy (tle) are associated with epileptogenic lesions of the temporal lobes, especially hippocampal sclerosis. (brain-knowledge-engine.org)
An increasing number of epilepsy patients are afflicted with drug-resistant temporal lobe epilepsy (TLE) and require alternative therapeutic approaches. (mdc-berlin.de)
AIM OF THE STUDY: This study aims to analyze differentially expressed proteins (DEPs) in the plasma exosomes of patients with temporal lobe epilepsy (TLE) and after the Chaihu-Longgu-Muli Decoction (CLMD) therapy and to explore the biomarkers of TLE and the potential targets of CLMD in treating TLE. (bvsalud.org)
The major challenges in realizing the full potential of epilepsy surgery, therefore, are not as much in the continued improvement of the treatment itself, as they are in addressing the treatment gap that is preventing appropriate patients from being referred to full-service epilepsy centers. (cureepilepsy.org)
In a study carried out at the Sahlgrenska University Hospital in Gothenburg, one group of 36 patients were given medication for their epilepsy while a second group of 51 patients underwent surgery. (medizin-aspekte.de)
Andersson-Roswall believes that it is important that patients with drug-resistant epilepsy are given an opportunity to be investigated for suitability for epilepsy surgery at an early stage of the disease, and that they are offered regular cognitive evaluations whatever the treatment. (medizin-aspekte.de)
Title of thesis: Longitudinal cognitive changes in medically and surgically treated patients with drug resistant partial epilepsy. (medizin-aspekte.de)
Seizure frequency and social outcome in drug resistant epilepsy patients who do not undergo epilepsy surgery. (ejournals.ca)
Health-related QoL and its determinants among ambulatory patients with epilepsy at Ambo General Hospital, Ethiopia: Using WHOQOL-BREF. (ejournals.ca)
QoL in adult patients with epilepsy and their family members. (ejournals.ca)
Potential factors impacting health-related QoL among patients with epilepsy: Results from the United Arab Emirates. (ejournals.ca)
3,4 As a group, patients with DRE account for ~80% of all epilepsy-related costs in the US. (neurosurgicalatlas.com)
Prior to epilepsy surgery, patients undergo a comprehensive assessment to determine their surgical candidacy and to plan the intervention. (neurosurgicalatlas.com)
17,18 Considering the risks that accumulate with chronic seizures and AED therapy, many have advocated for lower referral thresholds in an effort to increase utilization and avail more patients to the potential benefits of epilepsy surgery. (neurosurgicalatlas.com)
hippocampal sclerosis is the most frequent pathology encountered in resected tissue obtained from patients with temporal lobe epilepsy . (brain-knowledge-engine.org)
Unfortunately, not all drug-resistant patients are good candidates for such surgery for a simple reason: their brains appear normal on traditional MRI scans, making it impossible to locate precisely the source(s) of the seizures. (nih.gov)
The GAERS model is recognised as a true translational model for epilepsy absence as the pharmacology in the model is parallel to the one observed in human patients. (synapcell.com)
The schizophrenia-like psychosis of epilepsy , which is believed to affect between 2% and 8% of patients with long-standing complex partial seizures, has been associated primarily with temporal lobe epilepsy (TLE). (symptoma.com)
Epilepsy affects over 65 million people worldwide and significantly burdens patients, caregivers, and society. (biomedcentral.com)
Drug-resistant epilepsy occurs in approximately 30% of patients and growing evidence indicates that oxidative stress contributes to the development of such epilepsies. (biomedcentral.com)
Strategies to prevent the emergence of drug-resistant epilepsy (DRE) would be of significant value to patients and their healthcare providers. (biomedcentral.com)
Twenty-five years ago, when I was caring for patients in my clinic, half of epilepsy was considered idiopathic because we didn't know the cause," Kaye commented. (medscape.com)

Frontal lobe complex partial seizures (focal impaired awareness seizures) have certain distinct characteristics. (medscape.com)
With the exception of surgical referral for evaluation of treatment-resistant, disabling complex partial seizures, 15 there are no well-established indications for epilepsy surgery evaluation. (neurosurgicalatlas.com)

Temporal lobe epilepsy (TLE) is the most common form of intractable epilepsy with a risk of low quality of life due to uncontrolled seizures. (ejournals.ca)

During 2022-2025 we expect to begin the stereo-electroencephalography study of the patient affected by cryptogenic focal pharmacoresistant epilepsy. (researchid.co)

In this article, we will delve into the scientific research on how childhood trauma, in utero stress, and birth trauma can impact the temporal lobe and increase the risk of developing TLE. (kimiyahealing.co.uk)
The temporal lobe of the brain plays a key role in processing memories, including those associated with childhood trauma. (kimiyahealing.co.uk)
Research has shown that childhood trauma can lead to changes in the structure and function of the temporal lobe. (kimiyahealing.co.uk)
Treatment options and paradigms in childhood temporal lobe epilepsy. (brain-knowledge-engine.org)
From late childhood/adolescence, they presented with severe myoclonus epilepsy, stimulus-sensitive myoclonus, and progressive cognitive, speech, and cerebellar impairment, consistent with a typical PME syndrome. (researchid.co)
Targeting noncoding RNAs shows promise in sporadic, nongenetic epilepsies, and targeting of mRNAs shows promise in childhood monogenic epilepsies. (medscape.com)
Pharmacogenetic study of phosphatase and tensin homolog polymorphism (rs701848) in childhood epilepsy: relation to circulating Wnt signaling. (cdc.gov)

Medically intractable temporal lobe epilepsy is amenable to epilepsy surgery with a very high seizure-free rate. (medscape.com)
Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults: Seizure response rates, complications, and neuropsychological outcomes. (medscape.com)
Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. (medtronic.com)

Joudi Mashhad M, Harati H, Parooie F, Salarzaei M. Epilepsy surgery for refractory seizures: a systematic review and meta-analysis in different complications. (ejournals.ca)
Association between SCN1A polymorphism and risk of epilepsy in children: A systematic review and meta-analysis. (cdc.gov)

The Visualase MRI-Guided Laser Ablation System received Food and Drug Administration (FDA) clearance in the United States in July 2007 to necrotize or coagulate soft tissue. (medgadget.com)

A modest explosion in interest in epilepsy surgery at mid-century resulted from recognition that "invisible" epileptogenic lesions could be identified by EEG, especially for temporal lobe epilepsy. (cureepilepsy.org)

347-348 However, subsequent studies did not support the association of these behavioral traits with temporal lobe epilepsy. (wikipedia.org)
Artificial intelligence was able to determine different behavioral phenotypes at different stages in the development of epilepsy in mice. (neurosciencenews.com)
Moreover, DMF treatment reversed epilepsy-induced behavioral deficits in the treated rats. (biomedcentral.com)

Temporal lobe epilepsy is a neurological condition that impacts the temporal lobe of the brain. (kimiyahealing.co.uk)
If they are successful, this new tool could yield important insights into epilepsy and a variety of other neurological disorders in which glutamate is thought to play an important role, including schizophrenia, Alzheimer's disease, Parkinson's disease, and maybe even autism. (nih.gov)
Over 65 million people worldwide suffer from epilepsy, one of the most prevalent and debilitating neurological diseases [ 1 ]. (biomedcentral.com)

Anticonvulsant medications, epilepsy surgery and dietary treatments may improve seizure control. (wikipedia.org)
Epilepsy surgery received a second boost in popularity toward the end of the 20th century with the advent of structural and functional neuroimaging, and the number of epilepsy centers worldwide doubled between the first Palm Desert conference in 1986 and the second Palm Desert conference in 1992. (cureepilepsy.org)
Three randomized control trials now have definitively proved the safety and efficacy of epilepsy surgery, however this alternative therapy remains under-utilized even in the industrialized world, where less than 1% of potential candidates are being referred to epilepsy centers. (cureepilepsy.org)
But verbal memory can be affected by surgery in the left temporal lobe. (medizin-aspekte.de)
Muttaqin Z. Epilepsy Surgery in Indonesia : Achieving a Better Result with Limited Resources. (ejournals.ca)
7 Several randomized controlled trials (RCTs) and meta-analyses demonstrate that epilepsy surgery offers the best chance of seizure control when ≥2 AED trials have failed. (neurosurgicalatlas.com)
The purpose of this chapter is to highlight the main steps and modalities that constitute the presurgical evaluation for focal epilepsy surgery. (neurosurgicalatlas.com)
While lack of adherence to AED therapy (e.g. due to side effects) does not contribute to the diagnosis of DRE, poor medication tolerance could justify the decision to pursue epilepsy surgery in the absence of formally demonstrated drug resistance. (neurosurgicalatlas.com)
The notion of a surgically-remediable epilepsy syndrome refers to a pattern of epilepsy that is clinically stereotyped, frequently resistant to AEDs, and responsive to surgery. (neurosurgicalatlas.com)
advanced [(18)f]fdg and [(11)c]flumazenil pet analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis. (brain-knowledge-engine.org)
we have previously shown that an imaging marker, increased periventricular [(11)c]flumazenil ([(11)c]fmz) binding, is associated with failure to become seizure free (sf) after surgery for temporal lobe epilepsy (tle) with hippocampal sclerosis (hs). (brain-knowledge-engine.org)
A subpopulation of spikes predicts successful epilepsy surgery outcome. (anphylab.com)

Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis. (medscape.com)

Hippocampal intrinsic bursting-firing neurons and temporal lobe epilepsy]. (brain-knowledge-engine.org)

Surgical Treatment for Refractory Epilepsy: Review of Patient Evaluation and Surgical Options. (ejournals.ca)
Characterization of genetic variants in children with refractory epilepsy]. (cdc.gov)

Hippocampal sclerosis, brain tumor, traumatic brain injury, cerebral vascular malformation, neuronal migration disorders, infections such as encephalitis and meningitis, autoimmune disease (limbic encephalitis) and genetic disorders may cause temporal lobe epilepsy. (wikipedia.org)
Since epilepsy is also supposed to constitute a comorbidity of DMD, it is hypothesized that dystrophin plays a role in neuronal excitability. (frontiersin.org)
Sequencing as well as functional studies using antisense oligonucleotides, indicate important roles for microRNAs during the development of epilepsy through targeting transcripts involved in neuronal structure, gliosis and inflammation. (researchsquare.com)
Idiopathic generalised epilepsy: a pilot study of memory and neuronal dysfunction in the temporal lobes, assessed by magnetic resonance spectroscopy. (brain-knowledge-engine.org)

SynapCell will participate to the 14th EILAT Conference on New Antiepileptic Drugs and Devices in Madrid May 13-16. (synapcell.com)

Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. (medscape.com)
Neuroimaging also helped to increase application of surgical treatment to infants and young children with severe epilepsies. (cureepilepsy.org)
The results of our study can be used in investigations to advise on possible surgical treatment of those with drug-resistant epilepsy. (medizin-aspekte.de)
Miller JW, Hakimian S. Surgical treatment of epilepsy. (ejournals.ca)

layer ii stellate cells of the entorhinal cortex, which are hyperexcitable in animal models of temporal lobe epilepsy , provide the predominant synaptic input to the hippocampal dentate gyrus. (brain-knowledge-engine.org)
Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy. (cdc.gov)

The temporal lobe is the most epileptogenic region of the brain. (medscape.com)
Here, we aimed to study brain dystrophin distribution and expression in both, human and experimental temporal lobe epilepsy (TLE). (frontiersin.org)
Researchers discovered a shared brain circuit that may link diverse lesion locations that cause epilepsy. (neurosciencenews.com)
Such brain injuries, in turn, increase the risk for temporal lobe epilepsy. (sciencedaily.com)
Prolonged or repeated seizures are damaging to the brain and can establish lasting states of hyperexcitability that produce recurrent spontaneous seizures (epilepsy) [ 1 , 2 ]. (researchsquare.com)
These drugs affect whole brain, resulting in adverse effects. (lu.se)
A potential cause of temporal lobe epilepsy is primary brain injury, making prevention of epileptogenesis after the initial event an optimal method of treatment. (bvsalud.org)
The causes of epilepsy can be temporary or permanent damage to the brain, but cannot always be identified. (medizin-aspekte.de)
2) We found that our PET radioligand, 11C-desmethyl-loperamide (a metabolite of Imodium), is selective at the blood-brain barrier for one drug transporter that may cause resistance to treatment in several disorders, including cancer, epilepsy, and HIV infection of brain (Kannan et al. (grantome.com)
At the blood-brain barrier, the three most prevalent ABC transporters (ABCB1, ABCC1, and ABCG2) are expressed in the walls of the blood vessels and not only protect the brain from toxic substances but also impede delivery of therapeutic drugs. (grantome.com)
At the blood-brain barrier, over-expression of ABCB1 may contribute to drug-resistance in epilepsy and in HIV infection of the brain. (grantome.com)
We review the available evidence for the use of neurostimulation to treat pediatric epilepsy, including vagus nerve stimulation (VNS), responsive neurostimulation (RNS), deep brain stimulation (DBS), chronic subthreshold cortical stimulation (CSCS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). (mdpi.com)
GluCEST imaging of the brain of a person with drug-resistant epilepsy, showing the hippocampi (highlighted) with signal for high glutamate (red). (nih.gov)
Using a new MRI method, called GluCEST, that detects concentrations of the nerve-signaling chemical glutamate in brain tissue [2], researchers successfully pinpointed seizure-causing areas of the brain in four of four volunteers with drug-resistant epilepsy and normal traditional MRI scans. (nih.gov)

hence, ideal therapeutic interventions ought to be efficient for restraining these detrimental changes in order to block the propensity of most hippocampal injuries to evolve into learning deficits, memory dysfunction, depression, and temporal lobe epilepsy . (brain-knowledge-engine.org)
The second step consists in the evaluation of AED candidates for their therapeutic or aggravating effects on epilepsy absence with the GAERS model. (synapcell.com)
Finally, AED candidates are tested on the GAERS model to validate and de-risk the therapeutic potential in generalised epilepsy. (synapcell.com)
Taken together, these findings suggest that DMF, through the activation of Nrf2, has the potential to serve as a therapeutic target for preventing epileptogenesis and modifying epilepsy. (biomedcentral.com)

Familial temporal lobe epilepsy: a common disorder identified in twins. (medscape.com)
How Common is Temporal Lobe Epilepsy? (kimiyahealing.co.uk)
Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is often refractory to drug therapy. (bvsalud.org)
An emblematic case is temporal lobe epilepsy (TLE), the most common drug-resistant epilepsy that is electroclinically defined as a focal epilepsy and pathologically associated with hippocampal sclerosis. (mpg.de)
MTS is the most common cause of focal epilepsy in adults and is often refractory to medications. (neurosurgicalatlas.com)
Epilepsy affects over 50 million people worldwide, making it one of the most common neurologic disorders. (medscape.com)
Epilepsy is a common, serious neurologic diagnostic technology, three antiepileptic drug condition. (cdc.gov)

CURE Epilepsy is a qualified 501(c)3 tax-exempt organization. (cureepilepsy.org)

To understand why glutamate might be a useful marker for epilepsy, it's useful to note that this molecule serves as the brain's main excitatory nerve signal. (nih.gov)
In the study, led by Ravinder Reddy and Kathryn Davis of the University of Pennsylvania, the researchers turned to GluCEST to image hot spots specifically in people with drug-resistant epilepsy localized to the brain's temporal lobe. (nih.gov)

The major cognitive impairment in mesial temporal lobe epilepsy is a progressive memory impairment. (wikipedia.org)
Inactivating this nerve-cell population also induces the same cognitive losses that characterize chronic, drug-resistant temporal lobe epilepsy in humans, the scientists found. (sciencedaily.com)
People suffering from drug-resistant epilepsy are further affected by co-morbidities, such as cognitive impairment, depression, and sudden unexpected death in epilepsy (SUDEP). (lu.se)
We found that the members of this group had more cognitive difficulties than members of the control group, and their memory, attention and processing speed had also deteriorated relative to the control group," explains Lena Andersson-Roswall, registered psychologist and member of the Epilepsy Research Group at the Institute of Neuroscience and Physiology at the University of Gothenburg. (medizin-aspekte.de)
Hippocampal injury-induced cognitive and mood dysfunction, altered neurogenesis, and epilepsy: can early neural stem cell grafting intervention provide protection? (brain-knowledge-engine.org)
These results should lead to a reduction in the number of drugs received and the avoidance of medications with unfavorable cognitive profiles. (cureepilepsy.org)

In estimated the prevalence of active epilepsy as 40 addition, we also surveyed the definitions of to 100 in 10,000 and the incidence of treatment-resistant epilepsy in the published unprovoked seizures as 2 to 7 per 10,000. (cdc.gov)

Dr. Favre brings more than 25 years of experience in gene therapy, immunology and drug development throughout academia and the biopharma industry. (ucbventures.com)

The objective of this study was to characterize temporal and - spectral patterns of ANT ictal recruitment in drug-resistant temporal lobe epilepsy (TLE). (biorxiv.org)

At the American Epilepsy Society meeting this week, Longboard Pharmaceuticals Inc. presented data on their 5-HT2C receptor superagonist LP-352 for the treatment of epilepsy. (bioworld.com)
While medication is often the first line of treatment for temporal lobe epilepsy, some individuals may find that they are not able to achieve adequate seizure control with medication alone. (kimiyahealing.co.uk)
However, the drugs administered alone were found to be more effective in preventing neuron loss in the hippocampal CA3 field compared to combination treatment. (bvsalud.org)
Activation of the Nrf2 pathway, which is involved in cellular defense, offers a potential strategy for reducing oxidative stress and epilepsy treatment. (biomedcentral.com)
Moreover, DMF treatment even when initiated well after the diagnosis of epilepsy, reduced symptomatic seizures long after the drug was eliminated from the body. (biomedcentral.com)
Today, I believe we are on the verge of a fundamental shift in how we approach the treatment of Dravet syndrome and, hopefully, other genetic epilepsies," said Kaye. (medscape.com)
In this report, we evaluate and synthesize the This evidence report addresses nine key published literature on diagnosis of, and medical research questions encompassing 49 and nonmedical interventions for treatment- technologies, including several service-related resistant epilepsy. (cdc.gov)

Anatomy21

Organisms4

Diseases28

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology18

Phenomena and Processes12

Disciplines and Occupations1

Humanities2

Information Science6

Named Groups1

Health Care8

Hippocampus12

International League Against Epilepsy6

20234

Neurology1

ILAE3

Onset7

MTLE8

Mesial temporal2

Model of temporal lobe epi8

People with epilepsy9

Pilocarpine model1

Lateral temporal lobe3

Psychiatric3

Symptoms8

Epileptic8

Type of epilepsy3

Status epilepticus2

Preclinical5

Behavior4

Control seizures2

Therapies3

Therapeutics3

Adults With Epilepsy2

Patients28

Complex partial2

Intractable epilepsy1

20221

Childhood7

Medically3

Systematic review2

Laser Ablation1

Epileptogenic lesions1

Behavioral3

Neurological3

Surgery12

Outcome1

Neurons1

Refractory Epilepsy2

Neuronal4

Antiepileptic drugs1

Surgical4

Synaptic2

Brain14

Therapeutic4

Common7

CURE Epilepsy1

Brain's2

Cognitive6

Prevalence1

Gene1

Characterize1

Treatment7