• Median viral load at the time of tropism testing was 53,326 (IQR 16,328-113,018) and median CD4+ count 184 (IQR 142-217) cells/cmm. (biomedcentral.com)
  • The analysis included 2149 switchers with a median age of 50, a median CD4 count of 577, and a median viral load of 1.57 log (under 40 copies). (natap.org)
  • The prevalence of H208Y in antiretroviral treatment naïve and treatment experienced patients was 5/3783 (0.1%) and 12/1304 (0.9%), respectively, indicating a high degree of conservation of position 208 in wild type virus and an increase in prevalence under selective drug pressure. (ucl.ac.uk)
  • While the prevalence of X4-tropic viruses in subtype B is relatively well studied the distribution of tropism in CRF06_cpx (causing Estonian epidemic) is less known, especially in the treatment experienced patients with established multidrug-resistance and who are candidates for therapy with CCR5 antagonist. (biomedcentral.com)
  • The results of the study, which took place across 13 health facilities in six countries, examined the role of "pretreatment drug resistance" on patients' need to switch from first to second-line therapies, and on HIV-related illnesses and deaths. (thebodypro.com)
  • Lymphopenia is induced by lymphoablative therapies and chronic viral attacks. (elevateblogconference.com)
  • The item Breaking the Wall of Viral Drug Resistance : How Bioinformatics Can Help to Improve AIDS Therapies, Falling Walls Foundation, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in City Libraries, City of Gold Coast . (qld.gov.au)
  • Seeks to bring to market the first anti-HIV drug that solves the problems of viral resistance, a major shortcoming of all current therapies. (dmoztools.net)
  • This 2010 Falling Walls lecture video explores how his research has led to effective AIDS therapy, especially in the later stages of the disease, when the virus has evolved to high resistance. (qld.gov.au)
  • An AIDS research project that uses your computers idle resources to accelerate new anti-HIV drug design. (dmoztools.net)
  • An initiative to improve the clinical management of HIV/AIDS using large databases of clinical data to enhance understanding of HIV drug resistance. (dmoztools.net)
  • Information about NDRI and its purpose which is to advance scientific knowledge in the areas of drug abuse, HIV/AIDS, therapeutic communities and related areas of mental and public health. (dmoztools.net)
  • The two amplicons generated span 7,124 bp, providing substantial sequence length and number of informative sites for comprehensive phylogenic analysis and greater refinement of viral linkage analyses in HIV prevention studies. (krisp.org.za)
  • and Aim 4: Enhance analyses of viral failure, drug resistance accumulation and associated demographic and clinical factors by examining the longitudinal banked samples available for a subset of the study cohort (n=327). (elsevier.com)
  • Compositions including resistance test vectors comprising a patient-derived segment comprising an HCV or HCMV gene and an indicator gene and host cells transformed with the resistance test vectors are provided. (epo.org)
  • and (3) detailed investigation of adherence, drug concentration and other clinical data, to impact pediatric HIV care in resource limited settings. (elsevier.com)
  • however, there are few longitudinal data on rates of and factors associated with viral failure and resistance development in children, particularly in sub-Saharan Africa, where over 90% of HIV-infected children live. (elsevier.com)
  • However, 38% (70/183) had positive viral loads suggesting treatment non-response. (usp.br)
  • We will focus on interactions of the major HIV enzymes with their partners and effectors since they encompass key processes in the viral life cycle and as existing drug targets provide a rich base of structural, biological and evolutionary data that will serve to infom our goals. (grantome.com)
  • We will study the mechanistic implications of viral macromolecular interactions and dynamics and its broader impacts of the evolution of drug resistance. (grantome.com)
  • Evaluation of a viral vector system, based on a defective interfering RNA of tomato bushy stunt virus, for protein expression and the induction of gene silencing".Madalena Chaves Project-team BioCO 2. (slipcamgirls.ml)
  • Our approach is significant both for the promise of new structural insights into the interdependence of viral mechanisms, but also for the direct potential for new drug design methodologies and therapeutic strategies. (grantome.com)
  • Distribio Laboratoire de.Mechanisms of Antibiotic Resistance in the Microbial World. (slipcamgirls.ml)
  • He defined the structure of viral chromatin during latent infection of neurons and the mechanisms by which viral DNA is kept silenced during latent infection. (wikipedia.org)
  • and the viral latency-associated transcript promotes heterochromatin modifications on viral chromatin and silencing of lytic genes in neurons. (wikipedia.org)
  • This invention also provides a method for evaluating the biological effectiveness of a candidate HCV or HCMV anti-viral drug compound. (epo.org)
  • TDM involves analyzing the virus, giving drugs the virus is most sensitive to, monitoring drug blood levels to make sure there is enough drug to work against the virus, and changing the drug dose if it is too low. (clinicaltrials.gov)
  • If not enough of the drug is found in the blood, the dose of the drug will be increased and the amount of the drug in the blood will be checked again. (clinicaltrials.gov)
  • This study will evaluate a new treatment strategy called therapeutic drug monitoring (TDM) in HIV-infected children and adolescents. (clinicaltrials.gov)
  • The purpose of this proposal is to longitudinally investigate treatment failure, drug resistance and associated factors among a previously established, carefully characterized cohort of 685 HIV-infected children in western Kenya. (elsevier.com)
  • We will utilize the excellent AMPATH infrastructure, as well as a previous NIH-funded study that established this cohort of children (Vreeman: 1K23MH087225), to provide novel and significant data on the development of failure and resistance over five years. (elsevier.com)
  • This research will significantly impact understanding of longitudinal failure and resistance development and which factors influence their development. (elsevier.com)
  • 3. How does dynamics impact viral fitness and how can it be exploited for therapeutic targeting? (grantome.com)
  • Mutations around interferon sensitivity-determining region: a pilot resistance report of hepatitis C virus 1b in a Hong Kong population. (biomedsearch.com)
  • AIM: To explore mutations around the interferon sensitivity-determining region (ISDR) which are associated with the resistance of hepatitis C virus 1b (HCV-1b) to interferon-α treatment. (biomedsearch.com)
  • Significant discrepancies in resistance interpretations were observed in 9 cases, 6 of which were from the same laboratory. (asm.org)
  • Citation: Novitsky V, Zahralban-Steele M, McLane MF, Moyo S, Widenfelt E, Gaseitsiwe S, Makhema J, Essex M. Long-range HIV genotyping using viral RNA and proviral DNA for analysis of HIV drug-resistance and HIV clustering Journal of Clinical Microbiology,in press:in press (2015). (krisp.org.za)