• In earlier work, Elizabeth A. Hopper-Borge, Ph.D., an assistant professor at Fox Chase, showed that Abcc10 confers resistance to a number of anticancer agents, particularly taxanes, which include paclitaxel (Taxol) and docetaxel (Taxotere). (news-medical.net)
  • This mechanism of action is similar to that of taxanes (paclitaxel and docetaxel), but epothilones retain activity against multi-drug resistance (MDR) tumours. (knowcancer.com)
  • Taxane chemotherapy includes docetaxel, paclitaxel, or cabazitaxel, and even though many of these treatments are effective, the cancerous cells inevitably become resistant to taxane, causing the cancer to persist and return,'' says Xie. (corning.com)
  • These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
  • The following chemotherapeutic drugs: paclitaxel, docetaxel, doxorubicin, epirubicin and carboplatin were purchased from Sigma Aldrich (St. Louis, MO), dissolved in dimethyl sulfoxide (DMSO) from Sigma Aldrich (St. Louis, MO) and supplemented in complete media at increasing concentrations. (biomedcentral.com)
  • This is known as a multidrug resistant-associated protein (MRP1) that causes resistance amongst many organic drugs that are not conjugated to acidic ligands. (wikipedia.org)
  • Title: Different ability of multidrug-resistant and-sensitive counterpart cells to release and capture extracellular vesicles Abstract: Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. (up.pt)
  • One mechanism behind chemo-resistance involves the upregulation of multidrug resistance (MDR) genes (ABC transporters) that effectively transport (efflux) drugs out of the tumor cells. (muni.cz)
  • However, whether ascites drives multidrug resistance in ovarian cancer cells awaits elucidation. (muni.cz)
  • Collectively, our findings identify a novel activity for ascites in promoting ovarian cancer multidrug resistance. (muni.cz)
  • In this study, we investigated whether ulixertinib could antagonize multidrug resistance (MDR)-mediated by ATP-binding cassette (ABC) transporters. (cp-456773inhibitor.com)
  • Multidrug resistance (MDR) in cancer cells leads to synchronous resistance of cancer cells to structurally unrelated anticancer drugs, which is one of the most important factors that are responsible for the failure of cancer chemotherapy [1, 2]. (cp-456773inhibitor.com)
  • 68.1% of cisplatin-resistant cells were sensitive to paclitaxel. (dcu.ie)
  • Here, we demonstrate that when cultured with ascites derived from ovarian cancer-bearing mice, a murine ovarian cancer cell line became less sensitive to paclitaxel, a first line chemotherapeutic agent for ovarian cancer patients. (muni.cz)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • Once taxane is operating within the body, the drug will bind to the β-tubulin of the prostate cancer cells, eventually leading to cell mitosis arrest or apoptosis,'' explains Xie. (corning.com)
  • When treating 2D cell cultures with taxane, we found that the cells were sensitive to the drug and mostly arrested in mitosis, leading to apoptosis. (corning.com)
  • Decreased intracellular drug concentration, enhanced function of cell processing active products, enhanced repair ability of cellular DNA damage, and blockage of related apoptosis pathways play an important role in it. (eurekaselect.com)
  • An increasing body of evidence suggests that aberrant microRNA expression enhances the development of drug resistance by interfering with the expression of target proteins that may be drug transporters, drug targets, or cell apoptosis- and cell-cycle-related components, resulting in cells with different degrees of sensitivity to chemotherapeutic drugs. (biomedcentral.com)
  • USP7 inhibition induces cell apoptosis and cell cycle G2/M arrest, and overcomes taxane resistance by inducing the protein degradation of PLK1, resulting in chromosome misalignment in mitosis. (biomedcentral.com)
  • A series of mechanisms contributes to MDR in cancer, including reduced apoptosis, advanced DNA damage repair mechanisms, or altered drug metabolism. (cp-456773inhibitor.com)
  • However, it is still unknown whether it can improve the drug resistance of lung cancer cells. (researchsquare.com)
  • Though inducing more significantly pyroptosis by activating Caspase-1/GSDMD pathway, OP-B relieved DDP resistance of A549 cells. (researchsquare.com)
  • The mechanism of drug resistance in tumors are complex, which mainly includes drug concentration reduction in tumor cells, abnormal drug metabolic pathway, DNA damage repair dysfunction, regulation of autophagy, blocking of apoptotic pathways, and self-renewal or proliferation of tumor stem cells. (researchsquare.com)
  • combined BI2536 (an inhibitor of PLK1) with cisplatin (DDP) to treat ESCC cells and found the combination of two drugs had a synergistic effect on tumor inhibition and resulted in pyroptotic death of cancer cells by Caspase-3/GSDME pathway. (researchsquare.com)
  • We hypothesize that drug resistance may be associated with stress hormone-induced alterations in breast cancer cells. (usuhs.edu)
  • To test this hypothesis, MDA-MB-231 cells were cultured with paclitaxel and/or cortisol, norepinephrine and epinephrine and cytotoxicity, cell cycle analyses, genomic and proteomic analyses were performed. (usuhs.edu)
  • To identify miRNAs that potentially cause the resistance to taxanes, such as PTX, we performed microarray analysis of miRNAs in KFr13 and PTX-resistant KFr13Tx cells. (nature.com)
  • The researchers isolated cells from the knockout mice and tested the cells' reactions to taxanes and two other anticancer drugs, vincristine and Ara-C. Compared to cells from normal mice that still possessed the gene for Abcc10, the knockout mouse cells were much more sensitive to the drugs. (news-medical.net)
  • Abcc10 and its ilk work by pumping drugs out of cells, so one might expect to see the drugs accumulating in cells that lack Abcc10, and that's exactly what Hopper-Borge's group saw. (news-medical.net)
  • The results provide the first evidence from living organisms that Abcc10 is a cell's built-in protection against the effects of powerful drugs, and raises the possibility of using Abcc10 inhibitors to break down that resistance and sensitize tumor cells to anticancer agents. (news-medical.net)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • Metformin enhances the sensitivity of drug-resistant ovarian cancer cells to chemotherapy. (oncotarget.com)
  • After three adaptations, cells were cultured for 72 hours in an orthogonal experiment using drugs that were used for adaptation. (oncotarget.com)
  • Xie notes that in cases of resistance, the occurrence of microtubule bundling was much less apparent or failed to show at all, causing the microtubule structure to remain intact and therefore the cancer cells became taxane resistant. (corning.com)
  • Taken together, these results suggest that CAFs-derived exosomes confer cisplatin resistance of NSCLC cells through transferring miRNA-130a and that PUM2 is a critical factor for packaging miRNA-130a into exosomes. (dovepress.com)
  • 11 Chemoresistance, either acquired or intrinsic, is associated with a complicated and multifactorial process, including decreases of intracellular drugs, changes of drug targets, aberrant regulation of cell survival or death, and crosstalks between tumor microenvironment and cancer cells. (dovepress.com)
  • Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. (medsci.org)
  • In 2D culture, all cells can proliferate at a relatively constant rate in a planar space, and can be provided uniform access to nutrients, oxygen or drugs. (medsci.org)
  • Paclitaxel-resistant cells were also sensitive to cisplatin, suggesting that alternating between agents may be beneficial. (dcu.ie)
  • However, when PANC-1 cells were treated with GMPs alone, both markers went up suggesting an increase in resistance against gemcitabine. (aacrjournals.org)
  • Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
  • MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. (up.pt)
  • EVs' cargo may include different players of MDR, such as microRNAS and drug-efflux pumps, which may be transferred from donor MDR cells to recipient drug-sensitive counterparts. (up.pt)
  • The present work aimed to: (i) compare the ability of drug-sensitive and their MDR counterpart cells to release and capture EVs and (ii) study and relate those differences with possible distinct fate of the endocytic pathway in these counterpart cells. (up.pt)
  • Our results showed that MDR cells released more EVs than their drug-sensitive counterparts and also that the drug-sensitive cells captured more EVs than their MDR counterparts. (up.pt)
  • This difference in the release and capture of EVs may be associated with differences in the endocytic pathway between drug-sensitive and MDR cells. (up.pt)
  • Importantly, manipulation of the recycling pathway influenced the response of drug-sensitive cells to doxorubicin treatment. (up.pt)
  • Transduced cells and the drug-selected KB-8-5-11 and C3M cell lines were incubated with 1.5 M Rh123 either alone (gray bars) or in combination with the P-gp modulators. (unscburma.org)
  • Additionally, expression of chimeric P-gp was able to confer a paclitaxel-resistant phenotype to HeLa cells characteristic of P-gp-mediated drug resistance. (unscburma.org)
  • The development of drug resistance in cancer cells presents a major obstacle to cancer treatments of all types, including small molecule inhibitors, monoclonal antibodies, and hormone therapy. (targetedonc.com)
  • The researchers examined 3 groups of breast cancer cells: untreated, exposed to paclitaxel (stressed), and drug tolerant (from a clonal population that proliferated after paclitaxel exposure). (targetedonc.com)
  • Comparison of RNA variations between single cells and across cell populations showed a surprising return to diversity in the drug-tolerant group in only a few generations. (targetedonc.com)
  • Of the specific RNA variants found in the drug-tolerant cells, some were located in genes involved in paclitaxel resistance and others were in genes involved in cell adhesion and cell surface signaling. (targetedonc.com)
  • A large proportion of cells derived from a single, drug resistant cell reverted back to drug sensitivity within 5 generations, indicating that heterogeneity among the population was restored quickly. (targetedonc.com)
  • Interestingly, a larger proportion of precancerous cells became drug-resistant after paclitaxel exposure. (targetedonc.com)
  • Platinum drugs are a class of chemotherapeutic drugs that affect the cell cycle, and the main site of action is the DNA of cells, which are common chemotherapeutic drugs in clinical practice. (eurekaselect.com)
  • It is known that the pathogenic properties of glioma cells and the response of glioma towards platinum-based drugs are strongly influenced by non-coding RNAs, particularly, by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). (eurekaselect.com)
  • Here, we investigated the role of miR-186 in sensitizing ovarian cancer cells to paclitaxel and cisplatin. (biomedcentral.com)
  • Cells were exposed to an incremental dose escalation of paclitaxel (2 nM) for approximately 2 passages, up to a final concentration of 25 nM, once paclitaxel resistance was achieved. (biomedcentral.com)
  • Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner. (nih.gov)
  • Objective To investigate the relationship between miR-135a expression and paclitaxel sensitivity in gastric cancer cells, and explore the possible mechanisms. (magtechjournal.com)
  • The influence and possible mechanisms of miR-135a expression on the sensitivity of paclitaxel in gastric cancer cells were investigated by using cell proliferation curve, flow cytometry, and Western blot. (magtechjournal.com)
  • However, tumor cells have capacity of developing resistance to chemotherapy and radiotherapy. (drtaheriazam.com)
  • The treatment of HCC depends on the identification of oncogenic factors that lead tumor cells to develop resistance to therapy. (drtaheriazam.com)
  • Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
  • Similarly, in ABCG2-overexpressing cells, ulixertinib inhibited the efflux activity of ABCG2 and reversed resistance to substrate anticancer drugs. (cp-456773inhibitor.com)
  • Our finding provides a clue into a novel treatment strategy: a combination of ulixertinib with anticancer drugs to attenuate MDR mediated by ABCB1 or ABCG2 in cancer cells overexpressing these transporters. (cp-456773inhibitor.com)
  • Nanomaterials for targeted drug delivery to cancer stem cells. (docksci.com)
  • This drug was specifically designed to treat brain tumors. (wikipedia.org)
  • Today's anticancer drugs often work wonders against malignancies, but sometimes tumors become resistant to the effects of such drugs, and treatment fails. (news-medical.net)
  • These drugs--originally derived from the Pacific yew tree--work by disrupting cell division, thus arresting the growth and spread of tumors. (news-medical.net)
  • Chemotherapy with platinum drugs such as cisplatin, carboplatin, oxaliplatin, or a combination thereof is used to treat a variety of tumors. (eurekaselect.com)
  • The primary treatment of ovarian cancer is surgical resection of visible tumors followed by adjuvant chemotherapy such as paclitaxel and cisplatin, which are the conventional anticancer drugs with long-term clinical applications for cancer treatment with specific applications in ovarian cancer. (biomedcentral.com)
  • Determinants of drug delivery and transport to solid tumors. (springer.com)
  • Profiling of Relative Inhibition Simultaneously in Mixtures (PRISM), the Cancer Therapeutics Response Portal, and other pharmacogenomics resources are available (CTRP), and the Genomics of Cancer Drug Sensitivity (GDSC). (scholarsresearchlibrary.com)
  • The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian cancer cell lines. (dundee.ac.uk)
  • A second cell cycle regulator, p57Kip2, is also subject to epigenetic silencing in carboplatin resistance in vitro and in vivo, emphasising that cell cycle regulators are important determinants of sensitivity to chemotherapeutic agents and providing insights into the phenomenon of collateral drug sensitivity in oncology. (dundee.ac.uk)
  • miRNAs and lncRNAs control drug sensitivity and the development of tumor resistance towards platinum drugs. (eurekaselect.com)
  • This mini-review summarizes the resistance mechanisms of gliomas to platinum drugs, as well as molecules and therapies that can improve the sensitivity of gliomas to platinum drugs. (eurekaselect.com)
  • After miR-186 transfection, all the cell lines showed increased sensitivity to paclitaxel and cisplatin. (biomedcentral.com)
  • microRNA-135a (miR-135a), which had relationship with paclitaxel sensitivity, was selected in the following study. (magtechjournal.com)
  • Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
  • A thirst for greater understanding of the mechanisms responsible for taxane resistance motivated Xie to explore organoids, with 3D cell culture a favored method for the team. (corning.com)
  • Thesis Title: Study of the Drug Resistance Mechanisms in Cancer Against Antimitotic Agents Using Paclitaxel and Diaminothiazoles. (rgcb.res.in)
  • Use of combinatorial approaches that target different cell mechanisms have met with some success in overcoming drug resistance, but the underlying problem of diversification in cancer cell populations remains. (targetedonc.com)
  • We have generated paclitaxel resistant ovarian cell lines from their corresponding native cell lines to determine driver mechanisms of drug resistance using gene expression arrays. (biomedcentral.com)
  • These pre-clinical models were used to observe cytotoxicity, cell cycle modulation and changes in gene expression to examine the mechanisms driving drug resistance. (biomedcentral.com)
  • Research progress on mechanisms of resistance to somatostatin analogs in growth hormone-secreting pituitary adenomas [J]. Basic & Clinical Medicine, 2015, 35(6): 846-850. (magtechjournal.com)
  • It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
  • Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
  • Stordal, Britta , Pavlakis, Nick and Davey, Ross (2009) Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy. (dcu.ie)
  • Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer. (dcu.ie)
  • Methods: Medline was searched for 1) Cell models of acquired resistance reporting cisplatin, oxaliplatin and paclitaxel sensitivities and 2) Clinical trials of single agent oxaliplatin or paclitaxel salvage therapy for cisplatin/carboplatin-resistant ovarian cancer. (dcu.ie)
  • Oxaliplatin performed better in combination with other agents for the treatment of platinum-resistant cancer suggesting that the benefit of oxaliplatin may lie in its more favourable toxicity and ability to be combined with other drugs rather than an underlying activity in cisplatin resistance. (dcu.ie)
  • Conclusions: Cellular models reflect the resistance observed in the clinic as the cross resistant agent oxaliplatin has a lower response rate compared to the non-cross resistant agent paclitaxel in cisplatin-resistant ovarian cancer. (dcu.ie)
  • Comparison of effects between fluorouracil combined with oxaliplatin and paclitaxel in the treatment of advanced gastric cancer [J]. , 2019, 39(12): 1752-1755. (magtechjournal.com)
  • Once identified, targeting these genes may help to overcome chemoresistance to carboplatin or paclitaxel, thus, improving their efficacies for cancer treatment. (iu.edu)
  • Therefore, it's very urgent to develop new drugs or find sensitizers for them to improve clinical efficacy. (researchsquare.com)
  • These data demonstrate that stress hormones interfere with paclitaxel efficacy and contribute significantly to drug resistance. (usuhs.edu)
  • 9 , 10 As such, it is urgent to improve the efficacy of chemotherapy to NSCLC and explore the molecular mechanism underlying cisplatin resistance of NSCLC. (dovepress.com)
  • What you can achieve with this [information] is that you might understand the mechanism of action of that particular drug, but then you can also use that understanding to, for instance, design a new drug combination that actually has enhanced efficacy, and at the same time maybe identify a new biomarker candidate that has a mechanistic rationale behind it," he said. (genomeweb.com)
  • The most commonly used models for determining drug efficacy are cancer cell lines. (scholarsresearchlibrary.com)
  • The objective of this multi-institutional phase 2 trial was to evaluate the efficacy and toxicity of paclitaxel and bcl-2 modulators (13-cis retinoic acid and interferon alfa-2b) in patients with advanced-stage or recurrent cervical cancer. (bmj.com)
  • Efficacy and safety of first-line single-agent carboplatin vs carboplatin plus paclitaxel for vulnerable older adult women with ovarian Cancer: A GINECO/GCIG randomized clinical trial. (eurekaselect.com)
  • One of these paclitaxel mimetics showed toxicity, although at higher concentrations than paclitaxel itself. (lu.se)
  • In addition, two other spiro-bicyclic compounds, lacking the paclitaxel side chain, showed toxicity. (lu.se)
  • Drug toxicity due to bevacizumab (Avastin) was initially and incorrectly entertained as a cause. (biomedcentral.com)
  • This study indicates that CAFs-derived exosomal miRNA-130a may be a potential therapeutic target for cisplatin resistance in NSCLC. (dovepress.com)
  • Xie and his team are exploring taxane resistance, and how enhancing drug target engagement may help overcome this resistance and ultimately save lives. (corning.com)
  • Surprisingly, we have found that by using patient tumor biopsies, we were able to see that taxane-tubulin engagement did not work effectively in those patients that gained taxane resistance. (corning.com)
  • We also observed the same phenomenon in the patient-derived tumor xenograft mouse model, which gained taxane resistance. (corning.com)
  • It is likely that taxane resistance is mediated by drug-target engagement. (corning.com)
  • The correlation between USP7 level of tumor tissues and taxane-resistance was evaluated. (biomedcentral.com)
  • Conclusions Combination therapy with paclitaxel, 13-cis retinoic acid, and interferon alfa-2b is feasible and safe in treating patients with advanced and recurrent cervical cancer. (bmj.com)
  • citation needed] Paclitaxel trevatide contains paclitaxel, which stabilizes microtubule polymer formation. (wikipedia.org)
  • Therefore, paclitaxel binds at the site of β-tubulin and induces polymerization, thus protecting the microtubule from disassembling during mitosis. (wikipedia.org)
  • In our study collaborated with Cornell University, we used microtubule bundling to define this drug-target engagement," explains Xie. (corning.com)
  • Further exploration of downstream molecules affected by ceritinib treatment indicated that the drug inhibited phosphorylation of the transcription factor YB1, which has been found to facilitate resistance to microtubule-targeting agents like paclitaxel. (genomeweb.com)
  • Our results are the first to demonstrate that miR-186 may sensitize ovarian cancer cell to paclitaxel and cisplatin by targeting ABCB1 and modulating the expression of GST-π. (biomedcentral.com)
  • Currently, some studies found that there is any connection between tumor resistance and pyroptosis (11). (researchsquare.com)
  • Vinblastine enhances the expression of tumor resistance gene abcb4 in zebrafish [J]. Basic & Clinical Medicine, 2017, 37(6): 758-762. (magtechjournal.com)
  • Methods The differential microRNAs were screened using Taqman microRNA assay in the serum of gastric cancer patients with different efficacies treated with paclitaxel chemotherapy. (magtechjournal.com)
  • Research in the Lu Lab utilizes a broad range of advanced research techniques and experimental models to discover novel aspects of NF-κB regulation and new genes for drug resistance, with the hope of identifying innovative biomarkers, therapeutic targets in cancer and other NF-κB related diseases, and ultimately, lead to the development of new medicines to treat these devastating diseases. (iu.edu)
  • Acquired resistance has caused the therapeutic effectiveness of taxane to become limited. (corning.com)
  • Paclitaxel is a frontline therapy used to treat advanced ovarian cancer, and in many instances, paclitaxel is combined with platinum based therapeutic drugs, such as carboplatin to improve overall survival [ 4 , 7 ]. (biomedcentral.com)
  • Lastly, through gene expression profiling we have demonstrated disruption of the spindle assembly checkpoint in the paclitaxel resistant cell lines, indicating a potential therapeutic pathway. (biomedcentral.com)
  • The deubiquitinase USP7 has been identified as an oncogene with key roles in tumorigenesis and therapeutic resistance for a series of cancer types. (biomedcentral.com)
  • If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. (medscape.com)
  • Because of the blood brain barrier (BBB), many cancer therapy drugs are prevented from passing through the brain capillaries into the parenchyma. (wikipedia.org)
  • Inhibition of CDK-1 abrogated stress hormone-mediated reversal of paclitaxel-induced cytotoxicity, indicating that the protective effect of stress hormones act through a CDK-1-dependent mechanism. (usuhs.edu)
  • This is the first report of a reversal of clinical resistance to capecitabine (Xeloda) by changing from the schedule of 14/7 day to a biweekly 7/7 day schedule. (biomedcentral.com)
  • ABCB1 encodes a multi-drug-resistance gene ( MDR1 ), and is the most prominent member of the ABC transporter family, and it is the most thoroughly investigated member of this family [ 9 ]. (biomedcentral.com)
  • This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. (nih.gov)
  • Variation in MRP2 activity might thus directly affect the effective exposure to paclitaxel, on i.v. administration, but also on oral administration, especially when P-gp activity is inhibited. (nki.nl)
  • Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. (medscape.com)
  • Despite these recognised benefits, long-standing concerns regarding the risks of mutagenic and potentially carcinogenic drug exposure have hampered efforts for broad hydroxyurea use in SCA, although these are based largely on outdated experimental models and treatment experiences with myeloproliferative neoplasms. (cdc.gov)
  • 5 Although ovarian cancer in advanced stages initially appears to be chemotherapy sensitive as response rates to platinum-based therapy exceed 80%, long-term survival remains poor as a result of recurrence and emergence of drug resistance. (nature.com)
  • Our data show that Mrp2 can also be a major determinant of the pharmacokinetic behavior of highly lipophilic anticancer drugs, even in the presence of other efficient transporters. (nki.nl)
  • However, with the long-term application of basic chemotherapy drugs in clinical practice, the problem of tumor drug resistance becomes increasingly serious, which has been the main reason for the inefficiency of tumor chemotherapy (4). (researchsquare.com)
  • Importantly, extrapolation of these in vitro data to the clinical setting confirms that the methylation status of the PLK2 CpG island predicts outcomes in patients treated with carboplatin & paclitaxel chemotherapy. (dundee.ac.uk)
  • She had unique and medically important clinical features of radiologically occult liver metastases and drug resistance to schedule-dependent chemotherapy. (biomedcentral.com)
  • Sesquiterpene lactones alleviate insulin resistance and early renal injury in diabetic mice [J]. Basic & Clinical Medicine, 2018, 38(9): 1292-1297. (magtechjournal.com)
  • Multiple lipid derived cytokines are associated with insulin resistance of patients with type 2 diabetes [J]. Basic & Clinical Medicine, 2017, 37(9): 1247-1250. (magtechjournal.com)
  • miR-320e promotes drug resistance of pancreatic cancer cell line [J]. Basic & Clinical Medicine, 2016, 36(6): 777-782. (magtechjournal.com)
  • Analyse of clinic distribution and antibiotic resistance of 2 499 isolates of Klebsiella pneumoniae [J]. Basic & Clinical Medicine, 2016, 36(11): 1554-1557. (magtechjournal.com)
  • The role of AXL in tumor metastasis and drug resistance and strategy in anti-tumor therapies [J]. Basic & Clinical Medicine, 2016, 36(1): 112-115. (magtechjournal.com)
  • Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. (ecancer.org)
  • This disease is characterized by a lack of early warning signs, diverse clinical manifestations, and resistance to radiation and chemotherapy. (medscape.com)
  • Drug resistance val (CI) = 1.4-62) did not outperform corresponding classifiers based on clinical variables. (lu.se)
  • The present study investigated whether paclitaxel-loaded microparticles (PMPs), alone or in combination with GMPs, decreased gemcitabine resistance, colony formation and promoted cell death in two human pancreatic cancer cell lines, PANC-1 and MIAPaCa-2. (aacrjournals.org)
  • Subsequently, we tested the effect of single and combination treatments on two well-known resistance markers for gemcitabine, ribonucleotide reductase catalytic subunit M1 (RRM1) and cytidine deaminase (CDA), as well as on the promotion of cell death measuring cleaved caspase-3 (CC3). (aacrjournals.org)
  • In addition, preliminary drug release studies with GMPs demonstrated detection of gemcitabine up to 14 days. (aacrjournals.org)
  • Combination chemotherapy regimens, such as FOLFIRINOX and nab-paclitaxel plus gemcitabine, have demonstrated improved survival rates in advanced pancreatic cancer ( 7 , 8 ). (frontiersin.org)
  • Finally, discovery of novel drug resistance genes may help physicians to design more precise treatment to each individual cancer patient. (iu.edu)
  • Paclitaxel-mediated cytotoxicity and G2/M cell cycle arrest were reversed significantly by stress hormones. (usuhs.edu)
  • Currently, chemotherapy remains the standard of treatment for NSCLC patients due to approximately 85-90% NSCLC having no driver mutations defined for drug target (3). (researchsquare.com)
  • Chemotherapy comprises part of successful treatment regimens for breast cancer, however, up to 50% of patients develop resistance. (usuhs.edu)
  • Of interest for GBM indication, ZK 219477 is not metabolized by liver cytochrome P450, which is induced by phenytoin and other anti-convulsion drug, commonly used in post-surgery GBM patients. (knowcancer.com)
  • In most cases, patients initially begin their treatment with endocrine therapy, a stage where drug resistance often occurs. (corning.com)
  • In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods. (medsci.org)
  • Many FDA-approved drugs are available for LUAD patients, including chemotherapy agents, targeted agents, and Immune Checkpoint Blockers (ICBs). (scholarsresearchlibrary.com)
  • Some drugs overlap and are approved by the FDA for LUAD patients. (scholarsresearchlibrary.com)
  • As numerous patients with ovarian cancer eventually relapse following resistance to paclitaxel or cisplatin therapy, it is vital to identify novel and more effective treatments for human EOC. (biomedcentral.com)
  • Immunocompromised patients are often treated prophylactically with triazole anti-fungal drugs, including ITZ, particularly if there is a risk of aspergillosis . (ecancer.org)
  • Changes in levels of circulating tumor DNA very closely followed treatment responses in these patients, and tracking levels of ctDNA may provide us with an early indicator of treatment resistance," said Dawson. (medscape.com)
  • U373 inoculated subcutaneous in nude mice (2 mg/kg and 9 mg/kg) as well as paclitaxel (8 mg/kg), but on the contrary of paclitaxel, only ZK 219477 demonstrated antitumour activity against U373 implanted in nude mice (9 mg/kg): 8 complete response out 9 treated mice. (knowcancer.com)
  • This has then been shown to be a prospective cancer therapy drug that can not only be conjugated to paclitaxel but also peptides, monoclonal antibodies, siRNA and many other biological materials. (wikipedia.org)
  • It has been shown that cancer cell lines exposed to this hypoxic or serum-deprived condition will upregulate LRP1 expression, thus leading to an increased uptake of paclitaxel trevatide. (wikipedia.org)
  • In 2014, paclitaxel trevatide received orphan drug designation from FDA for the treatment of glioblastoma multiform As of January 2016, Angiochem has conducted phase II trials for the treatment of breast cancer with brain metastasis, glioblastoma, and high-grade glioma. (wikipedia.org)
  • Paclitaxel (PTX) is widely used for the treatment of ovarian cancer. (nature.com)
  • Paclitaxel is one of the most important anti-cancer agents introduced during the last 20 years. (lu.se)
  • New findings by Fox Chase Cancer Center researchers identify one protein, Abcc10 (also known as Mrp7), as being intimately involved in resistance to certain drugs used to treat breast, ovarian, lung, and other cancers. (news-medical.net)
  • This study aims to investigate the association of p53 and D-loop gene with drug resistance and sensitization induced by metformin in ovarian cancer. (oncotarget.com)
  • Dr. Fang Xie shares insights from his research into prostate cancer and offers hope of overcoming the growing problem of chemotherapy resistance to improve patient outcomes. (corning.com)
  • Paclitaxel - Cellular data suggests that paclitaxel is active in cisplatin-resistant cancer. (dcu.ie)
  • Alternating therapy with cisplatin and paclitaxel may therefore lead to an improved response rate in ovarian cancer. (dcu.ie)
  • Tumor heterogeneity, such as varying tumour microenvironment (TME) patterns or cancer cell types, is a major contributor to low response rates and drug resistance. (scholarsresearchlibrary.com)
  • Objective Overexpression of bcl-2 is a mechanism of drug resistance in cervical cancer. (bmj.com)
  • Chemotherapy resistance is the major reason for the failure of ovarian cancer treatment. (muni.cz)
  • We have generated model systems to explore drug resistance in ovarian cancer, which have revealed a key pathway related to the spindle assembly checkpoint underlying paclitaxel resistance in ovarian cell lines. (biomedcentral.com)
  • Besides, recent efforts have focused on developing targeted therapies for pancreatic cancer, including drugs that target specific molecular alterations like the KRAS oncogene, which is frequently mutated in pancreatic cancer ( 9 - 11 ). (frontiersin.org)
  • Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper. (ecancer.org)
  • Collectively, they transport and regulate levels of physiological substrates such as lipids, porphyrins, and sterols [7], and are widely expressed in the placenta, blood-brain barrier (BBB), intestines, livers, and kidneys to restrict the bioavailability of administered drugs [8, 9]. (cp-456773inhibitor.com)
  • We have generated isogenic paclitaxel resistant cell lines from their corresponding native cell lines which reflect the 3 most common ovarian histologic subtypes, these include serous, clear cell and endometrioid subtypes [ 2 ]. (biomedcentral.com)
  • The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
  • 0.01), suggesting that pre-treatment with paclitaxel improves the response of salvage paclitaxel therapy. (dcu.ie)
  • This led the researchers to test a combined ceritinib-paclitaxel treatment, which they found to be particularly effective, including in NSCLC lines where single-drug treatment was not effective. (genomeweb.com)
  • The treatment consisted of oral 13-cis retinoic acid, 1 mg/kg, and subcutaneous interferon alfa-2b, 6 mU/m 2 , days 1 to 4, and intravenous paclitaxel, 175 mg/m 2 , day 4 until disease progression or adverse events prohibited treatment. (bmj.com)
  • The limitations of current treatment strategies include: i) resistance to drug treatment, ii) significant side-effects and iii) cost. (vitamindwiki.com)
  • When starting treatment with [HA627 trade name], careful consideration should be given to the treatment history of the patient and the presence of darunavir resistance associated mutations (see sections 4.2, 4.4 and 5.1). (who.int)
  • ctDNA may provide us with an early indicator of treatment resistance. (medscape.com)
  • citation needed] Concentration has been found to play a key role paclitaxel trevatide's administration. (wikipedia.org)
  • Paclitaxel trevatide will cross the capillary medium via receptor mediated transcytosis of the low-density lipoprotein receptor-related protein 1 (LRP1) which is upregulated in some cancers. (wikipedia.org)
  • This receptor is an ATP-driven transporter that will pump drugs, drug metabolites, and endogenous metabolites out of the cell. (wikipedia.org)
  • This strategy was used to synthesize a series of spiro-bicyclic compounds designed to be paclitaxel mimetics, which were evaluated in human breast-derived cell lines. (lu.se)
  • Using unsupervised hierarchical clustering they found that drugs to the same target clustered together in terms of their effects on these cell lines. (genomeweb.com)
  • In addition to its intended target ALK and the known off-target IGF1R, the drug bound to kinases including FAK1, RSK1/2, ERK1/2, CAMKK2, and FER, with FAK1 and RSK1/2 being the most highly enriched in the cell lines where ceritinib was effective. (genomeweb.com)
  • The large-scale high-throughput sequencing technique allows for genome-wide drug response analysis in cell lines. (scholarsresearchlibrary.com)
  • PRISM and GDSC were used to obtain drug response data for LUAD cell lines. (scholarsresearchlibrary.com)
  • Cell lines were classified as sensitive, partial response, or resistance for each drug based on the mean 0.5 Standard Deviations (SD) of the IC 50 , log10 (IC 50 ), EC 50 , or log10 (EC 50 ) values. (scholarsresearchlibrary.com)
  • Cell lines that had an IC 50 , log 10 (IC 50 ), EC 50 , or log 10 (EC 50 ) value greater than the mean +0.5 SD were considered drug resistant. (scholarsresearchlibrary.com)
  • Cell lines with an IC 50 , log 10 (IC 50 ), EC 50 , or log 10 (EC 50 ) value less than the mean 0.5 SD were considered sensitive to the drug, while those with an IC 50 , log 10 (IC 50 ), EC 50 , or log 10 (EC 50 ) value between the mean +0.5 SD and the mean 0.5 SD were considered partially responsive to the drug. (scholarsresearchlibrary.com)
  • However, paclitaxel trevatide will effectively transport across the BBB with approximately a 100-fold higher transport rate compared to a free paclitaxel. (wikipedia.org)
  • Pharmacogenomics is critical for personalised drug therapy and is becoming increasingly important in precision medicine decision-making. (scholarsresearchlibrary.com)
  • Since hydroxyurea therapy for SCA carries minimal carcinogenic risks, the current drug labelling should be modified accordingly, and prescribing practices should be broadened to allow better access and increased utilisation of this highly effective drug. (cdc.gov)
  • Medical researchers would like to find ways of counteracting such resistance, but first they must understand why and how it happens. (news-medical.net)