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  • infection
  • Attempts are also under way to complete a textbook on emerging and epidemic fungal infection by the end of 2017 and the Atlas of Veterinary Pathogenic Fungi by 2020. (deepdyve.com)
  • C. albicans is the most common hospital-acquired fungal infection and can cause illness by sticking to and colonising plastic surfaces implanted in the body such as catheters, cardiac devices or prosthetic joints. (bio-medicine.org)
  • Antibiotic
  • Tetracycline does not help in Pityrosporum.Assessment of Antibiotic Resistance in. (04tattoos.cf)
  • Antibiotic resistance of Clostridium perfringens isolates from broiler. (04tattoos.cf)
  • A new molecule that can increase the vulnerability of antibiotic resistant superbugs to existing drugs, has been developed. (medindia.net)
  • Combination of the new molecule PPMO or peptide-conjugated phosphorodiamidate morpholino oligomer and carbapenem class antibiotic called meropenem can have a therapeutic potential against the drug resistant superbugs. (medindia.net)
  • Basilea Pharmaceutica Ltd. welcomes the launch in Europe of a pioneering approach to antibiotic research that will see pharmaceutical and biotechnology companies working alongside public partners to tackle the rising threat from antimicrobial resistance and address some of the key barriers to the development of effective antibiotics. (biospace.com)
  • The objective of the proposed research program, NewDrugs4BadBugs, is to improve the underlying scientific understanding of antibiotic resistance, design and implement efficient clinical trials and take novel drug candidates through clinical development. (biospace.com)
  • Basilea, GlaxoSmithKline, AstraZeneca, Janssen and Sanofi will work alongside public research organizations and scientific experts to address several aspects of antimicrobial resistance and stimulate new antibiotic research. (biospace.com)
  • Antibiotic resistance is increasingly becoming a worldwide health threat. (biospace.com)
  • Fungi
  • In fungi separated by ∼800 million years of evolution, Hsp90 potentiated the evolution of drug resistance in a different way, by enabling new mutations to have immediate phenotypic consequences. (sciencemag.org)
  • The study showed that the resistance of yeast (and possibly pathogenic fungi) to antimycotic agents is more complex than it was previously thought. (eurekalert.org)
  • Fungi are becoming very important human pathogens, and there are few drugs that can inhibit fungal growth. (asm.org)
  • They participate in fungal growth and development, such as mycelial growth and cellular differentiation, and in protecting fungi from oxidative damage under stressful conditions. (bioportfolio.com)
  • clinical
  • Resistance was abrogated by Hsp90 inhibitors and by febrile temperatures, suggesting new therapeutic strategies and a clinical benefit of fever. (sciencemag.org)
  • We have published hundreds of Neuropsychiatric Disorder Cluster Drug Development Pipeline Review 2017 news stories on BioPortfolio along with dozens of Neuropsychiatric Disorder Cluster Drug Development Pipeline Review 2017 Clinical Trials and PubMed Articles about Neuropsychiatric Disorder Cluster Drug Development Pipeline Review 2017 for you to read. (bioportfolio.com)
  • In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Neuropsychiatric Disorder Cluster Drug Development Pipeline Review 2017 Companies in our database. (bioportfolio.com)
  • We can then see whether this will be a feasible lead for the development of new drugs for clinical application. (bio-medicine.org)
  • humans
  • Most of the major cell wall components of fungal pathogens are not represented in humans, other mammals, or plants, and therefore the immune systems of animals and plants have evolved to recognize many of the conserved elements of fungal walls. (asmscience.org)
  • cell walls
  • Echinocandins, the first new antifungal class in decades, inhibit synthesis of β-(1,3) glucan, an essential component of fungal cell walls ( 14 ). (sciencemag.org)
  • The frontiers of research on fungal cell walls are moving from a descriptive phase defining the underlying genes and component parts of fungal walls to more dynamic analyses of how the various components are assembled, cross-linked, and modified in response to environmental signals. (asmscience.org)
  • bacteria
  • That's left us to try to develop new drugs to stay one step ahead of the bacteria, but the more we look the more we don't find anything new. (medindia.net)
  • The study demonstrated that in vitro, the ability of an ultra-broad-spectrum drug of the carbapenem class called meropenem to fight three different genera of bacteria that express NDM-1, was restored by the new PPMO. (medindia.net)
  • Despite this need and the continued emergence of bacteria resistant to existing drugs, research has diminished over the past 15 years and few companies remain active in this area. (biospace.com)
  • Multi-drug resistant bacteria risk perception by European intensivits (MDR-ICU) provided an overview of multi-drug resistant bacteria risk perception by intensivists working in European ICUs. (esicm.org)
  • fungicides
  • For similar reasons the enzymes that assemble fungal cell wall components are excellent targets for antifungal chemotherapies and fungicides. (asmscience.org)
  • High levels of resistance to site-specific fungicides are commonly associated with point mutations. (frontiersin.org)
  • This mechanism is associated with low levels of resistance to multiple fungicides including the anilinopyrimidines and phenylpyrroles. (frontiersin.org)
  • In order to elucidate the mechanism of the resistance, the whole genome of three different samples (gene pools) was sequenced, each containing DNA of 10 selected strains of the same genotype regarding resistance to seven different classes of fungicides including anilinopyrimidines. (frontiersin.org)
  • 2017
  • Here you can see the latest Neuropsychiatric Disorder Cluster Drug Development Pipeline Review 2017 articles that have been published worldwide. (bioportfolio.com)
  • You can also find out about relevant Neuropsychiatric Disorder Cluster Drug Development Pipeline Review 2017 Drugs and Medications on this site too. (bioportfolio.com)
  • proteins
  • Typical gene products responsible for multiple drug resistance in these organisms are ABC (ATP-binding cassette) transport proteins that are responsible for the efflux of toxic compounds (for a review, see reference 16 ). (asm.org)
  • 2007. Conserved processes and lineage-specific proteins in fungal cell wall evolution. (asmscience.org)
  • Farnesyltransferase activity is an important mediator of protein localization and subsequent signaling for multiple proteins, including Ras GTPases. (aspergillus.org.uk)
  • Our findings indicate that protein farnesylation underpins multiple cellular processes in A. fumigatus, likely due to the large body of proteins affected by ramA deletion. (aspergillus.org.uk)
  • azoles
  • Using the new test, which uses direct molecular detection rather than culturing the fungus in a Petri dish, the team found that 55% of aspergillosis patients had telltale signs known as 'markers' that indicated they had developed resistance to azoles. (healthcanal.com)
  • This is an extraordinarily high rate of resistance, so the findings have major implications for the sustainability of azoles for human antifungal therapy. (healthcanal.com)
  • Dr. Denning notes that one possible source of the resistance may be the frequent use of azoles as agricultural pesticides. (healthcanal.com)
  • mutations
  • In the fly Drosophila melanogaster , the plant Arabidopsis thaliana , and likely in other organisms, compromising Hsp90's buffering capacity (by drugs, mutations, or environmental stress) produces a multitude of new phenotypes. (sciencemag.org)
  • concentrations
  • Posaconazole has a long half-life (35 h) and attains steady-state concentrations after 7 to 10 days of multiple-dose administration. (asm.org)
  • In patients with fungal meningitis, Fluconazole concentrations in the CSF are approximately 80% of the corresponding plasma concentrations. (drugs.com)
  • Perlin
  • This innovative approach to drug resistance detection was made possible because of the application of molecular beacon technology, which was invented by scientists at New Jersey Medical School ," said study co-author David Perlin, Executive Director and Professor at New Jersey Medical School , whose laboratory designed and performed the advanced tests. (healthcanal.com)
  • Perlin is a world-renowned expert in fungal research. (healthcanal.com)
  • diagnosis
  • Professor Denning added, "Not only is molecular testing much more sensitive than conventional culture for diagnosis, but it enables testing for resistance, which until now has been impossible if cultures are negative. (healthcanal.com)
  • mechanism
  • This exciting study illuminates a mechanism of transcriptional control that couples cell wall integrity with cell cycle regulation, and uncovers circuitry governing resistance to the cell wall targeting antifungal caspofungin. (nature.com)
  • We're targeting a resistance mechanism that's shared by a whole bunch of pathogens," said Bruce Geller, professor of microbiology in OSU's College of Science and College of Agricultural Sciences, who's been researching molecular medicine for more than a decade. (medindia.net)
  • ubiquitous
  • We examined the evolution of fungal resistance to anti-microbial agents, an ancient and ubiquitous process in nature as microorganisms evolve new strategies for competition and survival. (sciencemag.org)
  • exposure
  • The C max and AUC data from a food-effect study involving administration of Fluconazole tablets to healthy volunteers under fasting conditions and with a high-fat meal indicated that exposure to the drug is not affected by food. (drugs.com)