• Drug resistance is one of the major problems in multiple myeloma (MM) clinical treatment. (currentscience.org)
  • was accepted by the FDA for treatment of relapsed multiple myeloma and mantle cell lymphoma. (elevateblogconference.com)
  • Acquired drug resistance is the greatest obstacle to the successful treatment of multiple myeloma (MM). Despite recent advanced treatment options such as liposomal formulations, proteasome inhibitors, immunomodulatory drugs, myeloma-targeted antibodies, and histone deacetylase inhibitors, MM is still considered an incurable disease. (beds.ac.uk)
  • The combination of an XPO1 inhibitor and liposomal doxorubicin was highly effective against acquired drug resistance in in vitro MM models, in in vivo xenograft studies, and in ex vivo samples obtained from patients with relapsed/refractory myeloma. (beds.ac.uk)
  • Multiple myeloma (MM) represents the 13% of the hematologic tumors and its social burden is increasing in western countries due to the progressive aging of the population. (unimi.it)
  • To test how Jagged1/2 overexpression affects MM cells response to chemotherapeutics, we performed double-silencing of Jagged1/2 (J1/2KD) in myeloma cell lines (HMCLs) and assessed their response to standard-of-care drugs (i.e. bortezomib, melphalan and lenalidomide), both in single culture and in a co-culture system composed of HMCLs and the human BMSC line HS5. (unimi.it)
  • Multiple myeloma (MM) is the second most prevalent hematological malignancy worldwide, with a median onset of 60 years. (cdrjournal.com)
  • These microorganisms employ several mechanisms in attaining multi-drug resistance: No longer relying on a glycoprotein cell wall Enzymatic deactivation of antibiotics Decreased cell wall permeability to antibiotics Altered target sites of antibiotic Efflux mechanisms to remove antibiotics Increased mutation rate as a stress response Many different bacteria now exhibit multi-drug resistance, including staphylococci, enterococci, gonococci, streptococci, salmonella, as well as numerous other gram-negative bacteria and Mycobacterium tuberculosis. (wikipedia.org)
  • Multiple drug resistance is characterized by over-expression of membrane transport proteins ABCG2 and ABCB1 that induce efflux of anticancer drugs out of the cell and subsequently cause tumor cell resistance to those drugs. (antibody-antibodies.com)
  • The MarkerGeneTM Multiple Drug Resistance Microtiterplate Assay Kit (M1580) is a high-throughput assay system based upon measurement of efflux of a green fluorescent dye that is known to bind to the MDR transporters ABCG2 and ABCB1 in a manner similar to many chemotherapeutic drugs. (antibody-antibodies.com)
  • These resistances can be due to the overexpression of efflux pumps, genetic and epigenetic aberrations and the microenvironment of MM. With the gain of knowledge regarding genetic and molecular changes, many molecular targeted therapies including cell signaling targeted therapies are being developed against relapsed/refractory MM. Additionally, epigenetic aberrations such as DNA methylation and histone modifications steered MM management in new directions. (cdrjournal.com)
  • Antibiotic resistance of environmental Escherichia coli in hospitals could be increased due to extensive use of biocides resulting in serious infections. (springer.com)
  • In this study, the prevalence of antibiotic resistance of environmental isolates of E. coli from hospitals and household settings were evaluated and compared. (springer.com)
  • However, the contribution of biocide use to antibiotic resistance is still controversial and, despite some evidence, remains largely unproven. (springer.com)
  • Oxazolidinone and Glycolipopeptides will be the fastest growing market in the drug class segment throughout the forecast period 2017-2025 majorly due to factors such as large development gap in the antibiotic development and emergence of effective antibiotics such as Linezolid and Dalbavancin exhibiting improved pharmacodynamic activity and technological advancement in the rapid diagnostics testing kits. (abnewswire.com)
  • In 2016, critical segment held the largest revenue share for the vector segment due to factors such as rising prevalence of Enterobacteriaceae and Pseudomonas aeruginosa Carbapenem resistance cases, rising public awareness leading to early disease diagnosis and treatment, and regulatory agencies such as WHO, CDC taking initiatives to promote public health and welfare. (abnewswire.com)
  • In 2016, Beta Lactam held the largest market in the drug class segment due to factors such as rising prevalence of multiple drug resistance cases and development of drugs such as Ceftazidime-avibactam and Doripenem which exhibit broad spectrum activity to counteract drug resistance by bacteria. (abnewswire.com)
  • The global multiple drug resistance bacterial infection treatment market was valued at US$ 26,169.09 Mn in 2016, and is expected to reach US$ 44,060.77 Mn by 2025 expanding at a CAGR of 6.01 % from 2017 to 2025. (abnewswire.com)
  • The phenotype for pleiotropic drug resistance (PDR) in Saccharomyces cerevisiae (SACE) was discovered in 1973 by R ANK and B ECH -H ANSEN [ 1 ], who reported that single gene mutations were responsible for resistance to multiple drugs of different chemical structures and different targets. (biomedcentral.com)
  • Mechanistic studies were performed to assess co-localization of topoisomerase II alpha (TOP2A), DNA damage, and siRNA knockdown of drug targets. (beds.ac.uk)
  • Since the drug concentration in the cell is limited by the dosages that can be given, the increased numbers of target molecules means that many of the targets do not get affected by the drug. (cancerquest.org)
  • Here, we provide an overview of the different classes of targets in MM and the factors that influence search for new drugs. (cdrjournal.com)
  • Numerous drugs are used in treatment of MM. These include the antineoplastic alkylating agents cyclophosphamide, busulfan and melphalan, immunomodulators such as lenalidomide and thalidomide, corticosteroids including dexamethasone, microtubule-targeting agents, such as paclitaxel and vinca alkaloids, as well as the proteasome inhibitors bortezomib and carfilzomib. (cdrjournal.com)
  • The median overall survival of patients with newly diagnosed MM was 2.5-3 years [ 3 ] , but could be extended with new drugs such as proteasome inhibitors (PIs) to 4-5 years. (cdrjournal.com)
  • LP INFORMATION offers a latest published report on Multiple Drug Resistance Bacterial Infection Treatment Market Analysis and Forecast 2019-2025 delivering key insights and providing a competitive advantage to clients through a detailed report. (industrydailyobserver.com)
  • According to this study, over the next five years the Multiple Drug Resistance Bacterial Infection Treatment market will register a xx% CAGR in terms of revenue, the global market size will reach US$ xx million by 2024, from US$ xx million in 2019. (industrydailyobserver.com)
  • In particular, this report presents the global market share (sales and revenue) of key companies in Multiple Drug Resistance Bacterial Infection Treatment business, shared in Chapter 3. (industrydailyobserver.com)
  • This report presents a comprehensive overview, market shares, and growth opportunities of Multiple Drug Resistance Bacterial Infection Treatment market by product type, application, key manufacturers and key regions and countries. (industrydailyobserver.com)
  • New Market Research Reports Title "Multiple Drug Resistance Bacterial Infection Treatment Market Is Expected To Reach US$ 44,060.77 Mn By 2025 - Credence Research" Has Been Added to Credenceresearch.com Report Database. (dovernewsnow.com)
  • Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. (springer.com)
  • Meanwhile, by MACS and FACS sorting of CD138+ subpopulation, we found that Notch activation could up-regulates anti-apoptotic proteins (Bcl-xL, Mcl-1 and Bcl-2) in CD138+ MM subpopulation, which also contribute to Notch activation mediated drug resistance. (currentscience.org)
  • Focal adhesion proteins g130Cas (Cas) is normally a multi-domain docking proteins, with an N-terminal SH3 domains, a central "substrate domains" consisting of multiple SH2-domains presenting motifs (Tyr-x-x-Pro), and a "Src-binding domains" near the C-terminus . (elevateblogconference.com)
  • Amikacin, ceftriaxone and gentamicin were the most effective drugs in general. (scielo.br)
  • A triplex PCR was employed to segregate each isolate into four different phylogenetic groups (A, B1, B2 and D). Drug resistance was evaluated by disc diffusion method. (scielo.br)
  • Community acquired urinary tract infections (UTI) are highly prevalent in developing countries and are usually difficult to eradicate because the pathogenic bacteria have acquired resistance to most of the drugs. (scielo.br)
  • Due to indiscriminate use of drugs in developing countries, the pathogenic bacteria are much more dynamic, versatile and 'battle-hardened' as compared with developed countries. (scielo.br)
  • The 36-megadalton Haemophilus influenzae R plasmid pHK539 was found to specify resistance to tetracycline (Tc) and ampicillin (Ap). (asm.org)
  • The result is the re-growth of a tumor that is not sensitive to the original drug. (cancerquest.org)
  • Indeed, MM cells establish complex interactions with BM stromal cells (BMSCs), which provide a source of pro-survival and growth factors that promotes drug resistance, finally causing patients' relapse. (unimi.it)
  • Lack of Cas also led to Rabbit polyclonal to ABCB5 level of resistance to the DNA-damaging agent Doxorubicin, which coincided with Doxorubicin-induced autophagy in Cas-/- (EV) cells. (elevateblogconference.com)
  • This kit contains protocols and reagents for use in the detection of Multiple Drug Resistance within cells. (antibody-antibodies.com)
  • Moreover, while HS5 are able to protect MM cells from drug-induced apoptosis, J1/2KD revert this effect, decreasing the ability of BMSCs to rescue MM cells. (unimi.it)
  • The improvement in drug-response promoted by J1/2KD can be observed also in ex-vivo co-cultures of cells from MM patients, that further validate the key role of J1/2 in this process. (unimi.it)
  • Purpose In multiple cell metazoans, the ability of polarized epithelial cells to convert to motile mesenchymal cells in order to relocate to another location is ruled by a exclusive procedure termed epithelial-mesenchymal transition (EMT). (elevateblogconference.com)
  • The phenomenon was discovered in 1911 by Heike Kamerlingh Onnes, who found that the resistance of mercury dropped suddenly to zero at a temperature of about 4. (thefreedictionary.com)