• Antimicrobial drug resistance was investigated for Escherichia coli from broilers raised on feed supplemented with antimicrobials, and the people who carry out evisceration, washing and packing of intestines in a high-throughput poultry abattoir in Gauteng, South Africa. (scielo.org.za)
  • SEOUL, South Korea, Nov. 26, 2018 /PRNewswire/ - Seegene Inc. (096530.KQ), a leading developer of multiplex PCR assays, announced that multi-site clinical trials for measuring clinical performance on screening the drug resistance of Enterobacteriaceae with the Allplex™ Entero-DR assay have been undergoing in 23 hospitals affiliated with the Italian Association for Clinical Microbiology (AMCLI). (healthytimes.com.sg)
  • On the other hand, conventional chemicals‐based sanitation do not prevent recontamination and can select drugresistant strains, resulting in over 50% of surfaces persistently contaminated. (pubmedcentralcanada.ca)
  • Second, disinfectants can select resistant microbial strains against the disinfectant itself (Bock et al . (pubmedcentralcanada.ca)
  • Drug resistance-based mutation reporters are used extensively to measure mutation rates, but they are suitable only when the compared strains have identical drug tolerance levels-a condition that is not satisfied under many "real-world" circumstances, e.g., when comparing mutation rates among a series of environmental or clinical isolates. (asm.org)
  • Such assays typically work well for laboratory strains but have significant limitations when comparing clinical or environmental isolates that have various intrinsic levels of drug tolerance, which confounds the interpretation of results. (asm.org)
  • Acquisition of mutations underlies evolution in all contexts, and in pathogenic microbes this process can result in the emergence of dangerous drug-resistant strains. (asm.org)
  • Although drug resistance-based mutation assays have a number of advantages, most particularly in their relative ease and rapidity, their major limitation is that they allow direct comparisons of mutation rates only between strains that have the same level of drug sensitivity. (asm.org)
  • This drug shows promise in infections from multi-drug resistant K. pneumoniae (K. pneumoniae carbapenemase [KPC]- and ESBL-producing strains) and Enterobacteriaceae with various mechanisms of resistance. (wikipedia.org)
  • Candida glabrata is a fungal pathogen that shows a high degree of genetic diversity and fast emergence of antifungal drug resistance. (asm.org)
  • 1. Aarestrup F M 2000 Characterisation of glycopeptide-resistant Enterococcus faecium (GRE) from broilers and pigs in Denmark: Genetic evidence that persistence of GRE in pig herds is associated with co-selection by resistance to macrolides. (scielo.org.za)
  • In such an assay, mutations in the reporter gene arise at some low rate in cells proliferating in culture and are then selected by plating the cultures on drug-containing medium, which kills wild-type cells. (asm.org)
  • However, no statistically significant differences were observed when the median MICs of antimicrobials used regularly in poultry and percentage resistance were compared, nor could an association between resistance among the enteric E. coli from packers and those from broilers be demonstrated. (scielo.org.za)
  • 2) phenotyping, which looks at the ability of different drugs to suppress virus growth in the laboratory. (clinicaltrials.gov)
  • The drugs in the OB regimen are chosen from among the currently approved antiretrovirals and permitted newly approved/investigational antiretrovirals available in the countries where the study is implemented, and must consist of 3 to 5 drugs, including no more than 1 newly approved/investigational agent. (clinicaltrials.gov)
  • Current Opinion in Investigational Drugs. (wikipedia.org)
  • We have analyzed the complex evolution of the pleiotropic drug resistance proteins (Pdrp) subfamily where gene duplications and deletions occur independently in individual genomes. (biomedcentral.com)
  • 2. Aarestrup F M, Seyforth A M, Emborg H D, Pedersen K, Hendriksen R, Bager F 2001 Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in faecal enterococci from food animals in Denmark. (scielo.org.za)