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  • mutation
  • Ethambutol resistance testing by mutation detection. (biomedsearch.com)
  • The G262S point mutation distinguishing the metallo-β-lactamase IMP-1 from IMP-6 has no effect on the hydrolysis of the drugs cephalothin and cefotaxime, but significantly improves catalytic efficiency toward cephaloridine, ceftazidime, benzylpenicillin, ampicillin, and imipenem. (caltech.edu)
  • Enterobacteriaceae
  • In 2016, critical segment held the largest revenue share for the vector segment due to factors such as rising prevalence of Enterobacteriaceae and Pseudomonas aeruginosa Carbapenem resistance cases, rising public awareness leading to early disease diagnosis and treatment, and regulatory agencies such as WHO, CDC taking initiatives to promote public health and welfare. (abnewswire.com)
  • These samples were tested for the presence of antibiotic resistance, both by selective culturing for ESBL-PE (Extended-Spectrum Beta-Lactamase Producing Enterobacteriaceae ) as well as by metagenomic sequencing. (diva-portal.org)
  • antimicrobial drug
  • They remain the biggest killer of children and young adults as well as the second-leading cause of death worldwide [ 4 , 5 ] despite remarkable successes of antimicrobial drug generations of the third part of the last century. (mdpi.com)
  • Mycobacterium
  • We conducted in vitro DNA supercoiling assays, utilizing recombinant DNA gyrases, to elucidate the influence of the lineage-specific serine or threonine residue at position 95 of GyrA on fluoroquinolone resistance in Mycobacterium tuberculosis. (biomedsearch.com)
  • stability
  • Surprisingly, though crucial for the stability of EcDHFR, significant sequence variation is found at this site among bacterial dihydrofolate reductases (DHFRs). (biochemj.org)
  • Our study demonstrates that trade-offs between structural stability and function can influence innate drug resistance as well as the potential for mutationally acquired drug resistance of an enzyme. (biochemj.org)
  • Substance
  • Mercury, which was used to treat syphilis, was the first substance not of plant origin to be used as a medical drug. (h2g2.com)
  • genetic
  • The program can analyse the entire genetic code of a bacterium in under 3 minutes, once a bacterial sample has been cultured and its DNA sequenced. (ox.ac.uk)
  • resistant
  • Drug-resistant infections pose a major threat to global health and could in future mean that serious and life-threatening infections become impossible to treat. (ox.ac.uk)
  • This is important for diagnosing infections such as 'extensively drug-resistant TB' (XDR-TB), which is resistant to at least four of the core TB drugs and is considered a global threat to public health by the World Health Organisation. (ox.ac.uk)
  • Multidrug-resistant E. coli EC302/04 was isolated from a tracheal aspirate, and its genome sequence is expected to provide insights into antimicrobial resistance as well as adaptive and virulence mechanisms of E. coli involved in LRTI. (biomedsearch.com)
  • protein
  • The bacterial serine-threonine protein kinase HipA promotes multidrug tolerance by phosphorylating the glutamate-tRNA ligase (GltX), leading to a halt in translation, inhibition of growth, and induction of a physiologically dormant state (persistence). (sciencemag.org)
  • efficacy
  • The study also demonstrates that by reducing p53, DnaK can also reduce the efficacy of anti-cancer drugs . (reliawire.com)
  • major
  • LIMITATIONS: The major limitation of this review is the relatively short duration of follow-up of the included studies, which does not allow complete reassurance regarding the development of antibiotic resistance. (biomedsearch.com)
  • development
  • Drug development is normally focused on improving binding to a biological target, and rarely focuses on assessing membrane-binding properties. (outbreaknewstoday.com)
  • MATERIALS AND METHODS: The antimicrobial effect of essential oils and the development of resistance to the essential oils were evaluated in vitro and in vivo. (biomedsearch.com)
  • CONCLUSIONS: These results demonstrate that the essential oils are bactericidal against H. pylori without the development of acquired resistance, suggesting that essential oils may have potential as new and safe agents for inclusion in anti-H. pylori regimens. (biomedsearch.com)
  • These findings were in striking contrast to previous reports analyzing GyrA with Thr95 and suggest an important impact of the amino acid in the development of fluoroquinolone resistance. (biomedsearch.com)