• CONCLUSIONS: First-trimester TMP-SUL exposure was not associated with a higher risk of the congenital anomalies studied, compared with exposure to penicillins and/or cephalosporins, or no exposure to antibacterials. (healthpartners.com)
  • Congenital heart diseases (CHD) are frequent fetal anomalies, with an important impact on perinatal mortality and morbidity. (benthamscience.com)
  • CONTEXT: The association between prenatal cocaine exposure and congenital anomalies is not definitive. (erowid.org)
  • CONCLUSIONS: This prospective, large-scale, blinded, systematic evaluation for congenital anomalies in prenatally cocaine-exposed children did not identify an increased number or consistent pattern of abnormalities. (erowid.org)
  • No babies delivered to women in group C had congenital anomalies but 25% of babies born to mothers in groups A and B had minor congenital anomalies, a statistically significant difference. (who.int)
  • 2,500 g), congenital abnormalities, and any maternal adverse events reported. (cdc.gov)
  • However, similarities exist among most of the congenital abnormalities caused by the AEDs (see the Table, below). (medscape.com)
  • Congenital defects are abnormalities of structure, function or metabolism that are present at birth. (vin.com)
  • These congenital defects included intestinal and urinary tract abnormalities, chest and hind leg deformities, umbilical hernia and other defects. (vin.com)
  • The most common congenital heart problems include heart valve defects, defects in the walls between the atria and ventricles of the heart, and heart muscle abnormalities that can lead to heart failure. (indiadiets.com)
  • monitor with electrocardiograms (ECGs) if concomitant electrolyte abnormalities, cardiac failure or arrhythmias, or use of other QT prolonging drugs. (nih.gov)
  • Leber Congenital Amaurosis (LCA) Pipeline Report is a comprehensive report on the pre-clinical and clinical stage pipeline candidates under development as of H1- 2023. (bharatbook.com)
  • The report estimates a promising pipeline for Leber Congenital Amaurosis (LCA) between 2023 and 2030. (bharatbook.com)
  • DelveInsight's,"Complicated Intra-Abdominal Infections - Pipeline Insights, 2023," report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Complicated Intra-Abdominal Infections pipeline landscape. (marketsampler.com)
  • Nevada, Las Vegas United States), " Congenital Diarrheal Disorders Pipeline Insight, 2023 " report by DelveInsight outlays comprehensive insights of the present clinical development scenario and growth prospects across the Congenital Diarrheal Disorders market . (marketsampler.com)
  • Press release - No. 8 / 2023 Zealand Pharma submits New Drug Application to US FDA for dasiglucagon in congenital hyperinsulinism Copenhagen, Denmark, June 30, 2023 - Zealand Pharma A/S. (globenewswire.com)
  • Congenital hyperinsulinism (HI or CHI) is a rare condition causing severe hypoglycemia (low blood sugar) in newborns due to the overproduction of insulin. (wikipedia.org)
  • Congenital forms of hyperinsulinism can be transient (short-term) or persistent (long-term) and mild or severe. (wikipedia.org)
  • Hyperinsulinism or congenital hyperinsulinism can be a genetic or acquired condition. (wikipedia.org)
  • An investigational glucagon-like peptide-1 (GLP-1) antagonist, exendin-(9-39), prevents fasting and protein-induced hypoglycemia among children with congenital hyperinsulinism, new data suggest. (medscape.com)
  • A rare disorder, occurring in 1 in 20,000 to 1 in 50,000 US live births, congenital hyperinsulinism is caused by several different genetic mutations. (medscape.com)
  • Even today with all we know, that's the frequency," said De León, chief of the Division of Endocrinology and Diabetes and director of the Congenital Hyperinsulinism Center at Children's Hospital of Philadelphia (CHOP). (medscape.com)
  • The most common and severe form of congenital hyperinsulinism is due to inactivating mutations of two genes that encode subunits of the beta-cell K ATP channel, leading to dysregulated insulin secretion. (medscape.com)
  • One drug, diazoxide, is a K ATP channel agonist that suppresses insulin release in some types of hyperinsulinism but not in the majority of patients who have those two particular K ATP channel mutations. (medscape.com)
  • Exendin-(9-39) has been granted an orphan drug designation by the European Medicines Agency for the treatment of congenital hyperinsulinism and by the US Food and Drug Administration for the treatment of hyperinsulinemic hypoglycemia (which includes congenital hyperinsulinism). (medscape.com)
  • The current study involved 16 children (6 girls, 10 boys), aged 10 months through 15 years with persistent hypoglycemia due to congenital hyperinsulinism. (medscape.com)
  • Details of New Paltusotine Tablet Formulation to be Unveiled - - Preclinical Evidence Supporting Programs in Congenital Hyperinsulinism and Congenital Adrenal Hyperplasia and Cushing's Disease. (globenewswire.com)
  • The earliest reports of congenital malformations associated with AEDs occurred in the 1960s. (medscape.com)
  • Congenital Malformations Associated with Prenatal Drug Exposure in Newborns in Kentucky, 2009-2013. (uky.edu)
  • DSN: CC37.NAMCS89.DRUG ABSTRACT This report provides documentation for users of the 1989 National Ambulatory Medical Care Survey (NAMCS) Micro-Data Tapes for Drug Mentions. (cdc.gov)
  • Overview of Congenital Adrenal Hyperplasia Congenital adrenal hyperplasia is a group of genetic disorders, each characterized by inadequate synthesis of cortisol, aldosterone, or both. (merckmanuals.com)
  • Although effects are poorly understood, fetal vasoconstriction and hypoxia are likely, and there is a risk of stillbirth, placental abruption, and possibly congenital malformations. (msdmanuals.com)
  • Second Trimester Screening of Congenital Heart Disease, 4D Fetal Echocardiography (2010) 1: 8. (benthamscience.com)
  • Congenital diaphragmatic hernia occurs when a portion of the fetal diaphragm is absent, allowing abdominal contents to enter the thorax, and is associated with impaired pulmonary development. (medworm.com)
  • A teratogen is anything that disrupts normal fetal development, e.g. a drug or chemical. (vin.com)
  • can cross the placenta, recreational use of marijuana use does not consistently appear to increase risk of congenital malformations or fetal growth restriction. (msdmanuals.com)
  • For each of the Leber Congenital Amaurosis (LCA) pipeline candidate, details of leading companies, phase of development, mechanism of action, route of administration, molecule type, and other critical information is provided. (bharatbook.com)
  • In addition, recent Leber Congenital Amaurosis (LCA) market trends, developments, and other market updates are provided in the Leber Congenital Amaurosis (LCA) pipeline study. (bharatbook.com)
  • The global Leber Congenital Amaurosis (LCA) industry is characterized by a robust pipeline. (bharatbook.com)
  • Further, emerging companies play an important role in the global share of the Leber Congenital Amaurosis (LCA) pipeline. (bharatbook.com)
  • The Leber Congenital Amaurosis (LCA) condition has one of the most promising pipelines with the presence of a large number of pharmaceutical companies. (bharatbook.com)
  • Amidst significant unmet market potential for Leber Congenital Amaurosis (LCA), several small and large-scale companies are investing in advancing their pipeline candidates into advanced phases. (bharatbook.com)
  • The current Leber Congenital Amaurosis (LCA) pipeline study examines the state of the drug pipeline and provides insights into the global vitiligo industry. (bharatbook.com)
  • A complete pipeline review of the current treatments and therapies being developed for Leber Congenital Amaurosis (LCA), Data, and insights into pipeline candidates including a detailed overview of the highlighted target and drug characteristics, companies, and developments are included. (bharatbook.com)
  • This quarterly updated report provides data and critical insights into the current pipeline of therapeutic candidates in development with the potential to address Leber Congenital Amaurosis (LCA). (bharatbook.com)
  • The current status of each of the Leber Congenital Amaurosis (LCA) drug pipeline candidates is provided in the study. (bharatbook.com)
  • Driven by robust market growth prospects for Leber Congenital Amaurosis (LCA) therapeutic drugs, a large number of companies are investing in the preclinical Leber Congenital Amaurosis (LCA) pipeline. (bharatbook.com)
  • The report provides in-depth information on the Leber Congenital Amaurosis (LCA) clinical trials of each pipeline product. (bharatbook.com)
  • The Leber Congenital Amaurosis (LCA) pipeline assessment report provides details of drug companies, originators, licensing and collaborating partners, and others involved in the Leber Congenital Amaurosis (LCA) pipeline industry. (bharatbook.com)
  • The company has two clinical-stage programs, ATSN-201 for X-linked retinoschisis (XLRS) and ATSN-101 for GUCY2D -associated Leber congenital amaurosis (LCA1). (tmcnet.com)
  • Leber congenital amaurosis (LCA) is the second most common group of inherited retinal dystrophies after retinitis pigmentosa, accounting for about 5% of all retinal dystrophies. (aao.org)
  • An independent European platform on congenital heart defects. (corience.org)
  • People with congenital heart defects suffer the same negative effects of nicotine and narcotics on the heart as the rest of the population, but they should be extra careful, as drugs can be even more dangerous if your heart is already stressed. (corience.org)
  • Narcotics do not affect just the brain (and therefore our vision, hearing and sensory impressions), they also affect the heart, and that can be fatal for those with congenital heart defects. (corience.org)
  • Congenital mitral stenosis with or without associated defects: an evolving surgical strategy. (medscape.com)
  • Congenital defects in stillborn kittens often go unrecognized because few stillborns are submitted for complete necropsy. (vin.com)
  • Many congenital defects are cosmetic or minor, while others may cause serious impairment of health. (vin.com)
  • Not all congenital defects are heritable. (vin.com)
  • It has been suggested that cats have fewer congenital defects than many other domestic animal species, such as the dog, cow or horse. (vin.com)
  • Congenital defects are also a significant contributor to neonatal mortality in the cat. (vin.com)
  • There are a few studies of congenital defects in pedigreed cats in the literature. (vin.com)
  • Scott et al (1979) reported 4.2% of Burmese kittens from one cattery had congenital defects, as well as 12.7% of Persian kittens from four catteries. (vin.com)
  • The most recent survey of congenital defects in pedigreed cats is found in Sparkes et al. (vin.com)
  • In that analysis of 14 breeds in the UK, 14.9% of the litters included one or more kittens with congenital defects, ranging from 6% of the Devon Rex litters to 31% of the Tonkinese litters. (vin.com)
  • Some statistics have been published for congenital defects in non-pedigreed cats in research colonies. (vin.com)
  • Young noted 2.8% of 633 kittens had congenital defects in a study of a specific pathogen free (SPF) colony. (vin.com)
  • Lawler and Monti found 10.7% of 477 kittens in a minimal disease colony had congenital defects. (vin.com)
  • Addie et al reported that less than 1% of 280 kittens from an SPF colony had congenital defects. (vin.com)
  • Congenital heart defects may produce symptoms at birth, during childhood, and sometimes not until adulthood. (indiadiets.com)
  • The surgical repair of congenital heart defects in children with preoperative pulmonary hypertension (PH) is to varying degree associated with the occurrence of postoperative PH. (lu.se)
  • Breast disorders occurring in pediatric patients range from congenital conditions to neonatal infections and from benign disorders such as fibroadenoma in females and gynecomastia in males to breast carcinoma and rhabdomyosarcoma . (medscape.com)
  • A detailed picture of the Congenital Diarrheal Disorders pipeline landscape is provided, which includes the disease overview and Congenital Diarrheal Disorders treatment guidelines. (marketsampler.com)
  • Congenital diarrheal disorders (CDDs) are a group of inherited enteropathies with a typical onset early in life. (marketsampler.com)
  • If concomitant use of ondansetron with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome. (nih.gov)
  • The objectives were to estimate absolute and relative risks of MCAs in children exposed to specific anxiolytic and hypnotic drugs taken in the first trimester of pregnancy, compared with children of mothers with depression and/or anxiety but not treated with medication and children of mothers without diagnosed mental illness during pregnancy. (nottingham.edu.cn)
  • We describe a 30-year-old woman who had congenital prolongation of QT interval and TdP occurred after taking astemizole and erythromycin. (tmu.edu.tw)
  • However, when no alternative safe drug is available and the illness is severe, some patients with CLQTS may be treated by physicians with expertise in the treatment of arrhythmias. (crediblemeds.org)
  • Congenital neck masses are associated with high perinatal mortality and morbidity secondary to airway obstruction due to a mass effect of the tumor with subsequent neonatal asphyxia and/or neonatal death. (karger.com)
  • Background: Despite their widespread use the effects of taking benzodiazepines and non-benzodiazepine hypnotics during pregnancy on the risk of major congenital anomaly (MCA) are uncertain. (nottingham.edu.cn)
  • These findings suggest that prescription of these drugs during early pregnancy may be safe in terms of MCA risk, but findings from other studies are required before safety can be confirmed. (nottingham.edu.cn)
  • Taking certain medications or alcohol or drug abuse during pregnancy. (indiadiets.com)
  • these drugs are being increasingly used during pregnancy. (msdmanuals.com)
  • The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time. (nih.gov)
  • We calculated absolute risks of MCAs for children with first trimester exposures of different anxiolytic and hypnotic drugs and used logistic regression with a generalised estimating equation to compare risks adjusted for year of childbirth, maternal age, smoking, body mass index, and socioeconomic status. (nottingham.edu.cn)
  • Results: Overall MCA prevalence was 2.7% in 1,159 children of mothers prescribed diazepam, 2.9% in 379 children with temazepam, 2.5% in 406 children with zopiclone, and 2.7% in 19,193 children whose mothers had diagnosed depression and/or anxiety but no first trimester drug exposures. (nottingham.edu.cn)
  • But the difference was not statistically significant and no individual breed of cat was significantly predisposed to congenital diseases in their data. (vin.com)
  • For those with a congenital heart defect, the risks are even greater, especially if they smoke. (corience.org)
  • Bronny James, the eldest son of NBA megastar LeBron James, suffered cardiac arrest in July due to a congenital heart defect, his family said in a Friday statement. (yahoo.com)
  • It is an anatomically and functionally significant Congenital Heart Defect which can and will be treated," the family's statement reads . (yahoo.com)
  • Congenital heart defect was the cause of Bronny James' cardiac arrest on July 24 and there is confidence he will make a full recovery and return to basketball in the very near future, per statement from James family spokesperson. (yahoo.com)
  • Congenital heart disease (CHD) is responsible for pulmonary hypertension (PH) in children in about 50% of cases. (nih.gov)
  • Congenital heart disease is a type of defect or malformation in one or more structures of the heart or blood vessels that occurs before birth. (indiadiets.com)
  • Decades of NIH-supported research led to advances in diagnosis, treatment, and newborn screening mandates for congenital heart disease (CHD). (nih.gov)
  • Congenital Toxoplasmosis in Goats, Congenital Toxoplasmosis in Humans and Domestic Animals (2018) 1: 96. (eurekaselect.com)
  • Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. (benthamscience.com)
  • The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. (benthamscience.com)
  • The objective of this study was to assess the association between first-trimester sulfonamide exposure and risk of specific congenital malformations. (healthpartners.com)
  • in the September, 2011 edition of Neuropsychopharmacology examining the relationship between exposure to selective serotonin reuptake inhibitor drugs (SSRIs) and adverse birth outcomes . (dangerousdrugs.us)
  • that appeared in the February, 2013 edition of Prescrire International examines additional risks of prenatal exposure to selective serotonin reuptake inhibitor drugs (SSRIs) . (dangerousdrugs.us)
  • OUTCOME MEASURES: Assessments were made by experienced examiners masked to maternal drug history. (erowid.org)
  • Three-dimensional echocardiography in the assessment of congenital mitral valve disease. (medscape.com)
  • This tape, called the drug mention tape, contains information on 38,948 drugs mentioned in the national sample of 38,384 patient visits. (cdc.gov)
  • The increased occurrence of microcephaly associated with cerebral damage characteristically seen in congenital infections in Zika virus-affected areas is suggestive of a possible relationship. (cdc.gov)
  • Tests for other congenital infections were negative. (cdc.gov)
  • The global vitiligo therapeutic pipeline is characterized by a significant number of drug candidates in the preclinical drug discovery and research phases. (bharatbook.com)
  • Amidst growth in R&D investment, pharmaceutical companies increasingly emphasize strengthening their pipeline product portfolio to ensure time-efficient drug developments. (bharatbook.com)
  • It covers the pipeline drug profiles, including clinical and nonclinical stage products. (marketsampler.com)
  • Establised under the 21st Century Cures Act, RMAT designation is a dedicated program designed to expedite the drug development and review processes for promising pipeline products, including gene therapies. (tmcnet.com)
  • There are over 290 medicines on the Drugs to Avoid (DTA) list for patients with Congenital LQTS (CLQTS). (crediblemeds.org)
  • Avoidance may not always be possible because many patients have conditions that require treatment with these drugs and safe alternatives are not available. (crediblemeds.org)
  • Because there are at least 17 different genes associated with CLQTS, some patients may respond differently to these drugs and be safely treated with some of the drugs on the DTA list. (crediblemeds.org)
  • The following information is provided to help patients, family members and healthcare providers to make these decisions and interpret the different categories of drugs on the DTA list. (crediblemeds.org)
  • These drugs should only rarely, if ever, be given to patients with CLQTS because the danger is clear. (crediblemeds.org)
  • These drugs have been found to increase QT intervals in some patients and for that reason could theoretically be dangerous in CLQTS. (crediblemeds.org)
  • However, if the drugs are medically necessary, they may be prescribed by medical specialists for patients with CLQTS. (crediblemeds.org)
  • Most of these can be prescribed safely for many patients with CLQTS because the drug's risk is confined to certain conditions, e.g. overdose, excessive duration of treatment, use with diuretics or drugs that block their elimination, or patients with other risk factors. (crediblemeds.org)
  • This is a list that includes all of the drugs in the three above categories and additional drugs that do not prolong QT but have a theoretical risk of causing arrhythmias in some CLQTS patients because they have adrenaline-like effects. (crediblemeds.org)
  • It alerts doctors and patients about drug effects that may be dangerous. (healthline.com)
  • A regenerative medicine therapy is eligible for RMAT designation if it is intended to treat, modify, reverse, or cure a serious or life-threatening disease or condition, and preliminary clinical evidence indicates that the drug or therapy has the potential to address unmet medical needs for that disease or condition. (tmcnet.com)
  • In 2009, the Food and Drug Administration (FDA) approved AL for the treatment of uncomplicated malaria. (cdc.gov)
  • Malaria treatment policies and drug efficacy in Author affiliations: Harvard T.H. Chan School of Public Health, Haiti from 1955-2012. (cdc.gov)
  • 18) received no drugs because they refused treatment for fear of harming the fetus. (who.int)
  • Atsena has also received orphan drug designation from the FDA for ATSN-101 for the treatment of LCA1. (tmcnet.com)
  • CRN04777 Phase 1 Program Progressing to Multiple Ascending Dose Cohorts to Advance Development as a Treatment for Congenital Hyperinsulinisms Demonstrated Dose-dependent Reductions in. (globenewswire.com)
  • These data emphasize the need to perform randomized, blinded trials on the use of PH-targeting drugs in children with postoperative PH before accepting it as an indication for routine treatment. (lu.se)
  • Treatment with dimercaprol (59529) (British Anti-Lewisite in Oil) and n-acetyl-d,1- penicillamine was not associated with significant immediate clinical improvement, although both drugs appeared to increase urinary excretion of mercury (7439976). (cdc.gov)
  • Approximately 3-5% of all human infants are born with a congenital defect and many childhood deaths in North America (30% or more) are due to congenital malformations. (vin.com)
  • In women who are pregnant, the volume of distribution and the hepatic metabolism of antiepileptic drugs (AEDs) are increased. (medscape.com)
  • Plasmodium falciparum K76T pfcrt gene mutations and graphic might improve antimicrobial drug stewardship and parasite population structure, Haiti, 2006-2009. (cdc.gov)
  • Note: If you'd like to get a target analysis report for Congenital Dysfibrinogenemia , or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Congenital Dysfibrinogenemia at a cost 90% lower than traditional approaches, please feel free to contact us at [email protected] . (silexon.tech)
  • We conducted a randomized, placebo-controlled trial of valganciclovir therapy in neonates with symptomatic congenital CMV disease, comparing 6 months of therapy with 6 weeks of therapy. (nih.gov)
  • Some bined therapy of carbamazepine and pheny- promising drugs are in various stages of toin and group C had no antiepileptic development and many are being tested to medication. (who.int)
  • As HI is a congenital condition, an infant usually starts to show signs and symptoms within the first few days of life, although very occasionally symptoms may appear later in life. (wikipedia.org)
  • Withdrawal symptoms are side effects that can occur when you stop taking a drug your body is dependent on. (healthline.com)
  • For a general overview of the drug, including details about its uses, see this article . (healthline.com)
  • Whether we like it or not, alcohol, tobacco and, in some cases, illegal drugs are a part of life, and many people use them despite the known health risks. (corience.org)
  • Treating symptomatic congenital CMV disease with valganciclovir for 6 months, as compared with 6 weeks, did not improve hearing in the short term but appeared to improve hearing and developmental outcomes modestly in the longer term. (nih.gov)
  • Cave et al noted that congenital disease was more common in pedigreed kittens than in the non-pedigreed kittens in their necropsy study of 274 kittens aged up to 16 weeks. (vin.com)
  • Ingrezza (valbenazine) is a prescription drug that's used to treat tardive dyskinesia and chorea caused by Huntington's disease. (healthline.com)
  • Brain disease , metabolic failure, or drugs can dull the normal signals that give rise to the urge to defecate. (britannica.com)
  • The risk of a congenital melanocytic nevus developing into melanoma is greater for children under 10, which account for 70% of all cases. (emedicinehealth.com)
  • In this way, the objective of this chapter is to describe the main aspects of congenital toxoplasmosis in pregnant goats, in different gestational stages, infected and reinfected with T. gondii and their offspring. (eurekaselect.com)
  • The remaining 17 children normalized their pulmonary arterial pressure without the use of PH-targeting drugs at any time during the follow-up. (lu.se)
  • An important gene associated with Dysfibrinogenemia, Congenital is FGA (Fibrinogen Alpha Chain), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. (silexon.tech)
  • This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. (benthamscience.com)
  • RMAT designation provides sponsors with intensive FDA guidance on efficient drug development, including the ability to discuss surrogate or intermediate endpoints, potential ways to support accelerated approval and satisfy post-approval requirements, potential priority review of the biologics license application (BLA), and other opportunities to expedite development and review. (tmcnet.com)
  • Decades of basic research supported by NIH laid the foundation for the development of two classes of diabetes drugs, GLP-1 receptor agonists and SGLT2 inhibitors. (nih.gov)
  • When compared with 2.7% in 351,785 children with no diagnosed depression/anxiety nor medication use, the adjusted odds ratios were 1.02 (99% confidence interval 0.63-1.64) for diazepam, 1.07 (0.49-2.37) for temazepam, 0.96 (0.42-2.20) for zopiclone and 1.27 (0.43-3.75) for other anxiolytic/hypnotic drugs and 1.01 (0.90-1.14) for un-medicated depression/anxiety. (nottingham.edu.cn)
  • After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. (healthline.com)
  • This information is also consistent with data showing acceleration of the aging process by drugs of addiction including alcohol, tobacco, cannabis, stimulants and opioids. (drugprevent.org.uk)
  • To facilitate analysis of these drug data, a data tape has been prepared which includes a separate record for each drug entered on each sample encounter form. (cdc.gov)
  • Characteristics of the drugs themselves (e.g., generic ingredients, composition status, etc.) are obtained from the Drug Product Information File, maintained and marketed by the American Druggist Blue Book Data Center, and from the National Drug Code Directory, produced by the National Center for Drugs and Biologics of the U.S. Public Health Service. (cdc.gov)
  • There are two important points relative to analyzing data from this micro-data tape that should be noted: 1-Micro-data tape users should be fully aware of the importance of the 'drug weight' and how it must be used. (cdc.gov)