Loading...
  • Patients
  • When opioids that are most often used for cancer pain were analyzed separately, the mandates had no effect, suggesting that the required checking was, as intended, mainly influencing prescribing to patients whose need for the drugs was not so clear. (philly.com)
  • This study reviewed data spanning five years regarding the frequency of finding low drug levels in patients with tuberculosis, the dosing adjustments that were required to achieve adequate levels and the factors associated with low drug levels. (hindawi.com)
  • RESULTS: In total, 20 patients were identified in whom TDM was performed, of whom 17 (87%) had at least one low drug concentration. (hindawi.com)
  • Within cases only, the 17 patients with low serum drug levels were significantly more likely to have comorbid illnesses, be smear positive, have lower serum albumin levels and had nonsignificantly longer time to culture conversion, compared with the three cases in whom all drug levels were within therapeutic ranges. (hindawi.com)
  • CONCLUSIONS: TB drug levels were frequently below clinically acceptable levels in patients with active TB, particularly in those with HIV infection or other comorbidities. (hindawi.com)
  • To protect practitioners and patients alike, toxicology laboratories across the country are starting to take the next step: adjusting drug tests to specifically monitor patient compliance. (practicalpainmanagement.com)
  • Different patients may not have the same response to the same drug or to the same dose. (gastro.org)
  • Patients with mechanistic failure will likely not respond to other drugs of the same class. (gastro.org)
  • Patients with this type of failure have low levels of the drug in their blood, and have a high amount of anti-drug antibodies. (gastro.org)
  • With a reportable range down to 1ng/mL, our Tacrolimus Immunoassay is the perfect aid for monitoring patients on multiple drug therapies. (thermofisher.com)
  • The system is used primarily by law enforcement and doctors to flag potential prescription drug abuse and better treat patients. (wmuk.org)
  • Post-transplant patients receiving immunosuppressive drugs-often for the rest of their lives-require regular therapeutic drug monitoring (TDM), given the narrow therapeutic interval of these drugs as well as the risk of graft rejection at low exposure and toxic effects at high levels. (aacc.org)
  • The investigators aim at testing a simplified algorithm for dose reduction in patients with documented virological efficacy, treated by a stable LPV/r or EFV based regimen with elevated plasma concentration of these drugs. (clinicaltrials.gov)
  • Prospective open label study in which all eligible patients screened with a plasma drug concentration of either EFV or LPV/r above percentile 75 will be included. (clinicaltrials.gov)
  • After confirmation of the results at baseline, patients will be offered to decrease drug dosage by a third or a half according to a standardised algorithm. (clinicaltrials.gov)
  • Number of patients who reach a plasma concentration within targets (P25-P75) after at least one cycle of dose reduction -percentage of spared drugs through TDM-guided dosage adaptation over a 6 months period. (clinicaltrials.gov)
  • overdose
  • According to the US Centers for Disease Control and Prevention (CDC), drug overdose is the leading cause of accidental death in the US, with 47,055 lethal drug overdoses in 2014. (sas.com)
  • Drug overdose death rates in the United States have more than tripled since 1990, outnumbering car accidents as the leading cause of accidental death in the country. (governing.com)
  • dose
  • by regulating the dose of drugs. (medindia.net)
  • TDM helps tailor the drug and dose to the body of each patient. (gastro.org)
  • Your doctor can figure out which type of failure is happening by measuring the amount of drug in your blood right before the next dose is usually taken (also known as a trough level) and comparing it with the amount of anti-drug antibodies in your blood. (gastro.org)
  • If you are taking a type of drug called anti-TNF agents (a type of biologic drug) for your IBD, TDM can help your doctor find the right drug and dose. (gastro.org)
  • Reactive TDM is done on a patient who is currently having IBD symptoms to guide changes in the drug type or dose. (gastro.org)
  • If your trough levels are low and you do not have a high level of antibodies, your doctor may decide to increase the dose of the drug you are currently taking. (gastro.org)
  • This is important data considering current treatment guidelines do not address how to dose epilepsy drugs once women become pregnant," said study author Page B. Pennell, MD, with Emory University School of Medicine in Atlanta, GA, and member of the American Academy of Neurology. (health.am)
  • For drugs such as EFV or LPV/r, lower doses than the ones validated for standard clinical use have demonstrated efficacy in dose-ranging studies. (clinicaltrials.gov)
  • PDMPs
  • To tackle this epidemic, a lot of effort has been put into state-run prescription drug monitoring programs (PDMPs) that establish databases of prescriptions written and filled, with secure online portals for accessing that data. (sas.com)
  • But a new study that sought to clarify the relationship between PDMPs and their effectiveness in attacking the nation's drug problem found limited to no evidence that they actually work. (ajmc.com)
  • Outcomes
  • In the treatment of active tuberculosis (TB), TDM is not routine, yet low levels of anti-TB drugs can be associated with poorer treatment outcomes. (hindawi.com)
  • Novus Medical Detox Center -a leading Florida-based drug treatment facility-analyzes the outcomes of these efforts, including how they might be implemented in other states and how they have affected illicit drug use overall. (prweb.com)
  • dosages
  • A limited range of therapeutically sound dosages is one of the reasons why the currently approved antiretroviral drugs are often difficult to take and of uncertain utility over a long period of time. (thebody.com)
  • This leads to safer dosages and combinations and helps monitor drugs that are easy to abuse. (himss.org)
  • program
  • Therapeutic Drug Monitoring is delighted to announce the initiation of a program for awarding continuing education CEM/CNE credits for Peer Review. (lww.com)
  • 2) Title of the Form/Collection: Prescription Drug Monitoring Program Questionnaire. (usdoj.gov)
  • 5) An estimate of the total number of respondents and the amount of time estimated for an average respondent to respond: It is estimated that 51 persons complete the Prescription Monitoring Program Questionnaire electronically, at 5 hours per form, for an annual burden of 255 hours. (usdoj.gov)
  • Pennsylvania's current Prescription Drug Monitoring Program began in August, too late to be included in the study. (philly.com)
  • Nearly every state has a prescription drug monitoring program, but most aren't being used by providers and pharmacists. (governing.com)
  • For example, even a 2012 report out of Brandeis University's Prescription Drug Monitoring Program Center of Excellence is itself conflicted. (governing.com)
  • The problematic state drug monitoring program has gotten a significant facelift. (wmuk.org)
  • Fink said his concern is "that when you take away a primary drug that somebody is dependent upon, what's going to happen in that next stage if a [rehabiliation] program isn't provided to help those individuals? (ajmc.com)
  • The researchers in this study developed a series of metrics to identify providers manifesting unusual prescribing practices using one state's prescription monitoring program. (umich.edu)
  • Located on 3.25 tree-lined acres in New Port Richey, Florida, Novus is also licensed by the Florida Department of Children and Families and is known for minimizing the discomfort of withdrawal from prescription medication, drugs or alcohol by creating a customized detox program for each patient. (prweb.com)
  • routinely
  • However, due to the high costs and complexity of testing, therapeutic drug monitoring is not routinely used in the treatment of individuals with active tuberculosis, despite the efficacy demonstrated in several randomized trials. (hindawi.com)
  • patient's
  • In the example I shared here, the clinical team cared about the patient and wanted to utilize clinical tools to monitor the patient's prescriptions in order to ensure the best care possible. (himss.org)
  • TDM is done through testing the patient's blood on a regular basis while they are taking drugs for IBD. (gastro.org)
  • This is when a patient's immune system breaks down the drug in the body too quickly for it to effectively treat the disease. (gastro.org)
  • This is when the drug is cleared from the patient's body too quickly for it to be helpful. (gastro.org)
  • commonly
  • It is commonly used for drugs such as tobramycin (Tobrex or TOBI, a broad-spectrum antibiotic) and digoxin (Lanoxin, used in the management of congestive heart failure and some dysrhythmias, or abnormal heart rhythms). (thebody.com)
  • This discussion focuses on the clinical and analytical issues surrounding the monitoring of commonly used analgesic drugs. (thefreelibrary.com)
  • Abuse
  • The two differences between therapeutic drug monitoring and testing for drugs of abuse (DOA) are simple but significant. (practicalpainmanagement.com)
  • The 2,000-ng/mL cut-off originally set by the Substance Abuse and Mental Health Services Administration (formally known as the National Institute for Drug Abuse) is drastically reduced to 20 or 25 in a drug test for patient compliance in order to accurately detect a therapeutic range. (practicalpainmanagement.com)
  • Additionally, screening may be used in situations when compliance or abuse of these drugs is questioned. (thefreelibrary.com)
  • The purpose of the study was to develop a set of metrics to identify prescription drug providers with unusual or uncustomary prescribing practices and how these metrics can be used to mitigate the misuse, abuse, and diversion of controlled substances. (umich.edu)
  • Other states would be wise to follow Florida's approach in targeting prescription drug abuse, since pain clinics will set up shop wherever there are lax laws and weak regulatory oversight. (prweb.com)
  • Chromatography
  • ELISA results are confirmed and quantified through gas chromatography/mass spectrometry (GC/MS), regarded as the "gold standard" in drug testing for its unique combination of chromatography for separation of drugs and mass spectrometry for identification and quantization. (practicalpainmanagement.com)
  • To address this problem, researchers at Karolinska University Hospital in Sweden used a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to simultaneously analyze immunosuppressive drugs as part of their TDM service. (aacc.org)
  • programs
  • Studying Medicaid also allowed the researchers, from Weill Cornell Medical College in New York and the University of Kentucky in Lexington, to analyze a vast trove of data to examine the impact of changes that different states made to their prescription-monitoring programs over several years. (philly.com)
  • Kate Tipping, a policy analyst with the Office of the National Coordinator (ONC) for Health Information Technology, said, "Forty-nine states have monitoring programs in place, but most of their providers and pharmacies are not accessing them regularly because it doesn't fit in with their workflow. (governing.com)
  • Last week, I wrote that the latest evidence on prescription drug monitoring programs suggests that they don't work so well . (theincidentaleconomist.com)
  • The Florida-based drug treatment facility provides individually customized treatment programs with 24/7 access to nursing care and withdrawal specialists for an easier detox and a successful recovery. (prweb.com)
  • Novus offers safe, effective alcohol and drug treatment programs in a home-like residential setting. (prweb.com)
  • levels
  • Even the minimum levels of many anti-HIV drugs needed to suppress viral replication below the limit of detection can cause unpleasant adverse effects, such as peripheral neuropathy (burning or tingling sensations in the hands and feet) or diarrhea (see 'Adverse Effects Associated with Antiretroviral Therapy' in BETA , Spring 2000). (thebody.com)
  • Low drug levels were found in 13 of 15 (87%) isoniazid, four of five (80%) rifabutin and eight of 12 (67%) rifampin measurements, but in only two of 13 (15%) pyrazinamide measurements. (hindawi.com)
  • Therapeutic drug monitoring (or TDM, for short) is when your doctor looks at the amount of IBD drugs in your blood to make sure that you are getting optimal levels of the drug. (gastro.org)
  • If your trough levels are low and you also have a high level of antibodies, your doctor may switch to another drug in the same class, or a completely new type of drug. (gastro.org)
  • blood
  • Just as there are various reasons to monitor drug use, there are also various ways to test it, with the most popular methods depending on samples of blood and urine. (practicalpainmanagement.com)
  • it takes only a few hours for a drug to filter through the blood, which can cause a negative result even if the patient is in compliance with their pain management regimen. (practicalpainmanagement.com)
  • This is when a patient does not respond to a specific drug even though that they have an acceptable amount of the drug in their blood. (gastro.org)
  • Now, new research shows that monitoring the level of the drug in the blood helps to reduce the increased seizure activity associated with the drug lamotrigine and improve the overall health of pregnant women and their fetuses. (health.am)
  • This type of drug monitoring is relatively easy since pregnant women can give blood for lamotrigine testing during their regular visits with their obstetrician or neurologist," said Pennell. (health.am)
  • Even though the method proved to be sufficient for routine use, the authors concluded, "we think there is still room for considerable improvement in the design of LC-MS methods for the analytical task of measuring immunosuppressive drugs in blood. (aacc.org)
  • exposure
  • More importantly, approximately 50% of people taking the recommended doses of highly active antiretroviral therapy, or HAART, are not able to maintain an undetectable viral load, indicating insufficient drug exposure, drug resistance, or both. (thebody.com)
  • Less
  • Medicaid spending on those drugs also was about 10 percent less than in states that lacked mandates. (philly.com)
  • pharmaceutical
  • Analgesic drugs comprise the largest category of pharmaceutical agents consumed by individuals in the United States. (thefreelibrary.com)
  • One major concern is that the analgesic class of drugs accounted for more exposures reported to the American Association of Poison Control Centers in 1995 than did any other category of pharmaceutical agents (3). (thefreelibrary.com)
  • The serious nature of these exposures is underscored by the fact that they also led to the highest number of pharmaceutical drug-related deaths during that same year (3). (thefreelibrary.com)
  • safer
  • Their medical origins lead to the perception that they are safer than street drugs, but their potency makes them dangerous. (sas.com)
  • physicians
  • New York has made prescription drug data available to physicians since 2010, "but the old system was underutilized," according to Terence O'Leary, director of the Bureau of Narcotic Enforcement for the New York State Department of Health (DOH). (governing.com)
  • Report
  • The EMA explained the introduction was not a comment on the safety of the drug, but an "invitation" to report any issues with it. (pmlive.com)