Pharmaceutical PreparationsCarbocysteineBiotransformationMandatory TestingPharmacokineticsSubstance Abuse DetectionGas Chromatography-Mass SpectrometryChromatography, High Pressure LiquidChromatography, LiquidMass SpectrometryTandem Mass SpectrometryCytochrome P-450 Enzyme SystemMicrosomes, LiverMetabolomicsMetabolomeMagnetic Resonance SpectroscopyHydroxylationGlucuronidesSpectrometry, Mass, Electrospray IonizationGlucuronatesMetabolic Networks and PathwaysPhthalic AcidsBileHomovanillic AcidLiverStereoisomerismAdministration, OralDose-Response Relationship, DrugCarbon RadioisotopesRats, Sprague-DawleyHalf-LifeKineticsDealkylationOxidation-ReductionArachidonic AcidSecondary MetabolismCytochrome P-450 CYP3AHydroxyindoleacetic AcidHydroxyeicosatetraenoic AcidsBenzeneChromatography, GasArea Under CurveAryl Hydrocarbon HydroxylasesCholineMetabolic Detoxication, Phase IChromatography, Thin LayerMetabolic Detoxication, DrugPhenolsCreatineCunninghamellaDrug InteractionsHydroxyestronesArachidonic AcidsTissue DistributionModels, Biological24,25-Dihydroxyvitamin D 3Epoxy CompoundsTime FactorsCarcinogensCatecholsSpectrophotometry, UltravioletMetabolism3,4-Dihydroxyphenylacetic AcidMetabolic Clearance RateProdrugsBiological AvailabilityBiosynthetic PathwaysPhenylacetatesDihydroxycholecalciferolsFecesFermentationBenzopyrenesBenzo(a)pyreneHydroquinonesGlutathioneKynurenineMetabolic Detoxication, Phase IICytochrome P-450 CYP2D6MutagensRats, WistarMorphine DerivativesMixed Function OxygenasesMethoxyhydroxyphenylglycolBrainReference StandardsReproducibility of Results