Drug metabolism idiosyncratic reactions. Medical search. Frequent questions

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Anatomy16

Microsomes, Liver Liver Hepatocytes Microsomes Cells, Cultured Hep G2 Cells Intestines Intestine, Small Kidney Cell Line Cell Line, Tumor Caco-2 Cells Brain Mitochondria Muscle, Skeletal Adipose Tissue

Organisms9

Rats, Sprague-Dawley Rats, Inbred Strains Macaca fascicularis Mice, Inbred C57BL Mice, Knockout Rats, Wistar Dogs Rats, Inbred F344 Mice, Transgenic

Diseases7

Drug-Related Side Effects and Adverse Reactions Drug-Induced Liver Injury Metabolism, Inborn Errors Body Weight Neoplasms Lipid Metabolism Disorders Liver Diseases

Chemicals and Drugs120

Pharmaceutical Preparations Cytochrome P-450 Enzyme System Hexobarbital Antipyrine Cytochrome P-450 CYP3A Aryl Hydrocarbon Hydroxylases Xenobiotics Cytochrome P-450 CYP2D6 Umbelliferones Mixed Function Oxygenases Oxidoreductases, N-Demethylating Receptors, Steroid Glucuronosyltransferase Aminopyrine Phenobarbital 7-Alkoxycoumarin O-Dealkylase Aminopyrine N-Demethylase Coumarins Steroid 16-alpha-Hydroxylase Cytochrome P-450 CYP1A2 Ketoconazole Ethylmorphine-N-Demethylase Dextromethorphan NADPH-Ferrihemoprotein Reductase Cytochromes b5 Nitrazepam Aniline Hydroxylase Methaqualone Glucose Midazolam Isoenzymes Receptors, Cytoplasmic and Nuclear Amobarbital Tolbutamide Steroid Hydroxylases Debrisoquin Cytochrome P-450 CYP2E1 Carboxylesterase Acetaminophen Mephenytoin Phenylbutazone Sparteine Oxygenases RNA, Messenger Glucuronides Aminoethylphosphonic Acid Cytochrome P-450 CYP1A1 Carbon Radioisotopes Phenytoin Chlorzoxazone P-Glycoprotein Hesperidin Glutathione Transferase Prodrugs beta-Naphthoflavone Bornanes Enzyme Inhibitors Cytochrome P-450 CYP2B1 Oxidoreductases Phenacetin Carboxylic Ester Hydrolases Bile Acids and Salts Testosterone Fatty Acids Methylcholanthrene Diclofenac Glutathione Theophylline Terfenadine Carbamazepine NAD(P)H Dehydrogenase (Quinone)Diazepam Carbon Isotopes Rifampin Arylamine N-Acetyltransferase Lactic Acid NADP Aniline Compounds Insulin Carbon Diphtheria-Tetanus-Pertussis Vaccine Lactates Recombinant Proteins Warfarin Antineoplastic Agents Acetates Nitrogen Triglycerides Pentobarbital Membrane Transport Proteins Cholesterol DNA, Complementary Triazines Cimetidine Blood Glucose Ethanolamines Anticonvulsants Transcription Factors Plant Extracts Pyruvic Acid Lipids Carbon Dioxide Serum Albumin Adenosine Triphosphate RNA DNA Primers Oxygen Analgesics, Non-Narcotic Pyruvates Fatty Acids, Nonesterified NF-E2-Related Factor 2 Heme Receptors, Aryl Hydrocarbon Glycerol Anti-Inflammatory Agents, Non-Steroidal Deoxyglucose Iron Ammonia Membrane Proteins Phosphates

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Metabolic Clearance Rate Chromatography, High Pressure Liquid Drug Evaluation, Preclinical Chromatography, Liquid Mass Spectrometry Models, Biological Liver, Artificial Gene Expression Profiling Reverse Transcriptase Polymerase Chain Reaction Oligonucleotide Array Sequence Analysis Administration, Oral Magnetic Resonance Spectroscopy Tandem Mass Spectrometry Drug Design Drug Discovery Area Under Curve Medicine, Kampo Models, Animal Body Weight Blotting, Western Organ Size Technology, Pharmaceutical Drug Monitoring Individualized Medicine Liver Function Tests Basal Metabolism Polymerase Chain Reaction Models, Molecular Reproducibility of Results Inhibitory Concentration 50 Gas Chromatography-Mass Spectrometry Cell Culture Techniques Molecular Dynamics Simulation Chromatography, Thin Layer

Phenomena and Processes66

Metabolic Detoxication, Drug Pharmacokinetics Biotransformation Lipid Metabolism Energy Metabolism Metabolic Detoxication, Phase I Metabolic Detoxication, Phase II Hydroxylation Drug Interactions Half-Life Metabolic Clearance Rate Metabolism Dealkylation Enzyme Induction Oxidation-Reduction Kinetics Gene Expression Regulation, Enzymologic Polymorphism, Genetic Substrate Specificity Time Factors Biological Transport Quantitative Structure-Activity Relationship Species Specificity Dose-Response Relationship, Drug Genotype Glycolysis Gene Expression Regulation Biological Availability Metabolic Networks and Pathways Tissue Distribution Stereoisomerism Phenotype Food-Drug Interactions Molecular Structure Intestinal Absorption Herb-Drug Interactions Area Under Curve Oxygen Consumption Gene Expression Polymorphism, Single Nucleotide Body Weight Signal Transduction Mutation Organ Size Alleles Base Sequence Citric Acid Cycle Amino Acid Sequence Sex Characteristics Genetic Variation Transcription, Genetic Protein Binding Catalysis Aging Basal Metabolism Homeostasis Metabolome Down-Regulation Gene Frequency Cell Survival Diet Inhibitory Concentration 50 Anaerobiosis Pentose Phosphate Pathway Aerobiosis Molecular Dynamics Simulation

Disciplines and Occupations5

Pharmacogenetics Drug Design Drug Discovery Technology, Pharmaceutical Individualized Medicine

Anthropology, Education, Sociology and Social Phenomena4

Safety-Based Drug Withdrawals United States Environmental Protection Agency Medicine, Kampo United States Food and Drug Administration

Technology, Industry, Agriculture1

Technology, Pharmaceutical

Information Science5

Serial Publications Molecular Sequence Data Base Sequence Amino Acid Sequence Molecular Dynamics Simulation

Health Care6

Safety-Based Drug Withdrawals Societies, Pharmaceutical United States Environmental Protection Agency Area Under Curve United States Food and Drug Administration Reproducibility of Results

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Anthropology, Education, Sociology and Social Phenomena Technology, Industry, Agriculture Information Science Health Care

Pharmaceutical Preparations Cytochrome P-450 Enzyme System Hexobarbital Metabolic Detoxication, Drug Antipyrine Cytochrome P-450 CYP3A Pharmacokinetics Microsomes, Liver Aryl Hydrocarbon Hydroxylases Biotransformation Liver Lipid Metabolism Energy Metabolism Xenobiotics Metabolic Detoxication, Phase I Metabolic Detoxication, Phase II Cytochrome P-450 CYP2D6 Umbelliferones Hepatocytes Pharmacogenetics Hydroxylation Mixed Function Oxygenases Oxidoreductases, N-Demethylating Receptors, Steroid Glucuronosyltransferase Aminopyrine Drug Interactions Phenobarbital 7-Alkoxycoumarin O-Dealkylase Aminopyrine N-Demethylase Half-Life Coumarins Steroid 16-alpha-Hydroxylase Cytochrome P-450 CYP1A2 Ketoconazole Metabolic Clearance Rate Ethylmorphine-N-Demethylase Dextromethorphan Metabolism NADPH-Ferrihemoprotein Reductase Cytochromes b5 Dealkylation Nitrazepam Enzyme Induction Chromatography, High Pressure Liquid Aniline Hydroxylase Methaqualone Glucose Drug-Related Side Effects and Adverse Reactions Midazolam Oxidation-Reduction Isoenzymes Kinetics Receptors, Cytoplasmic and Nuclear Amobarbital Tolbutamide Steroid Hydroxylases Debrisoquin Cytochrome P-450 CYP2E1 Carboxylesterase Acetaminophen Microsomes Mephenytoin Serial Publications Phenylbutazone Drug Evaluation, Preclinical Sparteine Oxygenases Safety-Based Drug Withdrawals Chromatography, Liquid RNA, Messenger Glucuronides Mass Spectrometry Rats, Sprague-Dawley Gene Expression Regulation, Enzymologic Polymorphism, Genetic Substrate Specificity Models, Biological Time Factors Aminoethylphosphonic Acid Cytochrome P-450 CYP1A1 Biological Transport Carbon Radioisotopes Phenytoin Quantitative Structure-Activity Relationship Liver, Artificial Societies, Pharmaceutical Chlorzoxazone P-Glycoprotein Species Specificity Dose-Response Relationship, Drug Cells, Cultured Hesperidin Glutathione Transferase Genotype Gene Expression Profiling Prodrugs Drug-Induced Liver Injury Hep G2 Cells Glycolysis

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