Drug metabolism and toxicity potential idiosyncratic toxicities. Medical search. Frequent questions

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Anatomy13

Liver Microsomes, Liver Hepatocytes Cells, Cultured Microsomes Kidney Cell Line Cell Line, Tumor Hep G2 Cells Intestines Mitochondria Intestine, Small Brain

Organisms9

Rats, Sprague-Dawley Mice, Inbred C57BL Macaca fascicularis Rats, Inbred Strains Rats, Wistar Rats, Inbred F344 Mice, Knockout Dogs Mice, Transgenic

Diseases12

Drug-Related Side Effects and Adverse Reactions Drug-Induced Liver Injury Neoplasms Body Weight Leukopenia Radiation Injuries Metabolism, Inborn Errors Neutropenia Lung Neoplasms Disease Models, Animal Hematologic Diseases Thrombocytopenia

Chemicals and Drugs115

Pharmaceutical Preparations Cytochrome P-450 Enzyme System Hexobarbital Antipyrine Cytochrome P-450 CYP3A Aryl Hydrocarbon Hydroxylases Xenobiotics Cytochrome P-450 CYP2D6 Umbelliferones Glucuronosyltransferase Mixed Function Oxygenases Oxidoreductases, N-Demethylating Receptors, Steroid Aminopyrine Phenobarbital Antineoplastic Agents Coumarins Cytochrome P-450 CYP1A2 7-Alkoxycoumarin O-Dealkylase Aminopyrine N-Demethylase Ketoconazole Steroid 16-alpha-Hydroxylase Acetaminophen Cytochrome P-450 CYP2E1 Dextromethorphan NADPH-Ferrihemoprotein Reductase Ethylmorphine-N-Demethylase Cytochromes b5 Glucose Nitrazepam Aniline Hydroxylase Isoenzymes Methaqualone Midazolam Receptors, Cytoplasmic and Nuclear Carboxylesterase Steroid Hydroxylases Prodrugs Amobarbital Glutathione Tolbutamide RNA, Messenger Debrisoquin Mephenytoin Enzyme Inhibitors Oxygenases Cytochrome P-450 CYP1A1 Glucuronides Phenylbutazone Sparteine Phenytoin Cisplatin P-Glycoprotein Fluorouracil Glutathione Transferase Plant Extracts Carbon Radioisotopes Recombinant Proteins Chlorzoxazone Cyclophosphamide Aminoethylphosphonic Acid Doxorubicin Oxidoreductases Hesperidin beta-Naphthoflavone Carboxylic Ester Hydrolases Antineoplastic Agents, Phytogenic Bornanes Deoxycytidine Cytochrome P-450 CYP2B1 Antimetabolites, Antineoplastic Testosterone Phenacetin Triazines Bile Acids and Salts Paclitaxel Fatty Acids NAD(P)H Dehydrogenase (Quinone)Diclofenac Methylcholanthrene Antidotes Camptothecin Aniline Compounds Theophylline Carbon Lactic Acid Carbamazepine Water Pollutants, Chemical Environmental Pollutants Teratogens Rifampin NADP Acetates Insecticides Diazepam Carboplatin Arylamine N-Acetyltransferase Insulin Terfenadine Taxoids Anticonvulsants Carbon Isotopes Oxygen Leucovorin Receptors, Aryl Hydrocarbon Membrane Transport Proteins Organoplatinum Compounds Iron Lactates Methotrexate Etoposide Cholesterol DNA, Complementary Nitrogen Vinblastine

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Toxicity Tests Toxicity Tests, Acute Metabolic Clearance Rate Lethal Dose 50 Chromatography, High Pressure Liquid Drug Evaluation, Preclinical Administration, Oral Antineoplastic Combined Chemotherapy Protocols Drug Administration Schedule Toxicity Tests, Chronic Models, Biological Treatment Outcome Area Under Curve Mass Spectrometry Chromatography, Liquid Infusions, Intravenous Body Weight Organ Size Gene Expression Profiling No-Observed-Adverse-Effect Level Reverse Transcriptase Polymerase Chain Reaction Maximum Tolerated Dose Oligonucleotide Array Sequence Analysis Drug Design Liver, Artificial Magnetic Resonance Spectroscopy Combined Modality Therapy Drug Discovery Drug Evaluation Models, Animal Blotting, Western Tandem Mass Spectrometry Drug Monitoring Survival Analysis Toxicity Tests, Subchronic Inhibitory Concentration 50 Disease-Free Survival Liver Function Tests Injections, Intravenous Radiotherapy Dosage Disease Models, Animal Survival Rate Medicine, Kampo Animal Testing Alternatives Models, Molecular Individualized Medicine

Phenomena and Processes59

Metabolic Detoxication, Drug Pharmacokinetics Biotransformation Lipid Metabolism Energy Metabolism Metabolic Detoxication, Phase I Metabolic Detoxication, Phase II Dose-Response Relationship, Drug Drug Interactions Hydroxylation Half-Life Metabolic Clearance Rate Time Factors Lethal Dose 50 Oxidation-Reduction Kinetics Metabolism Enzyme Induction Dealkylation Cell Survival Tissue Distribution Quantitative Structure-Activity Relationship Area Under Curve Species Specificity Polymorphism, Genetic Gene Expression Regulation, Enzymologic Body Weight Biological Transport Organ Size Molecular Structure Substrate Specificity Biological Availability No-Observed-Adverse-Effect Level Genotype Gene Expression Regulation Maximum Tolerated Dose Mutation Stereoisomerism Phenotype Gene Expression Metabolic Networks and Pathways Glycolysis Food-Drug Interactions Signal Transduction Intestinal Absorption Oxidative Stress Oxygen Consumption Amino Acid Sequence Herb-Drug Interactions Protein Binding Base Sequence Inhibitory Concentration 50 Polymorphism, Single Nucleotide Drug Resistance, Neoplasm Alleles Drug Resistance Apoptosis Sex Characteristics Transcription, Genetic

Disciplines and Occupations5

Pharmacogenetics Drug Design Toxicology Drug Discovery Individualized Medicine

Anthropology, Education, Sociology and Social Phenomena3

Safety-Based Drug Withdrawals United States Environmental Protection Agency Medicine, Kampo

Information Science5

Serial Publications Molecular Sequence Data Amino Acid Sequence Base Sequence Survival Rate

Health Care9

Treatment Outcome Safety-Based Drug Withdrawals Area Under Curve United States Environmental Protection Agency Societies, Pharmaceutical Radiation Injuries Survival Analysis Disease-Free Survival Survival Rate

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Anthropology, Education, Sociology and Social Phenomena Information Science Health Care

Pharmaceutical Preparations Cytochrome P-450 Enzyme System Hexobarbital Toxicity Tests Metabolic Detoxication, Drug Antipyrine Cytochrome P-450 CYP3A Liver Pharmacokinetics Microsomes, Liver Aryl Hydrocarbon Hydroxylases Biotransformation Toxicity Tests, Acute Lipid Metabolism Xenobiotics Energy Metabolism Metabolic Detoxication, Phase I Hepatocytes Metabolic Detoxication, Phase II Dose-Response Relationship, Drug Cytochrome P-450 CYP2D6 Drug Interactions Pharmacogenetics Umbelliferones Hydroxylation Glucuronosyltransferase Mixed Function Oxygenases Oxidoreductases, N-Demethylating Drug-Related Side Effects and Adverse Reactions Receptors, Steroid Half-Life Aminopyrine Phenobarbital Antineoplastic Agents Metabolic Clearance Rate Coumarins Cytochrome P-450 CYP1A2 7-Alkoxycoumarin O-Dealkylase Time Factors Aminopyrine N-Demethylase Ketoconazole Lethal Dose 50 Steroid 16-alpha-Hydroxylase Chromatography, High Pressure Liquid Drug Evaluation, Preclinical Acetaminophen Administration, Oral Cytochrome P-450 CYP2E1 Oxidation-Reduction Kinetics Dextromethorphan Antineoplastic Combined Chemotherapy Protocols NADPH-Ferrihemoprotein Reductase Rats, Sprague-Dawley Drug-Induced Liver Injury Metabolism Enzyme Induction Drug Administration Schedule Toxicity Tests, Chronic Dealkylation Ethylmorphine-N-Demethylase Cytochromes b5 Glucose Nitrazepam Neoplasms Aniline Hydroxylase Isoenzymes Methaqualone Cells, Cultured Midazolam Receptors, Cytoplasmic and Nuclear Cell Survival Carboxylesterase Models, Biological Treatment Outcome Steroid Hydroxylases Prodrugs Amobarbital Tissue Distribution Glutathione Tolbutamide Microsomes RNA, Messenger Debrisoquin Safety-Based Drug Withdrawals Quantitative Structure-Activity Relationship Area Under Curve Mass Spectrometry Mephenytoin Chromatography, Liquid Species Specificity Polymorphism, Genetic Enzyme Inhibitors Mice, Inbred C57BL Oxygenases Infusions, Intravenous Serial Publications Cytochrome P-450 CYP1A1 Gene Expression Regulation, Enzymologic Kidney

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