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  • assess drug-induced
  • To examine trends and assess drug-induced deaths during 2003--2007 in the United States, CDC analyzed data from the mortality component of the National Vital Statistics System. (cdc.gov)
  • Standardized protocols were used to assess drug-induced altered repolarization, and to identify important hiPSC-CM assay endpoints associated with high, intermediate, and low TdP risk using linear regression models. (selectscience.net)
  • Parkinson's
  • Drug induced Parkinson's? (medhelp.org)
  • Ok, I'm a little worried because I took a fairly large dose of various atypical neuroleptics for about 4 years, drugs which can induce Parkinson's due to their interaction with Dopamine. (medhelp.org)
  • Drugs used for the treatment of Parkinson's disease and endocrine diseases, like hyperprolactinemia, may also induce VHD. (bmj.com)
  • 1 Subsequently, drugs used for the treatment of Parkinson's disease and endocrine disease like hyperprolactinemia were also shown to induce VHD 2 More recently, the use of 3,4-methylendioxymetamphetamine (MDMA, 'Ecstasy') and benfluorex (as adjuvant therapy for dyslipidemia in diabetic patients) have also been found to be associated with DIVHD. (bmj.com)
  • Medications
  • Drug-induced liver injury is not a single, uncommon disease of the general population, but rather a series of rare diseases that occur only in persons who take specific medications," said Einar S. Björnsson, lead study author from the department of internal medicine, section of gastroenterology and hepatology, National University Hospital, Reykjavik, Iceland, and faculty of medicine at the University of Iceland. (redorbit.com)
  • Chen M, Borlak J, Tong W (2013) High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury. (springer.com)
  • These findings suggest a possible structural explanation for how so many commonly used medications block HERG but not other Kv channels and should facilitate the rational design of drugs devoid of HERG channel binding activity. (pnas.org)
  • Since there is no baseline nutritional analysis in clinical trials of new medications, interactions of medication and nutritional status go undiscovered until after the drug has already been released and is in use. (chiro.org)
  • Cutaneous
  • Suchak R, Benson K, Swale V. Statin-induced Ro/SSa-positive subacute cutaneous lupus erythematosus. (medscape.com)
  • Kong HH, Fine HA, Stern JB, Turner ML. Cutaneous pigmentation after photosensitivity induced by vandetanib therapy. (medscape.com)
  • Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. (hindawi.com)
  • Drug-induced cutaneous rashes, whether confined to the skin or part of a systemic disease, are characterised by a spectrum of inflammatory disease patterns that include perivascular dermatitis, nodular and diffuse dermatitis, vesiculobullous lesions, pustular eruptions, sclerodermoid reactions, vasculitis, folliculitis/perifolliculitis and panniculitis. (ovid.com)
  • Clues to the drug-induced nature of the cutaneous eruption include the presence of overlapping histological reaction patterns and incongruent clinical and histopathological features. (ovid.com)
  • penicillin
  • The most commonly implicated drugs were amoxicillin-clavulante (penicillin used to fight bacteria), azathioprine (an immunosuppressive drug used in organ transplantation and autoimmune diseases) and infliximab (also used to treat autoimmune disease). (redorbit.com)
  • 2001
  • This Information Paper is an update of information originally published in the article 'Drug-related Deaths' in the ABS publication Australian Social Trends, 2001 (cat. (abs.gov.au)
  • 1 It presents data for drug-induced deaths registered in the years 1991 to 2001 (the latest year for which deaths data are available). (abs.gov.au)
  • 2. Results from the 2001 National Drug Strategy Household Survey indicate that an estimated 2.6 million Australians, or 16.9 % of people aged 14 years and over, had used illicit drugs in the previous 12 months. (abs.gov.au)
  • 7. In 2001 there were 1,038 drug-induced deaths registered, constituting 0.8% of all deaths in that year (see summary table no. 3). (abs.gov.au)
  • clinical
  • Thus, despite the obvious clinical importance of HERG channel block to acquired LQT, the structural basis of the high-affinity drug binding site has not been adequately characterized. (pnas.org)
  • Incidence
  • Drug-induced disease is an alarming problem in every area of medical endeavor and indeed has had a major impact on the incidence, nature, and natural history of commonly encountered renal disease (Table 1). (springer.com)
  • The Fen-Phen anorexigen story has raised the question about the true incidence of fenfluramine-induced valvulopathy in the medical literature. (bmj.com)
  • hypersensitivity
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver. (uspharmacist.com)
  • occur
  • Detrimental effects of drugs on nutrition status are a common occurrence but, because they usually occur over time (vs. what is considered an adverse event or allergic reaction, which occurs quickly), they are seldom recognized or corrected. (chiro.org)
  • Pharmacology
  • The adverse effects of drugs like Celebrex and Vioxx based on their selective inhibition of COX-2 currently are a topic of intense discussion in the medical community," said Satpal Singh, Ph.D., associate professor of pharmacology and toxicology in the UB School of Medicine and Biomedical Sciences and senior author on the study. (medindia.net)
  • In the mainstream literature of pharmacology, drug-nutrient interactions are typically placed in three categories: drug-alcohol interactions, drug-food incompatibility, and drugs affecting nutritional status. (chiro.org)
  • Substances
  • 4. The term 'drug' refers to substances classified as drugs, medicaments or biological substances under ICD-10 guidelines. (abs.gov.au)
  • Osteoporosis
  • The present-day definitions of Osteoporosis and Osteopenia were arbitrarily conceived by the WHO in the early 90's and then projected upon millions of women's bodies seemingly in order to convince them they had a drug-treatable, though symptomless, disease. (greenmedinfo.com)
  • cannabis
  • 3 Cannabis was the most prevalent drug used (by 12.9% of total people in this age group), with the potentially more lethal illicit drugs being used by much smaller proportions of people. (abs.gov.au)
  • reaction
  • Do not take the drug that caused the reaction again in the future. (healthline.com)
  • Let your doctors and other healthcare professionals know that this drug caused the reaction so they can help you find alternative treatment. (healthline.com)
  • While a single drug can elicit a range of reaction patterns, no reaction pattern is specific for a particular drug. (ovid.com)
  • While eosinophils are an important tell-tale sign of a drug-induced reaction, they may also be conspicuous in skin rashes devoid of a drug association. (ovid.com)
  • In patients with ongoing hemolysis who have received multiple transfusions, the drug-induced component of hemolysis may be less of a contributing factor and a full transfusion reaction work-up should be considered. (oncologynurseadvisor.com)
  • heroin
  • This paper also uses the term drug-induced deaths involving opioids to describe drug-induced deaths where opium (ICD-10 code T40.0), heroin (T40.1) other opiates, (such as morphine or codeine, T40.2), methadone (T40.3), other synthetic narcotics (such as pethidine, T40.4) or other and unspecified narcotics (T40.6) were mentioned on official records. (abs.gov.au)
  • 8. The decrease in drug-induced deaths was primarily related to a fall in deaths due to heroin use, particularly amongst men. (abs.gov.au)
  • mechanisms
  • Thiol drugs are postulated to induce acantholysis through biochemical mechanisms without antibody formation. (medscape.com)
  • Additionally, as a validation site, ACEA executed studies confirming the electrophysiological effects, as well as sensitivity, specificity and reproducibility of hiPSC-derived cardiomyocytes in response to 28 well-characterized drugs through the observation of concentration-dependent effects on repolarization and of arrhythmia-related events consistent with known ionic mechanisms of single and multi-channel blocking drugs. (selectscience.net)
  • cases
  • Günes AT, Fetil E, Ilknur T, Birgin B, Ozkan S. Naproxen-induced lichen planus: report of 55 cases. (medscape.com)
  • Studies of cases of non-thiol-induced pemphigus reveal the presence of autoantibodies that recognize pemphigus antigens, in particular desmoglein 3, which is the pemphigus vulgaris antigen. (medscape.com)
  • Although some of these drugs were withdrawn from the market, several cases of patients requiring valve surgery even years after the cessation of therapy have been reported. (bmj.com)
  • In rare cases, a drug such as propranolol may be added to help control the tremor. (medlineplus.gov)
  • If the offending drug is stopped, most cases resolve and patients will do well as long as supportive measures can be initiated. (oncologynurseadvisor.com)
  • vitro
  • an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development. (medscape.com)
  • The Food and Drug Administration (FDA) established the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative through a public/private partnership, whose charter is to examine the possible modification to existing regulatory guidelines. (selectscience.net)
  • Severe
  • DIVHD is not infrequent, may be severe, and has been described in association with several drugs. (bmj.com)
  • Liver failure and damage are rare but severe unintended consequences of statin drug use. (greenmedinfo.com)
  • occurrence
  • A combination of methodological issues and observer bias led to an overestimation of the occurrence of fenfluramine-induced VHD in some of the reported studies. (bmj.com)
  • disease
  • Drug-induced cardiovascular disease. (bmj.com)
  • Breckenridge A M . Drug-induced cardiovascular disease. (bmj.com)
  • Several variants of the disease exist, including pemphigus vulgaris, pemphigus foliaceous, and drug-induced pemphigus. (medscape.com)
  • [ 4 ] An active amide group is found in the structure of many nonthiol drugs, which has resulted in the speculation that this structure may be responsible for the induction of disease. (medscape.com)
  • Drug-induced valvular heart disease (DIVHD) was first described in the 1960s. (bmj.com)
  • Likewise, if nutrient status of a person is compromised or marginal, but not deficient before drug therapy is initiated, it may not produce obvious symptoms until after the disease the drug is used to treat has run its course or the patient is on a maintenance dosage. (chiro.org)
  • Functional deficiencies may not be observed as symptoms, conditions or disease progression for a period of months or years after initiation of drug therapies. (chiro.org)
  • interactions
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • Discusses probable medication-induced ocular side effects and the possible interactions of drugs prescribed by the ophthalmologist with those the patient is already taking. (worldcat.org)
  • Because of this, doctors of chiropractic are in a unique position to recognize the interactions of medication and nutritional status and, if knowledgeable in the area of drug induced nutrient depletion, they have an opportunity to help their patients recover nutritional adequacy and restore metabolic homeostasis. (chiro.org)
  • overdoses
  • Included are deaths from accidental overdoses due to misuse of drugs, intentional self-harm, assault and deaths undetermined as to intent. (abs.gov.au)
  • Furthermore
  • Furthermore, eosinophils may be sparse or absent in some drug exanthems. (ovid.com)
  • Furthermore, since known existing drug induced nutrient depletions are not taught in medical school curriculums, only a limited number of nutrition related side effects of drugs are ever likely to be observed by a medical practitioner. (chiro.org)
  • increases
  • Drug-induced mortality rate increases were greatest for non-Hispanic whites, whereas rates for Hispanics did not increase with time. (cdc.gov)
  • Adverse
  • Adverse effects from drugs taken as directed and infections resulting from drug use are not included. (cdc.gov)
  • The adverse effect arising from this unexpected mechanism definitely needs to be studied more closely, because the potassium channels inhibited by the drug are present in heart, brain and many other tissues in the human body. (medindia.net)
  • statin
  • I first started educating medical professionals about the ability of statin drugs to deplete CoQ10 back in 1995. (chiro.org)
  • deaths
  • The majority of deaths are unintentional drug poisoning deaths, with suicidal drug poisoning and drug poisoning of undetermined intent comprising the majority of the remainder ( 2 ). (cdc.gov)
  • In 2007, drug-induced deaths were more common than alcohol-induced or firearm-related deaths in the United States ( 1 ). (cdc.gov)
  • During 2007 (the year in which the latest national NVSS mortality data are available), a total of 38,371 drug-induced deaths occurred in the United States ( Table ). (cdc.gov)
  • 1. Premature deaths due to drug use continue to be of major concern in Australia, despite recent reductions in the number of these deaths. (abs.gov.au)
  • 6. In addition, although not part of the ICD-10 itself, this paper classifies drug-induced deaths according to their intent. (abs.gov.au)
  • Accidental drug-induced deaths include ICD-10 codes X40-X44, F11-F16, F19 and F55. (abs.gov.au)
  • See Explanatory Notes for further details on definitions of drug-induced deaths. (abs.gov.au)
  • This represented a fall of more than one-third from 1999, when drug-induced deaths registered in Australia peaked at 1,739 (1.4% of all registered deaths). (abs.gov.au)
  • reduction
  • L-arginine prevents glucocorticoid-induced reduction of bone growth and bone turnover abnormalities in a growing rat model. (greenmedinfo.com)
  • Although drug-induced LQT theoretically could result from reduction of any voltage-gated K + current that contributes to ventricular repolarization, all known drugs with this side effect preferentially block I Kr ( 1 , 8 , 9 ). (pnas.org)
  • potentially
  • As for today, four main drug classes have been reported to be associated with potentially deteriorated tendon properties: 1. (springer.com)
  • With this information, physicians can better monitor and manage patients who are prescribed potentially liver-injuring drugs. (redorbit.com)