Drug hypersensitivity idiosyncratic drug. Medical search. Frequent questions

NSAID (or nonsteroidal anti-inflammatory drug) hypersensitivity reactions encompass a broad range of allergic or allergic-like symptoms that occur within minutes to hours after ingesting aspirin or other NSAID nonsteroidal anti-inflammatory drugs. (wikipedia.org)
Hypersensitivity drug reactions differ from drug toxicity reactions in that drug toxicity reactions result from the pharmacological action of a drug, are dose-related, and can occur in any treated individual. (wikipedia.org)
Hypersensitivity reactions are idiosyncratic reactions to a drug. (wikipedia.org)
SNIDR are most commonly skin reactions that may be relatively mild moderately severe such as maculopapular rash, fixed drug eruptions, photosensitivity reactions, delayed urticaria, and contact dermatitis or extremely severe such as the DRESS syndrome, acute generalized exanthematous pustulosis, the Stevens-Johnson syndrome, and toxic epidermal necrolysis (also termed Lyell's syndrome). (wikipedia.org)
Idiosyncratic drug reactions occur rarely and unpredictably amongst drug users. (helsinki.fi)
Inflammation and liver damage can sensitize to idiosyncratic drug reactions. (helsinki.fi)
The overreported prevalence of penicillin allergy is secondary to imprecise use of the term "allergy" by families and clinicians and lack of clarity to differentiate between immunoglobulin E (IgE)-mediated hypersensitivity reactions, drug intolerances, and other idiosyncratic reactions that can occur days after exposure. (cdc.gov)
This structural similarity has led to considerable confusion regarding cross-reactivity of these drugs and the risks for allergic reactions from cephalosporins among penicillin-allergic patients. (cdc.gov)
Isosorbide Mononitrate Extended-Release Tablets are contraindicated in patients who have shown hypersensitivity or idiosyncratic reactions to other nitrates or nitrites. (prescriptiondrugs.com)
Clinical diagnosis of adverse drug reactions and patient management are complex, interwoven processes. (springer.com)
Clinical information and experiences about individual patients will aid prevention of adverse drug reactions. (springer.com)
Adverse effects and adverse drug reactions constitute major morbidity and sometimes mortality, but how to make a diagnosis and manage adverse drug effects in an individual to avoid or reduce serious harm does not receive much attention. (springer.com)
In some more unusual instances, adverse drug reactions may be more commonly related to drug or chemical exposure than to alternative possible causes (such as agranulocytosis or Stevens-Johnson syndrome), making the diagnostic challenge somewhat easier. (springer.com)
Drug hypersensitivity reactions represent a significant clinical problem and an impediment to drug development. (liverpool.ac.uk)
In this study, we focused on two drugs: piperacillin and telaprevir as examples of idiosyncratic hypersensitivity reactions. (liverpool.ac.uk)
9 Only three drugs - paracetamol, erythromycin and carbamazepine - have been associated with overdose pancreatitis in children, while most of the reactions appear to be idiosyncratic and therefore unpredictable, non-dose-dependent and with low incidence. (pharmaco-vigilance.eu)
Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions. (cdc.gov)
A Comprehensive Review of HLA and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine. (cdc.gov)
Genotyping HLA alleles to predict the development of Severe cutaneous adverse drug reactions (SCARs): state-of-the-art. (cdc.gov)
Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions. (cdc.gov)
Genetic Variants Associated with T-Cell Mediated Cutaneous Adverse Drug Reactions: A Prisma-Compliant Systematic Review - an EAACI Position Paper. (cdc.gov)
Pharmacogenomic Advances in the Prediction and Prevention of Cutaneous Idiosyncratic Drug Reactions. (cdc.gov)
Idiosyncratic reactions include excitement, severe muscular weakness, and syncope without marked hypotension. (medicalbrandnames.com)

NERD does not appear to be due to a true allergic reaction to NSAIDs but rather at least in part to the more direct effects of these drugs to promote the production and/or release of certain mediators of allergy. (wikipedia.org)
SNIDR result from the drug-specific stimulation of CD4+ T lymphocytes and CD8+ cytotoxic T cells to elicit a delayed type hypersensitivity reaction. (wikipedia.org)
Idiosyncratic drug reaction denotes a non-immunological hypersensitivity to a substance unrelated to drug toxicity. (helsinki.fi)
Provision of adverse drug reaction information must be timely, and relevant to support busy health professionals in their consultations. (springer.com)
An 'adverse drug reaction' (ADR) is the clinical response of a patient to a drug, defined here as "An appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the drug regimen, or withdrawal of the product" [ 1 ]. (springer.com)
The National Pharmaceutical Regulatory Agency (NPRA) has received information from the European Medicines Agency (EMA) regarding the risk of amnesia and the risk of drug reaction with eosinophilia and systemic symptoms (DRESS), both of which have been associated with mirtazapine use. (npra.gov.my)
DRESS is a rare, severe idiosyncratic, potentially fatal hypersensitivity reaction to a drug. (npra.gov.my)
An idiosyncratic drug reaction, known as the dapsone hypersensitivity syndrome (DHS), appears in about 0.5-3.6% of persons treated with dapsone. (bvsalud.org)
A drug-induced reaction should be considered in any patient who is taking medications and who suddenly develops a symmetric cutaneous eruption. (medscape.com)
6. Changes in the individual pharmacokinetic parameters of adsorption, distribution, or elimination may result in high concentrations of the drug in the body, leading to which type of adverse drug reaction? (testbankltd.com)
This is a Type __ allergic drug reaction. (testbankltd.com)
He is at risk for what type of adverse drug reaction? (testbankltd.com)
Mitomycin should not be used in patients who have an idiosyncratic reaction or demonstrated hypersensitivity. (ikrispharmanetwork.com)

The mechanisms of damage can be different: immune-mediated or hypersensitivity, direct drug, inflammatory or mitochondrial toxicity. (pharmaco-vigilance.eu)

The magnitude of increased weight loss of drug-treated patients over placebo-treated patients is only a fraction of a pound a week. (nih.gov)
Yet, felbamate may still be an important drug in the armamentarium for refractory patients, because it may control seizures when other drugs fail, and tends to be alerting rather than sedating. (pocketdrugguide.com)
A recent very large, randomized open-label study indicated that lamotrigine might be the drug of choice in patients with partial epilepsy, as it was equally effective but better tolerated, but in a companion study it was substantially less effective than valproate in patients with generalized or unclassified epilepsy. (pocketdrugguide.com)
Risk is increased for children under 16, and is also more common with concomitant valproate use, and in patients who have experienced rash on other anti-epileptic drugs. (pocketdrugguide.com)
Risks are increased in patients with personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (eg. (drugcentral.org)
4,5 Among the latter, drugs are very important, contributing in more than a quarter of cases and being associated with other risk factors in at least a third of patients. (pharmaco-vigilance.eu)
Caution should be used if [NT005 trade name] is given to patients with liver disease, since albendazole is metabolised by the liver and has been associated with idiosyncratic hepatotoxicity. (who.int)
Conclusion: In patients using antiepileptic drugs, complete blood count may be affected. (jsurgmed.com)

He knows everything about medications - to which pharmacological group the drug belongs, what components are included in its composition, how it differs from its analogs, what indications, contraindications, and side effects remedy has. (medicalbrandnames.com)

Genetic testing for prevention of severe drug-induced skin rash. (cdc.gov)
Diagnostic utility of HLA-B*5801 screening in severe allopurinol hypersensitivity syndrome: an updated systematic review and meta-analysis. (cdc.gov)
Indapamide has severe interactions with at least 48 other drugs. (rxlist.com)

Other serious idiosyncratic adverse events include rash and Stevens-Johnson syndrome. (pocketdrugguide.com)
Trichloroethylene (TCE) hypersensitivity syndrome (THS) is a dose-independent and potentially life-threatening disease. (biomedcentral.com)
Occupational TCE poisoning incidents are commonly reported, of which trichloroethylene hypersensitivity syndrome (THS) is in the majority in China. (biomedcentral.com)
Real-time clinical note monitoring to detect conditions for rapid follow-up: A case study of clinical trial enrollment in drug-induced torsades de pointes and Stevens-Johnson syndrome. (cdc.gov)

These syndromes have recently been classified by the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity. (wikipedia.org)
It is important to understand the mechanisms of action and the pharmacokinetics of antiepileptic drugs (AEDs) so that these agents can be used effectively in clinical practice, especially in multidrug regimens (see the image below). (medscape.com)
Adult obese subjects instructed in dietary management and treated with anorectic drugs, lose more weight on the average than those treated with placebo and diet, as determined in relatively short term clinical trials. (nih.gov)
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
Greater clinical importance than potencyIf undesired effects of a drug limit its dose, its efficacy will be correspondingly limited. (freezingblue.com)
Subjects have been confined to the clinical facility from at the least 10 hours earlier than each drug administration until not less than 24 hours postdose, for a complete of at least 34 hours for every examine period. (getcleanedgetorganized.com)
I. Drugs in preclinical and early clinical development. (jsurgmed.com)
for older drugs, this information can only be found in case reports, while for newer medications the results of clinical trials as well as case reports are available. (abdominalkey.com)

Addiction can occur at recommended dosages and if the drug is misused or abused. (drugcentral.org)
This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. (rxlist.com)

It is not considered to be a first-line drug because of its potential for serious idiosyncratic side-effects, including potentially fatal aplastic anaemia (incidence of 1 in 3000) and hepatic failure (incidence of 1 in 10000). (pocketdrugguide.com)

Although the term NSAID was introduced to signal a comparatively low risk of adverse effects, NSAIDs do evoke a broad range of hypersensitivity syndromes. (wikipedia.org)
Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice? (wikipedia.org)

Legal and illegal drugs are common causes of abnormal LFTs. (abdominalkey.com)
Drugs used in mental health that are commonly associated with abnormal liver function include antidepressants and atypical/typical antipsychotics. (abdominalkey.com)

The most common drug‐induced liver injury (DILI) is idiosyncratic, dose independent, and not predictable. (abdominalkey.com)

Often the drug is implicated as concause in the presence of other risk factors, typically genetic (this is the case with thiopurins) or for other underlying diseases (this is the case with Crohn's disease). (pharmaco-vigilance.eu)

Lamivudine is a very rare cause of clinically apparent drug induced liver injury, but is associated with flares of underlying hepatitis B during therapy or with abrupt withdrawal. (nih.gov)

Moreover, penicillin allergy labels lead to the use of more expensive and less effective drugs and can result in adverse consequences, including longer length of hospital stay and increased risk for infection. (cdc.gov)

The absorption half-life of the drug from the immediate release 35 mg phendimetrazine tablets is appreciably more rapid than the absorption rate of the drug from the extended-release formulation. (nih.gov)
The optimistic management article used in the study, that's, the reference listed drug, was Viagra (sildenafil citrate) a hundred mg tablets and was purchased from a industrial provider. (getcleanedgetorganized.com)

Lamotrigine is a broad-spectrum anti-epileptic drug that has been widely accepted as a first-line drug for both partial and generalized epilepsy syndromes. (pocketdrugguide.com)

This is because susceptibility is a function of the chemistry of the drug, the genetic background of the patient and environmental factors such as patient demographics, disease and concomitant medications. (liverpool.ac.uk)

The major route of elimination is via the kidneys where most of the drug and metabolites are excreted. (nih.gov)

Antiepileptic drugs should be used carefully, with consideration of medication interactions and potential side effects. (medscape.com)
Together, our results define in immunological, chemical and quantitative terms the drug immune receptor interactions that can drive a T-cell response. (liverpool.ac.uk)
Test Bank For Pharmacotherapeutics For Advanced Practice 3rd Edition By Virginia Poole Arcangelo, Andrew M. Peterson also includes coverage of key topics such as drug interactions, adverse effects, and prescribing for special populations. (testbankltd.com)
Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. (medilib.ir)
Consult drug interactions database for more information. (medilib.ir)
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. (rxlist.com)
Indapamide has serious interactions with at least 42 other drugs. (rxlist.com)
Indapamide has moderate interactions with at least 165 other drugs. (rxlist.com)
Visit the RxList Drug Interaction Checker for any drugs interactions. (rxlist.com)

Studies do not permit conclusions as to the relative importance of the drug and non-drug factors on weight loss. (nih.gov)
The extrinsic factors include ultraviolet radiation and drugs ( 5 ). (spandidos-publications.com)

Therapeutic error, unexpected failure of effect (perhaps related to a substandard/counterfeit product), drug abuse, accidental or suicidal self-administration, and homicidal use of drugs are all also adverse drug effects, which the wise clinician needs to bear in mind. (springer.com)
furthermore, it is very difficult to predict which individuals will develop hypersensitivity when exposed to a therapeutic treatment regimen. (liverpool.ac.uk)

This paper describes the personal views of the author about diagnosis and management of an adverse drug effect. (springer.com)
It proposes that diagnosis is complicated and is also supported by carefully observed management of changes in drug therapy. (springer.com)
Drug-related adverse effects may be due to the drug itself, though many are due to systematic errors occurring in the process from diagnosis of the primary treated condition, through prescribing and dispensing, to the way the drug is used by the patient. (springer.com)
It is much more difficult to decide on the diagnosis in an individual when other causal probabilities are more likely than a drug, and when actual evidence that exposure to a particular drug has occurred, in what dose and when, may be difficult to ascertain. (springer.com)
3,4 An early diagnosis of DRESS and immediate discontinuation of the suspected drug are crucial for its treatment. (npra.gov.my)
A "response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. (freezingblue.com)

The rate of weight loss is greatest in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks. (nih.gov)
The majority of the drugs commonly used in cancer therapy have been involved in the radiation recall phenomenon. (scienceopen.com)
or (4) any type of nitrate drug therapy, alpha blockers, other PDE5 inhibitors, or endothelin receptor antagonist inside 30 days before first drug administration. (getcleanedgetorganized.com)

Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. (nih.gov)

In 1940, phenytoin (PHT) was found to be an effective drug for the treatment of epilepsy, and since then it has become a major first-line antiepileptic drug (AED) in the treatment of partial and secondarily generalized seizures. (medscape.com)
Pearls of antiepileptic drug use and management. (medscape.com)
Guerrini R, Zaccara G, la Marca G, Rosati A. Safety and tolerability of antiepileptic drug treatment in children with epilepsy. (jsurgmed.com)

Drug eruptions can mimic a wide range of dermatoses. (medscape.com)

Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. (nih.gov)

To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefadroxil capsules and other antibacterial drugs, cefadroxil capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)

Drug molecule (external source): Acute regulation of physiological & biochemical functions. (freezingblue.com)

If the patient is receiving valproate at the time of initiation, starting doses and doses during titration should be cut in half, whereas if they are receiving enzyme-inducing anti-epileptic drugs such as phenytoin, carbamazepine or phenobarbital, doses can be doubled. (pocketdrugguide.com)
Drugs are more meaningful compared in terms of relative potency (ratio of equi-effective doses). (freezingblue.com)
Harm directly caused by the drug at normal doses, during normal use. (freezingblue.com)

Drug is usually described b it's more prominent effects: targets specific receptors, rarely sufficiently selective to be described as specific. (freezingblue.com)

Felbamate has a complex metabolism and elimination, by both the hepatic and renal routes, and inhibits the metabolism of some drugs while inducing others. (pocketdrugguide.com)
Verrotti A, Coppola G, Parisi P. Bone and calcium metabolism and antiepileptic drugs. (jsurgmed.com)

The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)
Expenses related to medical errors include increased length of hospital stay, prescription drug costs, outpatient care, lost work, and lost productivity. (nursingce.com)

The possible origin of the increased weight loss due to the various drug effects is not established. (nih.gov)
because the effects of isosorbide mononitrate are difficult to terminate rapidly, this drug is not recommended in these settings. (prescriptiondrugs.com)
There is a strengthening view that we have neglected this area of adverse effects related in some way to drug use. (springer.com)
However, side-effects are also enhanced when the drugs are combined. (pocketdrugguide.com)
Advocates of responsible drug use point to the many well-known artists and intellectuals who have used drugs, experimentally or otherwise, with few detrimental effects on their lives. (psychonautwiki.org)
Seizure type, effectiveness and side effects are important in drug selection. (jsurgmed.com)
It is not known exactly how and how often the hematological side effects of antiepileptic drugs take place. (jsurgmed.com)

major depression).Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. (drugcentral.org)

Cross tolerance within classes of drugs. (freezingblue.com)

Over 90% of the drug is excreted unchanged in the urine within 24 hours. (nih.gov)

Aim: The incidence of pediatric epilepsy ranges between 1-3%, and various anticonvulsant drugs are used in its treatment. (jsurgmed.com)

Diseases12

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Reactions23

Reaction13

Toxicity1

Patients8

Contraindications1

Severe3

Syndrome4

Clinical8

Occur2

Potentially fatal1

NSAIDs2

Abnormal2

DILI1

Diseases1

Liver injury1

Allergy1

Tablets2

Syndromes1

Concomitant1

Metabolites1

Interactions10

Factors2

Therapeutic2

Diagnosis6

Therapy3

Pharmacological1

Antiepileptic drug3

Eruptions1

Tachyphylaxis1

Antibacterial drugs1

Acute1

Doses3

Rarely1

Metabolism2

Include2

Effects7

Abusers1

Tolerance1

Unchanged in the urine1

Epilepsy1