Drug hydrogel. Medical search. Frequent questions

The hydrogel platform is made of branched polymer chains that are covalently crosslinked, and can be engineered to increase or decrease the crosslink density, which alters their degradation rate. (ophthalmologytimes.com)

Dubbed as "smart hydrogels" or "stimuli-responsive hydrogels", these gels are able to dynamically respond to external or internal stimuli in addition to possessing similar swelling-deswelling properties of traditional hydrogels. (wikipedia.org)
Various examples of external stimuli that have been used to control smart hydrogels in drug delivery systems include temperature, pH, light, ultrasound, and enzymes. (wikipedia.org)
Additional considerations in designing smart hydrogels involve fundamental understanding of bond strength, molecular weight, degree of polymerization, polymer structure, and molecular assembly. (wikipedia.org)
Similar to conventional hydrogels, the polymeric chain (or backbone) of the smart hydrogels is derived from polysaccharides, polypeptides, and polynucleotides. (wikipedia.org)
This development led to the development of "smart hydrogels" that are polymeric matrices with a broad spectrum of tailorable attributes [7]. (biomedres.us)

The team, led by Brown School of Engineering bioengineer Antonios Mikos and graduate student Jason Guo, has developed modular, injectable hydrogels enhanced by bioactive molecules anchored to the chemical crosslinkers that give the gels structure. (materialstoday.com)
Injectable hydrogels are a class of hydrogels that can be administered through a syringe and needle, forming a gel in situ upon injection. (thewitfire.in)
Researchers from the University of Hong Kong (HKU), the HKU-Shenzhen Hospital and the Princeton University, collaborated to achieve a breakthrough in the development of injectable hydrogels, a highly effective method of administering medicine. (hku.hk)
Injectable hydrogels have a number of applications - from cancer therapy where they can deliver drugs directly to the tumours, to treating diabetes, regenerating human tissues, and chronic pain management. (hku.hk)

Integrating such multifunctional tough hydrogels with advanced manufacturing techniques has provided opportunities in the fabrication of medical devices that never existed before, including implantable devices, engineered tissue, medical wearables, soft electrodes and bioelectronics, artificial organs, soft actuators, rapid diagnostics, and platforms for drug discovery and disease studies. (mdpi.com)
The Special Issue of "Advances in Multifunctional Tough Hydrogels for Medical Devices" emphasizes new synthetic hydrogels and their associated advanced fabrication techniques for engineering medical devices. (mdpi.com)
Recent developments in tough hydrogels for biomedical applications. (nature.com)
On the Race for More Stretchable and Tough Hydrogels. (nih.gov)

Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. (nature.com)
Unique molecular interactions between graphene derivatives and various small or macromolecules enable the fabrication of various functional hydrogels appropriate for different biomedical applications. (nature.com)
In this mini-review, we highlight the recent progress in GO-incorporated hydrogels for biomedical applications while focusing on their specific uses as mechanically strong materials, electrically conductive scaffolds/electrodes, and high-performance drug delivery vehicles. (nature.com)
Hydrogels for biomedical applications. (nature.com)
Chai Q, Jiao Y, Yu X. Hydrogels for biomedical applications: their characteristics and the mechanisms behind them. (nature.com)
Biomedical applications of hydrogels: a review of patents and commercial products. (nature.com)
After that, the research on the topic of hydrogels and their biomedical applications started to rise [4]. (biomedres.us)
Hybrid gels have shown potential in various biomedical applications, including drug delivery, tissue engineering, and regenerative medicine. (thewitfire.in)
8,9 3D printing of nanocellulose hydrogels is being used in biomedical applications to support living cell growth for tissue engineering, implants, and cardiovascular devices. (cdc.gov)

Hydrogels are three dimensional structures consisting of hydrophilic polymers (i.e., polymers, colloids, etc.) that form networks through cross-linking processes. (wikipedia.org)
Synthesis of hydrogels are developed from a combination or isolated forms of natural and synthetic polymers. (wikipedia.org)
The main examples of natural polymers used to derive hydrogels include polysaccharides, polypeptides, and polynucleotides. (wikipedia.org)
Analogous to how zipper teeth link together, the short segments on the new polymers also interlock, thickening the water-based solution into re-moldable and compliant hydrogels. (medgadget.com)
Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic polymers. (biomedres.us)
A hydrogel can be described as a three dimensional network formed by hydrophilic polymers which can expand in water. (biomedres.us)
Hydrogels, which consist of networks of watery polymers, have come to offer a delivery vehicle with plenty of potential in this area, keeping the drugs stable and intact until they reach their destination. (newatlas.com)
The team's hydrogel is made from synthetic polymers and organic compounds and incorporates amino groups. (newatlas.com)
Hydrogels are three-dimensional, cross-linked networks of hydrophilic polymers that can absorb and retain large amounts of water or biological fluids. (thewitfire.in)
Synthetic hydrogels are made from synthetic polymers, such as polyacrylamide, poly(ethylene glycol), and poly(N-isopropylacrylamide). (thewitfire.in)
Hybrid hydrogels are composed of both natural and synthetic polymers. (thewitfire.in)
Here, we describe an analytical theory as well as a Monte Carlo simulation of concurrent drug release from and degradation of Tetra-PEG polymers. (huji.ac.il)
Hydrogel polymers present a versatile coating option for electrodes as they can be chemically modified to provide a soft and conductive scaffold. (frontiersin.org)

Ultrasound-triggered drug delivery using stimuli-responsive hydrogels refers to the process of using ultrasound energy for inducing drug release from hydrogels that are sensitive to acoustic stimuli. (wikipedia.org)
This method of approach is one of many stimuli-responsive drug delivery-based systems that has gained traction in recent years due to its demonstration of localization and specificity of disease treatment. (wikipedia.org)
Hydrogels are generally classified based on the following characteristics: material, crosslinking mechanism, physical structure, electric charge, and response to stimuli. (wikipedia.org)
This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. (nature.com)
Thus, chemists and pharmacologists persistently desire to prepare directed self-assemble hydrogels, referring to self-delivering, self-releasing, stable, injectable and stimuli-responsive hydrogels without any structural modification and delivery cargoes. (nature.com)
Other possibilities include designing the hydrogels to respond to certain stimuli in the tumor microenvironment, like swelling or shrinking when exposed to temperature or pH changes, and releasing their drugs that way. (newatlas.com)
According to the scientists, hydrogels developed to deliver anti-cancer drugs have so far responded to a singular stimuli, so they set out to develop a more versatile solution. (newatlas.com)
Hydrogels have been widely studied for drug delivery applications due to their unique characteristics, such as high water content, tunable mechanical properties, and stimuli-responsive behavior. (thewitfire.in)
Scientists previously had not considered that hydrogels could do more than simply shrink and expand in phase with specific stimuli. (nanowerk.com)
The experiment involved sending sequential stimuli (in the form of copper or acid) to a widely used hydrogel. (nanowerk.com)
However, sending the copper or acid stimuli sequentially caused the hydrogel to respond with a cascading series of energy conversion reactions in the form of brief bursts of competing localized chemical and mechanical energy flows. (nanowerk.com)
Stimulus-responsive hydrogels , which can undergo significant physicochemical changes in response to various physical or chemical stimuli, have drawn wide attention in many fields. (bvsalud.org)
Enhancement of oral insulin bioavailability: in vitro and in vivo assessment of nanoporous stimuli-responsive hydrogel microparticles. (bvsalud.org)

In this study, the hydrophobic drug Tanshinone ⅡA (Tan ⅡA) as a therapeutic drug was loaded into naphthalene acetic acid-phenylalanine-phenylalanine-glycine hydrogel (Nap-FFG) to construct the supramolecular hydrogels. (jascoinc.com)

Methods of synthesis of hydrogels … a review. (nature.com)
The present review discusses the history, description of hydrogels, basic properties, classification, different techniques or methods of hydrogel synthesis and the areas in which hydrogels find applications. (biomedres.us)

However, the in vivo chronic inflammatory response of these conductive hydrogels remains unknown. (frontiersin.org)

Scientific understanding of the molecular weight of gels is taken into account when loading drugs of increasing weight. (wikipedia.org)
A lack of knowledge about natural drug gels limits there current application. (nature.com)
Several architectural topologies, such as double-network hydrogels, hybrid-ionic gels, nanocomposite gels, and dynamic crosslinked gels, have been introduced over the last two decades to surpass the poor mechanical properties of conventional hydrogels. (mdpi.com)
These gels have gained considerable attention for localized drug delivery due to their minimal invasiveness, ease of administration, and ability to conform to irregularly shaped spaces within the body. (thewitfire.in)
The gels contain two self-cleaving β-eliminative linkers: one that covalently tethers the drug to the gel and releases it at a predictable rate, and another with slower cleavage that is installed in each cross-link of the polymer to control gel degradation. (huji.ac.il)

A surprise is coming from researchers at IBM and Institute of Bioengineering and Nanotechnology in Singapore who have developed a novel hydrogel capable of penetrating biofilms and delivering antimicrobials right to the buggers. (medgadget.com)
The handiwork of scientists at the Tokyo University of Science, the novel hydrogel was developed in response to the susceptibility of many cancer drugs to quickly and easily break down in the human body after administration. (newatlas.com)

Montheil T, Echalier C, Martinez J, Subra G, Mehdi A. Inorganic polymerization: an attractive route to biocompatible hybrid hydrogels. (nature.com)
Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate. (nature.com)
There are three main types of hydrogels based on their origin and composition: natural, synthetic, and hybrid hydrogels. (thewitfire.in)

Researchers have developed a polymer hydrogel that looks and feels like a squishy jelly, but acts like an ultra-hard, shatterproof glass when compressed. (materialstoday.com)

Aim: Due to the various drawbacks associated with current treatment therapy of onychomycosis, the main aim was to develop thermosensitive hydrogels and thermosensitive polypseudorotaxanes hydrogels-based nail lacquer for transungual delivery of Efinaconazole for the management of onychomycosis. (eurekaselect.com)
The composite hydrogel showed a thermosensitive swelling behavior reaching 183% of swelling ratio at 37 °C. The composite hydrogel showed the elastic component to be higher than the viscous component, indicating characteristics of a strong hydrogel. (udt.cl)

Song F, Li X, Wang Q, Liao L, Zhang C. Nanocomposite hydrogels and their applications in drug delivery and tissue engineering. (nature.com)
Preparation two hydrogel (SA-g-P(Ac-co-AM) hydrogel and the second hydrogel after loading CNT/ZnO onto hydrogel and these new hydrogel surfaces were prepared from two monomers (acryl acid, acrylamide) to remove Chloramphenicol CHZ drug .The physical characterizations of new super adsorbent hydrogel nanocomposite were performed using XRD, FTIR, TGA, EDX and TEM. (ac.ir)
The practical experiments involved calculation of the best wavelength and study of best condition of adsorption factors like: effect of equilibrium time, weight of hydrogel nanocomposite, temperature solution, pH solution and adsorbent regeneration experiments (desorption). (ac.ir)
The removal percentage of CHZ drug increase from 55.45 to 89.8%, and adsorption capacity decrease from 65.5 to 110 mg g -1 on to hydrogel nanocomposite. (ac.ir)

Nov. 29, 2023 Scientists have developed an injectable or catheter-administered hydrogel with enhanced capabilities for treating hepatocellular carcinoma, a deadly form of liver cancer. (sciencedaily.com)
RWCS 2023 Perioperative Antirheumatic Drug Guideline Contains Caveats Experts say the 2022 ACR/AAHKS guideline for patients undergoing total hip or total knee arthroplasty have a number of caveats that limit the usefulness of the recommendations. (medscape.com)

Hydrogels possess a comfortable degree of flexibility similar to natural tissue, due to their significant water content. (ophthalmologytimes.com)
Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both active pharmaceutical ingredients, such as antibiotics and non-steroidal anti-inflammatory drugs, and growth factors, such as morphogens, required after bone-tissue replacement surgeries. (us.es)
As native tissue populates the area, the hydrogel can degrade and eventually disappear. (materialstoday.com)
With our previous hydrogels, we typically needed to have a secondary system to deliver the biomolecules to effectively produce tissue repair,' Guo said. (materialstoday.com)
Hydrogels, owing to their high water load, show flexibility that is similar to natural tissue. (biomedres.us)
These novel dendrimer-based hydrogels are able to integrate the structural and functional advantages of both dendrimers and hydrogels, allowing for controlled release of drug and gene delivery, tissue regeneration, and wound dressing. (technologypublisher.com)
Owing to their unique properties, hydrogels have found applications in a wide range of fields, including tissue engineering, wound healing , drug delivery systems, and contact lenses. (thewitfire.in)
Natural hydrogels have been extensively used in drug delivery and tissue engineering applications due to their excellent biocompatibility and biodegradability. (thewitfire.in)
This is very important because the processes of healing and tissue regeneration consist of a sequence of different stages which require administration of specific growth factors and drugs. (hku.hk)
Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. (eurekaselect.com)
These microcarriers may offer an entirely different approach to treating solid human tumors of numerous pathologic subtypes by delivering their encapsulated drug cargo to a tumor and protecting against collateral tissue damage. (uab.edu)
A more recent approach proposes tissue engineering the electrode interface through the use of encapsulated neurons within hydrogel coatings. (frontiersin.org)

The high water content of hydrogels can help to solubilize hydrophilic drugs, while their tunable properties allow for the incorporation of various drugs with different physicochemical characteristics. (thewitfire.in)

A few examples of hydrogel use include organ regeneration, wound healing, and drug delivery. (wikipedia.org)
Since traditional hydrogels were able to encapsulate and carry materials, research into drug-loaded hydrogels began to expand in the field of drug delivery. (wikipedia.org)
Hydrogel size and type are the two main properties considered in designing hydrogels when seeking the optimal delivery route for drug administration. (wikipedia.org)
The final parameter considered in developing hydrogels for drug delivery systems revolve around the embedded payload within the hydrogel. (wikipedia.org)
Cells, proteins, and therapeutic drugs are the main payloads used in hydrogel-based drug delivery platforms. (wikipedia.org)
The company has created a way to encapsulate a wide range of pharmaceuticals within its hydrogel to provide targeted, sustained delivery of therapeutic levels of drugs to ocular tissues. (ophthalmologytimes.com)
Through containment, localization, and protection from inflammatory response, the hydrogel expands the utility of therapeutic molecules via more effective and consistent delivery. (ophthalmologytimes.com)
Conclusion: The polypseudorotaxanes based nail lacquer with the incorporation of penetration enhancer was able to achieve a high rate of drug penetration and retention, thus supporting the potential use of aqueous based-nail lacquer in transungual drug delivery for the onychomycosis treatment. (eurekaselect.com)
Here, we demonstrate an injectable filamentous hydrogel depot (FM-depot) engineered for low dosage, sustained delivery of anti-inflammatory nanocarriers. (frontiersin.org)
Get the latest news and trends happening now in drug delivery. (drugdeliverybusiness.com)
Graphene and graphene derivatives (e.g., graphene oxide (GO)) have been incorporated into hydrogels to improve the properties (e.g., mechanical strength) of conventional hydrogels and/or develop new functions (e.g., electrical conductivity and drug loading/delivery). (nature.com)
To circumvent the blood-brain barrier, a natural impediment for efficient drug delivery to the brain, researchers at the Cancer Epigenetics lab are developing, in collaboration with the Department of Materials Science and Engineering at the University of Delaware, a nano-hydrogel approach for direct drug delivery to brain tumors. (une.edu)
Hydrogels are novel drug deliverers that can aid in the delivery of several kinds of drug molecules either therapeutic or diagnostic nature. (biomedres.us)
Loading anti-cancer medicines into drug delivery vessels that can carry them to the site of the tumor before releasing them could offer new highly effective forms of treatment, and scientists in Japan have developed a promising new technology for these purposes. (newatlas.com)
Where the hydrogel from the Tokyo University of Science team breaks new ground is in the multi-faceted approach it takes to drug delivery. (newatlas.com)
This was demonstrated through lab experiments that replicated the acidity and temperatures of a tumor microenvironment, with the network structure of the hydrogel proving capable of preserving the drugs until it came time for delivery. (newatlas.com)
One of the release mechanisms of drug delivery systems based on hydrogel involves the degradation of the matrix that carries the drug. (rheolution-store.com)
Hydrogels have recently been investigated as promising drug delivery systems due to their ability to provide spatial and temporal control over the release of a number of therapeutic agents. (rheolution-store.com)
The dye in this study was used to simulate the therapeutic agent added in the matrix of the drug delivery system. (rheolution-store.com)
Because of the high structural adaptability of these hyrdogels, they can be used in the delivery of a variety of therapeutics including hydrophilic or hydrophobic drugs, proteins, genes and other materials. (technologypublisher.com)
Hydrogels: Pharmaceutical dosing and drug delivery systems have been evolving over the years to improve patient outcomes, enhance drug efficacy, and minimize side effects. (thewitfire.in)
Their applications in pharmaceutical dosing and drug delivery include oral, topical, transdermal, and injectable systems. (thewitfire.in)
Oral drug delivery is one of the most common and convenient routes of administration. (thewitfire.in)
Topical drug delivery involves the application of drug-loaded formulations directly onto the skin or mucosal surfaces. (thewitfire.in)
Transdermal drug delivery systems deliver drugs through the skin and into the systemic circulation. (thewitfire.in)
In a recent paper published in Advanced Healthcare Materials ( 'Crystalline Antibody-Laden Alginate Particles: A Platform for Enabling High Concentration Subcutaneous Delivery of Antibodies' ), these researchers describe a hydrogel platform for delivering monoclonal antibodies (MABs) - one type of biologic - through subcutaneous injection. (nanowerk.com)
Singhatanadgit to develop material composites for drug delivery in the treatment of jaw bone infection. (mahidol.ac.th)
Injectable hydrogel delivery is a highly effective method of administering medicine. (hku.hk)
A novel composite hydrogel was prepared as a dual drug delivery carrier. (udt.cl)
The biocompatibility was evaluated with in vitro cytotoxicity assays and the results indicated that this composite hydrogel could be considered as a potential biomaterial for dual drug delivery, mainly for wound healing applications. (udt.cl)
We have recently reported drug-releasing, degradable Tetra-PEG hydrogels as a new drug delivery system. (huji.ac.il)
The models described allow design of an optimal Tetra-PEG drug delivery vehicle for a particular use. (huji.ac.il)
Polymer based drug delivery platforms are an effective strategy for the delivery of PSs for PDT applications. (rsc.org)
This active drug-delivery system addresses the limitations seen for the anti-cancer drug BA-TPQ - poor solubility and low bioavailability. (uab.edu)
Multiresponsive hydrogels based on xylan-type hemicelluloses and photoisomerized azobenzene copolymer as drug delivery carrier. (bvsalud.org)

Natural hydrogels are derived from biological sources and are biodegradable, biocompatible, and often possess cell-adhesive properties. (thewitfire.in)
Here, Biodegradable composite hydrogels comprised of carboxymethyl chitosan (CMCS) and clindamycin (CDM)- loaded mesoporous silica nanoparticles (MCM-41), possessing dual antibacterial activity and osteogenic potency, were developed. (mahidol.ac.th)

The formulations were optimized by varying the concentration of poloxamer and water: ethanol ratio and evaluated based on the basis of drying time, sol-gel transition temperature, ex vivo drug release, and viscosity. (eurekaselect.com)
Particularly, hydrogel-based formulations present real potential to fulfill all requirements of an ideal PDT platform by overcoming the solubility issues, while improving the selectivity and targeting drawbacks of the PSs alone. (rsc.org)
6,7] Unlike older alcohol-based gel formulations, which could be drying to dermatitic skin, the hydrogel vehicle has been shown to increase epidermal moisturization. (jcadonline.com)

Until now, hydrogels for healing have been biologically inert, and required growth factors and other biocompatible molecules to be added to the mix. (materialstoday.com)
The researchers knew from toxicity literature that their hydrogel capsules would be biocompatible, and would behave in a syringe. (nanowerk.com)
What sets aside Fibro-Gel from the existing hydrogels is that it is solely aqueous-based, without using oils - which makes it more biocompatible, stable and cheaper to make. (hku.hk)

Synthetic hydrogels can be designed to release drugs in a controlled manner, making them ideal for pharmaceutical dosing applications. (thewitfire.in)
In synthetic hydrogels, by contrast, the cascade of reactions ends almost instantly. (nanowerk.com)

In this short application note, the ElastoSens™ Bio was used to non-destructively monitor the viscoelastic properties of a degrading composite hydrogel made of dye-loaded gelatin beads and alginate. (rheolution-store.com)
Its release was measured along the study and correlated to the composite hydrogel viscoelasticity. (rheolution-store.com)
The hydrogel is prepared conveniently with hydroxyethyl acrylate, cross-linker, gelatin and photoinitiator, and can be printed into certain 3D patterns with the direct ink write (DIW) 3D printer designed and developed by the research group.Design/methodology/approachIn this paper, the authors designed a composite sensitization initiation system that is suitable for hydrogels. (deepdyve.com)
With the DIW 3D printer, pre-gel hydrogel solution can be printed into objects with certain dimension.Originality/valueIn this work, a composite sensitization initiation system was designed, and fast curing hydrogels with adjustable mechanical properties had been prepared conveniently, which has high equilibrium water content and 3D printability with the DIW 3D printer. (deepdyve.com)
This composite hydrogel showed for both drugs a slower release than the obtained release from microparticles and hydrogel separately. (udt.cl)

However, clinical researchers continually find that the involvement of drug carriers may lead to poor biocompatibility and biodegradability, low loading efficacy, and potential side effects. (nature.com)

The macromolecules involved in the formation of hydrogels are able to absorb and retain large amounts of water and other aqueous substances. (wikipedia.org)
Among them, hydrogels and 3D polymer scaffolds with the ability to swell in aqueous media have been deeply investigated. (rsc.org)
Desonide is a low-potency corticosteroid recently formulated in a novel aqueous gel (hydrogel) formulation. (jcadonline.com)
4,5]Advances in formulation technology have enabled the development of desonide into a novel aqueous gel (hydrogel) that is alcohol-free and disappears quickly without leaving a greasy residue. (jcadonline.com)

Conventional testing instruments are difficult to use for evaluating the mechanical properties of hydrogel-based drug release systems during degradation. (rheolution-store.com)
Because conventional mechanical testing techniques are destructive, they prevent the re-testing of the same hydrogel sample for long term degradation studies. (rheolution-store.com)
Unlike most conventional drugs that are formulated chemically and comprised of small molecules, biologics are sprawling and unruly chains of proteins, sugars, and DNA segments, genetically engineered from living sources. (nanowerk.com)

Hydrogels have been used in various areas including industry and medicine due to their excellent characteristics such as high swelling capacity, high content of water, compatibility with other biological molecules, controlled chemical and physical properties, high mechanical integrity and biodegradability. (biomedres.us)
We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (β-cyclodextrin) concentration on swelling and drug (metoclopramide) release characteristics of PAA hydrogels. (bath.ac.uk)

Scientists discovered that, when exposed to the sequential addition of acid and metal ions, a type of material called a hydrogel polymer responded with unexpected gel expansion, contraction, and color change. (nanowerk.com)
Scientists have developed many kinds of hydrogels that respond in specific ways to chemical signals. (nanowerk.com)
By programming how hydrogels respond and behave, scientists could design hydrogels for complex applications. (nanowerk.com)
In this research, scientists sought to form longer-lifetime response complexes in a hydrogel and use those longer responses to produce unique reactions in the hydrogel. (nanowerk.com)

The in situ formed hydrogel encapsulates the therapeutic molecule and releases the agent over time as the hydrogel degrades. (ophthalmologytimes.com)
And once the job is done, the hydrogel degrades into water-soluble oligomers and can be easily excreted from the body. (newatlas.com)

The crosslinking mechanism of the hydrophilic macromolecules are driven by covalent bonding, resulting in a physical- or chemical-type hydrogel. (wikipedia.org)
Additionally, under UV irradiation the trans-conformation of azobenzene in the hydrogel would generally convert into the cis-conformation and resulted in the hydrophilic/hydrophobic balance variation of the hydrogel . (bvsalud.org)

Other variables considered in hydrogel design include safety, biodegradability, drug loading capacity, and on-demand control of drug release [23]. (wikipedia.org)

Poly(hydroxybutyrate- co -hydroxyvalerate) (PHBV) microparticles were prepared to encapsulate simultaneously ketoprofen and mupirocin, as hydrophobic drug models. (udt.cl)

The degradation rate of the hydrogel can also be controlled based on the need and use of the structure. (technologypublisher.com)

The highly lubricating hyaluronic acid increases comfort, but displaces films from the eye , reducing drug exposure and efficacy. (cdc.gov)

Regardless, the company said it plans to discuss filing for regulatory approval of its obesity treatment, which is a capsule containing small hydrogel particles. (drugdeliverybusiness.com)
The drug's hydrogel particles are designed to mix with food in the body and swell to almost 100 times their original size once in the stomach. (drugdeliverybusiness.com)
Hydrogel particles without the cancer immunotherapy drug pembrolizumab. (nanowerk.com)
Hydrogel particles loaded with crystals of the cancer immunotherapy drug pembrolizumab. (nanowerk.com)
The insight we had was to use hydrogel particles, made from sugar-based, water-loving biopolymers that provide a nice environment where a protein is going to be very happy," says Doyle. (nanowerk.com)
The hydrogel particles are squeezy, and can roll over each other, and actually flow," says Erfani. (nanowerk.com)
Environmentally responsive hydrogel composites embedded with submicron-sized spherical silica particles for the modulation of the mid-infrared radiation derived from the Bragg reflection are therein designed for personalized body thermoregulation. (rsc.org)

The hydrogels are expected to be capable of superior solubility, optimal therapeutic efficacy, and almost no cytotoxicity. (nature.com)
One of the release mechanisms of therapeutic agents is based on the controlled degradation of the hydrogel that carries the drug. (rheolution-store.com)
Viscoelasticity measurements and degradation profiles can be correlated with the amount of drug released in order to control the release for specific therapeutic applications. (rheolution-store.com)

The swelling behavior and drug release were dependent upon the crosslink density. (farmaciajournal.com)

The potential use of carboxymethyl sago pulp (CMSP) extracted from sago waste for producing hydrogel nanofibers was investigated as a methylene blue drug carrier. (utm.my)

Various examples of hydrogel type designs include nanoparticles, nanogels, and microgels. (wikipedia.org)
proposed gelatin-based hydrogel nanoparticles that were stimulated by magnetic forces. (wikipedia.org)

The word "hydrogel", as stated by Lee, Kwon and Park, has been used since 1894 but that material was not a hydrogel but a colloidal gel (of inorganic salts) [1]. (biomedres.us)

Additionally, these biological materials from drug carriers require complex syntheses and are relatively expensive 12 , which create great obstacles for effective clinical application. (nature.com)

Since its discovery in 1960, hydrogels have become a crucial component in biomedical research and applications. (wikipedia.org)
Previously approved for use in spinal, neurological, and angioplasty procedures, the company is now engineering the hydrogel technology to design therapies specifically for sustained-release ocular drug applications. (ophthalmologytimes.com)
Hydrogel: preparation, characterization, and applications: a review. (nature.com)
Bahram M, Mohseni N, Moghtader M. An introduction to hydrogels and some recent applications. (nature.com)
In: Emerging concepts in analysis and applications of hydrogels. (nature.com)
Fu J, In Het Panhuis M. Hydrogel properties and applications. (nature.com)
The Global Market for Hydrogels 2024-2034 provides a comprehensive analysis of the global hydrogel landscape, technologies, companies, and applications across major industry verticals. (researchandmarkets.com)
This study serves as a strategic guide for companies and investors looking to capitalize on the major growth opportunities for hydrogels across a diverse set of high-potential markets and applications. (researchandmarkets.com)
This article delves into the world of hydrogels, discussing their types, applications in pharmaceutical dosing, advantages, and potential challenges. (thewitfire.in)
Their innovative product, Fibro-Gel, offers numerous advantages over existing hydrogels and has promising applications in wound healing. (hku.hk)
In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. (eurekaselect.com)

The hydrogel consists of a three-dimensional nanofiber network that prevents premature degradation. (nature.com)

Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. (nature.com)
Finally, the third generation then focused on investigating and developing stereo complex materials and hydrogels that were cross-linked through physical interactions. (biomedres.us)
Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. (bath.ac.uk)

Despite these endeavors, designing directed self-assemble hydrogels formed by natural small molecules is still a formidable challenge. (nature.com)
The new process makes these essential molecules part of the hydrogel itself, specifically part of the crosslinkers that allow the material to keep its structure when swollen with water. (materialstoday.com)
Fibro-Gel is made by squeezing out a polymer, that contains the molecules of the required drug, through a narrow channel (not unlike toothpaste squeezed out of a tube), and snapping off the microfibres by using a pulse of ultra-violet light. (hku.hk)
Longer microfibres become very entangled, resulting in a stiffer, less fluid gel, and it takes longer for the molecules of the drug to be released from it. (hku.hk)

The secondgeneration hydrogels were made to overcome the problems of mechanical strength. (biomedres.us)

Best of all, the Rice lab's customized, active hydrogels can be mixed at room temperature for immediate application. (materialstoday.com)
The team's versatile new hydrogel can be packed with cancer-fighting drugs and then release them in response to temperature and pH changes in the tumor microenvironment, as a tool for taking out lingering cancer cells following surgical removal. (newatlas.com)

These microparticles were embedded in a physically crosslinked hydrogel of κ-carrageenan/locust bean gum. (udt.cl)
Also, the drug loaded microparticles were spherical with average mean particle size of 1.0 μm, mesoporous, and distributed homogeneously in the hydrogel. (udt.cl)

Physical hydrogels contain reversible matrices of hydrogen and non-covalent bonds, while chemical hydrogels are composed of irreversible matrices that are molecularly held together by covalent bonds. (wikipedia.org)
A research group has developed a novel method to synthesize dendrimer-based hydrogels with various controlled physical and chemical properties. (technologypublisher.com)

The bond strength describes the cross-linking strength of the hydrogel, which is considered in designing drug release mechanisms of hydrogel-based platforms. (wikipedia.org)
demonstrated the stimulated release of gallic acid from chitin-based hydrogel via ultrasound induction. (wikipedia.org)
The release of these drugs can be tailored to produce the required efficacy with the potential for an improved safety profile since they are used in lower peak concentrations and are preservative-free. (ophthalmologytimes.com)
These aVD-loaded filaments underwent morphological transitions to release monodisperse drug-loaded micelles upon oxidation. (frontiersin.org)
Initial studies confirmed that the hydrogels are suitable drug carriers with a sustained drug release profile. (une.edu)
This enables them to shrink and swell in response to both changing temperatures and pH levels, and release their drugs as a result. (newatlas.com)
The controlled release of drugs at precise locations within the body can prevent systemic toxicity and deliver accurate dosages to patients. (rheolution-store.com)
The use of these instruments requires the monitoring of multiple samples for a complete drug release study as a function of time. (rheolution-store.com)
The hydrogels have been developed to allow controlled release of materials based on the pH changes in its surroundings. (technologypublisher.com)
Hydrogels have been explored as carriers for the controlled release of drugs in the gastrointestinal tract. (thewitfire.in)
By encapsulating drugs within hydrogel networks, the release rate can be modulated, improving drug bioavailability and reducing side effects. (thewitfire.in)
Hydrogel-based transdermal patches are an attractive alternative to traditional patches as they can provide controlled drug release, enhanced drug permeation, and improved patient comfort. (thewitfire.in)
Novel (p)-MCM41-CDM-CMCS hydrogels with combined controlled release of CDM and osteogenic potency were successfully developed for the first time, suggesting their potential clinical benefit for treatment of intraoral bone infection. (mahidol.ac.th)
A revolutionary feature of Fibro-Gel is that it allows the use of different drugs within the same gel, thus enabling controlling and tuning the time of their release. (hku.hk)
The crucial breakthrough was made by PhD student Yanting Shen and postdoctoral fellow Dr Yuan Liu of HKU's Department of Mechanical Engineering - the researchers realised that the release of the drugs from the gel can be controlled and tailored by setting the length of microfibres that the gel consists of. (hku.hk)
Conversely, Fibro-Gel with shorter microfibers has lower stiffness and is more fluid fluid-like, resulting in faster rates of drug release. (hku.hk)
Leveraging this feature, the researchers designed a multiple drug release system - a gel consisting of multiple layers with different length of microfibres and containing different drugs. (hku.hk)
Furthermore, using a two-layer Fibro-Gel model, the researchers demonstrated that the release of distinct drugs at different rates enhanced wound healing. (hku.hk)
In particular, increased β-cyclodextrin concentrations led to reduced swelling and reduced drug release efficiency. (bath.ac.uk)
The release of both drugs was observed during a period of 7 days at 37 °C. Different kinetic models were analyzed and the results indicated the best fitting to a Higuchi model suggesting that the release was mostly controlled by diffusion. (udt.cl)
The release data were fitted to an empirical equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport. (farmaciajournal.com)
Using these models, we are able to (a) compute the time courses of drug release and gel degradation as well as the amount of fragment-drug conjugate present at any time and (b) estimate the rate constants of drug release and gel degradation necessary to control each of the above. (huji.ac.il)
Therefore, the hydrogel loaded with vitamin B12 (VB12) showed a higher drug cumulative release rate under UV irradiation than that without UV irradiation. (bvsalud.org)

However, unlike most antibiotics and hydrogels, which target the internal machinery of bacteria to prevent replication, this hydrogel kills bacteria by membrane disruption, precluding the emergence of any resistance. (medgadget.com)
Hydrogels can deliver growth factors, antibiotics, or anti-inflammatory drugs directly to the wound, aiding the healing process. (hku.hk)

Hydrogels can also provide a moist environment, which can promote wound healing and reduce inflammation in the case of wound dressings. (thewitfire.in)

Fan, Jun 2021-06-04 00:00:00 This paper aims to show a series of hydrogels with adjustable mechanical properties, which can be cured quickly with visible light. (deepdyve.com)

Hydrogels as emerging materials for translational. (nature.com)

This enables rhein hydrogels to significantly dephosphorylate IκBα, inhibiting the nuclear translocation of p65 at the NFκB signalling pathway in lipopolysaccharide-induced BV2 microglia. (nature.com)

ElastoSens™ Bio can be used to develop/formulate hydrogels, to tune their degradation profile and to test/optimize degradation mechanisms (enzymatic degradation, hydrolysis, etc. (rheolution-store.com)

Currently US Food and Drug Administration approved for use in the treatment of mild-to-moderate atopic dermatitis, this hydrogel formulation may offer aesthetic advantages over traditional vehicles. (jcadonline.com)
8] Currently US Food and Drug Administration (FDA) approved for use in mild-to-moderate atopic dermatitis, this hydrogel formulation may offer aesthetic advantages over traditional vehicles that can be messy and time consuming to apply. (jcadonline.com)

A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol. (us.es)
While adding various content of gelatin and cross-linker, the mechanical properties of hydrogels show from soft and fragile (elastic modulus of 121.18 kPa and work of tension of 218.11 kJ·m−3) to rigid and tough (elastic modulus of 505.15 kPa and work of tension of 969.00 kJ·m−3). (deepdyve.com)

Merck has patented this formulation of the drug as Keytruda. (nanowerk.com)
Since these areas are highly visible and frequently hair bearing, patients may benefit from the use of the hydrogel formulation, which has been shown in other studies as a suitable treatment for multiple body areas, including glabrous areas. (jcadonline.com)

Anatomy2

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes9

Disciplines and Occupations2

Technology, Industry, Agriculture17

Health Care1

Branched polymer1

Smart hydrogels5

Injectable hydrogels4

Tough Hydrogels4

Biomedical applications9

Polymers13

Stimuli13

Supramolecular1

Synthesis2

Conductive hydrogels1

Gels5

Novel hydrogel2

Hybrid hydrogels3

Polymer hydrogel1

Thermosensitive2

Nanocomposite4

20232

Tissue12

Physicochemical1

Delivery35

Biodegradable2

Formulations3

Biocompatible3

Synthetic2

Composite5

Biocompatibility and biodegradability1

Aqueous4

Conventional3

Characteristics2

Scientists4

Degrades2

Hydrophilic2

Biodegradability1

Hydrophobic1

Degradation rate1

Hyaluronic acid1

Particles7

Therapeutic3

Behavior1

Carboxymethyl1

Nanoparticles2

Colloidal1

Biological1

Applications11

Nanofiber1

Interactions3

Molecules4

Mechanical strength1

Temperature2

Microparticles2

Physical2

Release23

Antibiotics2

Wound1

20211

Emerging1

Signalling pathway1

Mechanisms1

Advantages2

Gelatin2

Formulation2