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  • chemotherapy
  • Researchers at Duke University found that Bevacizumab (Avastin), a drug that stunts the growth of blood vessels that feed a tumour's growth and spread, may increase the amount of time that patients can survive without tumour growth if given in conjunction with a standard chemotherapy drug. (netdoctor.co.uk)
  • The double-blind, randomized, placebo-controlled test was designed to determine whether bevacizumab could increase the effectiveness of gemcitabine and cisplatin, two chemotherapy drugs that have been used to treat mesothelioma for years. (asbestos.com)
  • Although chemotherapy combinations have improved the cure rate for CLL, side effects often are severe. (innovations-report.com)
  • The results were as good as that achieved with intravenous combination chemotherapy, but without the side effects of nausea, vomiting and hair loss as well as low blood counts, the risk of infection and the need for a central venous catheter. (innovations-report.com)
  • India
  • In 2012, the Parliamentary Standing Committee on Health & Family Welfare has tabled before Parliament a unanimous 118-page report on the state of drug regulation in India and the manner in which it severely compromises the safety of Indian patients. (medindia.net)
  • Our research wholly supports the need for a complete overhaul of the new Drugs Bill and we urge the government of India to make this a priority," noted professor Allyson Pollock, global health expert and study co-author. (medindia.net)
  • Cancer
  • A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a deadly form of brain cancer . (netdoctor.co.uk)
  • Nasdaq: CPXX), a biopharmaceutical company that is transforming the science of combination therapy and developing products to improve patient outcomes in cancer, announced their successful R&D efforts to apply the CombiPlex technology platform to optimize the efficacy of anticancer drug combinations incorporating molecularly targeted agents (MTAs). (thefreedictionary.com)
  • With our platform, you can profile your compounds as single agents or combinations across hundreds of well-annotated cancer cell lines, and gain actionable insights in a short period of time. (horizondiscovery.com)
  • The study , conducted by professor Des Richardson of the Sydney Medical School, illustrate that drugs can control the spread and growth of cancer cells. (asbestos.com)
  • So, when a novel compound is tested against cell lines in the NCI-60, it's possible to determine not just whether it kills the cells, but how it affects the molecular machinery of a cancer cell-information that is critical for understanding how a drug works. (cancer.gov)
  • The report from our NCI group in Cancer Research provides an ideal case report of what the NCI ALMANAC results might mean for advancing new drug combinations into human trials. (cancer.gov)
  • Data in the NCI ALMANAC showed that the combination of nilotinib and paclitaxel had robust cell-killing effects in blood cancer and triple-negative breast cancer cell lines. (cancer.gov)
  • However, with 300 FDA-approved cancer drugs on the market, there almost 45,000 possible two-drug combinations and almost 4.5 million three-drug combinations for to choose from. (wikipedia.org)
  • The National Cancer Institute has recently highlighted combination therapy as a top research priority in oncology. (wikipedia.org)
  • BET inhibitors are a class of drugs with anti-cancer, immunosuppressive, and other effects in clinical trials in the United States and Europe and widely used in research. (wikipedia.org)
  • therapeutic
  • For one anti-inflammatory example, we show how such selectivity is achieved through differential expression of the drugs' targets in cell types associated with therapeutic, but not toxic, effects and validate its therapeutic relevance in a rat model of asthma. (nih.gov)
  • Electronic orange book: approved drug products with therapeutic equivalence evaluations. (emedtv.com)
  • Combination therapy has gained momentum in oncology in recent years, with various studies demonstrating higher response rates with combinations of drugs when compared to monotherapies, and the FDA recently approving therapeutic combination regimens that demonstrated superior safety and efficacy to monotherapies. (wikipedia.org)
  • cystic fibrosis patients
  • Just a few years ago, ivacaftor became the only FDA-approved drug for the genetic defect in cystic fibrosis, but it only works for genetic mutations found in a small portion of cystic fibrosis patients," states study author Dr. Susanna McColley, professor of pediatrics at Northwestern University Feinberg School of Medicine, IL. (medicalnewstoday.com)
  • They found that adding a third drug to an existing combination of two drugs could improve the symptoms of cystic fibrosis patients, and might even help some of them live longer. (nbcnews.com)
  • diabetes
  • So in addition to insulin or diabetes pills, other drugs are often needed to control these problems - statins for high cholesterol , diuretics or beta-blockers for high blood pressure, antidepressants for depression or neuropathy pain, and a daily aspirin to prevent a heart attack. (diabetesselfmanagement.com)
  • The nonsteroidal anti-inflammatory drugs (such as ibuprofen), anticoagulants , diuretics, and drugs to treat diabetes are on this list. (diabetesselfmanagement.com)
  • Empagliflozin/linagliptin is a drug combination used for the treatment of type II diabetes. (wikipedia.org)
  • medication
  • In the search for medication against Alzheimer's disease, scientists have focused - among other factors - on drugs that can break down Amyloid beta (A-beta). (medindia.net)
  • Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone). (wikipedia.org)
  • Polypill, a medication which contains a combination of multiple active ingredients Drug combination database. (wikipedia.org)
  • anticipate
  • We anticipate that people who will start this drug earlier, as children, are going to live normal lives with the exception of having to take these pills every day. (nbcnews.com)
  • pharmaceutical
  • Epigenetic drugs target the epigenome and are currently in high demand by many pharmaceutical companies. (medindia.net)
  • This ban is likely to affect many leading pharmaceutical drug manufacturers such as Pfizer, Abbott, Macleods Pharma and Glenmark Pharmaceuticals. (medindia.net)
  • FDC drug products may be developed by a pharmaceutical company as a way to in effect extend proprietary rights and marketability of a drug product. (wikipedia.org)
  • Sometimes "polymedicine" is used to refer to pharmaceutical combination therapy. (wikipedia.org)
  • Consequently, this allows saving time and cost and resources as well as increasing efficiency an effectiveness in medical, pharmaceutical research and new drug development. (wikipedia.org)
  • pairs
  • The NCI ALMANAC includes data on more than 5,000 pairs of FDA-approved drugs that were tested against the NCI-60-a total of 300,000 experiments. (cancer.gov)
  • We began by conducting follow-up experiments on a subset of drug pairs identified in the database that exhibited potent cell-killing effects. (cancer.gov)
  • In an ideal world, no pharmacy would have dispensed any of these drug pairs, period! (peoplespharmacy.com)
  • simvastatin
  • Ezetimibe/simvastatin is a drug combination used for the treatment of dyslipidemia. (wikipedia.org)
  • It is a combination of ezetimibe (known as Zetia in the United States and Ezetrol elsewhere) and the statin drug simvastatin (known as Zocor in the U.S.). Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. (wikipedia.org)
  • trials
  • In both trials, patients around the world got either the combination with one of the two new drugs, or a placebo. (nbcnews.com)
  • In the two trials of the two experimental Vertex drugs, lung function improved by between 11 percent and 13 percent, the two teams reported. (nbcnews.com)
  • Side Effects
  • Taking sertraline and digoxin together may increase your risk of having side effects with either drug. (emedtv.com)
  • Early combinations of NIs with classic heart drugs called angiotensin-converting enzyme inhibitors (ACE-Is) caused more side effects together than with either drug alone. (healthcentral.com)
  • That makes it the perfect choice for folks who are looking for a heart-healthy supplement that can help them lower their blood pressure and LDL cholesterol, without the harsh side effects of drugs. (healthiertalk.com)
  • tend
  • In man, emetine poisoning is characterized by muscular tremors, weakness and pain in the extremities which tend to persist until drug administration is stopped. (wikipedia.org)
  • multiple
  • Once the effect of each compound as a single agent is removed, an Excess Matrix is generated that provides a simple visual representation of information about combination activity at the multiple concentrations and ratios of the two drugs and where synergies or antagonism can be seen. (horizondiscovery.com)
  • Multiple formulations included drugs which are restricted, banned or were never approved in other countries because of associations with serious adverse events including death. (medindia.net)
  • Recent precision medicine approaches have focused on targeting multiple biomarkers found in individual tumors using combinations of drugs. (wikipedia.org)
  • The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection. (wikipedia.org)
  • The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy (HAART). (wikipedia.org)
  • genetic
  • As personalized medicine moves from the present emphasis on diagnosis and prognosis to therapy, the problem of searching for optimal drug combinations uniquely suited to the genetic and molecular profile of each patient will need to be solved. (thefreedictionary.com)
  • An international research team has demonstrated that a combination of two different drugs targeting the most common genetic cause of cystic fibrosis helped to improve lung function and reduce the rate of pulmonary exacerbations. (medicalnewstoday.com)
  • New drugs can help correct some of the malfunctions in the cell, but how well they work depends on the particular genetic mutation causing a patient's disease. (nbcnews.com)
  • 300,000
  • The big catch: the current drugs already cost around $300,000 a year and adding a third drug would likely boost that cost significantly. (nbcnews.com)
  • equally
  • This situation is unlikely to arise these days, as equally good alternative drugs like metronidazole are available. (wikipedia.org)
  • dosages
  • Ability to compose combined profiles of for example pharmacokinetics, effects and adverse effects that may be specific for the relative dosages in a given FDC product, providing a simpler overview compared to when looking at the profiles of each single drug individually. (wikipedia.org)