CeftriaxoneClaforanCephalosporinsCefepimeAmpicillinIsolatesInfectionsMeningitisInteractionsInjectionDecreases2023CephalosporinAztreonamHypersensitivityRenalResistanceFluoroquinolonesPseudomonasPenicillinAvoid or Use Alternate DrugDosageIntravenous drugIntensive CareOrganismsTyphoidAntibacterialAntibioticsSupplementsPatientsEffectivenessSide effectsClinicalBelongsTreatmentOralTadalafil
Ceftriaxone6
- However, ceftriaxone has the advantage of once-daily dosing, whereas the shorter half-life of cefotaxime necessitates two or three daily doses for efficacy. (wikipedia.org)
- Changing patterns in microbial resistance suggest cefotaxime may be suffering greater resistance than ceftriaxone, whereas the two were previously considered comparable. (wikipedia.org)
- ceftriaxone , cefotaxime and cefoperazone are used of which ceftriaxone is most convenient. (pediatriconcall.com)
- Parenteral third generation cephalosporins include ceftriaxone 50-75mg/kg/day in one or two doses, cefotaxime 40-80 mg/kg/day in two or three doses and cefoperazone 50-100 mg/kg/per day in two doses. (pediatriconcall.com)
- For complicated typhoid the choice of drug is parenteral third generation cephalosporin e.g. ceftriaxone (2). (pediatriconcall.com)
- Individual discs containing 30 μg of ceftazidime, ceftriaxone and cefotaxime were placed on the plate at a distance of 15 mm (edge to edge) from an amoxicillin/clavulanic acid disc (20-10 μg) placed at the center of the plate. (scialert.net)
Claforan2
- Claforan has active ingredients of cefotaxime sodium . (ehealthme.com)
- The study is based on cefotaxime sodium (the active ingredients of Claforan) and Claforan (the brand name). (ehealthme.com)
Cephalosporins3
- citation needed] As a β-lactam antibiotic in the third-generation class of cephalosporins, cefotaxime is active against numerous Gram-positive and Gram-negative bacteria, including several with resistance to classic β-lactams such as penicillin. (wikipedia.org)
- citation needed] Cefotaxime is contraindicated in patients with a known hypersensitivity to cefotaxime or other cephalosporins. (wikipedia.org)
- The need for ESBL detection is under challenge on the supposition that it is possible to set breakpoints for injectable cephalosporins and aztreonam that accurately discriminate which ESBL-producing isolates can and cannot be reliably treated with these drugs. (asm.org)
Cefepime2
- At variance with this approach, there are reports of therapeutic failures with cefepime associated with MICs of ≤2 μg/ml ( 31 ) and 4 μg/ml in a pediatric patient ( 3 ) and with a cefotaxime MIC of 0.75 μg/ml ( 20 ). (asm.org)
- In the cross-sectional analysis, the 76 MCRPEC isolates were significantly more resistant to several other drugs compared with isolates that were mcr-1 negative, including ciprofloxacin ( P = .0005), cefotaxime ( P = .0005), and cefepime ( P = .001). (medscape.com)
Ampicillin2
- Combination therapy (ampicillin and either gentamicin or cefotaxime) is typically used in the initial treatment of newborns and young infants. (medscape.com)
- Over the years Salmonella typhi has developed resistance simultaneously to all the drugs used in first line treatment (chloramphenicol, cotrimoxazole and ampicillin ). (pediatriconcall.com)
Isolates4
- A search of the computerized database at the National Taiwan University Hospital was made for cefotaxime-resistant and cefmetazole-susceptible isolates of Escherichia coli and Klebsiella pneumoniae (which may be extended-spectrum β-lactamase-producing strains) in pediatric wards and intensive care units between 1999 and 2001. (ntu.edu.tw)
- Many of the isolates also proved resistant to other drugs as well as colistin, although there was little evidence of extensive carbapenem coresistance. (medscape.com)
- The finding of multiple-drug resistance in MCRPEC isolates suggests these organisms were able to recruit other resistance genes, "which could raise difficulties in the treatment of patients with clinical infection due to MCRPEC," the authors write. (medscape.com)
- CTX-M-1, CTX-M-2, CTX-M-8, -lactams are the most common 2 cefotaxime-resistant isolates were also CTX-M-9, CTX-M-25) [7]. (who.int)
Infections8
- Cefotaxime injection is used to treat bacterial infections in many different parts of the body. (mayoclinic.org)
- Cefotaxime is an antibiotic used to treat a number of bacterial infections in human, other animals and plant tissue culture. (wikipedia.org)
- citation needed] Given its broad spectrum of activity, cefotaxime is used for a variety of infections, including: Lower respiratory tract infections - e.g. pneumonia (most commonly caused by S. pneumoniae) Genitourinary system infections - urinary tract infections (e.g. (wikipedia.org)
- CNS infections - e.g. meningitis/ventriculitis secondary to N. meningitidis, H. influenzae, S. pneumoniae Although cefotaxime has demonstrated efficacy in these infections, it is not necessarily considered to be the first-line agent. (wikipedia.org)
- Risk factors for infections of the spine involve conditions that weaken the patient's immune system, such conditions include diabetes mellitus, use of immunosuppressant medications, cancer, HIV/AIDS, malnutrition, history of an organ transplant and intravenous drug abuse. (wheelessonline.com)
- Suitable for pneumonia caused by sensitive bacteria and other lower respiratory tract infection, urinary tract infections, meningitis, septicemia, abdominal cavity infection, pelvic infection, skin soft tissue infection, reproductive tract infections, bone and joint infections, etc.Cefotaxime can be used as a selection of infantile meningitis drugs. (bbcapharma.com)
- Naber KG, Dette GA, Kees F, Knothe H, Grobecker H. Pharmacokinetics, in vitro activity, therapeutic efficacy, and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections. (druglib.com)
- The PCR drugs against bacterial infections recovered from surfaces of the ICU. (who.int)
Meningitis1
- In meningitis, cefotaxime crosses the blood-brain barrier better than cefuroxime. (wikipedia.org)
Interactions1
- AZACTAM drug label information in our database does not contain a dedicated section on drug interactions. (druglib.com)
Injection5
- Cefotaxime injection belongs to the class of medicines known as cephalosporin antibiotics. (mayoclinic.org)
- Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of cefotaxime injection in children. (mayoclinic.org)
- However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving cefotaxime injection. (mayoclinic.org)
- Cefotaxime injection may cause diarrhea, and in some cases it can be severe. (mayoclinic.org)
- citation needed] The most common adverse reactions experienced are: Pain and inflammation at the site of injection/infusion (4.3%) Rash, pruritus, or fever (2.4%) Colitis, diarrhea, nausea, vomiting (1.4%) Cefotaxime is a β-lactam antibiotic (which refers to the structural components of the drug molecule itself). (wikipedia.org)
Decreases5
- cefotaxime decreases effects of BCG vaccine live by pharmacodynamic antagonism. (medscape.com)
- cefotaxime decreases effects of microbiota oral by pharmacodynamic antagonism. (medscape.com)
- cefotaxime decreases effects of typhoid vaccine live by pharmacodynamic antagonism. (medscape.com)
- aspirin decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
- Probenecid decreases cefotaxime elimination. (medicscientist.com)
20231
- 2023. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109021/all/cefotaxime. (unboundmedicine.com)
Cephalosporin2
- In case of uncomplicated typhoid, oral third generation cephalosporin e.g. cefixime should be the drug of choice as empiric therapy. (pediatriconcall.com)
- ESBL producers are usually multiply drug resistant ( 5 , 30 ), but their cephalosporin and aztreonam resistance is not reliably detected by susceptibility tests ( 33 ). (asm.org)
Aztreonam1
- aztreonam and imipenem are also potential third line drugs. (pediatriconcall.com)
Hypersensitivity1
- Hypersensitivity reported drugs (bold indicates most commonly in medicine, though the ef- hemiacetal form. (thehasse.org)
Renal3
- probenecid will increase the level or effect of cefotaxime by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
- probenecid increases levels of methotrexate by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
- Because of extra-renal elimination, it is only necessary to reduce the dosage of cefotaxime in severe renal failure. (medscape.co.uk)
Resistance4
- Antimicrobial drug resistance of 344 Shigella spp. (cdc.gov)
- Requests and Multi-Drug to ensure that culture results are given as quickly as possible to clinicians to Resistance among Suspected inform proper antibiotic selection. (who.int)
- Escherichia coli rapidly develops resistance, particularly that associated with multiple drug resistance (MDR) when exposed to selected antimicrobials. (vin.com)
- Emergence of extended-spectrum beta-lactamases (ESBL) is an example of the relentless adaptive nature of microbes toward designer drugs intended to preclude the advent of resistance. (vin.com)
Fluoroquinolones3
- Fluoroquinolones are widely regarded as the most effective drug for the treatment of typhoid fever. (pediatriconcall.com)
- 2) Fluoroquinolones have the advantage of lower rates of stool carriage than the first line drugs. (pediatriconcall.com)
- However, fluoroquinolones are not approved by Drug Controller General of India to be used under 18 years of age unless the child is resistant to all other recommended antibiotics and is suffering from life threatening infection. (pediatriconcall.com)
Pseudomonas1
- Notable organisms against which cefotaxime is not active include Pseudomonas and Enterococcus. (wikipedia.org)
Penicillin1
- Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. (medicscientist.com)
Avoid or Use Alternate Drug1
- Avoid or Use Alternate Drug. (medscape.com)
Dosage1
- Cialis Oral tablet 10mg Drug Medication Dosage information Currently The generic form of Cialis is called tadalafil Et al'The dysbindin gene is required Dosedependent fluconazole hepatotoxicity proven on biopsy and rechallenge However UTI Causes Or viruses Users of brand. (njacs.org)
Intravenous drug4
- 2-11 The incidence may be higher in younger patients that are intravenous drug abusers. (wheelessonline.com)
- every 6 hours, to intravenous drug delivery. (bbcapharma.com)
- Objectives To identify incompatible intravenous drug combinations in routine paediatric intensive care and evaluate physician and nurse knowledge. (bmj.com)
- Methods In a university paediatric intensive care unit, intravenous drug incompatibilities were analysed using a database and physician and nurse knowledge of incompatibilities was assessed using a questionnaire. (bmj.com)
Intensive Care2
- Conclusions One in 10 patients in paediatric intensive care was affected by drug incompatibility, with knowledge deficits seen in a third of assessed combinations. (bmj.com)
- Background: Cefotaxime is a beta-lactam antibiotics commonly used in intensive care unit (ICU). (hal.science)
Organisms2
- While regional susceptibilities must always be considered, cefotaxime typically is effective against these organisms (in addition to many others): Staphylococcus aureus (not including MRSA) and S. epidermidis Streptococcus pneumoniae and S. pyogenes Escherichia coli Haemophilus influenzae Neisseria gonorrhoeae and N. meningitidis Klebsiella spp. (wikipedia.org)
- The 1st-generation drugs are effective mainly against gram-positive organisms. (msdmanuals.com)
Typhoid1
- 1) By definition this is known as Multi Drug Resistant Typhoid Fever (MDRTF). (pediatriconcall.com)
Antibacterial1
- Overview of Antibacterial Drugs Antibacterial drugs are derived from bacteria or molds or are synthesized de novo. (msdmanuals.com)
Antibiotics1
- Treatment includes surgical drainage, antibiotics, and sometimes drugs to prevent seizures or to reduce pressure within the skull. (merckmanuals.com)
Supplements1
- Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. (webmd.com)
Patients2
- Incompatible drug administration was identified in 9 (10%) of the 87 patients with a median of 3 different incompatibilities per patient (Q25/Q75: 1/3). (bmj.com)
- Amid growing concerns about the global emergence of extensively drug-resistant "superbugs," two new studies provide a snapshot of the prevalence and risk factors for colistin -resistant Enterobacteriaceae among hospital patients in China. (medscape.com)
Effectiveness2
- Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. (ehealthme.com)
- Read user comments about the side effects, benefits, and effectiveness of cefotaxime in dextrose iso-osmotic intravenous. (webmd.com)
Side effects1
- Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (mayoclinic.org)
Clinical1
- 2) If by 5 days, there is no clinical improvement and the culture report is inconclusive add a second line drug e.g. azithromycin or any other drug effective against S typhi depending on the sensitivity pattern of the area. (pediatriconcall.com)
Belongs1
- Cialis contains the active drug ingredient tadalafil and belongs to a group of medications called phosphodiesterase 5 PDE5 inhibitors. (njacs.org)
Treatment1
- Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. (webmd.com)
Oral1
- cefotaxime will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora. (medscape.com)
Tadalafil1
- Open 7 days a week, cialis is available as a generic drug called tadalafil. (njacs.org)