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  • 2018
  • The 2018 Gordon Conference on Drug Carriers in Medicine and Biology builds on a rich tradition encompassing chemical, biological, physical and engineering principles through clinical application. (grc.org)
  • tumor cells
  • To promote chemotherapeutic efficacy, a dynamic drug delivery system was prepared, which remained stealthy and stable in blood vessels, improved drug penetration and retention in response to extracellular stimuli, enhanced membrane permeability through unique functional groups, and then achieved rapid drug release to improve toxicity to tumor cells in response to intracellular stimuli. (rsc.org)
  • nanocarriers
  • Nanometer-scale vehicles known as nanocarriers can be programmed to travel the body and selectively target cancer and other sites of disease and therefore, can convey higher concentrations of drugs to bombard specific areas of the body while curtailing systemic side effects. (azonano.com)
  • Nanocarriers can also convey drugs and diagnostic agents that are normally not soluble in blood or water as well as considerably decrease the effective dosage. (azonano.com)
  • The gel itself re-assembles into the nanocarriers, so after the entire drug has been delivered, no residual material is left to trigger fibrous tissue formation or inflammation. (azonano.com)
  • nanomaterials
  • To avoid this issue, Scott created a nanocarrier using self-assembled, filament-shaped nanomaterials, which are loaded with an imaging or drug agent. (azonano.com)
  • After the filaments are injected into the body, the resulting hydrogel network works as a drug depot that gradually degrades by breaking down into spherical nanomaterials called micelles, which are programmed to travel to precise targets. (azonano.com)
  • poly
  • New surface hydroxylated and internally quaternised poly(propylene imine) dendrimers as efficient biocompatible drug carriers of norfloxacin. (nih.gov)
  • This study intended to describe the development of two novel, biocompatible and potential surface hydroxylated quaternary ammonium chloride based poly(propylene imine) (PPI) dendrimers for effective delivery of the drug Norfloxacin (NFN). (nih.gov)
  • injection
  • Scott's team prepared a nanocarrier formulation that - after rapidly forming into a gel inside the body at the site of injection - can continuously discharge nanoscale drug-loaded vehicles for months. (azonano.com)
  • Chemotherapy usually requires the delivery of multiple toxic drugs at high concentrations, and we could deliver all of these drugs in one injection at much lower dosages. (azonano.com)
  • The measured surface hydrophobicities of particles and fat emulsions were well in agreement with the in vivo organ distribution data obtained after i. v. injection of the carriers. (uni-regensburg.de)
  • vaccines
  • This system could, for instance, enable single-administration vaccines that do not require boosters as well as a new method to deliver hormone therapy, chemotherapy, or drugs that assist wound healing. (azonano.com)
  • aqueous
  • It was observed that the QPPI-OH (G2)/QPPI-OH (G3) dendrimers have excellent solubilising potential/drug loading abilities of NFN in aqueous medium and can also sustain delivery of NFN. (nih.gov)
  • compounds
  • The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. (mdpi.com)
  • The physiological conditions in the peripheral lung with scarce lining fluid, acting as the solvent, and low enzymatic activity of the fragile tissue largely restrict the selection of compounds for the design of pulmonary carriers. (uni-marburg.de)
  • solubility
  • The potential of these dendrimers were examined as drug carrier for NFN, by carrying out solubility, in vitro release, cytotoxicity and anti-bacterial studies. (nih.gov)
  • hence
  • Resealed erythrocytes are rapidly taken up by macrophages of the Reticuloendothelial System (RES) of the liver, lung, and spleen of the body and hence drugs also. (igi-global.com)
  • immune
  • PFE ) executive who joined Rubius as its president in January, calls red blood cells a "potent and convenient" way to deliver a drug and likens them to engineered immune cells that are becoming cancer-fighting drugs in their own right. (xconomy.com)
  • cells
  • Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. (igi-global.com)
  • Medicine
  • This GRC will be held in conjunction with the "Drug Carriers in Medicine and Biology (GRS)" Gordon Research Seminar (GRS). (grc.org)
  • Results
  • Results obtained with surface-modified polystyrene particles as model carriers and parenteral fat emulsions are discussed as examples. (uni-regensburg.de)
  • form
  • The biocompatible hydrogel alginate, degrading as a function of the phosphate concentration, was utilized in order to form the backbone of the carrier system. (uni-marburg.de)
  • specific
  • Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. (dovepress.com)
  • chemical
  • Namdee has been working in the lab of chemical engineering professor Omolola Eniola-Adefeso, where they are testing new forms of drug carriers. (nsf.gov)