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  • patients
  • Respiratory failure requiring orotracheal intubation (OTI) and mechanical ventilation (MV) is almost always a fatal complication in patients who undergo hematopoietic progenitor transplantation (HPT). (ebscohost.com)
  • donor
  • He also helped establish the World Marrow Donor Association in 1990, and served (at various different times) as the president of the International Society for Experimental Haematology, the European Group for Blood and Marrow Transplantation, the European Haematology Association and several other medical and scientific organisations. (wikipedia.org)
  • abnormal
  • AML is caused by the rapid multiplication of abnormal and immature neutrophils or similar cells that build up within the bone marrow and interfere with the production of normal cells. (encyclopedia.com)
  • Physical symptoms generally include coarse or rough facial features (including a flat nasal bridge, thick lips, and enlarged mouth and tongue), short stature with disproportionately short trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly), hernias, and excessive body hair growth. (wikipedia.org)
  • liver
  • Over time, this excessive storage of fats can cause permanent cellular and tissue damage, particularly in the brain, peripheral nervous system, liver, spleen and bone marrow. (wikipedia.org)
  • In 2002, doctors at Xijing Hospital of the Fourth Military Medical University described three cases of living related liver transplantation. (wikipedia.org)
  • The drug was recently used in a study to examine the role of platelet-transported serotonin in liver regeneration. (wikipedia.org)
  • severe
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • short stature
  • Shwachman-Diamond syndrome (SDS) or Shwachman-Bodian-Diamond syndrome is a rare congenital disorder characterized by exocrine pancreatic insufficiency, bone marrow dysfunction, skeletal abnormalities, and short stature. (wikipedia.org)
  • cells
  • The bone marrow (soft tissue that is located within the hard outer shell of the bones) is responsible for the production of all types of blood cells. (thefreedictionary.com)
  • The crowding that results from such cells makes the bone marrow unable to produce healthy blood cells. (wikipedia.org)
  • This divides leukemias into lymphoblastic or lymphocytic leukemias and myeloid or myelogenous leukemias: In lymphoblastic or lymphocytic leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (wikipedia.org)
  • In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (wikipedia.org)
  • These long chains of sugar carbohydrates occur within the cells that help build bone, cartilage, tendons, corneas, skin and connective tissue. (wikipedia.org)
  • The decrease in blood cell counts does not occur right at the start of chemotherapy because the drugs do not destroy the cells already in the bloodstream (these are not dividing rapidly). (wikipedia.org)
  • Instead, the drugs affect new blood cells that are being made by the bone marrow. (wikipedia.org)
  • These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that produce the various mature cells in the blood and can be used to test the effects of single drugs or the effects of drugs administered in combination with others. (wikipedia.org)
  • The net effect is that this type of drug links T cells (via CD3) and monocytes/macrophages, natural killer cells, dendritic cells or other Fc receptor expressing cells to the tumor cells, leading to their destruction. (wikipedia.org)
  • skeletal
  • These features may not be apparent at birth but progress as storage of glycosaminoglycans affects bone, skeletal structure, connective tissues, and organs. (wikipedia.org)
  • chronic
  • A specialist in chronic myeloid leukaemia, Goldman conducted pioneering research into leukaemia treatment - he was instrumental in the development of bone marrow transplantation as a clinical method, and later in the development of the drug imatinib. (wikipedia.org)
  • colony
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • Furthermore
  • Furthermore, gene thereapies and bone marrow transplantation may prove to be effective for certain lipid storage disorders. (wikipedia.org)
  • Furthermore, despite the development of anti-drug antibody responses after the first catumaxomab application cycle a repeated cycle of catumaxomab also leads to a treatment success in recurrent malignant ascites. (wikipedia.org)
  • produces
  • After application, the patient's immune system usually produces anti-drug antibodies, which represent early indicators for a beneficial clinical outcome. (wikipedia.org)
  • efficacy
  • In developing new chemotherapeutics(化疗方法),the efficacy of the drug against the disease is often balanced against the likely level of myelotoxicity the drug will cause. (wikipedia.org)
  • organs
  • In 2007, China issued regulations banning the commercial trading of organs, and the Chinese Medical Association agreed that the organs of prisoners should not be used for transplantation, except for members of the immediate family of the deceased. (wikipedia.org)
  • tissues
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Procedure
  • Called the "Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases", or MOTION, the study aims to assess the effectiveness and safety of cryoablation therapy to treat patients with painful bone metastases and document the effects the procedure has on their condition. (advancingyourhealth.org)
  • results
  • This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and Fanconi anemia, where all cell lines are affected resulting in pancytopenia. (wikipedia.org)
  • CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
  • major
  • Major research strengths of the Department include microbial pathogenesis, host-pathogen interactions, molecular virology, antimicrobial drug discovery, mechanisms of gene regulation, and viral oncogenesis. (pittsource.com)
  • disease
  • Some studies test new drugs or surgical procedures and devices, while others look for better ways to prevent diseases in people who have either never had a disease or are trying to prevent one from coming back. (advancingyourhealth.org)
  • Within 4 to 5 days it is safe to give the patient the COX-2 selective agent nimesulide (Aulin),* because this drug is not associated with relapse of the disease (the safety of other COX-2 selective agents has not been formally tested). (rrnursingschool.biz)
  • The drug was noted to increase the risk of veno-occlusive disease in the absence of bone marrow transplantation. (wikipedia.org)
  • cases
  • Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articular surface and, in extreme cases, bone can be exposed in the joint. (wikipedia.org)
  • pain
  • Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain. (wikipedia.org)