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  • benzodiazepine drugs
  • Attention to the risks of off-label use of propofol increased in August 2009 due to the Los Angeles County coroner's conclusion that music icon Michael Jackson died from a mixture of propofol and the benzodiazepine drugs lorazepam, midazolam and diazepam on June 25, 2009. (wikipedia.org)
  • The potential for misuse among those taking it for medical reasons is controversial, with some expert reviews stating that the risk is low and similar to that of other benzodiazepine drugs. (wikipedia.org)
  • placebo
  • A 2014 review of the probability of added benefit of perampanel to the standard of care was unable to come to any conclusions, as no trial conducted by Eisai compared perampanel to a drug within the standard of care, but only to placebo. (wikipedia.org)
  • potent
  • Mice, dogs, and monkeys, have been used in tests which showed the drug was almost equivalently potent to morphine, and had a very steep dose response curve. (wikipedia.org)
  • AB-FUBINACA is a drug that acts as a potent agonist for the cannabinoid receptors, with Ki values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. (wikipedia.org)
  • opioid
  • AH-7921 is an opioid analgesic drug selective for the µ-opioid receptor, having around 80% the potency of morphine when administered orally. (wikipedia.org)
  • In 2009 and 2010, hydrocodone was the second-most frequently encountered opioid pharmaceutical in drug evidence submitted to U.S. federal, state, and local forensic laboratories as reported by DEA's National Forensic Laboratory Information System (NFLIS) and System to Retrieve Information from Drug Evidence (STRIDE). (wikipedia.org)
  • Dizziness
  • Other serious side effects include suicidal thoughts or behavior (like all anti-epileptic drugs), dizziness and gait disturbance, somnolence and fatigue, risk of falls, and increased risk of seizures if the drug is quickly withdrawn. (wikipedia.org)
  • behavior
  • Compared to the large number of prescriptions, relatively few individuals increase their dose on their own initiative or engage in drug-seeking behavior. (wikipedia.org)
  • selective
  • It was the first antiepileptic drug in the class of selective non-competitive antagonist of AMPA receptors. (wikipedia.org)
  • chronic
  • The investigators will monitor the safety and efficacy of carvedilol administration in children with chronic CHF due to systemic ventricular dysfunction. (clinicaltrials.gov)
  • Chronic administration of diazepam, another benzodiazepine, to nursing mothers has been reported to cause their infants to become lethargic and to lose weight. (wikipedia.org)
  • Scheduling
  • Until 30 June 2010, scheduling decisions were made by the National Drugs and Poisons Schedule Committee (NDPSC), an independent expert committee established under now repealed provisions of the Therapeutic Goods Act 1989 (the Act). (tga.gov.au)
  • Important notice regarding matters for consideration at the June 2010 meeting of the National Drugs and Poisons Scheduling Committee. (tga.gov.au)
  • In another case, a 22 year old woman was found dead with a femoral blood to AH-7921 concentration of 450μg/L. AH-7921 was made a Prohibited Substance (Schedule 9 of the Standard for the Uniform Scheduling of Medicines and Poisons) in Australia in May 2014. (wikipedia.org)
  • As of October 29, 2014 Louisiana placed ADB-CHMINACA into Schedule I by emergency scheduling. (wikipedia.org)
  • curve
  • Heroin also produced thermal antinociception (ED 5°C = 0.18 mg/kg) and maintained drug self-administration under both a fixed ratio schedule [dose-effect curve peak at 0.0032 mg/kg/injection (inj)] and under a food versus heroin concurrent-choice schedule (ED 50 = 0.013 mg/kg/inj), whereas SNC80 did not produce thermal antinociception or maintain self-administration. (aspetjournals.org)
  • citation needed] Critically, a steep dose-response curve makes recreational use of propofol very dangerous, and deaths from self-administration continue to be reported. (wikipedia.org)
  • side effects
  • Viral load (amount of HIV in the blood) and drug side effects will be measured. (clinicaltrials.gov)
  • Inhibitors of the hepatic enzyme CYP3A4 may also increase the risk, severity, and duration of side effects, many drugs inhibit this enzyme as do some foods such as grapefruit and the blood orange. (wikipedia.org)
  • self-administration
  • The present study compared interactions between the δ agonist SNC80 [(+)-4-[(α R )-α-((2 S ,5 R )-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N , N -diethylbenzamide] and the μ agonist heroin in assays of schedule-controlled responding, thermal nociception, and drug self-administration. (aspetjournals.org)
  • In Arm C, drugs are taken once a day under directly observed therapy during Weeks 0-24, and then by self-administration during Weeks 25-48. (clinicaltrials.gov)
  • Recreational use of the drug via self-administration has been reported, but is relatively rare due to its potency and the level of monitoring required for safe use. (wikipedia.org)
  • include
  • Many United States insurance companies do not include Motofen as one of their formulary drugs, causing consumers to pay the highest copay, if it is covered by their health insurance at all. (wikipedia.org)
  • Studies
  • Intensive pharmacokinetic (PK) studies was done at Weeks 2 and 12 to determine if dose adjustments were required for any of the drugs. (clinicaltrials.gov)
  • complete
  • Both SNC80 (ED 50 = 0.43 mg/kg) and heroin (ED 50 = 0.088 mg/kg) produced a dose-dependent and complete suppression of response rates in the assay of schedule-controlled responding. (aspetjournals.org)
  • found
  • A comprehensive article about the subgroup of anti-diarrhoeal drugs including Motofen can be found as the article Diphenoxylate. (wikipedia.org)