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GastricForms of leishmaniasisNasalAbsorptionVisceralIntranasal administrationNonsteroidal anti-TissuesLesionsFormulationsDosageSymptomsRashUlcersImmunologyDiseasesSystemic administrationToxicityNSAIDsProtectiveSublingual administrationOral administrationMedicationsNicotineMouthCoadministrationRespiratoryAntiretroviralBarrierAvoid or Use Alternate DrugIncidenceEruptionsOrphan drugClinical trialsChronicInjectionBenzodiazepinesSymptomResponsesExposureCaspofunginImmunosuppressiveSurgicalIncludeTreatmentTherapyTabletsAspirinCANCIDASSteroidsBlood
Gastric9
  • 3. Both doses of aspirin significantly inhibited gastric mucosal synthesis of prostaglandin E2 and reduced the serum thromboxane concentration. (nih.gov)
  • 4. Aspirin significantly increased bleeding induced by mucosal biopsy and was associated with significant enhancements in the rate of bleeding per gastric erosion. (nih.gov)
  • Objective -To determine the effects of dobutamine, norepinephrine, and vasopressin on cardiovascular function and gastric mucosal perfusion in anesthetized foals during isoflurane-induced hypotension. (avma.org)
  • Gastric mucosal perfusion was measured by tonometry at the same time points. (avma.org)
  • GastricSoothe™ utilizes a compound of zinc and l-carnosine that soothes and protects the gastric mucosal lining. (picknsave.com)
  • These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease. (uzh.ch)
  • The gastro-toxicity of non-steroidal anti-inflammatory drugs (NSAIDs), often leading to gastric ulceration and delayed healing, remains a crucial problem, despite recent pharmaceutical advances. (rsc.org)
  • The cytoprotective action of the green tea- catechins against ethanol - or restraint plus water -immersion stress-induced acute gastric mucosal injury, and acetic acid-induced chronic gastric ulcers in rats has been reported. (rsc.org)
  • The prophylactic action of the tea seed-derived triterpene saponins against ethanol -induced gastric mucosal lesions, 6,7 and of BT extract against various ulcerogens 8,9 have been reported in rat models. (rsc.org)
Forms of leishmaniasis1
  • This includes the three forms of leishmaniasis: cutaneous, visceral and mucosal. (wikipedia.org)
Nasal6
  • After nasal dosing, drug input was substantial even during the first minute and showed two peaks at 10 min and 45 min after ingestion. (erowid.org)
  • Since the second peak after nasal dosing closely resembled drug input after oral administration, we hypothesized that, after nasal administration, a part of the dose is swallowed and thereafter absorbed gastrointestinally. (erowid.org)
  • The data from the sessions with nasal cocaine administration were reanalyzed assuming the same shape for gastrointestinal drug input as after oral dosing. (erowid.org)
  • Monitor for nasal mucosal changes. (empr.com)
  • S. Gizurarson: The relevance of nasal physiology to the design of drug absorption studies. (hi.is)
  • Aggregated AgNP were not associated with microscopic changes in other tissues except for nasal mucosal erosions. (cdc.gov)
Absorption2
  • The advantage of this approach is that absorption through the oromucosal lining can improve the bioavailability of drugs that have a high first-pass metabolism in the gastrointestinal tract. (pmlive.com)
  • Other advantages include rapid absorption and onset of action, and these characteristics have made oromucosal delivery a popular route of administration for medicines such as painkillers, nausea treatments and drugs for acute symptoms such as angina (see table). (pmlive.com)
Visceral1
  • Manifestations include cutaneous, mucosal, and visceral syndromes. (msdmanuals.com)
Intranasal administration4
  • All could be expeditiously tested with inhalational or intranasal administration in H5N1 models with mice, ferrets, pigs, and monkeys. (cdc.gov)
  • In mice, intranasal administration of IFN-α and IFN-γ prevents lethal vaccinia infection ( 3 ). (cdc.gov)
  • EVs-ACE2 can inhibit the an infection of S-pseudovirus in varied cells, and importantly, the mice handled with intranasal administration of EVs-ACE2 can suppress the entry of S-pseudovirus into the mucosal epithelium. (aidstar-one.com)
  • Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells. (mdbioproducts.com)
Nonsteroidal anti-3
  • The debate over nonsteroidal anti-inflammatory drugs (NSAIDs) and the level of gastrointestinal (GI) side effects is not new, but has recently been intensified by the finding that horses with small intestinal strangulating obstruction treated with flunixin meglumine have delayed recovery of mucosal integrity. (ivis.org)
  • Mefenamic acid, like all nonsteroidal anti-inflammatory drugs (NSAIDs), may exacerbate hypertension and congestive heart failure and may cause an increased risk of serious cardiovascular thromboembolism, myocardial infarction, and stroke, which can be fatal. (pdr.net)
  • Among them, the nonsteroidal anti-inflammatory drugs (NSAIDs) are probably the most studied medications, showing effective outcomes in controllingperiodontal breakdown in pre-clinical experiments when systemically administered 3-5 . (bvsalud.org)
Tissues2
  • Eosinophils are most numerous in tissues with a mucosal epithelial interface with the environment, such as the respiratory, gastrointestinal, and lower genitourinary tracts. (merckmanuals.com)
  • Mucosal leishmaniasis affects nasopharyngeal tissues and can cause gross mutilation of the nose and palate. (msdmanuals.com)
Lesions3
  • Prognosis regarding the clinical behavior of the mucosal lesions has been extrapolated from knowledge of the cutaneous lesions. (medscape.com)
  • The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive, and ultimately ulcerative lesions. (uzh.ch)
  • Mucosal involvement occurs in approximately 40% of cases, including genital, perianal, and oropharyngeal lesions ( 5 ). (cdc.gov)
Formulations5
  • There has been fantastic in vitro work for several decades on muco-adhesive formulations for oral drug delivery, but in vivo results have generally been disappointing," according to Khutoryanskiy, who noted that, in earlier cases, the muco-adhesive properties have meant that the tablet is retained in the stomach rather than the lower intestine. (pmlive.com)
  • Despite setbacks, work still goes on, spurred by the promise of being able to develop orally bio-available formulations of biologic drugs that are currently delivered via injection. (pmlive.com)
  • More than 25 protocols were performed in rabbits to: i) screen all the Ags in Parenteral studies, ii) evaluate optimal route of administration and formulations in Mucosal studies. (europa.eu)
  • Long-term stabilization of aqueous doxycycline formulations, in mucoadhesive hydrogels for treatment of oral mucosal conditions. (hi.is)
  • The present study demonstrated that systemic administration of both formulations of Cordia verbenacea may attenuate the progression of ligatureinduced periodontitis. (bvsalud.org)
Dosage2
  • Current efforts are focused on the design of materials with improved performance, and the development and validation of new physical techniques to study muco-adhesion and formulation of new dosage forms for mucosal administration. (pmlive.com)
  • Titrate dosage during the initial week of treatment to reduce the incidence of drug-related nausea. (drugs.com)
Symptoms2
  • BACKGROUND: Proton pump inhibitors (PPIs) are currently the reference drugs for gastroesophageal reflux disease (GERD), but symptoms often recur after their withdrawal. (bvsalud.org)
  • Symptoms and signs of mucosal leishmaniasis typically develop months to years after the appearance of the skin lesion. (msdmanuals.com)
Rash1
  • Acyclovir is a drug that is now given to some people within the first day after rash onset to make the signs of chickenpox milder. (ehd.org)
Ulcers1
  • In contrast to guidelines that have been established in people for the optimal treatment of gastroduodenal ulcers and gastroesophageal reflux disease, effective clinical dosages of antisecretory drugs have not been well established in the dog and cat to date. (uzh.ch)
Immunology1
Diseases1
  • When high doses of methotrexate are administered to treat various malignancies or autoimmune diseases, it can inadvertently affect rapidly dividing normal cells, causing bone marrow suppression and mucosal toxicity. (onlinepaperexperts.com)
Systemic administration2
  • We have previously published findings in the anaesthetised in vivo pig, that cisapride and mebeverine when infused IL into the sigmoid colon resulted in a pharmacological dose dependent responses, which was more efficacious and localised than systemic administration of these drugs. (annals.edu.sg)
  • Owing to the excellent efficacy of systemic administration of corticosteroids, most patients achieve remission even if they required second-line treatment. (hindawi.com)
Toxicity2
  • Collectively, our in vivo results demonstrating 4'-ethynyl-2-fluoro-2'-deoxyadenosine's excellent efficacy in preventing both vaginal and oral HIV transmission together with its relatively low toxicity and high potency against drug-resistant HIV strains support 4'-ethynyl-2-fluoro-2'-deoxyadenosine as a potential PrEP agent for use in women and infants, two of the most vulnerable populations at risk for acquiring HIV. (natap.org)
  • Which drug is commonly given as a "rescue" medication to prevent bone marrow suppression and mucosal toxicity from high-dose methotrexate? (onlinepaperexperts.com)
NSAIDs3
  • NSAIDs and GI mucosal integrity: what holds up? (ivis.org)
  • Although this would seem to be a logical extension of what we already know about NSAIDs and GI function, it has taken the equine community somewhat by surprise because of the wellknown association between colic and administration of flunixin meglumine. (ivis.org)
  • However, now that we have a preferential COX-2 inhibitor (meloxicam) and a selective COX-2 inhibitor (firocoxib) available on the market, a full appraisal of NSAIDs in horses should include all classes of these drugs. (ivis.org)
Protective1
  • CONCLUSION: Using PPIs and mucosal protective drugs resulted in significant symptom alleviation. (bvsalud.org)
Sublingual administration3
  • An opioid withdrawal syndrome is likely to occur with parenteral misuse of buprenorphine sublingual tablets by individuals physically dependent on full opioid agonists, or by sublingual administration before the agonist effects of other opioids have subsided. (nih.gov)
  • Sublingual administration involves placing a drug under your tongue to dissolve and absorb into your blood through the tissue there. (drjack.world)
  • Sublingual Administration is a way of giving medication through the mouth. (drjack.world)
Oral administration1
  • Collectively, these data show that oral administration of 4'-ethynyl-2-fluoro-2'-deoxyadenosine protects BLT mice from HIV infection following multiple high-dose vaginal HIV challenges (P = 0.0002) (Figure 2h). (natap.org)
Medications3
  • The National Institutes of Health and Department of Defense have funded developing novel biodefense medications designed to stimulate innate mucosal immunity by using interferons (IFNs) and interferon inducers. (cdc.gov)
  • Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. (medscape.com)
  • Avoid or substitute another drug for these medications when possible. (medscape.com)
Nicotine1
  • Reduction in nicotine intake and oral mucosal modifications amongst 38 users of Swedish oral moist snuff after switching to a low-nicotine product. (ehd.org)
Mouth1
  • 3d Animation - Sublingual way and buccal medication administration are two different ways of giving medication by mouth. (drjack.world)
Coadministration1
  • No identified drug interactions would preclude coadministration of tecovirimat with antiretroviral therapy (ART) for HIV infection. (cdc.gov)
Respiratory1
  • Others drugs are being tested for aerosolized delivery to modulate mucosal immunity of the respiratory tract. (cdc.gov)
Antiretroviral2
  • Other specific initiatives were conducted such as evaluation of the sublingual route for immunization, investigation of the Principal Immunodominant Domain (PID) of gp41, and direct HIV inhibition with an Ag family which demonstrated in vitro antiviral activities comparable to the antiretroviral drug T20 (Fuzeon). (europa.eu)
  • Prophylactic regimens against opportunistic pathogens and more potent antiretroviral drugs appear to be important factors influencing this decline in incidence. (cdc.gov)
Barrier1
  • Moreover, whether prokinetics or barrier drugs used alongside PPIs are more effective remains under debate. (bvsalud.org)
Avoid or Use Alternate Drug1
Incidence2
  • The cause of oral melanoma or melanoma of any mucosal surface remains unknown, and the incidence has remained stable for more than 25 years. (medscape.com)
  • The surveillance data also indicate that the incidence of some opportunistic infections is not decreasing among either men who have sex with men or injecting-drug users, indicating that preventive strategies need to be developed and applied to a wider spectrum of opportunistic infections. (cdc.gov)
Eruptions1
  • Sulfonamide antibiotic-associated drug eruptions occur in 1.5-3% of patients in the general population and in up to 30% of patients infected with HIV . (dermnetnz.org)
Orphan drug2
  • It has orphan drug status in the United States for acanthamoeba keratitis and primary amebic meningoencephalitis (PAM). (wikipedia.org)
  • NOTE: Bexarotene has been designated an orphan drug by the FDA for this indication. (pdr.net)
Clinical trials1
  • These drugs have either been approved by the Food and Drug Administration (FDA) (Aldara), are in clinical trials (Alferon LDO, inhalable IFN-γ, Resiquimod, CPG7909, and CpG10101), or at a preclinical stage of development (Ampligen). (cdc.gov)
Chronic2
  • The pressor response to adrenaline and noradrenaline (1 and 2 'g/kg) was reduced by chronic administration of Abana in these hypertensive animals. (ijp-online.com)
  • The vascular reactivity to noradrenaline in isolated aortic strip and portal vein was also reduced by the chronic administration of Abana in the hypertensive rats. (ijp-online.com)
Injection1
  • Conventional IFN administration by injection often results in low concentrations at target sites and high concentrations in circulation, which may cause serious side effects. (cdc.gov)
Benzodiazepines1
  • Warn patients of the potential danger of self-administration of benzodiazepines or other CNS depressants while under treatment with buprenorphine sublingual tablets ( 5.2 , 5.3 ). (nih.gov)
Symptom1
  • Mild reactions may simply require cessation of the drug and antihistamines for symptom relief. (dermnetnz.org)
Responses2
  • The vaccine was safe and well tolerated, induced potent serum IgG & IgA responses waning post last vaccination, and low and intermittent mucosal IgG, but did not induce neutralizing activity neither in serum nor vaginal samples. (europa.eu)
  • Bavarian Nordic has also previously reported strong results from a Phase II trial of MVA-BN RSV in 421 older adults, demonstrating that the vaccine was well-tolerated and induced both broad and durable antibody and T-cell responses against RSV, as well as mucosal immune responses that may be important for protection against RSV. (prnewswire.com)
Exposure1
  • In contrast to cutaneous melanomas, which are etiologically linked to sun exposure, risk factors for mucosal melanomas are unknown. (medscape.com)
Caspofungin1
  • Our Cancidas (caspofungin acetate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Immunosuppressive1
  • 3) exclusion of individuals undergoing radiotherapy or administration of the following types of drugs: anti-inflammatory, immunosuppressive, cytotoxic, or psychotropic agents or antibiotics. (medscape.com)
Surgical3
  • Surgical antibiotic prophylaxis (SAP) refers to the administration of antibiotics prior to clean and clean-contaminated surgeries to prevent postoperative surgical site infections (SSIs). (annals.edu.sg)
  • In the U.S., surgical masks are cleared for marketing by the U.S. Food and Drug Administration (FDA). (cdc.gov)
  • This can interfere with drugs used during and after surgical procedures and cause severe side effects. (medlineplus.gov)
Include1
  • ERLEADA ® remains the only ARI with labeling to include approved alternate methods of administration for patients who have difficulty swallowing tablets whole. (jnj.com)
Treatment6
  • This drug is now listed as a core medication for the treatment of leishmaniasis under the WHO Model List of Essential Medicines. (wikipedia.org)
  • Other drugs such as thiopurines are used for maintaining remission when the remission was achieved with calcineurin inhibitors because of the absence of long-term treatment data. (hindawi.com)
  • USPHS guideline for the treatment of tobacco use and dependence recommends varenicline as one of several first-line drugs that may reliably increase long-term smoking abstinence rates. (drugs.com)
  • The timing and dosing of Leucovorin administration depend on factors such as the specific methotrexate regimen, individual patient characteristics, and the indication for treatment. (onlinepaperexperts.com)
  • However, the administration of prokinetics caused higher dropouts due to treatment failure. (bvsalud.org)
  • Treatment of monkeypox with tecovirimat as a first-line agent is available through CDC for compassionate use through an investigational drug protocol. (cdc.gov)
Therapy1
  • Hence, we suggest that anti-H5N1 prophylaxis by IFN-stimulated innate mucosal immunity is a promising therapy worth immediate investigation in animal models. (cdc.gov)
Tablets1
  • The tablets that are supposed to stick somewhere in our GI tract simply don't, so this is still a theoretical concept for drug delivery," he said. (pmlive.com)
Aspirin4
  • 1. An increasing body of data suggests that the antihaemostatic as well as the ulcerogenic actions of aspirin and other non-steroidal anti-inflammatory drugs may be operative when patients present with haematemesis and melaena. (nih.gov)
  • The presence of erosions was associated with enhanced spontaneous bleeding, but only during aspirin administration. (nih.gov)
  • Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow. (greenmedinfo.com)
  • To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow, and the effect of rebamipide. (greenmedinfo.com)
CANCIDAS1
  • What Drugs, Substances, or Supplements Interact with Cancidas? (rxlist.com)
Steroids1
  • More severe reactions may require topical or oral steroids and hospital admission for drug hypersensitivity syndrome or rare and serious reactions such as SJS-TEN ). (dermnetnz.org)
Blood2
  • Procedures -Foals were anesthetized and instrumented to measure direct blood pressure, heart rate, arterial blood gases, end-tidal isoflurane and carbon dioxide concentrations, and CO. Various COs were achieved by administration of dobutamine, norepinephrine, vasopressin, phenylephrine, and isoflurane to allow comparisons between LiDCO and NICO methods. (avma.org)
  • Therefore, IN administration of AgNP permits systemic distribution, produces reversible oxidative stress in the nose and in blood, and mildly enhances macrophage-mediated erythrocyte destruction in the spleen. (cdc.gov)