• A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. (harvard.edu)
  • A recently published method uses in situ Hi-C followed by chromatin immunoprecipitation (HiChIP) to enrich the overall yield of significant genome-wide interactions mediated by a specific protein. (springer.com)
  • Genome-wide analysis of SR-dependent splicing by RNA-seq, reveals that SR proteins are required for the regulation of many types of alternative splicing events, and can act as positive or negative regulators of splice site choice depending on their binding location on the target RNA. (ku.edu)
  • MP43 was subsequently discovered to be one of the two human homologs of Aspergillus nidulans NudE, a protein that is important for the even distribution of nuclei along the hyphae ( Efimov and Morris, 2000 ). (biologists.org)
  • IN early Drosophila oogenesis, a series of highly controlled divisions initiate the developmental pathway that leads to the formation of an oocyte ( S pradling 1993 ). (genetics.org)
  • However, in the absence of NudE, the `shedding' of proteins off the kinetochore is abrogated and the SAC cannot be turned off, implying that NudE regulates dynein function at the kinetochore. (biologists.org)
  • Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling. (wikipedia.org)
  • Pre-mRNA splicing is typically regulated by RNA-binding proteins that recognize cis-acting RNA elements, and either activate or repress splicing of adjacent exons in a temporal, and tissue specific, manner. (ku.edu)
  • Here, we present a comprehensive study to elucidate how the SR proteins coordinate to regulate alternative pre-mRNA splicing (AS) in Drosophila. (ku.edu)
  • Interestingly, lem-d double mutants displayed distinct developmental and cellular mutant phenotypes, suggesting that Drosophila LEM-D proteins have developmental functions that are differentially shared with other LEM-D family members. (genetics.org)
  • This conclusion is supported by studies showing that ectopically produced LEM-D proteins have distinct capacities to rescue the tissue-specific phenotypes found in single lem-d mutants. (genetics.org)
  • Localisation of PAK proteins to distinct cellular compartments appears to be an important mechanism to control their function in the reorganisation of the cytoskeleton. (biologists.org)
  • We find that SR proteins bind a distinct, but functionally diverse, class of RNAs that includes mRNAs, both constitutive and alternatively spliced, as well as non-coding RNAs. (ku.edu)
  • The sequence similarity with importin indicates that Pendulin may play a role in the nuclear import of karyophilic proteins and some of these may be required for the normal transmission and function of proliferative signals in the cells. (rupress.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • This region of the protein is highly conserved throughout the ADARs and sequence comparisons with human ADAR2 at the DNA level show it has the potential to be edited at the same site as dADAR. (bl.uk)
  • a third PAK protein (D-PAK3) is predicted from the genome sequence. (biologists.org)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Universal protein resource accession number O94910 at UniProt. (wikipedia.org)
  • Similar observations have been made in Drosophila suggesting that the cellular mechanisms underlying human glutamine-repeat diseases are conserved in invertebrates [ 4 ]. (hindawi.com)
  • From a therapeutic view point, Drosophila provides a unique system in which to search for novel genetic factors that suppress cellular toxicity. (hindawi.com)
  • This comprehensive analysis reveals position-dependent RNA splicing maps, in vivo consensus binding motifs, and a high level of cross- and coordinated regulation of alternative splicing by the SR protein family. (ku.edu)
  • The mutant phenotype of mbt is characterised by fewer neurones in the brain and the eye, indicating a role of the protein in cell proliferation, differentiation or survival. (biologists.org)
  • The coupling of DNA replication to mitosis is absent in Drosophila endoreplication cycles (endocycles), during which discrete rounds of chromosome duplication occur without intervening mitoses. (rupress.org)
  • In endocycles of Drosophila salivary gland cells, successive S phases take place in the absence of mitosis. (rupress.org)
  • Together, these findings emphasize that LEM-D proteins have the capacity to make diverse contributions to many nuclear processes, ranging from transcriptional regulation to maintenance of genome stability. (genetics.org)
  • The SR proteins are a well-conserved class of RNA-binding proteins that have an essential role in the regulation of splice site selection, and have also been implicated as key regulators during other stages of RNA metabolism. (ku.edu)
  • In addition, a vast majority of regulated targets require multiple SR protein members for regulation. (ku.edu)
  • Proteins containing coiled-coil domains have many functions and have been identified in all cell compartments. (genetics.org)
  • OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila. (nih.gov)
  • The position and nature of these unusual ord mutations demonstrate that the C-terminal half of ORD is essential for sister chromatid cohesion and suggest that it mediates protein binding. (nih.gov)
  • The α B-crystallin protein is found to be overexpressed in many neurological diseases, and mutations in α A- or α B-crystallin can cause cataracts and myopathy [ 11 ]. (hindawi.com)
  • Although the mechanisms underlying oocyte determination are unclear, the initial establishment of oocyte identity is dependent on the accumulation of oocyte-specific transcripts and proteins. (genetics.org)
  • Identification of ORD, a Drosophila protein essential for sister chromatid cohesion. (nih.gov)
  • section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)
  • Drosophila Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate. (uniprot.org)
  • These observations all suggest that NudE proteins might also be part of the dynein-related machinery at the kinetochore. (biologists.org)
  • One group of proteins that represent important physiological regulators of both EGFR and JAK/STAT signalling is the members of the SOCS family. (whiterose.ac.uk)
  • NPFs have been divided into two types: the WASP/N-WASP and the SCAR/WAVE family of proteins comprise type I NPFs, while Cortactin and the closely related hematopoetic-specific protein-1 (HS1) comprise type II NPFs ( Goley and Welch, 2006 ). (biologists.org)
  • LEM domain (LAP2, emerin, MAN1 domain, LEM-D) proteins represent one family of lamin interacting proteins. (genetics.org)
  • The complexity of the RNA targets, and specificity of RNA binding location remains poorly understood for many members of the SR protein family. (ku.edu)
  • Using single-nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP), we define the specific RNA-binding maps of the entire family of SR proteins in the transcriptome of Drosophila S2 cells. (ku.edu)
  • This graph shows the total number of publications written about "Drosophila Proteins" by people in Harvard Catalyst Profiles by year, and whether "Drosophila Proteins" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Drosophila Proteins" by people in Profiles. (harvard.edu)
  • 1 It has been suggested that the protein modification mechanisms might have wider functional implications and might form the basis for an understanding of complex phenomena such as information storage and retrieval. (springer.com)