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  • shape
  • We have used the Drosophila wing epithelium to demonstrate that cell-ECM interactions mediated by integrins also regulate the changes in cell shape that underly epithelial morphogenesis. (biologists.org)
  • The developing Drosophila wing provides an excellent system to investigate the molecular mechanisms that control the changes in cell shape associated with rearrangement of epithelial sheets during organogenesis. (biologists.org)
  • All 11 insertions were within or near protein-coding transcription units, none of which were previously known to affect wing shape. (genetics.org)
  • Genes
  • Drosophila Adf-1, a transcription factor first identified on the basis of its interaction with the alcohol dehydrogenase promoter but that binds the promoters of a diverse group of genes. (wikipedia.org)
  • All vertebrate species, including Drosophila, have only one vasa ortholog but C. elegans has four Vasa genes, but only one (GLH-1) is essential. (wikipedia.org)
  • Other post-translational modification includes phosphorylation of the Vasa ortholog in C. elegans, and arginine methylation in a conserved region of mice, Xenopus and Drosophila Vasa genes. (wikipedia.org)
  • The Drosophila hedgehog (hh) gene was identified as one of several genes important for creating the differences between the anterior and posterior parts of individual body segments. (wikipedia.org)
  • synaptic
  • 3 Greengard and coworkers have shown that phosphorylation of a set of synaptic membrane proteins, collectively known as protein I is stimulated specifically in response to cAMP and calcium. (springer.com)
  • fruit flies
  • The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. (wikipedia.org)
  • repeats
  • They form a G-protein regulator family that also contains TPR repeats. (wikipedia.org)
  • As with other Vasa related proteins, human Vasa has a N terminus rich in glycine and RGG motif repeats that function in RNA binding. (wikipedia.org)
  • phosphorylation
  • W.B. Huttner and P. Greengard, Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium, Proc. (springer.com)
  • GPCR
  • This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GPCR). (wikipedia.org)
  • found
  • For example, the residues found at the C-terminus of drosophila PIMT (dPIMT) are rotated 90 degrees so as to allow more space for a substrate to interact with the enzyme. (wikipedia.org)
  • During Drosophila research, it was found that a mutation in the gene MAD in the mother repressed the gene decapentaplegic in the embryo. (wikipedia.org)
  • It is found in a single copy in Drosophila proteins and is often associated with the MADF domain. (wikipedia.org)
  • In Drosophila, Fzo is found in postmeiotic spermatids and the dysfunction of this protein results in male sterility. (wikipedia.org)
  • The Vasa protein is found primarily in germ cells in embryos and adults, where it is involved in germ cell determination and function, as well as in multipotent stem cells, where its exact function is unknown. (wikipedia.org)
  • For example, Oskar protein was found to localize to pole plasm and may be involved in anchoring Vasa to polar granules in the posterior pole of the oocyte. (wikipedia.org)
  • residues
  • Dual-specificity protein phosphatases remove phosphate groups from phosphorylated tyrosine and serine / threonine residues. (wikipedia.org)
  • human
  • However, given their location close to regulatory elements, it is possible that they are involved in gene regulation, which suggests that common variance in brain structure could be associated with differences in gene regulation rather than protein structure, consistent with findings in other complex human traits. (wikipedia.org)
  • The enzyme is present in human cytosol in two forms due to alternative splicing and differs among individuals in the population due to a single polymorphism at protein 119, either valine or isoleucine. (wikipedia.org)
  • The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. (wikipedia.org)
  • Human proteins containing this domain include: GPSM1, GPSM2, GPSM3 PCP2 RAP1GAP. (wikipedia.org)