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  • axons
  • We demonstrate that Dscam mediates the sorting of axons in the developing mushroom body (MB). (nih.gov)
  • Using mosaic analysis with a repressible cell marker (Lee, T. and Luo, L. (1999) Neuron 22, 451-461), we have positively marked the axons and dendrites of multicellular and single-cell mushroom body clones at specific developmental stages. (biologists.org)
  • In the Drosophila embryonic ventral nerve cord, many axons still cross the midline in the absence of the Netrin genes or their receptor frazzled . (biologists.org)
  • Here we show that mutation of mushroom body defect ( mud ) dramatically enhances the phenotype of Netrin or frazzled mutants, resulting in many more axons failing to cross the midline, though mutations in mud alone have little effect. (biologists.org)
  • proteins
  • The Drosophila homolog of human DSCAM has been isolated in a screen for tyrosine-phosphorylated proteins interacting with Dock, an intracellular adaptor protein homologous to mammalian Nck ( 17 ). (pnas.org)
  • Dscam
  • Recent studies indicate that DSCAM plays an important role in neurite arborization, cell body spacing, and lamina-specific synaptic targeting in vertebrate retina ( , 25 , , 26 ). (pnas.org)
  • brain
  • The mushroom bodies (MBs) are prominent structures in the Drosophila brain that are essential for olfactory learning and memory. (biologists.org)
  • 1995 ) Structural plasticity in the Drosophila brain. (biologists.org)
  • However, to fully elucidate the neural circuitry of complex behavior, it is crucial to understand brain interactions with the whole body, which can be achieved only by mapping the whole-body connectome. (jneurosci.org)
  • the brain cannot function in isolation from interactions with the external environment and other internal body parts. (jneurosci.org)
  • Here, we review the current technologies available for mapping the brain connectome and discuss the challenges associated with mapping whole-body connectomes. (jneurosci.org)
  • It was further suggested that deep sleep in foragers (determined as periods lacking antennal movements) is correlated with rhythmic electrophysiological activity in the brain, including the mushroom bodies ( Schuppe, 1995 ). (biologists.org)
  • Memory
  • We identified 10 genes that enhance or decrease memory when knocked-down in the mushroom body. (genetics.org)
  • Our observation that Drosophila flies double their sucrose intake at an early stage of long-term memory formation initiated the investigation of how energy metabolism intervenes in this process. (espci.fr)
  • Strikingly, upregulation of mushroom body energy flux is both necessary and sufficient to drive long-term memory formation. (espci.fr)
  • Hence, dopamine signalling mediates an energy switch in the mushroom body that controls long-term memory encoding. (espci.fr)
  • Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. (princeton.edu)
  • Pavlovian olfactory learning in Drosophila produces two genetically distinct forms of intermediate-term memories: anesthesia-sensitive memory, which requires the amnesiac gene, and anesthesia-resistant memory (ARM), which requires the radish gene. (cshl.edu)
  • The Drosophila mushroom body is involved in learning and memory. (jneurosci.org)
  • mechanisms
  • It allows for future studies on the molecular mechanisms of mushroom body development. (biologists.org)
  • In this review, we discuss how intrinsic, extrinsic, and stochastic mechanisms contribute to wiring specificity within lineages in both Drosophila and mouse nervous systems, using findings from six relatively well-studied systems and dividing these findings into intrinsic and extrinsic/stochastic sections based on our current understanding. (springer.com)
  • Cell
  • Also, their cell bodies are randomly distributed or pulled into clumps rather than being regularly spaced mosaics. (nature.com)