• Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, D. melanogaster continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. (wikipedia.org)
  • D. melanogaster is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. (wikipedia.org)
  • In FlyBase (the Drosophila genetics database) we have therefore developed a pipeline to obtain such summaries from researchers who have worked extensively on each gene. (stanford.edu)
  • Her lab at UAB utilizes a classical genetics model system, the fruit fly Drosophila melanogaster , to study various open questions in the area of epigenetics and chromatin. (uab.edu)
  • We are using molecular genetics and genomics approaches to understand the relationship between HP1a, HP1B, and HP1C, and their effect on gene regulation. (uab.edu)
  • Taking advantage of the genetics resources available in Drosophila, our experiments are designed to determine the relative importance of genetics and epigenetics in generating the variability in exercise response. (uab.edu)
  • My main interest is in the evolutionary genetics of sex differences, especially sexually antagonistic genetic variation-in other words, when the same gene has opposite effects on the fitness of males and females. (lu.se)
  • Here, we investigated, in females of both D. melanogaster and D. nigrosparsa , the gene expression between animals uninfected and infected with w Mel, using RNA sequencing to see if the two Drosophila species respond to the infection in the same or different ways. (nature.com)
  • Significant changes shared by the fly species belong to the expression of genes involved in processes such as oxidation-reduction process, iron-ion binding, and voltage-gated potassium-channel activity. (nature.com)
  • Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. (wikipedia.org)
  • The developmental period for D. melanogaster varies with temperature, as with many ectothermic species. (wikipedia.org)
  • Here, we report 25 newly sequenced genomes from museum specimens of the model organism Drosophila melanogaster , including the oldest extant specimens of this species. (biorxiv.org)
  • By comparing historical samples ranging from the early 1800s to 1933 against modern day genomes, we document evolution across thousands of generations, including time periods that encompass the species' initial occupation of northern Europe and an era of rapidly increasing human activity. (biorxiv.org)
  • 2013). Drosophila americana as a model species for comparative studies on the molecular basis of phenotypic variation . (up.pt)
  • 2011). A comparative study of the short term cold resistance response in distantly related Drosophila species: The role of regucalcin and Frost . (up.pt)
  • Performance of phylogenetic foot-printing depends on the evolutionary distance between given species and on the conservation level of individual genes. (biomedcentral.com)
  • We are a hybrid computational and experimental lab who couple genome-scale computational and experimental analysis of gene regulation in Drosophila melanogaster and Saccharomyces cerevisiae with extensive analysis of comparative sequence data and experimental analysis of species closely related to these model systems. (berkeley.edu)
  • My lab is applying the high-resolution fluorescent imaging methods developed for D. melanogaster to systematically analyze gene expression, and dissect regulatory networks, in other Drosophila species and in several inbred lines of D. melanogaster . (berkeley.edu)
  • The detailed experimental data we are generating for D. melanogaster , and the genome sequences of 12 Drosophila species are a tremendous resource for studying the evolution of gene regulation. (berkeley.edu)
  • While it is impractical to repeat every experiment done in D. melanogaster in every other strain and species, we are extending several classes of experiment to selected strains and species so that we can better understand regulatory variation at each of its multiple levels: how sequence variation affects binding, how binding variation affects expression, and how expression variation affects phenotype. (berkeley.edu)
  • Multiple strains representing four species of bacteria belonging to the genus Providencia have been isolated from wild caught Drosophila melanogaster: Providencia sneebia, Providencia burhodogranariea strain B, Providencia burhodogranariea strain D, Providencia rettgeri, and Providencia alcalifaciens. (cornell.edu)
  • I sequenced and annotated draft genomes of these four species then compared them to each other. (cornell.edu)
  • I found that about 50% of each genome belongs to the Providencia core genome and about 15% of each genome consists of genes unique to that species. (cornell.edu)
  • Four Providencia genomes of isolates originating from the human gut have also been sequenced, which include additional isolates of P. rettgeri and P. alcalifaciens as well as isolates of the species Providencia stuartii and Providencia rustigianii. (cornell.edu)
  • Although highly conserved across mammalian species, invertebrate model organisms such as Drosophila melanogaster and C. elegans lack this epigenetic mark. (qmul.ac.uk)
  • I will perform genome-wide profiling of 5mC methylation patterns at three stages (embryos, larvae and adults) of the life cycle of the annelid Owenia fusiformis, as well as in adults of two other separate species, Capitella teleta and Dimorphilus gyrociliatus. (qmul.ac.uk)
  • comparison of a query genome from one species (i.e. human) against an informant genome of another species (i.e. from mouse). (crg.eu)
  • Its binding characterizes the heterochromatic regions of the fly genome, and homologs have been identified in species ranging from yeast to humans. (uab.edu)
  • Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
  • Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. (nih.gov)
  • Therefore, to address the growing volumes of available genomic sequence, a number of algorithms that identify putative cis-regulatory modules and transcription factor binding sites using evolutionary comparisons, whole-genome data, and known descriptions of transcription factor binding sites, have been successfully developed. (biomedcentral.com)
  • Combined evidence annotation of transposable elements in genome sequences. (genscript.com)
  • The following EMC8-9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
  • Comparatively short sequences (several hundred to several thousand base pairs, depending on thespecies) upstream or downstream of the transcription start site often play a major role in the regulation of gene expression. (biomedcentral.com)
  • Using these DNA and RNA sequences, the team put together - and annotated - a 691 million base assembly that spans more than three-quarters of the fly's complete genome sequence and contains an estimated 14,810 protein-coding genes. (genomeweb.com)
  • The house fly genome contained sequences for some 771 apparent immune-related genes, for example, including 355 that are not homologous to Drosophila immune genes. (genomeweb.com)
  • With these technologies, the complete genome sequences of thousands of organisms have been determined, including those of many individual humans. (ddw-online.com)
  • For many scientists, the next step is to begin to manipulate these genome sequences for a variety of specific goals, including analysis of gene function, creating models of human disease, generating better models for drug discovery and, ultimately, human gene therapy. (ddw-online.com)
  • My lab studies how the genomic sequences that control gene expression function and evolve. (berkeley.edu)
  • We focus on short evolutionary timescales where it is possible to couple specific changes in genome sequences with alterations in gene regulation and expression. (berkeley.edu)
  • We now have extensive comparative sequence data for fruitflies (12 Drosophila genomes) and yeasts (many fungal genomes), and are using these data to characterize how the individual building blocks of regulatory sequences (transcription factor binding sites) and higher order structures (e.g. developmental enhancers) evolve. (berkeley.edu)
  • An in-house algorithm predicts and ranks expert authors for each gene based on the data within FlyBase and extracts their email addresses from papers that we have curated. (stanford.edu)
  • These clones can be integrated into predetermined attP sites in the genome using UC31 integrase to rescue mutations. (nih.gov)
  • sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)
  • This includes both identification and functional characterization of putative resistance genes and/or mutations. (ugent.be)
  • Two mutations both reduced sensitivity and destabilized the newly duplicated gene shortly after its birth 450 million years ago. (beacon-center.org)
  • A third mutation - neutral without the first two mutations - buffered the destabilization, and allowed to gene to go fixation (Carroll et al. (beacon-center.org)
  • We also found the novel mutations in these genes in azole-resistant isolates with different genetic backgrounds. (cdc.gov)
  • Furthermore, a large portion of the non- cyp51A azole-resistant A. fumigatus strains have yet to be investigated to determine which genes and mutations could be responsible for azole resistance. (cdc.gov)
  • Objective 2: Determine gene function and utilize existing genomic resources to develop gene disruption approaches for mitigating the impact of invasive ants. (usda.gov)
  • Using single cell genomic technologies, we analyze the gene expression and epigenetic profiles of various cells to understand cell heterogeneity. (ccmb.res.in)
  • Methods of this type assume that regulatory regions are highly conserved in cross-genomic comparison, and conserved segments can be extracted from evolutionary related genomes. (biomedcentral.com)
  • As they reported online today in Genome Biology , the researchers pooled genomic DNA from half a dozen female house flies, using it as a template to generate sequence reads that were then assembled into a 691 million base M. domestica genome. (genomeweb.com)
  • Gene and genome duplications are the primary source of new genes and have played a pivotal role in the evolution of genomic and organismal complexity [ 1 - 4 ]. (biomedcentral.com)
  • In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
  • However, writing such summaries is a daunting task, given the number of genes in each organism (e.g. 13,929 protein coding genes in Drosophila melanogaster). (stanford.edu)
  • I have studied sexually antagonistic genetic variation in fruit flies ( Drosophila melanogaster ) for a number of years, and have added a new study organism to my lab since I started working in Lund: the hermaphroditic flatworm Macrostomum lignano . (lu.se)
  • The importance of Drosophila as an animal model was realised by Thomas Hunt Morgan, who was awarded the 1933 Nobel Prize for physiology or medicine after demonstating that genetic information is carried on chromosomes using drosophila. (animalresearch.info)
  • Tissue specificity of cyclin B expression in D. melanogaster]. (nih.gov)
  • Different gene expression patterns, shown by tools such as quantitative PCR, microarrays, and high-throughput RNA sequencing, reveal how organisms respond to different environments. (nature.com)
  • RNA sequencing is a powerful method to study differential gene expression because it can detect a whole gene expression across particular tissues 1 . (nature.com)
  • Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
  • Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
  • Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)
  • Genes with higher network connectivity are under stronger stabilizing selection, suggesting that stabilizing selection on expression plays an important role in promoting network robustness. (nature.com)
  • Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. (oeaw.ac.at)
  • Despite having an identical genome, cells can be regulated differently via epigenetic mechanisms that result in cell specific gene expression patterns. (ccmb.res.in)
  • Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes. (ccmb.res.in)
  • The sequence data offered a peek at other fly features as well - from sex determination and sex-biased gene expression to house fly gene regulation. (genomeweb.com)
  • To provide a solid experimental foundation for our evolutionary studies, we are working with several other labs in Berkeley to systematically dissect gene expression and regulation in the early D. melanogaster embryo. (berkeley.edu)
  • Coinfections in D. melanogaster with P. sneebia and P. rettgeri, which induces greater antimicrobial peptide expression and is less virulent than P. sneebia, allowed me to conclude that P. sneebia is actively avoiding recognition by the immune response. (cornell.edu)
  • This ancestral epigenetic mechanism modulates gene expression in mammalian genomes, where DNA methylation is essential for development and cell differentiation and appears altered in many human diseases. (qmul.ac.uk)
  • Claremont, Calif. (December 13, 2013)- Associate Professor of Biology Jennifer Armstrong received a $450,000 three-year grant from the National Science Foundation (NSF) to research chromosome structure and gene expression. (pitzer.edu)
  • The grant, "RUI: Chromatin Dynamics and Transcription in Drosophila melanogaster, " will support Armstrong's ongoing research on the structure of the chromosome and gene expression. (pitzer.edu)
  • The NSF grant will allow me and my students to continue using advanced technologies and techniques, such as chromatin immunoprecipitation, to ask questions about the maintenance of chromosome structure during gene expression," Armstrong said. (pitzer.edu)
  • Epigenetic information is heritable, affects gene expression states and phenotypes, but is independent of DNA sequence. (uab.edu)
  • DNA repair pathways function less well, chromatin modifiers become misregulated, and noise in gene expression increases. (uab.edu)
  • In contrast, natural selection for increased gene expression may represent an important mechanism by which duplicate gene copies are maintained in populations [ 14 ]. (biomedcentral.com)
  • Sääf AM, Halbleib JM, Chen X, Tsan Yuen S, Yi Leung S, Nelson WJ, Brown PO "Parallels between Global Transcriptional Programs of Polarizing Caco-2 Intestinal Epithelial Cells In Vitro and Gene Expression Programs in Normal and Colon Cancer. (openwetware.org)
  • Rubins KH, Hensley LE, Wahl-Jensen V, Daddario Dicaprio KM, Young H, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW "The temporal program of peripheral blood gene expression in the response of non-human primates to Ebola hemorrhagic fever. (openwetware.org)
  • Buess M, Nuyten DS, Hastie T, Nielsen T, Pesich R, Brown PO "Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. (openwetware.org)
  • Rinn JL, Bondre C, Gladstone HB, Brown PO, Chang HY "Anatomic demarcation by positional variation in fibroblast gene expression programs. (openwetware.org)
  • Palmer C, Diehn M, Alizadeh AA, Brown PO "Cell-type specific gene expression profiles of leukocytes in human peripheral blood. (openwetware.org)
  • Sood R, Zehnder JL, Druzin ML, Brown PO "Gene expression patterns in human placenta. (openwetware.org)
  • Some of these stress-specific cis- eQTLs fall within putative binding sites of the three main ER stress response transcription factors, providing a potential mechanism by which these cis- eQTLs might be impacting gene expression under ER stress conditions through altered TF binding. (bvsalud.org)
  • Deletion of the gene resulted in azole-sensitive phenotypes ( 10 ), and an azole-resistant strain with constitutive expression of cdr1B has been isolated from a patient ( 11 ). (cdc.gov)
  • The house fly genome provides a rich resource for enabling work on innovative methods of insect control, for understanding the mechanisms of insecticide resistance, and genetic adaptation to high pathogen loads, and for exploring the basic biology of this important pest," corresponding author Jeffrey Scott, an entomology researcher at Cornell University, and his colleagues wrote. (genomeweb.com)
  • My research focuses on understanding the mechanisms establishing and regulating epigenetic information, and how epigenetic systems ultimately contribute to gene regulation, disease, and other phenotypes. (uab.edu)
  • We discuss this progress for a series of different insecticide targets, but also report a number of unsuccessful or inconclusive attempts that highlight some inherent limitations of using Drosophila to characterize resistance mechanisms identified in arthropod pests. (ugent.be)
  • Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. (genscript.com)
  • Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. (genscript.com)
  • The most renowned biological ontology, Gene Ontology (GO) is widely used for annotations of genes and gene products of different organisms. (biomedcentral.com)
  • As of August 2007, it contains approximately 23,700 terms, linked to a database of more than 16 million annotations of genes and gene products, originating from about 20 organisms. (biomedcentral.com)
  • As a Semantic Web application domain, Gene Ontology Consortium provides a RDF-XML data file http://archive.geneontology.org/full/2007-08-01/go_200708-assocdb.rdf-xml.gz . (biomedcentral.com)
  • Clustering of gene ontology terms in genomes. (lu.se)
  • By spelling out protein-coding genes in the genome and comparing the house fly sequence to that of the fruit fly, Drosophila melanogaster , the team has endeavored to unravel genetic factors coinciding with house fly features. (genomeweb.com)
  • In the fruit fly Drosophila, it has been suggested that nearly equal numbers of two subtypes of EEs (Allatostatin A: AstA and Diuretic hormone 31 : Dh31) are alternately produced from the intestinal stem cells in the posterior midgut. (bioone.org)
  • Relative to the fruit fly, the house fly genome contained far more repetitive sequence elements and copy number variants, the researchers noted, along with an especially robust representation of immune system components. (genomeweb.com)
  • Drosophila melanogaster, or fruit-fly is widely used in scientific and medical research. (animalresearch.info)
  • The project will use the genetic system of Drosophila melanogaster (the fruit fly) to understand how DNA is managed in the cell and how genes are regulated. (pitzer.edu)
  • My lab uses the fruit fly Drosophila melanogaster as a model system to investigate epigenetic systems and their influence on development and gene regulation. (uab.edu)
  • We are using the fruit fly Drosophila melanogaster as a model for exercise biology. (uab.edu)
  • Drosophila melanogaster is a holometabolous insect, so it undergoes a full metamorphosis. (wikipedia.org)
  • Analysis of the insect os-d-like gene family. (gc.ca)
  • Drosophila melanogaster flies can sense air currents with the hairs on their backs. (wikipedia.org)
  • At the genome-wide level, we find that historical flies from the same time and place show much greater evidence for relatedness than flies from modern collections, and some show evidence of inbreeding as well, potentially reflecting either much smaller local population sizes in the past or else the specific circumstances of the collections. (biorxiv.org)
  • Consistent with their role as scent-based waste scavengers, the house flies had higher-than-usual representation by chemoreceptor and odorant-related genes in their genome, authors of the study noted. (genomeweb.com)
  • Mutant flies with defects in any of several thousand genes are available, and the entire genome has recently been sequenced. (animalresearch.info)
  • We are driven by a desire to understand the molecular basis of organismal diversity, and the belief that many differences in physiology, morphology and behavior arise from changes in gene regulation. (berkeley.edu)
  • Fluorescent reporter proteins in the Drosophila model system offer a degree of specificity that allows monitoring cellular and biochemical phenomena in vivo, such as autophagy, mitophagy, and changes in the redox state of cells. (intechopen.com)
  • Based on this domain structure, four additional HP1 family proteins have been identified in Drosophila melanogaster. (uab.edu)
  • Sub-objective 2B: Functionally characterize specific candidate genes targeted for disruption. (usda.gov)
  • My lab is interested in understanding how the variation in genomes of Indians predisposes them to disparities in health and disease. (ccmb.res.in)
  • As part of large nation-wide population genomics programs, we map the natural variation in healthy genomes. (ccmb.res.in)
  • Gene copy-number variation (CNVs), which provides the raw material for the evolution of novel genes, is widespread in natural populations. (biomedcentral.com)
  • Sexually antagonistic genes and traits are interesting because they may hold the key to one of the long-standing paradoxes in evolutionary biology: the maintenance of standing genetic variation. (lu.se)
  • We also discuss an experimental framework that may circumvent current limitations while retaining the genetic versatility and robustness that Drosophila has to offer. (ugent.be)
  • Several lines of evidence suggest that these changes were adaptive: (i) copy-number changes reached high frequency or were fixed in a short time, (ii) many independent populations harbored CNVs spanning the same genes, and (iii) larger average size of CNVs in adapting populations relative to spontaneous CNVs. (biomedcentral.com)
  • We show that gene copy-number changes are a common class of adaptive genetic change. (biomedcentral.com)
  • The rates of spontaneous gene duplication and deletion are extraordinarily high and speak to the enormous potential of these structural variants for generating new adaptive variability [ 5 - 10 ]. (biomedcentral.com)
  • Altogether, my PhD will facilitate a further understanding of the evolution and role of a major epigenetic mechanism in animal genomes. (qmul.ac.uk)
  • These epigenetic systems play vital roles in gene regulation, and defects in epigenetic regulation have been implicated in a variety of human diseases including cancer. (uab.edu)
  • 2013). Patterns of evolution at the gametophytic self-incompatibility Sorbus aucuparia (Pyrinae) S pollen genes support the non-self recognition by multiple factors model . (up.pt)
  • This work establishes D. melanogaster-Providencia as a model system for the study of host-pathogen interactions. (cornell.edu)
  • The Drosophila genome is used as a model for studies of the human genome, helping scientists design genetic experiments that increase their understanding of aging, neurodegenerative diseases and cancer. (pitzer.edu)
  • Together with our colleges in IISAGE, we investigate this question using Drosophila as a model. (uab.edu)
  • Research on this topic has been greatly facilitated by using powerful genetic model insects like Drosophila melanogaster, and more recently by advances in genome modification technology, notably CRISPR/Cas9. (ugent.be)
  • Most azole-resistant strains harbor a mutation in the cyp51A gene, encoding a target protein for azole drugs ( 4 ). (cdc.gov)
  • Whereas such cyp51A -related azole-resistant strains have been reported frequently in the past 10 years, strains without any mutation in the cyp51A gene showing low susceptibility to azole drugs have, to some extent, been isolated ( 9 ). (cdc.gov)
  • the mutation was discovered by genome comparison between azole-resistant strains and corresponding susceptible strains ( 13 ). (cdc.gov)
  • Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regulation. (nih.gov)
  • A) Hypothetical genotype-phenotype map with three modules of groups of genes affecting three traits: eyes, lungs, and blood-clotting. (beacon-center.org)
  • Drosophila melanogaster have served as the foundation of genetic and developmental studies for more than a century. (pitzer.edu)
  • This study provides the first genome-wide captures of the dynamics of in vivo AmtR binding events and the regulatory network they define. (frontiersin.org)
  • Ohno [ 1 ] theorized that newly duplicated genes were freed from the constraints of natural selection, implicating a dominant role of genetic drift in their early evolutionary dynamics. (biomedcentral.com)
  • A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. (ensembl.org)
  • March 2006 hg18 human genome assembly (NCBI Build 36). (crg.eu)
  • May 2004 hg17 human genome assembly (NCBI Build 35). (crg.eu)
  • July 2003 hg16 human genome assembly (NCBI Build 34). (crg.eu)
  • April 2003 hg15 human genome assembly (NCBI Build 33). (crg.eu)
  • November 2002 hg13 human genome assembly (NCBI Build 31). (crg.eu)
  • June 2002 hg12 human genome assembly (NCBI Build 30). (crg.eu)
  • April 2002 hg11 human genome assembly (NCBI Build 29). (crg.eu)
  • Typically, with age, both genome and epigenome stability decreases. (uab.edu)
  • To take advantage of sequence diversity outside of the genus Drosophila, we are sequencing developmentally important loci from several non-Drosophilid fly families to provide insights into the underlying principles of gene regulation. (berkeley.edu)
  • The requirement for a total of 6-12 fingers, each of which binds three base pairs, provides enough specificity to address a unique sequence in a genome as complex as the three billion base pairs of human DNA. (ddw-online.com)
  • Genome Biology and Evolution, 5 (4), 661 - 679. (up.pt)
  • Genome Biology and Evolution. (lu.se)
  • Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. (nih.gov)
  • Orthologous to several human genes including CCNB1 (cyclin B1). (nih.gov)
  • They are being used to explore gene function and create disease models and they hold great promise for human gene therapy. (ddw-online.com)
  • December 2013 hg38 human genome assembly (GRCh38). (crg.eu)
  • March 2006 hg19 human genome assembly (GRCh37). (crg.eu)
  • comparison of the Human genome (hg15) against the Rat genome (rn3.1). (crg.eu)
  • B) Human liver coexpression network and corresponding gene modules. (beacon-center.org)
  • Diehn M, Bhattacharya R, Botstein D, Brown PO "Genome-Scale Identification of Membrane-Associated Human mRNAs. (openwetware.org)
  • This work attempts to better understand this mechanism by first creating a computational pipeline to identify potential binding sites throughout the human genome. (bvsalud.org)
  • Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel. (nih.gov)
  • Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex. (oeaw.ac.at)
  • Halbleib JM, Sääf AM, Brown PO, Nelson WJ "Transcriptional Modulation of Genes Encoding Structural Characteristics of Differentiating Enterocytes During Development of a Polarized Epithelium In Vitro. (openwetware.org)
  • APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. (ensembl.org)
  • Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. (nih.gov)
  • In this study, we seek to determine if gene copy-number changes are a common class of genetic change during adaptation and what role, if any, natural selection plays in the maintenance and frequency increase of copy-number variants (CNVs henceforth) in experimental populations. (biomedcentral.com)
  • Other candidates are novel, such as the circadian-related gene Ahcy , which yields a selection signal that rivals that of the DDT resistance gene Cyp6g1 . (biorxiv.org)
  • Here, we present the advances that have been made through the application of genome modification technology in insecticide resistance research. (ugent.be)
  • Douris V, Denecke S, Van Leeuwen T, Bass C, Nauen R, Vontas J. Using CRISPR/Cas9 genome modification to understand the genetic basis of insecticide resistance : Drosophila and beyond. (ugent.be)
  • The cdr1B gene, encoding an ABC transporter, plays a role in azole resistance. (cdc.gov)
  • The Wolbachia strain w Mel was recently found to increase locomotor activities and possibly trigger cytoplasmic incompatibility in the transinfected fly Drosophila nigrosparsa . (nature.com)