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  • annotation
  • however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. (osti.gov)
  • BIOLOGY
  • The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. (osti.gov)
  • phenotypes
  • In the study described here, we analyzed 178 second chromosome P insertions with potentially misleading symbols in the Bloomington Drosophila Stock Center collection to determine whether the insertions are responsible for recessive lethal or sterile phenotypes. (g3journal.org)
  • Bergman
  • The Haddrill and Bergman labs intend to use these data to study patterns of genetic diversity in the nuclear and cytoplasmic genomes, to estimate the ratio of diversity on the X chromosome relative to the autosomes, to detect signatures of both positive and negative selection in the nuclear and cytoplasmic genomes, and investigate the impact of variation in recombination rate around the genome. (uga.edu)
  • Haddrill, P. and C.M. Bergman (2012) 20 Drosophila melanogaster genomes from Montpellier, France. (uga.edu)
  • subunit
  • Binding of the Smc1 cohesin subunit to the non-repetitive genome in Sg4, Kc, and ML-DmBG3 (BG3) Drosophila cells as determined by chromatin immunoprecipitation. (nih.gov)
  • Overexpression of CG11340 increased sensitivity to dietary copper, and RNAi and ends-out knockout of CG11340 resulted in copper tolerance, providing evidence for a specific nonneuronal role for this subunit in D. melanogaster . (g3journal.org)
  • characterize
  • Here we report on the development of the first monoclonal antibody to the phospho-specific form of Drosophila H2AV and characterize the specificity of this antibody to programmed DSBs in oocytes and rereplication sites in endocycling cells by immunofluorescence assays and to DSBs resulting from irradiation in both cell culture and whole tissue by Western blot assays. (g3journal.org)
  • NCBI
  • Adhering to a core principle of the Human Genome Project (HGP), the research collaborators sequencing the fruitfly genome have deposited their data into the public database ( www.ncbi.nlm.nih.gov/Genbank ) so that all scientists, in industry as well as academia, can use it at no cost and without restrictions. (genome.gov)
  • gene expression
  • Differences in cohesin and Nipped-B binding between Drosophila cell lines often correlate with differences in gene expression. (nih.gov)
  • This observation is compatible with the hypothesis that D. melanogaster immune function genes lose control of gene expression as flies age. (hindawi.com)
  • human genome
  • This is a remarkable achievement," said Dr. Francis Collins, director of the National Institutes of Health's (NIH) National Human Genome Research Institute (NHGRI), about the sequencing, or decoding, of the genetic makeup of the fruitfly. (genome.gov)
  • Through an extensive simulation study, it is demonstrated that the method allows more accurate inference, and exhibits greater robustness to the effects of natural selection and noise, compared to a well-used previous method developed for studying fine-scale recombination rate variation in the human genome. (warwick.ac.uk)
  • variants
  • We calculated the linkage disequilibrium between all pairs of variants in the Drosophila Genome Reference Panel, and make available the list of all highly correlated SNPs for use in association studies. (haldanessieve.org)
  • genus
  • Fruit flies belonging to the genus Drosophila are a model system well suited for the study of thermal adaptation in natural and laboratory conditions. (biomedcentral.com)
  • genes required
  • This maternal effect on development was highlighted in saturating mutational screens in Drosophila aimed at identifying genes required for normal development ( Nüsslein-Volhard and Wieschaus 1980 ). (g3journal.org)
  • chromatin
  • Using chromatin immunoprecipitation, we find that Nipped-B and cohesin bind to the same sites throughout the entire non-repetitive Drosophila genome. (nih.gov)
  • resistance
  • In this work fully sequenced inbred lines of Drosophila melanogaster were analyzed to study the nature of genetic control of environmental variance for two quantitative traits: starvation resistance (SR) and startle response (SL). (genetics.org)
  • To evaluate which heat-responsive genes are potential candidates for heat resistance with higher resolution than previous QTL mapping studies, we performed genome-wide deficiency screen for QTL for heat resistance. (biomedcentral.com)
  • 9 ] searched for QTL that influenced knockdown resistance to high temperature (KRHT), mapped QTL for KRHT in 2 major autosomes of D. melanogaster , and examined the X -linked effects on KRHT. (biomedcentral.com)
  • polymorphisms
  • Drosophila melanogaster, an ancestrally tropical insect that has spread to temperate regions and become cosmopolitan, offers a powerful opportunity for identifying the molecular polymorphisms underlying clinal adaptation. (nih.gov)
  • project
  • The collaborators on the fruitfly genome project used different but very complementary strategies for sequencing the insect's genetic code, which consists of 165 million base pairs or chemical units. (genome.gov)
  • data
  • Celera's work on the fly genome shows that the "whole shotgun" approach can be successfully applied to such an organism, said Dr. Collins who added that Celera scientist Dr. Gene Myers "deserves a lot of credit for developing software to deal with the massive amount of data" resulting from the whole genome shotgun sequencing strategy. (genome.gov)