• Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, D. melanogaster continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. (wikipedia.org)
  • D. melanogaster is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. (wikipedia.org)
  • Why are Drosophila melanogaster used in genetics? (greatgreenwedding.com)
  • Drosophila melanogaster are so popular when studying genetics because they have a short life cycle of 10-14 days, they are inexpensive to care for, and because they have numerous mutations that can be studied. (nmmra.org)
  • It is known from earlier studies that the heat shock (HS) response in Malpighian tubules (MTs) of Drosophila larvae is different from that in other tissues because instead of the Hsp70 and other common heat shock proteins, Hsp64 and certain other new proteins are induced immediately after HS. (bioone.org)
  • Drosophila melanogaster porcupine and its mouse homologue PORCN gene encode transmembrane bound endoplasmic reticulum proteins needed for the secretion of Wnt (Wingless and INT-1) proteins. (medscape.com)
  • Bicoid morphogen is among the earliest triggers of differential spatial pattern of gene expression and subsequent cell fate determination in the embryonic development of Drosophila melanogaster. (soton.ac.uk)
  • Drosophila melanogaster flies can sense air currents with the hairs on their backs. (wikipedia.org)
  • Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
  • Given the versatility of Drosophila as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI. (lu.se)
  • This presentation intends to provide insights into the mechanisms by which cold adaptation and acclimation is achieved in chill susceptible D. melanogaster flies.complete affiliation for HC: Unité d'Écologie et de Biogéographie, Biodiversity Research Centre, Université catholique de Louvain, Louvain-la-Neuve, Belgium. (univ-lyon1.fr)
  • Here we explore for the first time the contribution of the Drosophila phenoloxidase (PO) system to host survival and defenses against Zika virus ( ZIKV ) infection by analyzing the role of mutations in the three prophenoloxidase (PPO) genes in female and male flies . (bvsalud.org)
  • The developmental period for D. melanogaster varies with temperature, as with many ectothermic species. (wikipedia.org)
  • Within a quantitative genetic framework, we sequenced RNA from Drosophila melanogaster at different developmental stages to examine sex-biased gene expression and how selection acts upon it. (biorxiv.org)
  • Mutations of the segment polarity group in Drosophila melanogaster produce additional denticles with reversed polarity in every segment of the larval cuticle. (biologists.com)
  • Germ cell mutations were not inducted in male Drosophila- melanogaster. (cdc.gov)
  • Drosophila melanogaster is a powerful model organism for exploring the molecular basis of longevity regulation. (jove.com)
  • Here, we report 25 newly sequenced genomes from museum specimens of the model organism Drosophila melanogaster , including the oldest extant specimens of this species. (biorxiv.org)
  • Drosophila melanogaster is an apt model organism to decipher these behavioural paradigms. (who.int)
  • The results of this work were used in the assembly of a working model for the molecular mechanism of the H-P switch in Drosophila. (uni-marburg.de)
  • In a study to better understand the neuroanatomical substrates and molecular pathways underlying ethanol sensitivity in Drosophila, we found that genetic manipulation of a small group of insulin producing cells results in a strong increase in sensitivity to ethanol-induced sedation. (escholarship.org)
  • SUMMARY STATEMENT We designed an adhesion test to measure the pull-off force required to detach drosophila pupae and found that Drosophila glue adheres similarly to various substrates of different chemical properties. (biorxiv.org)
  • Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity. (bcm.edu)
  • Flybase BLAST -Searches all Drosophila reads and provides links to the individual matched sequences through the NCBI. (bcm.edu)
  • Fat body cells from 3rd instar larvae of Drosophila melanogaster were dissected, fixed with formalin-acetic acid containing 0.1% Triton-X 100, and squashed on a glass slide. (cellimagelibrary.org)
  • Under optimal growth conditions at 25 °C (77 °F), the D. melanogaster lifespan is about 50 days from egg to death. (wikipedia.org)
  • Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. (nih.gov)
  • Here, using the model species Drosophila melanogaster , we used a combination of Genome Wide Association mapping (GWAS) and transcriptomic profiling to characterize whether genes associated with thermal tolerance are primarily involved in dynamic stress responses or preparatory processes that influence physiological condition at the time of thermal stress. (frontiersin.org)
  • In this presentation I will describe transcriptional patterns of some genes (Hsps, Frost and Stravin) with respect to cold stress and I will discuss their roles in cold tolerance of Drosophila melanogaster. (univ-lyon1.fr)
  • In recent years, the fruit fly, Drosophila melanogaster, has proven itself as an attractive model system in which to study the genes and pathways that modify acute and chronic behavioral responses to ethanol exposure. (escholarship.org)
  • We show that only PPO1 and PPO2 genes contribute to host survival and appear to be upregulated following ZIKV infection in Drosophila . (bvsalud.org)
  • Although arthropods represent the largest and most diverse animal group, most other Fox genes have not been investigated in detail, not even in the arthropod model species Drosophila melanogaster. (lu.se)
  • In a collaborative effort with the Berkeley Drosophila Genome Project (BDGP) and Celera Genomics , we have mapped and sequenced the euchromatic portion of the Drosophila melanogaster genome. (bcm.edu)
  • The Drosophila Genome Project was funded by the National Human Genome Research Institute , National Cancer Institute , and Howard Hughes Medical Institute . (bcm.edu)
  • Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster. (bcm.edu)
  • Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines. (bcm.edu)
  • The Release 5.1 annotation of Drosophila melanogaster heterochromatin. (genscript.com)
  • Comparative validation of the D. melanogaster modENCODE transcriptome annotation. (bcm.edu)
  • Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. (nih.gov)
  • however, it has not yet been reported in adult Drosophila melanogaster. (lu.se)
  • Given the obvious advantages for studying the Drosophila melanogaster frataxin homolog (Dfh) over its orthologs, we have undertaken a structural characterization of apo-Dfh as the first step towards solving the solution structure of the protein alone and in complex with protein partners within the Fe-S cluster assembly pathway. (curefa.org)
  • To address this question, the expression of Fermitin 1 and Fermitin 2 (Fit1, Fit2), the two Drosophila orthologs of Kind2, was silenced in Drosophila cardiomyocytes. (ed.ac.uk)
  • Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly used model organisms for biomedical science. (greatgreenwedding.com)
  • The larval brain of the fruit fly Drosophila melanogaster is a small, tractable model system for neuroscience. (vrvis.at)
  • There are four distinct stages in a Drosophilas life cycle: egg, larva, pupa, and adult. (nmmra.org)
  • We conducted a genetic screen in Drosophila using a locomotor video tracking system to identify mutants with altered ethanol sensitivity. (escholarship.org)
  • Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura. (bcm.edu)
  • Laboratory populations of D.melanogaster have been subjected to selection for survival after live spores of B. cereus were introduced as a pathogenic agent. (unl.edu)
  • Phenotypic and genetic variability of morphometrical traits in natural populations of Drosophila melanogaster and D simulans. (gse-journal.org)
  • Drosophila melanogaster ornithine decarboxylase 1 (Odc1), mRNA. (genscript.com)
  • Title: A genetic screen for maternal-effect suppressors of decapentaplegic identifies the eukaryotic translation initiation factor 4A in Drosophila. (genscript.com)
  • Here, we examined the adhesive properties of the larval glue of D. melanogaster . (biorxiv.org)
  • In vertebrates as well as in Drosophila an increase in histone H4 acetylation precedes the H-P switch, while the switch is accompanied by introduction of DNA breaks. (uni-marburg.de)
  • Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. (nih.gov)
  • Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. (wikipedia.org)
  • Multiple strains representing four species of bacteria belonging to the genus Providencia have been isolated from wild caught Drosophila melanogaster: Providencia sneebia, Providencia burhodogranariea strain B, Providencia burhodogranariea strain D, Providencia rettgeri, and Providencia alcalifaciens. (cornell.edu)
  • Although the amino acid sequences of mammalian and Drosophila calmodulins differ by only three conservative amino acid changes, the refined model reveals a number of significant differences between the two structures. (rcsb.org)
  • In Drosophila melanogaster , the PORCN gene is involved in the processing of the wingless protein. (medscape.com)
  • This means that presence of a type 3 secretion system does not correlate to those found to be virulent toward D. melanogaster. (cornell.edu)
  • The data definitively demonstrate a role for Fermitins in the development of a functional cardiac syncytium in Drosophila. (ed.ac.uk)
  • Drosophila melanogaster Selection for Survival after Infection" by Junjie Ma, Andrew K. Benson et al. (unl.edu)
  • The Drosophila melanogaster prophenoloxidase system participates in immunity against Zika virus infection. (bvsalud.org)
  • Also, we present data suggesting that a complex regulatory system exists between Drosophila PPOs, potentially allowing for a sex -dependent compensation of PPOs by one another or other immune responses such as the Toll, Imd, and JAK/STAT pathways. (bvsalud.org)
  • In Drosophila melanogaster, we found that both standard components of sperm competition, sperm defence and sperm offence, showed non-significant or insignificant heritability across several offspring cohorts. (datadryad.org)
  • The H-P switch is also found in developing spermatids of Drosophila. (uni-marburg.de)
  • Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. (genscript.com)
  • These data support a model in which Tum/RacGAP, via its interaction with Pbl, provides a critical link between the anaphase microtubule spindle and cytokinetic furrow formation in Drosophila cells. (biologists.com)
  • eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. (genscript.com)
  • Title: A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation. (genscript.com)
  • Using this laboratory-friendly and natural host, D. melanogaster, I determined how these bacteria differ in their ability to cause host mortality, replicate within the fly and trigger the fly's immune response as measured by transcription of antimicrobial peptides. (cornell.edu)
  • This work establishes D. melanogaster-Providencia as a model system for the study of host-pathogen interactions. (cornell.edu)
  • To test our hypotheses, we measured the critical thermal minimum (CT min ) and critical thermal maximum (CT max ) of 100 lines of the Drosophila Genetic Reference Panel (DGRP) and used GWAS to identify loci that explain variation in thermal limits. (frontiersin.org)
  • To determine the broad metabolic effects of oxidative stress, we have quantified the response in Drosophila melanogaster to both genetically and environmentally derived oxidative stress. (nih.gov)
  • Coinfections in D. melanogaster with P. sneebia and P. rettgeri, which induces greater antimicrobial peptide expression and is less virulent than P. sneebia, allowed me to conclude that P. sneebia is actively avoiding recognition by the immune response. (cornell.edu)