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  • sensory
  • The second category of genes found to be differentially expressed between the null mutant AMC and the other alleles concerned the development of the sensory organs and more particularly the larval olfactory system. (biomedcentral.com)
  • The fruit fly Drosophila, with sensory modalities, neural circuits, and complex behaviors that are strongly evolutionarily conserved, has emerged as a model system for neural research. (grantome.com)
  • Using genetic tools provided by our collaborators and new tools that we are developing for optical physiology and behavior quantification in freely moving animals, we will investigate how pathways within the larval brain use information gathered across the larvum?s sensory periphery to make decisions and result in physical behavior. (grantome.com)
  • Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons. (ed.ac.uk)
  • The dorsal bipolar dendritic (dbd) sensory neurons are putative stretch receptors in the Drosophila larval body wall. (ed.ac.uk)
  • The files comprise the raw data that are the basis of our work "Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons. (ed.ac.uk)
  • pathways
  • By contacting different targets, the two larval PR-subtypes create two converging pathways potentially underlying the computation of ambient light intensity and temporal light changes already within this first visual processing center. (elifesciences.org)
  • The developing eye of Drosophila has been extensively used as a model system to determine how common signalling pathways can induce the generation of cellular diversity. (biomedcentral.com)
  • Interestingly, these Drosophila neurodegenerative disease models show a high degree of conservation in the fundamental biological pathways and in the molecular, genetic and pathophysiological aspects of neurodegenerative human diseases. (ed.ac.uk)
  • Growth
  • Genome instability is therefore inherent to Drosophila malignant neoplastic growth at a variable extent that is tumor type dependent. (g3journal.org)
  • In Drosophila, the sequencing of a single tumor caused by the loss of Polyhomeotic (Ph) revealed that neither single nucleotide polymorphisms (SNPs) nor copy number variations (CNVs) were significantly increased in comparison with non-tumoural control tissue, suggesting that genome instability (GI) may not be a pre-requisite for neoplastic epithelial growth in this model system. (g3journal.org)
  • Together, our analyses reveal KDM5 as a key regulator of larval growth and offer an invaluable tool for defining the biological activities of KDM5 family proteins. (genetics.org)
  • Thus, dMyc is required for endoreplication and larval growth. (biologists.org)
  • Our results indicate that larval growth and endoreplication are coupled processes that, although linked to cell cycle control mechanisms, are regulated by dMyc and dMnt. (biologists.org)
  • The cellular response to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves as one of the best-studied models for understanding the long-range control of tissue growth and pattern formation during animal development. (biologists.org)
  • The lines did not differ significantly in larval competitive ability at either growth density. (ucl.ac.uk)
  • underlie
  • In preliminary work, we have used a novel tracking system to quantify the algorithms that underlie larval chemotactic, phototactic, and thermotactic behavior. (grantome.com)
  • cellular
  • The larval heart preparation provides an additional model besides the Drosophila skeletal NMJ to investigate the role of intracellular calcium regulation on cellular function. (biomedsearch.com)
  • In addition Drosophila serve as a good model for physiological function at a cellular level. (biomedsearch.com)
  • Despite the prominence of iron-sulfur cluster (ISC) proteins in bioenergetics, intermediary metabolism, and redox regulation of cellular, mitochondrial, and nuclear processes, these proteins have been given scarce attention in Drosophila . (springer.com)
  • genomes
  • To determine if these genetic lesions appear in Drosophila tumors we have sequenced the genomes of 17 malignant neoplasms caused by mutations in l(3)mbt , brat , aurA , or lgl . (g3journal.org)
  • indicate
  • Previous studies indicate that mutations in the Shaker (Sh) locus alter excitability in both nerve and muscle in Drosophila. (jneurosci.org)
  • These studies indicate that CREB is dispensable for the activity-dependent modulation of bouton number at the Drosophila larval NMJ [ 6 ], a process that shares compelling mechanistic similarities to morphological changes required for long-term facilitation in Aplysia . (springer.com)
  • antagonist
  • In support of this, dMyc, as well as its antagonist dMnt, are expressed in larval tissues in a pattern consistent with their involvement in regulating endoreplication. (biologists.org)
  • phenotypes
  • Poor parental nutrition in Drosophila has been demonstrated to result in a mix of potentially maladaptive and adaptive phenotypes in offspring. (g3journal.org)
  • The present results clearly suggest that the suite of phenotypes through which the evolution of greater competitive ability is achieved in fruitflies depends critically not just on larval density per unit volume of food, but also on the total amount of food available in the culture vials. (haldanessieve.org)
  • Animals
  • We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. (forskningsdatabasen.dk)
  • density
  • We discuss these results in the context of an hypothesis about how larval density and the height of the food column in culture vials might interact to alter the fitness costs and benefits of increased larval feeding rates, thus resulting in different routes to the evolution of greater competitive ability, depending on the details of exactly how the larval crowding was implemented. (haldanessieve.org)
  • model
  • The generality of the CREB-switch model has been specifically questioned by two previous studies at the Drosophila motor synapse. (springer.com)
  • results
  • Our results suggest that 5-HT modulates larval turning by regulating the activity level of downstream ABLK neurons and secretion of the neuropeptide leucokinin. (jneurosci.org)