• Caspase Dronc is a Drosophila melanogaster protein codified by the Dronc gene. (wikipedia.org)
  • Initiator caspases, such as Dronc, which is the only initiator caspase in Drosophila melanogaster, are activated through different mechanisms, the main one being autocleavage. (wikipedia.org)
  • One study showed that, in Drosophila melanogaster S2 cells, Dronc autocleavage is essential for the zymogen activation. (wikipedia.org)
  • Even though uncleavable mutations of Dronc may have the ability to process caspase DrICE, it is autocleaved Dronc that processes caspase DrICE in Drosophila melanogaster cells. (wikipedia.org)
  • Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
  • In this paper, we show that Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster . (rupress.org)
  • Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. (xcessbio.com)
  • To investigate correlation between nitric oxide synthase, heat shock protein Hsp70 and apoptosis regulatory gene grim in D. melanogaster. (nbuv.gov.ua)
  • Within each tissue, downstream PCP effectors link the signal to tissue specific readouts such as stereocilia orientation in the inner ear and hair follicle orientation in vertebrates or the polarization of ommatidia and wing hairs in Drosophila melanogaster. (uni-wuerzburg.de)
  • Following this discovery, the other mammalian caspases, in addition to caspases in other organisms such as the fruit fly Drosophila melanogaster , were soon identified and characterised. (wikidoc.org)
  • Drosophila melanogaster SL-2 cells were managed in Schneider's insect medium. (bio2009.org)
  • Using a genetic complementation assay to identify additional genes which inhibit apoptosis during infection with a p35 mutant, we have isolated a gene from Orgyia pseudotsugata NPV (OpMNPV) that was able to functionally substitute for AcMNPV p35. (embl.de)
  • He is focusing on the effect of low dose ionizing radiation on lifespan and aging of Drosophila strains with defects in apoptosis, DNA repair, and defense genes. (esaam.global)
  • Strikingly, overexpression of imd leads to constitutive transcription of these genes and to apoptosis, and both effects are blocked by coexpression of the caspase inhibitor P35. (cnrs.fr)
  • Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)
  • Following completion of the Drosophila genome sequence, we carried out comprehensive BLAST searches to annotate it with respect to apoptosis, and found sequence homologues of virtually all mammalian cell death genes with the exception of death receptors. (caltech.edu)
  • The only Drosophila cell death genes for which mammalian homologues have not been identified are the cell death activators Rpr, Hid, and Grim. (caltech.edu)
  • Even though not a outcome of Cdk exercise, the Rb protein is effectively inacti vated in HCMV contaminated cells, and E2F selelck kinase inhibitor responsive genes are very expressed. (thrombin-inhibitor.com)
  • Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. (cancerindex.org)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3'UTR AU-rich elements (AREs). (oncotarget.com)
  • The transcriptional activation from CACNA1F the p21 gene by these inhibitors is normally marketed by chromatin redecorating pursuing acetylation of histones H3 and H4 in the p21 promoter area (32 54 This activation of p21 takes place within a p53-unbiased fashion and for that reason HDAC inhibitors are appealing realtors for cancers therapy being that they are operative in cells with mutated p53 genes a hallmark of several tumors. (bio2009.org)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. (embl.de)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • The distinct freshwater alleles either increase or decrease expression of the bone growth inhibitor gene Stanniocalcin2a in developing spines, providing a simple genetic mechanism for either increasing or decreasing spine lengths in natural populations. (bvsalud.org)
  • Cell}, volume = {1}, number = {4}, pages = {503--514}, abstract = {We report the molecular characterization of the immune deficiency (imd) gene, which controls antibacterial defense in Drosophila. (cnrs.fr)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
  • Simultaneous work in the field of developmental biology and work with Drosophila has established the INT1 gene is a homologue of the Drosophila segment polarity gene [2]. (chemdiv.com)
  • Cloning and characterization of a serine/threonine protein phosphatase2A-encoding gene IbPP2A1 from Ipomoea batatas (L.) Lam. (tubitak.gov.tr)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • The Hh gene family encodes a secreted protein that plays a critical regulatory role in the process of embryogenesis and environmental stabilization in adult tissues of invertebrates and vertebrates [ 44 ]. (regenmedres-journal.org)
  • This gene encodes a large protein that functions as a GDP to GTP exchange factor. (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • The importance of caspases to apoptosis and programmed cell death was originally established by Robert Horvitz and colleagues who found that the ced-3 gene was required for the cell death that took place during the development of the nematode C. elegans . (wikidoc.org)
  • Horvitz and his colleague Junying Yuan [2] found in 1993 that the protein encoded by the ced-3 gene was a cysteine protease with similar properties to the mammalian interleukin-1-beta converting enzyme (ICE) (now known as caspase 1) which at the time was the only known caspase. (wikidoc.org)
  • One bacteria-induced gene encodes a proteinthat, after expression in the baculovirus system, was shown to be apeptidoglycan recognition protein (PGRP). (embl-heidelberg.de)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
  • The X-linked mammalian inhibitor of apoptosis protein (XIAP) has been shown to bind several partners. (rupress.org)
  • imd encodes a protein with a death domain similar to that of mammalian RIP (receptor interacting protein), a protein that plays a role in both NF-kappaB activation and apoptosis. (cnrs.fr)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • IHH signal induces activation of Parathyroid Hormone-related Protein (PTHRP) on the articular surface and gets rid of the hypertrophy of chondrocytes [ 49 ]. (regenmedres-journal.org)
  • Protein crowding induces membrane curvatures through an entropic mechanism. (portlandpress.com)
  • Death regulator Nedd2-like caspase (Nc, Nedd2-like caspase or Dronc) was firstly identified and characterised in Drosophila in 1999 as a cysteine protease containing an amino-terminal caspase recruitment domain. (wikipedia.org)
  • At first, it was thought of as an effector caspase involved in apoptosis, but subsequent findings have proved that it is, in fact, an initiator caspase with a crucial role in said type of programmed cell death. (wikipedia.org)
  • Caspase Dronc's active site is located between positions 271 and 318 of the protein sequence. (wikipedia.org)
  • Just as caspase 9 in mammals, caspase Dronc is a protein that has a caspase activation and recruitment domain (CARD). (wikipedia.org)
  • It is the only Drosophila caspase presenting this domain: this can represent the possibility of establishing a valuable comparison between their activation or inhibition mechanisms. (wikipedia.org)
  • Even though caspase Dronc goes through other processes which will be discussed later, Dronc autocleavage was found to be absolutely necessary to induce apoptosis, whereas other cell cofactors seemed to not be enough to induce activation of Dronc if it had not previously been autocleaved at residue E352. (wikipedia.org)
  • Acts as a direct inhibitor of caspase enzymes. (embl.de)
  • In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. (embl.de)
  • Triple point mutants, unable to bind caspase 9, caspase 3, and DIABLO/HtrA2/Omi, were completely ineffectual in inhibiting apoptosis. (rupress.org)
  • A closer look at Drosophila male testes revealed the surprising observation that high levels of caspases are present in wild type testes, along with the caspase activator Ark. (caltech.edu)
  • The initiation of this cascade reaction is regulated by caspase inhibitors. (wikidoc.org)
  • The exact contribution that the cleavage of many caspase substrates makes to the biochemistry and morphology of apoptosis is unclear. (wikidoc.org)
  • Interestingly, while GT1b enhanced caspase-3 activity, DEVD, a caspase-3 inhibitor, failed to rescue DA neuronal death. (biomedcentral.com)
  • Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
  • Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila . (sdbonline.org)
  • To identify novel regulators of JNK-dependent cell death, this study performed a dominant-modifier screen in Drosophila and found that the Toll pathway participates in JNK-mediated cell death. (sdbonline.org)
  • The SHH pathway should be off at most of the time, by the inhibition of specific factors such as Patched 1 (PTC1), Protein Kinase A (PKA), Casein Kinase1 (CK1), and Glycogen Synthase Kinase 3 beta (GSK3b), and only valid at precise time points [ 98 ]. (regenmedres-journal.org)
  • The inhibition of porin under the control of neuronal Ddc-Gal4 result in short lifespan and in an age-dependent loss in locomotor function, phenotypes that are strongly associated with Drosophila models of Parkinson disease . (sdbonline.org)
  • It has shown that miR-429 could inhibit the development of colorectal cancer via targeting in large tumor suppressor kinase (LATS2), and decreased miR-429 could promote the expression of SRY-box transcription factor 2 (SOX2) and B-cell lymphoma 2 (BCL2) to attenuate the neuronal injury induced by accumulation of amyloid β -protein [ 12 ]. (hindawi.com)
  • Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. (frontiersin.org)
  • Despite its small genome and limited number of effector proteins, Ehrlichia efficiently establishes an intracellular infection and avoids immune defenses in vertebrate and invertebrate hosts through complex molecular and cellular reprogramming strategies. (frontiersin.org)
  • Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)
  • In addition acetylation of transcription factors offers been shown elsewhere to impact the stability and intracellular localization of proteins or to modulate the affinity for DNA or additional proteins (34). (bio2009.org)
  • Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
  • Myc proteins control multiple cellular processes, including cell growth, proliferation, metabolism and apoptosis, and deregulation of Myc plays an important role in oncogenesis ( Dang, 2012 ). (silverchair.com)
  • β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
  • β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
  • Betaherpesvirus summary While cellular Cdks dont appear to perform a role while in the phosphorylation of Rb during HCMV infection, their action is required for efficient viral replication as evi denced by reduced viral yields inside the presence of a Cdk inhibitor for instance roscovitine or perhaps a dominant damaging Cdk2. (thrombin-inhibitor.com)
  • Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
  • The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
  • MDR1 codes for P-glycoprotein (P-gp), a member of the ABC transporter superfamily of proteins that promote cellular efflux of chemotherapeutic agents. (sphingolipidclub.com)
  • The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. (intechopen.com)
  • Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease. (neurotree.org)
  • It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
  • Moreover, HCMV encodes a number of anti apoptotic proteins and infection is proven to prevent the death of some cancerous cells. (thrombin-inhibitor.com)
  • pro prolifera tive or anti apoptotic proteins were for being driving forces behind oncogenesis, their continued expression in tumors would appear to get necessary to keep the transformed phenotype. (thrombin-inhibitor.com)
  • This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
  • To determine which of these interactions are required for it to inhibit apoptosis, we generated point mutant XIAP proteins and correlated their ability to bind other proteins with their ability to inhibit apoptosis. (rupress.org)
  • The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
  • Autophagy is generally considered as a cell survival/protection mechanism because it removes toxic or obsolete proteins and organelles and recycles the degradation products for use as sources for energy and metabolites in anabolic pathways 3 . (nature.com)
  • Therefore, in this review, we avoid a lengthy repetition of the description of autophagy and cell death processes and focus on the death-promoting roles of autophagy and the intertwined connection between autophagy and apoptosis. (nature.com)
  • At an early stage, blocking nutrition and oxygen supply in response to brain ischemia activates various cell death processes, including apoptosis, autophagy and necrosis [ 4 ]. (thno.org)
  • VCP identifies ubiquitylated substrates through numerous dedicated adaptor proteins and unfolds substrates by threading them through a central pore in the hexamer ( Figure 1 ). (portlandpress.com)
  • VCP interacts with adaptor proteins to identify ubiquitylated substrates for degradation by the proteasome. (portlandpress.com)
  • In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
  • Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
  • HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
  • Drosophila has long been an attractive, genetically tractable model system in which to study fundamental processes such as apoptosis which are common to higher eukaryotes. (caltech.edu)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • On top of that, some HCMV proteins are muta genic and consequently may result in genomic instability lead ing to cancer by means of a hit and run mechanism. (thrombin-inhibitor.com)
  • Both pathways culminate in the induction of inflammatory cytokines (TNF, IL-6, IL-12), type I interferons (IFN-alpha, IFN-beta), or apoptosis. (antibodies-online.com)
  • VCP primarily identifies ubiquitylated proteins in these pathways and mediates their unfolding and degradation by the 26S proteasome. (portlandpress.com)
  • Valosin-containing protein (VCP, also p97, or Cdc48p in yeast) is an evolutionarily conserved, homo-hexameric, ubiquitin-selective, AAA-ATPase that functions in numerous ubiquitin-dependent protein quality control pathways. (portlandpress.com)
  • Please note that proteins can be included in multiple pathways, ie. (embl-heidelberg.de)
  • PAI-1, an important component of the hemostasis system, is a specific inhibitor of both urokinase type and tissue type plasminogen activators. (nbuv.gov.ua)
  • It is presumed that its autocatalytic cleavage activates the protein by generating a dimerisation in which both monomers stabilise their active sites mutually. (wikipedia.org)
  • article{georgel_drosophila_2001, title = {Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis}, author = {Philippe Georgel and S Naitza and Christine Kappler and Dominique Ferrandon and Daniel Zachary and C Swimmer and C Kopczynski and G Duyk and Jean-Marc Reichhart and Jules A Hoffmann}, issn = {1534-5807}, year = {2001}, date = {2001-10-01}, journal = {Dev. (cnrs.fr)
  • Using a genetic screen for modifiers of Drosophila Myc ( dMyc )-induced growth, we identified and characterized a ubiquitin-specific protease (USP), Puffyeye (Puf), as a novel regulator of dMyc levels and function in vivo . (silverchair.com)
  • In addition to its effects on dMyc, Puf regulates both Ago and its cell cycle substrate Cyclin E. Therefore, Puf influences cell growth by controlling the stability of key regulatory proteins. (silverchair.com)
  • The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
  • In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
  • MiRNAs are characterized by binding the 3 - UTR of special mRNA to regulate the expression of the related proteins [ 10 , 11 ]. (hindawi.com)
  • This provokes speculation that core components of the cell death machinery can function to regulate processes other than apoptosis, such as spermatogenesis. (caltech.edu)
  • HDACs form a family of enzymes that catalyze 67346-49-0 the removal of acetyl moieties from acetylated proteins including histones structural proteins or transcription factors (25 31 Together with their counterparts the histone acetyltransferases HDACs regulate the reversible acetylation of core histones and additional proteins. (bio2009.org)
  • GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. (xcessbio.com)
  • Here, we examine the therapeutic potential of targeting HuR using MS-444, a small molecule HuR inhibitor. (oncotarget.com)
  • Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. (xcessbio.com)
  • Thus it appears likely that HHV 6 and 7 a minimum of phosphorylate Rb as a result of the action of their virally encoded protein kinase. (thrombin-inhibitor.com)
  • Even so, we all Tyrosine Kinase Inhibitor Library cell line believe that this kind of removing will be regarding minor result simply because protecting against apoptosis, and thus mobile or portable opposition, in individuals compartments does not affect how big the actual clones or size the actual chambers. (chk-signal.com)
  • Caspases are a family of calcium -dependent cysteine proteases , which play essential roles in apoptosis (programmed cell death), necrosis and inflammation . (wikidoc.org)
  • CASP14 , is not involved in apoptosis or inflammation, but instead is involved in skin cell development. (wikidoc.org)
  • This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
  • Crowding of asymmetric proteins results in an asymmetric lateral pressure across the membrane which can be used by cells in a number of biological processes involving membrane remodeling. (portlandpress.com)
  • Future research will aim at identifying specific inhibitors and/or inducers of UPR regulatory markers as well as expand the list of UPR-related animal models. (molvis.org)
  • However, since proteins with similar activities are present in mammals and since their mechanisms are likely to be conserved even if true sequence homologues are not identified, understanding how Rpr, Hid, and Grim act to bring about death is an important area of research. (caltech.edu)
  • This study concluded that autocleavage at residue E352, just as autocleavage at other sites such as E143, is not needed for Dronc to activate and, consequently, to induce apoptosis. (wikipedia.org)
  • tumor suppressor p53 may induce cell cycle arrest or apoptosis in response to a variety of stress signals such as DNA damage oncogenic stimuli or hypoxia (reviewed in reference 49). (bio2009.org)
  • rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
  • GSK461364 is a potent inhibitor of cell proliferation causing 50% growth inhibition (GI50) below 100 nM in most of the cell lines tested with limited toxicity against human nonproliferating cells. (xcessbio.com)
  • Interest ingly, these proteins robustly phosphorylate Rb in trans fected Saos 2 cells. (thrombin-inhibitor.com)
  • In terms of pathogenesis, several research have found HCMV, HHV 6, and HHV 7 genomes or proteins in can cerous cells or tissues. (thrombin-inhibitor.com)
  • Caspases are essential in cells for apoptosis , one of the main types of programmed cell death in development and most other stages of adult life, and have been termed "executioner" proteins for their roles in the cell. (wikidoc.org)
  • From development to aging and disease, the brain parenchyma is under the constant threat of debris accumulation, in the form of dead cells and protein aggregates. (frontiersin.org)
  • Then, we will discuss several principles that govern macrophage phagocytosis of apoptotic cells (efferocytosis), including the existence of redundant recognition mechanisms ("find-me" and "eat-me") that lead to a tight coupling between apoptosis and phagocytosis. (frontiersin.org)
  • Thesoluble form of Tag7 triggers apoptosis in mouse L929 cells in vitro anddoes not involve NF-kappaB activation. (embl-heidelberg.de)
  • The 'baculovirus inhibitior of apoptosis protein repeat' (BIR) [ ( PUBMED:8139034 ) ( PUBMED:8552191 ) ] is a domain of about 70 residues arranged in tandem repeats separated by a variable length linker, that seems to confer cell death-preventing activity. (embl.de)
  • This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. (cancerindex.org)
  • Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
  • To alter the expression of Buffy in the dopaminergic neurons of Drosophila. (sdbonline.org)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • It is concluded that the inhibition of Buffy in DA neurons produces a novel model of PD in Drosophila. (sdbonline.org)
  • Importantly, MS-444 was well tolerated and inhibited xenograft CRC tumor growth through enhanced apoptosis and decreased angiogenesis upon intraperitoneal administration. (oncotarget.com)
  • He is also studying mechanisms of aging, longevity and stress resistance in animal models, including DNA repair, heat shock proteins, NF-kB, Tor- and PI3K-signaling cascade, apoptosis. (esaam.global)
  • He revealed the geroprotective and synergistic effects of different inhibitors of PI3K, TOR, NF-kB using fruit flies Drosophila as a model. (esaam.global)
  • Sequence evaluation and preliminary data indi cate that a minimum of 1 with the HHV 6 and HHV 7 orthologs of those proteins, the UL97 orthologous U69 protein kinases, are likely to possess related results. (thrombin-inhibitor.com)
  • This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl-heidelberg.de)
  • Percentage points are related to the number of proteins with PGRP domain which could be assigned to a KEGG orthologous group, and not all proteins containing PGRP domain. (embl-heidelberg.de)
  • Unexpectedly, cell treatment with the specific calpain inhibitor calpeptin resulted in a decreased extent of pol η foci after UV irradiation, indicating that calpain positively regulates pol η accumulation in replication foci. (cnrs.fr)
  • In the absence of SHH, PTC and G Protein-coupled Receptor161 (GPR161) are located at the base of primary cilium (PC), while accumulation of SMO is diminished by transporting sterol-like SMO ligand outside by a 'tunnel' structure of PTC1. (regenmedres-journal.org)
  • Accumulation of unfolded proteins in the ER lumen triggers the dissociation of GRP78 from its quiescent UPR mediators. (molvis.org)
  • The membrane protein EsaA is a conserved component of the type VIIb secretion system. (uni-wuerzburg.de)
  • A peptidoglycan recognition protein in innate immunity conserved frominsects to humans. (embl-heidelberg.de)
  • From our results and the sequence homology, weconclude that PGRP is a ubiquitous protein involved in innate immunity,conserved from insects to humans. (embl-heidelberg.de)
  • These conditions include but are not limited to artery or vein occlusion in diabetic retinopathy, hypoxic retina in retinopathy of prematurity, aging in age-related macular degeneration, expression of mutant proteins in inherited retinal degeneration, traumatic injury leading to retinal detachment, and light sensitivity in the case of light-induced retinal degeneration. (molvis.org)