• Because of the availability of remarkably powerful genetic, molecular and cell biological tools, we use the fruitfly, Drosophila melanogaster, as our primary model for investigating the fundamental mechanisms of PCP signaling. (stanford.edu)
  • The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. (bvsalud.org)
  • In the arthropod model species Drosophila melanogaster, a dipteran fly, segmentation of the anterior-posterior body axis is under control of a hierarchic gene cascade. (bvsalud.org)
  • Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)
  • Although wing morphology has been extensively studied in Drosophila melanogaster (Meigen, 1830), a comprehensive understanding of developmental plasticity and the impact of sex on wing size and shape plasticity is missing for other Diptera. (frontiersin.org)
  • Therefore, we raised flies of the three Diptera species Drosophila melanogaster , Ceratitis capitata (Wiedemann, 1824) and Musca domestica (Linnaeus, 1758) at different environmental conditions and applied geometric morphometrics to analyze wing shape. (frontiersin.org)
  • Most of our current understanding of intraspecific variation in wing size is based on extensive work in Drosophila melanogaster (Meigen, 1830). (frontiersin.org)
  • 4. Graham PL, Yanowitz JL, Penn JK, Deshpande G, Schedl P. The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster. (prolekarniky.cz)
  • Drosophila melanogaster presents a simpler model system in which to study FGF signaling, with only three ligands and two FGF receptors (FGFRs) identified. (biologists.com)
  • We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. (biomedcentral.com)
  • There are several reasons for choosing Drosophila melanogaster as an organism for the global study of gene expression during embryonic development. (biomedcentral.com)
  • Under ordinary conditions there is so little crossing over in the fourth chromosome of Drosophila melanogaster that the usual method of constructing a map is not practicable. (caltech.edu)
  • In a series of papers, Serebrovsky (1930), Dubinin (1929), Agol (1930) and their colleagues have described an extremely interesting group of bristle-reducing mutant genes lying at the scute locus of the X-chromosome of Drosophila melanogaster. (caltech.edu)
  • Seven mutant genes of Drosophila simulans have been shown to be allelomorphic to previously known mutant genes of D. melanogaster. (caltech.edu)
  • Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
  • Jumonji (JmjC) domain proteins (see Jarid2 ) influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome. (sdbonline.org)
  • The initial domains of homeotic gene repression are set by the segmentation proteins, which also divide the embryo into segments. (nih.gov)
  • Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • In yet another coup for a research concept known as "big data," researchers at the Stanford University School of Medicine have developed a computerized algorithm to understand the complex and rapid choreography of hundreds of proteins that interact in mindboggling combinations to govern how genes are flipped on and off within a cell. (pharmaceuticalintelligence.com)
  • Proteins control gene expression by either binding to specific regions of DNA, or by interacting with other DNA-bound proteins to modulate their function. (pharmaceuticalintelligence.com)
  • The ENCODE, for the Encyclopedia of DNA Elements , project was a five-year collaboration of more than 440 scientists in 32 labs around the world to reveal the complex interplay among regulatory regions, proteins and RNA molecules that governs when and how genes are expressed. (pharmaceuticalintelligence.com)
  • In this study, the researchers combined data from genomics (a field devoted to the study of genes) and proteomics (which focuses on proteins and their interactions). (pharmaceuticalintelligence.com)
  • They studied 128 proteins, called trans-acting factors , which are known to regulate gene expression by binding to regulatory regions within the genome. (pharmaceuticalintelligence.com)
  • Before our work, only the combination of two or three regulatory proteins were studied, which oversimplified how gene regulators collaborate to find their targets," Xie said. (pharmaceuticalintelligence.com)
  • A fourth miR-10 gene (mir-10d) is found elsewhere in the genome, at a location homologous to the pufferfish HoxDd cluster. (wikipedia.org)
  • The mir-10 gene is located near to the HoxB1a and HoxB3a genes within the zebrafish genome, Hox-1 and Hox-3 paralogues located on different Hox clusters are not targets of miR-10. (wikipedia.org)
  • In 2015, researchers reported that they had used components of the CRISPR/Cas9 genome editing system to edit genes so that they could propagate in a "Super-Mendelian" fashion. (elifesciences.org)
  • including the two researchers involved in the 2015 work - have used a new active genetic element called a CopyCat element and more traditional genome editing to analyze the control of a gene that coordinates the formation of a simple structure in a fruit fly - a vein in the wing. (elifesciences.org)
  • used genome editing to make mutations in a stretch of DNA that regulates the gene involved in wing vein formation. (elifesciences.org)
  • The Drosophila genome is about one twentieth the size of the human genome. (nih.gov)
  • However, the range of gene expression patterns, the extent of the correlation of expression with function, and the classes of genes whose spatial expression are tightly regulated have been unclear due to the lack of an unbiased, genome-wide survey of gene expression patterns. (biomedcentral.com)
  • These genes encode transcription factors which are important in embryonic development. (wikipedia.org)
  • Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)
  • The genes encode homeodomain-containing transcription factors that control cell fates by regulating the transcription of downstream target genes. (nih.gov)
  • In C. elegans , the ten-1 gene can be transcribed from two distinct promoters to produce the transcripts ten-1a and ten-1b , which respectively encode two isoforms of the protein: TEN-1L, which contains all the teneurin domains described above (see Fig. 1F ), and TEN-1S, which lacks the ICD but contains the rest of the protein including the transmembrane domain. (biomedcentral.com)
  • The mir-10 microRNA precursor is a short non-coding RNA gene involved in gene regulation. (wikipedia.org)
  • We find that both the Brd box and the GY box are also present in the 3′ UTRs of several basic helix-loop-helix repressor-encoding genes of the E(spl)-C, often in multiple copies, suggesting that a novel mode of post-transcriptional regulation applies to Brd and many E(spl)-C genes. (biologists.com)
  • Future research should therefore focus on these issues, in addition to the role of Polycomb and trithorax-mediated regulation, the identification of regulatory regions, cofactors or spider-specific target genes, and the significance of non-coding RNAs transcribed from within the Hox cluster and even from the antisense strand of particular Hox genes. (bvsalud.org)
  • These are accompanied by major changes in gene regulation and the molecular evolution of caste determination. (nature.com)
  • Regulation of gene expression in time and space is a major driving force of this process. (biomedcentral.com)
  • the process that governs the early embryonic patterning of the Drosophila body plan is now the best understood example of a complex cascade of transcriptional regulation during development [ 14 , 15 ]. (biomedcentral.com)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • The increase in variability that is a familiar result of the rearing of second generations from crosses between different races is certainly due chiefly to segregation and recombination of genes in which the parental races differed. (caltech.edu)
  • Loss of porin function was achieved through exploitation of RNAi while derivative lines were generated by homologous recombination and tested by PCR. (sdbonline.org)
  • While these transgenic assays have been important in defining the structure of the cis -regulatory elements and identifying trans -acting factors that bind to them, their functions within the context of the endogenous genes remain poorly understood. (nih.gov)
  • We used a large number of existing chromosomal aberrations in the Scr homeotic gene to investigate the functions of the cis -acting elements within the endogenous gene. (nih.gov)
  • The transcriptional silencers are clustered in the two regions whose interactions are required for the maintenance of silencing in the endogenous genes. (nih.gov)
  • ten-1 mutants have defects in all pharyngeal neurons that we examined, and in vivo reporters show that only the long form of the ten-1 gene is expressed in the pharynx, specifically in six marginal cells and the M2 neurons. (biomedcentral.com)
  • Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. (cnrs.fr)
  • The directed expression of alpha-synuclein , a gene contributing to inherited forms of Parkinson disease (PD), in the dopaminergic neurons (DA) of flies provides a robust model of PD complete with the loss of neurons and accompanying motor defects. (sdbonline.org)
  • To alter the expression of Buffy in the dopaminergic neurons of Drosophila. (sdbonline.org)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • It is concluded that the inhibition of Buffy in DA neurons produces a novel model of PD in Drosophila. (sdbonline.org)
  • There is now in progress in several laboratories a comparative study of the genetics of the species of Drosophila. (caltech.edu)
  • A recent paper in this journal by Detlefsen(1) is introduced as follows: "There is a well intrenched concept of recent genetics that hereditary factors or genes may be given fairly definite loci on chromosome maps and that these maps correspond to or represent, roughly perhaps, the actual conditions in the chromosome. (caltech.edu)
  • At a very basic level, we are learning who likes to work with whom to regulate around 20,000 human genes," said Michael Snyder , PhD, professor and chair of genetics at Stanford. (pharmaceuticalintelligence.com)
  • Gain-of-function alleles of the Drosophila gene Bearded ( Brd ) cause sensory organ multiplication and loss pheno-types indistinguishable at the cellular level from those caused by loss-of-function mutations in the genes of the Notch pathway (Leviten, M. W. and Posakony, J. W. (1996). (biologists.com)
  • In Drosophila expression of miR-10-3p is highest in 12- to 24-hour-old embryos and in 1st and 3rd instar larvae. (wikipedia.org)
  • In stage 5 Drosophila embryos (130-180 minutes post-fertilisation), miR-10 is distributed throughout 50-80% of the length of the egg. (wikipedia.org)
  • Expression of miR-10ba in mouse embryos shows a similar pattern to that of the Hoxb4 gene. (wikipedia.org)
  • In zebrafish embryos, miR-10 binds to sites in the three prime untranslated region (3'UTR) of the HoxB1a and HoxB3a genes, which are important in anterior-posterior patterning during embryonic development. (wikipedia.org)
  • Our data for the remaining seven NKL genes revealed expression in different structures associated with the developing nervous system in embryos of E. rowelli . (biomedcentral.com)
  • Heterogeneity in synaptic transmission along a Drosophila larval motor axon. (neurotree.org)
  • Erratum: Heterogeneity in synaptic transmission along a Drosophila larval motor axon Nature Neuroscience . (neurotree.org)
  • article{shia_toll-dependent_2009, title = {Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes}, author = {Alice K H Shia and Marcus Glittenberg and Gavin Thompson and Alexander N R Weber and Jean-Marc Reichhart and Petros Ligoxygakis}, doi = {10.1242/jcs.049155}, issn = {1477-9137}, year = {2009}, date = {2009-12-01}, journal = {J. Cell. (cnrs.fr)
  • volume = {122}, number = {Pt 24}, pages = {4505--4515}, abstract = {In Drosophila, the humoral response characterised by the synthesis of antimicrobial peptides (AMPs) in the fat body (the equivalent of the mammalian liver) and the cellular response mediated by haemocytes (blood cells) engaged in phagocytosis represent two major reactions that counter pathogens. (cnrs.fr)
  • The effects of these mutations unexpectedly suggested that pairs of chromosomes might be interacting to control the activity of this gene. (elifesciences.org)
  • Genetic studies showed several years ago that the third chromosomes of wild strains of Drosophila pseudoobscura often carry suppressors of crossing-over. (caltech.edu)
  • Belling(1) suggested that the chromosome rings found in Oenothera by Cleland(2) and others are to be explained as resulting from exchanges of ends between non-homologous chromosomes, so that one chromosome of a given complex is homologous at one end to one chromosome of a second complex, and at the other end to a different chromosome of the second complex. (caltech.edu)
  • Assays in transgenes in Drosophila previously identified cis -acting transcriptional regulatory elements from homeotic genes. (nih.gov)
  • However, most JmjC genes do not critically regulate development, as 10 members are viable and fertile with no obvious developmental defects. (sdbonline.org)
  • However, despite its smaller size, most developmental genes and at least half of the disease- and cancer-causing genes in humans are conserved in Drosophila , making Drosophila an excellent model system for the study of human development and disease. (nih.gov)
  • One of the important groups of conserved developmental genes are the homeotic genes. (nih.gov)
  • Within each of these categories, we identified clusters of genes associated with particular cellular and developmental functions. (biomedcentral.com)
  • So much of talk is going around about Hox genes in the field of evolution and some might wonder what makes them so important in this field as well, along with developmental biology. (iflybio.com)
  • Beaded Minute males are not intersexual, but are often aberrant because of incomplete development of the anal and genital imaginal discs-as are also Beaded Minute females. (caltech.edu)
  • In some of these species the presence of miR-10 has been shown experimentally, in others the genes encoding miR-10 have been predicted computationally. (wikipedia.org)
  • metabolic response, or gene or gene variant to the members of one species. (lookformedical.com)
  • Drosophila repleta Wollaston and D. neorepketa Patterson and Wheeler are closely similar species, the former widely distributed and the latter known from Guatemala. (caltech.edu)
  • So far we have found at least fourteen different gene-sequences in wild stocks, and have found that in most geographical regions several sequences are present, though no single sequence appears to occur throughout the range of the species. (caltech.edu)
  • This highly sensitive phenotypic readout of enhancer function in a native genomic context reveals novel features of CRM function undetected by traditional reporter gene analysis. (elifesciences.org)
  • Moreover, the 3′ UTRs of Brd and of the m4 transcription unit of the Enhancer of split gene complex [E(spl)-C] exhibit an unusually high degree of sequence identity that includes not only Brd box sequences but also a second motif we refer to as the 'GY box' (GTCTTCC). (biologists.com)
  • The chromosomal aberrations identified an imaginal leg enhancer about 35 kb upstream of the Scr promoter. (nih.gov)
  • The enhancer is not only able to activate transcription of the Scr promoter that is 35 kb distant but can also activate transcription of the Scr promoter on the homologous chromosome. (nih.gov)
  • Although the imaginal leg enhancer can activate transcription in all three pairs of legs, it is normally silenced in the second and third pairs of legs. (nih.gov)
  • Vertebrate insulin gene enhancer binding protein isl-1. (embl.de)
  • a beta-cell-specific transcriptional enhancer found in the insulin gene. (embl.de)
  • To further investigate the ancestral roles of NK family genes, we analyzed the expression patterns of NKL genes in the onychophoran Euperipatoides rowelli . (biomedcentral.com)
  • In Drosophila larvae, miR-10-3p is found in the imaginal discs (groups of cells which are destined to become adult structures upon metamorphosis). (wikipedia.org)
  • To characterise the signals with which infection might be communicated between blood cells and fat body, we ablated circulating haemocytes and defined the parameters of AMP gene activation in larvae. (cnrs.fr)
  • Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. (neurotree.org)
  • Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity. (neurotree.org)
  • Many spider Hox genes have not been investigated beyond their mRNA expression patterns, and the role of Hox genes with apparently plesiomorphic or dual functions, like ftz and Hox3 is still unclear. (bvsalud.org)
  • Individual expression patterns are extraordinarily diverse, but by supplementing qualitative in situ hybridization data with quantitative microarray time-course data using a hybrid clustering strategy, we identify groups of genes with similar expression. (biomedcentral.com)
  • Of 4,496 genes with detectable expression in the embryo, 2,549 (57%) fall into 10 clusters representing broad expression patterns. (biomedcentral.com)
  • the expression patterns of over 1,500 of these genes are documented here for the first time. (biomedcentral.com)
  • We have assembled an atlas of gene expression patterns during Drosophila embryogenesis. (biomedcentral.com)
  • This work was based upon a method developed by Hadorn previously which involved the transplantation of imaginal discs. (balzan.org)
  • Imaginal discs are the primordia of the Drosophila larva, which during metamorphosis give rise to the various parts of the adult fruit fly. (balzan.org)
  • Hadorn sometimes was playful in his approach and transplanted imaginal discs into an adult fly rather than a larva. (balzan.org)
  • Evolutionary changes in Hox gene function are believed to be involved in the emergence of the diverse body plans we observe in animals today. (bvsalud.org)
  • Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer. (prolekarniky.cz)
  • The lack of comparative data for many of the remaining NKL genes, including Bari , Hhex and Nedx currently hampers further evolutionary conclusions. (biomedcentral.com)
  • By altering intracellular Ca 2+ and InsP 3 levels through genetic means, we now show that signaling through the InsP 3 R is required at multiple steps for generating the neural circuit required in air puff-stimulated Drosophila flight. (jneurosci.org)
  • A conserved role in neural development has also been reported from NK2.2 , suggesting that the NKL genes might have been primarily involved in neural development in the last common ancestor of bilaterians or at least nephrozoans (all bilaterians excluding xenacoelomorphs). (biomedcentral.com)
  • Characterization of the chromosomal rearrangements shown in Figure 1 also revealed that two genetic elements (proximal and distal MES [maintenance elements for silencing]), about 70 kb apart in the Scr gene, must be in cis to maintain proper repression. (nih.gov)
  • Human HOXD10 gene has also been shown experimentally to be repressed by miR-10a and miR-10b. (wikipedia.org)
  • When not physically linked, the elements interact with elements on the homologous chromosome and cause derepression of its wild-type Scr gene. (nih.gov)
  • 2) If the normal X's of such hyperploids carry the recessive gene for yellow, the flies are wild-type in appearance because of the presence of +y in the duplicating chromosome. (caltech.edu)
  • In September, 1913, a wild female Drosophila of a stock from Liverpool, Nova Scotia, was crossed to a male bearing the second chromosome mutant characters vestigial and speck. (caltech.edu)
  • Morgan considered these two genes as lying in a "second chromosome," the first chromosome being the sex chromosome. (caltech.edu)
  • In Drosophila most mature miR-10 sequences are produced from the 3' arm of the precursor while in the beetle Tribolium castaneum most production comes from the 5' arm. (wikipedia.org)
  • The changes provide powerful assays for identifying the trans -acting factors that regulate the homeotic genes and the cis -acting sequences through which they act. (nih.gov)
  • Furthermore, these FGF ligands are not regulated solely by differential expression, but the sequences of these linked genes have evolved to serve different functions. (biologists.com)
  • Loss of Bmdsx gene expression significantly reduced the peripheral perception of the major pheromone component bombykol by reducing expression of the product of the BmOR1 gene which completely blocked courtship in adult males. (prolekarniky.cz)
  • The large majority of the early embryologists thought that the genes played only a minor role in development, for example by determining eye color, and that development is rather controlled by tissue interactions. (balzan.org)
  • By analyzing lethal mutations in the fruit fly Drosophila Hadorn accumulated evidence that genes control development to a large extent and that they determine the body plan in great detail. (balzan.org)
  • The trans -acting factors are also conserved between Drosophila and human and have important functions, not only in development but also in stem-cell maintenance and cancer. (nih.gov)
  • More important for the development of the fly, however, are the parasegmental boundaries that are established at the interface of en expressing cells and anteriorly adjacent wingless (wg) expressing cells. (bvsalud.org)
  • 5. Hashiyama K, Hayashi Y, Kobayashi S. Drosophila Sex lethal gene initiates female development in germline progenitors. (prolekarniky.cz)
  • In Drosophila , InsP 3 R activity is required in aminergic interneurons during pupal development for normal flight behavior. (jneurosci.org)
  • Cell and tissue specific gene expression is a defining feature of embryonic development in multi-cellular organisms. (biomedcentral.com)
  • RNA in situ hybridization has the potential to reveal both spatial and temporal aspects of gene expression during development. (biomedcentral.com)
  • According to this hypothesis, the normal allelomorph of the scute genes is not a single unit, but is made up of a series of "sub-genes" arranged in linear order, each sub-gene being concerned with the development of one or of a few bristles on the fly. (caltech.edu)
  • Zebrafish have seven Hox gene clusters, genes encoding miR-10 (mir-10a, mir-10b-1, mir-10b-2 and mir-10c) are found in the Hox Ba, Bb, Ca and Da clusters. (wikipedia.org)
  • Although these genes are found in various metazoans, plants, fungi and even unicellular eukaryotes, bilaterians have evolved the largest diversity of homeobox genes that arose predominantly due to extensive tandem duplications [ 2 , 4 , 5 ]. (biomedcentral.com)
  • The homeobox genes of animals are categorized into eleven classes, with the Antennapedia class (ANTP) being one of the largest, comprising the Hox, ParaHox and NK gene families [ 5 , 9 ]. (biomedcentral.com)
  • Even if they are considered to be intersexual, the abnormality may be induced by any one of at least seven different Minutes, or by other independent combinations of genes, and therefore cannot be used to support the view that there are very few loci involved in the determination of sex. (caltech.edu)
  • The homeotic genes are expressed in precise spatial patterns that are crucial for the proper determination of cell fate. (nih.gov)
  • Compartmentalization of dJmj in nucleolus together with some of PcG may be necessary to de-repress the expression of genes required to cellular growth and proliferation in the following meiotic divisions. (sdbonline.org)
  • Instead, they act at the cellular blastoderm stage, and cleavage of the ICD may allow it to directly regulate the transcription of target genes in alternate parasegments. (biomedcentral.com)
  • Binding of miR-10 leads to the repression of these genes. (wikipedia.org)
  • In multicellular organisms, signal transduction is essential to these processes, yet while our understanding of how signals regulate gene expression is relatively advanced, our understanding of how signals direct the acquisition of specific shapes and forms is less advanced. (stanford.edu)
  • Here by using CRISPR/Cas9 and electrophysiological techniques we found that courtship and mating behaviors are regulated in male silk moths by mutating genes in the sex determination cascade belonging to two conserved pathways. (prolekarniky.cz)
  • 3. Gempe T, Beye M. Function and evolution of sex determination mechanisms, genes and pathways in insects. (prolekarniky.cz)
  • Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
  • Mutants in the gene encoding the InsP 3 R ( itpr ) in Drosophila exhibit a range of defects including altered wing posture, increased spontaneous firing, and loss of rhythmic flight patterns in response to an air puff stimulus. (jneurosci.org)
  • Nearly 60% of the genes with detectable expression exhibit broad patterns reflecting quantitative rather than qualitative differences between tissues. (biomedcentral.com)
  • Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila . (sdbonline.org)
  • To identify novel regulators of JNK-dependent cell death, this study performed a dominant-modifier screen in Drosophila and found that the Toll pathway participates in JNK-mediated cell death. (sdbonline.org)
  • This paper explores the involvement of the Toll/NF-kappaB pathway in the localized activation of wound repair genes around epidermal breaks. (sdbonline.org)
  • The mir-10 genes are found within the Hox gene clusters. (wikipedia.org)
  • Interestingly, we found that mating behavior was regulated independently by another sexual differentiation gene, Bmfru . (prolekarniky.cz)
  • We found that targeted ablation of blood cells influenced the levels of AMP gene expression in the fat body following both septic injury and oral infection. (cnrs.fr)
  • Studies of spider Hox genes have already provided insights into evolutionarily conserved and derived features of the spider body plan and their genetic basis. (bvsalud.org)
  • Using a genetic screen for modifiers of Drosophila Myc ( dMyc )-induced growth, we identified and characterized a ubiquitin-specific protease (USP), Puffyeye (Puf), as a novel regulator of dMyc levels and function in vivo . (silverchair.com)
  • However, many aspects of Hox gene biology have been insufficiently studied in spiders so far. (bvsalud.org)
  • We also identify aspects of Hox gene biology that need to be studied in greater detail. (bvsalud.org)
  • In this review, we highlight previous comparative studies of Hox genes in spiders and their significance for our understanding of the evolution of the spider body plan. (bvsalud.org)
  • Hence, future studies should focus on the expression of these genes in other bilaterians, which would provide a basis for comparative studies and might help to better understand the role of NK genes in the diversification of bilaterians. (biomedcentral.com)
  • This study systematically tested the function of all 13 Drosophila JmjC genes. (sdbonline.org)
  • Although the function of the SPGs in establishing and maintaining segmental and parasegmental boundaries is highly conserved among arthropods, parasegmental grooves have only been reported for Drosophila, and a spider (Cupiennius salei). (bvsalud.org)
  • Gain-of-function mutations in the STAT3 gene have been reported to cause multi-organ early onset auto-immune diseases. (statpathway.com)
  • The inhibition of porin under the control of neuronal Ddc-Gal4 result in short lifespan and in an age-dependent loss in locomotor function, phenotypes that are strongly associated with Drosophila models of Parkinson disease . (sdbonline.org)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • In Drosophila , the homeotic genes specify cell identities at both embryonic and adult stages. (nih.gov)
  • Spiders have a duplicated Hox gene cluster, but possible sub- or neofunctionalisation of duplicates have not yet been studied systematically. (bvsalud.org)
  • They are typically divided into two subgroups, the NK cluster (NKC) and NK-linked genes (NKL). (biomedcentral.com)
  • Generation of molecularly defined null mutants revealed that loss of 8 out of 13 JmjC genes modify position effect variegation (PEV) phenotypes, consistent with their ascribed role in regulating chromatin organization. (sdbonline.org)
  • The mir-10a gene is located upstream of Hoxb4 and the mir-10b gene is located upstream of Hoxd4. (wikipedia.org)
  • There are many potential targets for miR-10* in Drosophila, including several Hox genes, indicating that miR-10* may also be functional. (wikipedia.org)
  • Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spätzle was knocked down in haemocytes. (cnrs.fr)
  • Deletion of Jarid2 leads to impaired orchestration of gene expression during cell lineage commitment. (sdbonline.org)
  • We demonstrate that the Drosophila FGFs have different activities and that cell migration and differentiation have different ligand requirements. (biologists.com)
  • The remaining 1,947 (43%) genes fall into 29 clusters representing restricted expression, 20% patterned as early as blastoderm, with the majority restricted to differentiated cell types, such as epithelia, nervous system, or muscle. (biomedcentral.com)
  • A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection. (elifesciences.org)
  • Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)
  • Therefore, I switched to Drosophila for my doctoral thesis, a model organism which can be manipulated much more easily. (balzan.org)
  • Subsequently, the expression of Buffy was altered in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)