The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. (embl.de)
Polarity3
Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene. (wikipedia.org)
In Drosophila , a pool of SGG isoenzymes encoded by a single gene is necessary to establish cell fate and polarity within embryonic segments [ 8 ] as well as for development of the nervous system [ 9 ]. (biomedcentral.com)
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. (wikipedia.org)
A Drosophila tumor suppressor gene prevents tonic TNF signaling through receptor N-glycosylation. (sdbonline.org)
The cell cortex of syncytial Drosophila embryos is patterned into cap and intercap regions by centrosomes, specific sets of proteins that are restricted to their respective regions by unknown mechanisms. (bvsalud.org)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
Cytoplasmic1
We have investigated the guidance roles of the morphogens Hedgehog and Decapentaplegic during directed outgrowth of cytoplasmic extensions in the Drosophila trachea. (biologists.com)
Protein3
Thus, our study provides new mechanistic insights into the regulation of axin protein homeostasis and presents new avenues for targeted Wnt pathway therapies. (plasignaling.com)
Thus, it is likely that axin protein levels need to be tightly regulated to ensure proper Wnt pathway signalling. (plasignaling.com)
Our study uncovers a new mechanism that controls axin protein stability and Wnt pathway signalling, and its therapeutic exploitation holds promise for treating Wnt-pathway- dependent cancers. (plasignaling.com)
Interact2
DVL1 has been shown to interact with: AXIN1, DVL3, EPS8, and Mothers against decapentaplegic homolog 3. (wikipedia.org)
Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway. (plasignaling.com)
Transcription1
We found that heat shock transcription factor 1d (HSFA1d) and its homologs are necessary for plant thermomorphogenesis during the day. (bvsalud.org)
Component1
XAV939 stimulates b-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex. (plasignaling.com)
Cell1
Axin has been reported to be the concentration-limiting factor in regulatingtheefficiencyofthe b-catenindestructioncomplex7,8 andover- expression of axin induces b-catenin degradation in cell lines expressing truncated APC9-11. (plasignaling.com)
Complex1
The principal constituents of the b-catenin destruction complex are adenomatous polyposis coli (APC), axin and glycogen synthase kinase 3a/b (GSK3a/b). (plasignaling.com)
Adenomatous2
[ 13 , 20 ] In the absence of Wnt, glycogen synthase kinase (GSK)-3β forms a stable complex with axin and adenomatous polyposis coli proteins and phosphorylates the transcription factor β-catenin in the cytoplasm. (medscape.com)
14. The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling. (nih.gov)
Wingless3
Here we report that Wingless (Wg)signaling is also essential for SSC maintenance in the Drosophilaovary. (biologists.com)
Osteoblast differentiation is predominantly regulated by Wnts, which are mammalian homologs of the Drosophila secreted morphogen wingless, and bone morphogenetic proteins, which are members of the TGF-β superfamily. (medscape.com)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
Scaffold1
6. Axin: a master scaffold for multiple signaling pathways. (nih.gov)
Beta-catenin2
13. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. (nih.gov)
In the absence of Wnt, β-catenin is phosphorylated by GSK-3β in a complex containing axin and APC, thus targeting its ubiquitination and degradation by the proteasome. (medscape.com)
Degradation2
(B) Binding of Wnt to its receptor Fz and coreceptor LRP5/6 causes Dsh-mediated degradation of GSK-3β and anchoring of axin to LRP5/6, thus resulting in inhibition of β-catenin phosphorylation. (medscape.com)
17. The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation. (nih.gov)
Pathways1
1. Diversity of axin in signaling pathways and its relation to colorectal cancer. (nih.gov)
Roles1
20. Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling. (nih.gov)
Destruction Complex1
19. The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2. (nih.gov)
Maintains1
15. Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin. (nih.gov)
Stem2
In the Drosophilaovary, Hedgehog is the only known signal for maintaining somatic stem cells (SSCs). (biologists.com)
Possibly, mechanisms regulating proliferation and differentiation of epithelial cells, including epithelial stem cells, is conserved from Drosophila to man. (biologists.com)
Negative1
Constitutive Wg signaling in SSCs through the removal of its negative regulators, Axin and shaggy , also causes SSC loss. (biologists.com)
Only the 20S fraction contains an appreciable portion of the cellular axin and small but detectable amounts of glycogen synthase kinase 3β and β-catenin. (silverchair.com)