• Using the Drosophila nephrocyte as a genetic screen platform, most genes involved in endocytosis and cell trafficking were screened, and the key components were identified of the cell trafficking pathway required for SD protein endocytosis and recycling. (sdbonline.org)
  • The SD protein endocytosis and recycling pathway was found to contain clathrin , dynamin , AP-2 complex, like-AP180 (Lap) , auxilin and Hsc70-4 (the endocytosis part) followed by Rab11 and the exocyst complex (the recycling part). (sdbonline.org)
  • Endocytosis of Wingless via a dynamin-independent pathway is necessary for signaling in Drosophila wing discs. (ncbs.res.in)
  • However, shibire (SHI), the Drosophila dynamin that regulates endocytosis, was found in the distinct region. (biologists.com)
  • We show that Wingless transcytosis involves dynamin-dependent endocytosis from the apical surface. (elsevierpure.com)
  • The function of endocytosis is best demonstrated in the Drosophila mutant shibire ts where ts denotes temperature sensitive, in which inactivation of the csgo spoofer buy cheap dynamin at nonpermissive temperatures e. (goldenmeats.com.uy)
  • 1997). Determined by the presence of Delta-Notch vesicular structures within ligand signaling cells in Drosophila, the authors suggested that ligands could possibly undergo endocytosis though bound to Notch. (calcimimeticagent.com)
  • In Drosophila, Fzo is found in postmeiotic spermatids and the dysfunction of this protein results in male sterility. (wikipedia.org)
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
  • A genome-wide resource for the analysis of protein localisation in Drosophila. (tcd.ie)
  • In a forward screen for genes affecting neurotransmission in Drosophila, we identified mutations in dynamin-related protein (drp1). (nih.gov)
  • Shibire is the name given to an unusual mutation in the fruit fly Drosophila's dynamin gene, which normally makes a protein that helps to release tiny little packets of molecules from nerve cells enabling them to transmit information. (thenakedscientists.com)
  • sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)
  • The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
  • Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)
  • Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
  • As Tau becomes hyperphosphorylated in Alzheimer's, it facilitates interactions with other cellular proteins, namely dynamin-related protein 1 (DRP1) an enzyme involved in mitochondrial fission. (vbiognostics.com)
  • I have identified Drosophila shibire as a critical gene mediating rapid tolerance to ethanol in flies. (utexas.edu)
  • All of these molecules are GTP hydrolyzing proteins (GTPases) that belong to the dynamin family. (wikipedia.org)
  • Arguelles J, Lee J, Cardenas LV, Govind S, Singh S. In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation-Polar-Cation Clip Motif in Knottin Proteins. (cuny.edu)
  • A cell-adhesion molecule fasciclin 2 (FAS2), which is required for synaptic growth and still life (SIF), an activator of RAC, were found to localize in the surrounding region of the active zone, defining the periactive zone in Drosophila neuromuscular synapses. (biologists.com)
  • therefore, in Drosophila (fruit flies) and yeasts, the process is controlled by the mitochondrial transmembrane GTPase, Fzo. (wikipedia.org)
  • We also develop and use live-cell assays to show that {PCs} take up soluble macromolecules in a Dynamin-dependent manner and colloids by a Dynamin-independent pathway. (amrita.edu)
  • Investigators administered the anti-inflammatory caffeic acid to drosophila and mouse models, aiming to lessen the impact of the arachidonic acid pathway and alleviate ALS symptoms. (vbiognostics.com)
  • This gene is the Drosophila homolog of dynamin and regulates vesicle recycling at the synapse and neuronal communication in the brain. (utexas.edu)
  • This study implicates the Drosophila GAK homolog, auxilin (aux) , in a broad spectrum of parkinsonian-like symptoms. (sdbonline.org)
  • We report here the functional characterization of Drosophila larval {PCs} with important insights into their cellular uptake pathways. (amrita.edu)
  • Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg hybridoma library. (tcd.ie)
  • Social communication of predator-induced changes in Drosophila behavior and germline physiology. (tcd.ie)
  • Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. (shengsci.com)
  • Cyclin-G-associated kinase (GAK) , a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating (see Drosophila Clathrin heavy chain ), though its PD-related function remains elusive. (sdbonline.org)
  • DYNAMIN also functions at the synapse to mediate rapid neurotransmission and critically modulate neuronal excitability. (utexas.edu)
  • Adult Drosophila acquire rapid functional tolerance to ethanol after a single sedation due in part to a transcriptional up-regulation of the slowpoke message. (utexas.edu)
  • Specific membrane-anchored dynamin family members mediate fusion between mitochondrial outer membranes known as Mfn1 and Mfn2. (wikipedia.org)
  • However, a single dynamin family member known as OPA1 in mammals mediates fusion between mitochondrial inner membranes. (wikipedia.org)
  • Choudhury SD, Mushtaq Z, Reddy-Alla S, Balakrishnan SS, Thakur RS, Krishnan KS, Raghu P, Ramaswami M, Kumar V. σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila. (tcd.ie)
  • Using the binary GAL4/UAS system to express slowpoke in different parts of the Drosophila nervous system I show that slowpoke induction in the mushroom bodies of the adult fly brain, a region critical for olfactory learning and memory, is important for ethanol tolerance. (utexas.edu)
  • A survey of brain structures mediating drug tolerance in the genetically tractable Drosophila could potentially reveal evolutionarily conserved molecular pathways regulating tolerance. (utexas.edu)
  • Brenner, R, Atkinson, NS (1997) Calcium-activated potassium channel gene expression in the midgut of Drosophila. (utexas.edu)
  • Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila. (tcd.ie)
  • A Drosophila Circuit for Habituation Override. (tcd.ie)
  • The Drosophila giant fiber (GF) escape circuit is an extensively studied model for neuron connectivity and function. (eneuro.org)
  • The Drosophila giant fiber circuit has long served as such a model, due to large neuron size, genetic malleability, and easily visualized behavioral output: a jump in response to a threat. (eneuro.org)
  • In drosophila models they observed improvements to the flies' abilities to move and climb, whilst they also survived for longer. (vbiognostics.com)
  • In help of this idea, following asymmetric cell division through Drosophila sensory cell fate determinations, Delta is concentrated in recycling endosomes enriched to signal-sending cells (Emery et al. (calcimimeticagent.com)
  • Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in the Drosophila Antennal Lobe. (tcd.ie)