Drosophila cell cycle progression. Medical search. Frequent questions

Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression. (mpg.de)
We are taking a multi-pronged approach to address these questions in the model organism Drosophila melanogaster and in lung cancer. (wayne.edu)
Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
We use the genetically tractable model organism Drosophila melanogaster to examine how meiotic progression is both coordinated with and instructed by the developmental and metabolic program of the egg. (nih.gov)
In this project, I aimed to understand how the APC/C coordinates the cell cycle with the cell specialisation process using the fruit fly, Drosophila melanogaster, as a model organism. (europa.eu)
Bällchen participates in proliferation control and prevents the differentiation of Drosophila melanogaster neuronal stem cells. (mpg.de)
Bällchen is required for self-renewal of germline stem cells in Drosophila melanogaster. (mpg.de)
Since cell size has been shown to affect the strength of the SAC, the authors compared the cell size, kinetochore number, and kinetochore-to-cell volume ratio in 2-celled embryos of their species and additionally analyzed previous published data from the model organisms, C. elegans , D. melanogaster , and X. laevis . (biologists.com)

Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. (nih.gov)
These drugs, called GGTIs, inhibit proliferation of various human cancer cells and inhibit tumor growth in animal model systems. (uclahealth.org)
Cellular senescence is a fundamental cellular program that is activated after a finite number of cell divisions and operates to avoid further cell proliferation. (plos.org)
Recent technological advances have enabled us to gain new insights at the single-cell level, revealing an interplay between metabolic state and developmental progression that impacts the timing of proliferation and neurogenesis. (bvsalud.org)
However, a function for SET8 in mammalian cell proliferation has not been determined. (rupress.org)
We show that small interfering RNA inhibition of SET8 expression leads to decreased cell proliferation and accumulation of cells in S phase. (rupress.org)
Finally, these authors report that conserved DVL-1 lysines modulate various oncogenic functions such as cell migration, proliferation, cell-cycle progression, 3D-spheroid formation and in-vivo tumor growth in breast cancer models. (oncotarget.com)
Figure 6: K69 and K285 residues significantly influence rate of cell proliferation and xenograft tumor growth respectively in MDA-MB-231 cells. (oncotarget.com)
Here we show that NMD components are required for cell proliferation in Drosophila. (ox.ac.uk)
Many important developmental procedures including proliferation development patterning and differentiation need the cell routine to be carefully coordinated with several signaling pathways. (bioerc-iend.org)
During the natural developmental process of Drosophila, the developing eye shows a remarkable, tight coordination between cell proliferation and the steps for cell specialisation. (europa.eu)
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. (nature.com)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
She proposed a completely new way of thinking about the G0 stage in cell cycle, suggesting that quiescent stem cells are poised for proliferation or differentiation rather than simply lying dormant. (biologists.com)
Bruggeman SWM, Valk-Lingbeek ME, van der Stoop PPM, Jacobs JJL, Kieboom K, et al: Ink4A and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. (karger.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)

The Ras-superfamily G-proteins play critical roles in cell growth and differentiation. (uclahealth.org)
A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection. (elifesciences.org)
Furthermore, these studies have highlighted the need to reassess the instructive role of glucose metabolism in determining progenitor cell division, differentiation, and fate. (bvsalud.org)
Thus, an understanding of how meiotic progression and gamete differentiation are coordinated during oogenesis is essential to studies in both reproductive biology and medicine. (nih.gov)
How does cell-cycle status within the ovarian cyst influence the differentiation of the oocyte? (nih.gov)
Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
The endocycle is certainly popular among multicellular microorganisms and it is associated with development and differentiation (e.g. nurse cells and follicular cells from the oocyte cyst). (bioerc-iend.org)
After implantation differentiation of trophoblast large cells which get excited about the remodeling from the maternal uterus during implantation is certainly achieved through many endocycles resulting in boosts of DNA articles up to 1000N (48). (bioerc-iend.org)
In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
Cell Death and Differentiation. (elsevierpure.com)

and syncytial blastoderm mitotic cell cycle. (nih.gov)
Furthermore, Par-complex patches resembling Par-islands exist in Drosophila mitotic neuroblasts. (elifesciences.org)
First, the number of motor neurons was reduced, possibly caused by the premature withdrawal of the precursors from mitotic cycles. (biologists.com)
Altogether, these new studies on transcription factors and chromatin modifiers not only shed light on the fundamental problem of neuronal identity maintenance, but also outline mechanistic principles of gene regulation that may operate in other long-lived, post-mitotic cell types. (bvsalud.org)
In yeast and Drosophila, Cdh1-dependent APC (Cdh1-APC) activity targets mitotic cyclins from the end of mitosis to the G 1 phase. (elsevierpure.com)
However, similarly to yeast and Drosophila, loss of Cdh1 induced unscheduled accumulation of mitotic cyclins in G 1 , resulting in abrogation of G 1 , arrest caused by treatment with rapamycin, an inducer of p27 Kipl . (elsevierpure.com)
In yeast and Drosophila, Cdh1-dependent APC (Cdh1-APC) activity targets mitotic cyclins from the end of mitosis to the G1 phase. (elsevierpure.com)
However, similarly to yeast and Drosophila, loss of Cdh1 induced unscheduled accumulation of mitotic cyclins in G1, resulting in abrogation of G1, arrest caused by treatment with rapamycin, an inducer of p27Kipl. (elsevierpure.com)
Thus, the products of chromosome replication (sister chromatids) generated during S-phase must be identified over time until mitosis when sisters associate with the mitotic spindle and segregate away from each other into the newly forming daughter cells. (rupress.org)
Most eukaryotic cells use the spindle assembly checkpoint (SAC) to ensure faithful chromosome segregation in each round of cell division by delaying mitotic progression until all chromosomes are properly attached to spindle microtubules at their kinetochores. (biologists.com)
However, in other large-celled organisms such as sea urchins and clams, treatment with microtubule depolymerizing drugs caused a delay in mitotic progression, suggesting that these embryos may be SAC competent. (biologists.com)
They monitored the mitotic marker phospho-histone H3 (pH3) over time to assess whether each species arrests in mitosis or continues to cycle through cell division, thus demonstrating whether embryos respond to or lack SAC signaling, respectively. (biologists.com)
Similar to the published data in Xenopus and zebrafish, the chordate tunicate P. mammillata showed pH3 oscillations and continued to cycle, while multiple species of sea urchin (echinoderms), the mussel M. galloprovincialis (a mollusk), and the jellyfish C. hemisphaerica (a cnidarian) delayed mitotic progression. (biologists.com)
Treatment with the Mps1 inhibitor reversine shortened the nocodazole-induced mitotic arrest and restored cell cycle timing, which confirms the SAC dependence of the mitotic arrest. (biologists.com)

More generally, we study the reversible enzymatic coupling of proteins to other proteins within cells. (yale.edu)
One such protein that we study, SUMO, is attached to many proteins and is crucial for cell-cycle progression. (yale.edu)
First, we wish to understand, at a mechanistic and molecular level, how specific proteins are rapidly degraded within eukaryotic cells while most proteins are spared. (yale.edu)
The Ubl called SUMO is attached to many proteins in vivo and is crucial for cell-cycle progression. (yale.edu)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
Our results suggest that in young cells Polycomb proteins are recruited to the INK4/ARF locus through CDC6 and the resulting silent locus is replicated during late S-phase. (plos.org)
Evidence supporting the direct control of the cell cycle by Pc-G proteins in vertebrates came from studies on mouse Bmi1 mutants. (plos.org)
Neuronal Ca2+ is found in different forms, with a minority being freely soluble in the cell and more than 99% being bound to proteins. (bvsalud.org)
The DNA in the cell is packaged with histone proteins into chromatin. (usc.edu)
DAZ family proteins are found almost exclusively in germ cells in distant animal species. (ijbs.com)
DAZ family proteins are located in the nucleus and/or in the cytoplasm of male and female germ cells at different developmental stages throughout the gametogenesis. (ijbs.com)
One of the critical factors for the control of the protein levels during the cell cycle is the Anaphase Promoting Complex/Cyclosome (APC/C). This complex recognises proteins with specific signatures (or degrons) and targets them for degradation via the protein destruction machinery called the proteasome. (europa.eu)
Drosophila gene tao-1 encodes proteins with and without a Ste20 kinase domain that affect cytoskeletal architecture and cell migration differently. (mpg.de)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)

We are trying to understand the functional consequences of SUMO-protein modification, particularly in the cell cycle and chromatin-mediate gene transcription, and to determine the basis of specificity for the SUMO-cleaving proteases. (yale.edu)
Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)
Point mutations in the Drosophila RHEB gene inhibits cell growth while overexpression promotes cell growth. (signalchem.com)
Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
Oncotarget published " Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling " which reported that K69 and K285 regulate binding of DVL-1 to Wnt target gene promoters and modulate expression of Wnt target genes including CMYC, OCT4, NANOG, and CCND1, in cell line models and xenograft tumors. (oncotarget.com)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains. (mpg.de)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)

Much of our work is conducted in baker's yeast, a model organism ideal for genetic and biochemical analysis, but we also use human tissue culture cells and Drosophila in certain studies. (yale.edu)

We characterized dCTCF-binding sites according to their occupancy status during the cell cycle, and identified three classes: interphase-mitosis-common (IM), interphase-only (IO) and mitosis-only (MO) sites. (biomedcentral.com)
Early stages of drosophila development are marked by rapid cell cycles that go directly from S phase to mitosis without any obvious gap phases. (libsyn.com)
Alternatively in endocycles DNA replication (the S stage) and cell development take place lacking any intervening mitosis (M stage) phase resulting in polyploidy. (bioerc-iend.org)
The G 2 gap phase further separates S-phase from mitosis, allowing for continued cell growth and maturation before cell division. (rupress.org)
Experimental schematic (A) and two examples of different responses to nocodazole treatment, where the tunicate P. mammillata continues to cycle through cell divisions (B) and the sea star H. attenuata arrests in mitosis (C). From Figure 1. (biologists.com)

cnd-1 expression was first detected in neuroblasts of the AB lineage in 14 cell embryos and maintained in many neuronal descendants of the AB lineage during embryogenesis, diminishing in most terminally differentiated neurons prior to hatching. (biologists.com)

rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
curled encodes the Drosophila homolog of the vertebrate circadian deadenylase nocturnin. (mpg.de)

Barabara Pernaute (National Institute of Medical Research, UK) presented her work on the role of miRNAs in naive embryonic stem cells compared to epiblast cells in post-implantation embryos. (biologists.com)
As part of the post-graduate symposium, Siyao Wang (University of Manchester, UK) presented her PhD research on the role of MLL in germ line cells of the C. elegans embryos and Richard Kaschula (University of Sussex, UK) talked about ubx-targeting miRNAs in Drosophila . (biologists.com)
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. (cshlpress.com)
Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. (cshlpress.com)
Embryos continue to cycle through these early divisions despite the presence of microtubule depolymerizing drugs, suggesting that the SAC is silenced or weakened in these fast division cycles. (biologists.com)
In order to determine which species activated SAC signaling for cell division, the authors treated two-celled embryos with nocodazole to completely depolymerize microtubules. (biologists.com)

This upregulation was correlated with tumor progression. (molvis.org)
These changes can be inherited and are, therefore, found in every cell, but more often, they are somatically acquired and restricted to tumor cells. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Mitra A, Vo L, Soukar I, Chaubal A, Greenberg ML, Pile LA. Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival. (wayne.edu)
Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. (sdbonline.org)
DEAF-1 activates the expression of Mtk and Drs promoter-luciferase fusion genes in S2 cells. (sdbonline.org)
We show that UPF1, UPF2, UPF3, SMG1, SMG5, and SMG6 regulate in concert the expression of a cohort of genes with functions in a wide range of cellular activities, including cell cycle progression. (ox.ac.uk)
The majority of cell cycle regulators, including APC/C, as well as the genes regulating cells' responses to external cues, are very similar between Drosophila and mammals, although the genetic circuit in Drosophila is relatively simple and less complex compared to mammals. (europa.eu)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

The Journal of Cell Biology. (wikipedia.org)
Seminars in Cell and Developmental Biology, 72. (unibas.ch)
Dr. Lilly was recruited to the Cell Biology and Metabolism Branch of NICHD in 1998. (nih.gov)
Dr Tabancay received his BS in Molecular, Cell, and Developmental Biology in 1998 from the University of California, Los Angeles. (usc.edu)
from the March 9, 2009 and October 5, 2009 issues of the Journal of Cell Biology and includes interviews with authors Mark McCleland and Patrick O'Farrell. (libsyn.com)
biosights is a series of life science videos highlighting original scientific research published in The Journal of Cell Biology. (libsyn.com)
With stem cell biology and molecular understanding of reproductive failure, new therapies for previously untreatable infertility are currently on the near horizon. (infertile.com)
This would add a whole new dimension to consider in the study of cell biology, which seems both exciting and daunting at the same time. (biologists.com)

Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic cells. (plos.org)
1. Stocker, H. et al: Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. (signalchem.com)
It is proposed that DEAF-1 is a regulator of Drosophila immunity (Reed, 2008). (sdbonline.org)
Used jointly these total outcomes claim that can be an important regulator from the cell routine in the preimplantation embryo. (bioerc-iend.org)
A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. (mpg.de)

The manual features primers on live imaging of a variety of standard model organisms including C. elegans, Drosophila, zebrafish, Xenopus, avian species, and mouse. (cshlpress.com)
Studies in C. elegans have also suggested that the larger cell size at earlier embryonic divisions causes the SAC signaling cascade to be too dilute to mount a meaningful response. (biologists.com)
They examined ~15 different organisms across multiple metazoan groups and combined their findings with those from the literature of previously characterized organisms, such as Xenopus , Danio rerio , Drosophila , and C. elegans . (biologists.com)

In mammals, studies on the early stages of oogenesis face serious technical challenges in that entry into the meiotic cycle, meiotic recombination, and the initiation of the highly conserved prophase I arrest all occur during embryogenesis. (nih.gov)
While highly conserved through evolution the cell routine continues to be modified to adjust to brand-new developmental applications extensively. (bioerc-iend.org)

TATA-box binding protein is not required for RNA Polymerase II transcription in mouse embryonic stem cells. (elifesciences.org)
How plastic the normal cell cycle is usually becomes clear when comparing the so-called "embryonic cleavage cycles" and the endoreplication cycle also referred to as the endocycle. (bioerc-iend.org)
The embryonic cleavage cycles are maternally powered as nutrition and cell routine factors are kept in the egg cytoplasm during oogenesis. (bioerc-iend.org)
Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, et al: Polycomb complexes repress developmental regulators in murine embryonic stem cells. (karger.com)
For example, the early embryonic cleavages of both Xenopus frogs and zebrafish do not have cell cycle checkpoints until the mid-blastula transition and zygotic genome activation. (biologists.com)

Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)

Many transitions in the business from the cell routine are found during early mammalian advancement. (bioerc-iend.org)
Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)

The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function. (elifesciences.org)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
However, changes of CTCF-binding sites during the cell cycle, and functions of this protein at different cell cycle phases, remain largely uncharacterized. (biomedcentral.com)
RHEB is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. (signalchem.com)
Drosophila RHEB is a direct target of Tsc2 GTPase-activating protein (GAP) activity both in vivo and in vitro. (signalchem.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

Defining the epithelial stem cell niche in skin. (nature.com)
The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)
The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)

Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)

J Cell Biol, 2007 Jun 18. (nih.gov)
Nature Cell Biol. (signalchem.com)
J Cell Biol (2007) 179 (7): 1337-1345. (rupress.org)
Nat Rev Mol Cell Biol , Art. (mpi-cbg.de)
J Cell Biol (2005) 169 (6): 841-846. (rupress.org)

Motor control of Drosophila feeding behavior. (unibas.ch)

Genetic studies using fission yeast and Drosophila established that Rheb plays critical roles in both cell growth and cell cycle progression at the G1/S boundary and that this function of Rheb is mediated by its ability to activate the TOR/S6K signaling pathway. (uclahealth.org)
Easy access to the early stages of oogenesis, coupled with the available genetic and molecular genetic tools, makes Drosophila an excellent model for studies on meiotic progression and oocyte development. (nih.gov)
As patients with MDS have widely variable prognosis, we need to stratify them according to chromosomal abnormalities, genetic alterations, and epigenetic deregulations associated with progression to AML in order to treat these patients appropriately. (karger.com)

Our lab has as its general focus one of the fundamental regulatory systems of eukaryotic cells - the ubiquitin system. (yale.edu)
2006 There has been remarkable progress in the last 20 years in defining the molecular mechanisms that regulate initiation of DNA synthesis in eukaryotic cells. (usc.edu)

When cells enter senescence the binding to RD of both PRC1 and PRC2 complexes is lost leading to a decreased level of histone H3K27 trimethylation (H3K27me3). (plos.org)
Histone supply regulates S phase timing and cell cycle progression. (mpg.de)
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. (karger.com)

Furthermore, we find that SET8 interacts with proliferating cell nuclear antigen through a conserved motif, and SET8 is required for DNA replication fork progression. (rupress.org)
For instance, DNA replication and DNA damage checkpoints delay cell cycle progression until each chromosome is fully replicated and physically intact. (rupress.org)

A series of precise temporal transitions within progenitor cell populations generates all the appropriate neural cell types while maintaining a pool of self-renewing progenitors throughout embryogenesis. (bvsalud.org)
The splicing co-factor Barricade/Tat-SF1, is required for cell cycle and lineage progression in Drosophila neural stem cells. (unibas.ch)

This review focuses on glucose metabolism (glycolysis) in cortical progenitor cells and the emerging focus on glycolysis during neurogenic transitions. (bvsalud.org)
2017). Nuclear receptors connect progenitor transcription factors to cell cycle control . (up.pt)
With great relevance to my own work, I was also excited to hear about Jyotsna Dhawan's (National Centre for Biological Sciences, India) research into the factors which mediate reversible quiescence in muscle progenitor cells. (biologists.com)
We have reported that the expression of BMI1 , a member of PcG, in hematopoietic stem cells or progenitor cells predicts the prognosis of patients with MDS and progression to acute leukemia. (karger.com)

However, the role of CTCF in the maintenance and propagation of genome architectures throughout the cell cycle remains elusive. (biomedcentral.com)
Our results revealed different functions of dCTCF during the cell cycle and suggested that dCTCF might contribute to the establishment of the three-dimensional architecture of the Drosophila genome by maintaining local chromatin compartments throughout the whole cell cycle. (biomedcentral.com)
On the two-cell stage transcription from the zygotic genome takes place and is necessary for the next cleavages to occur (11). (bioerc-iend.org)

and human spermatogenic stem cell culture to treat azoospermia, and to preserve fertility in pre-pubertal boys undergoing cancer treatment. (infertile.com)
Fuchs, E. The tortoise and the hair: slow-cycling cells in the stem cell race. (nature.com)
There is emerging evidence indicating that the PcG complexes are indispensable for sustaining stem cell activity and cancer stem cells. (karger.com)

SIN3 is required for viability of multi-cellular organisms and mutations in components in the complex have been linked to defects in cell cycle progression. (wayne.edu)
Polarization is a fundamental cellular property that plays a vital role in various biological processes in multi-cellular as well as single-cell organisms. (elifesciences.org)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Cells are the basic building blocks for living organisms, including us, humans. (europa.eu)
The right balance between these two fates of cells is essential not only for forming proper shapes of organs and tissues but also for maintaining their functions throughout the life of the organisms. (europa.eu)
Given the variability of SAC signaling between organisms and cell size, the authors used a multi-species comparative analysis to determine if the SAC activity and response correlated with any particular cellular characteristic or evolutionary group. (biologists.com)

Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells. (mpg.de)
Finally, the vast majority of NMD targets in Drosophila are not orthologs of targets previously identified in yeast or human cells. (ox.ac.uk)

Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. (nature.com)

Autofluorescence imaging permits label-free cell type identification in live airway tissue and reveals the dynamic formation of airway secretory cell associated antigen passages. (elifesciences.org)
The blastocyst includes two cell Dalcetrapib types: the trophectoderm (TE) that provides rise towards the placenta and an internal cell mass Dalcetrapib (ICM) that the complete fetus and area of the extraembryonic tissue will establish. (bioerc-iend.org)
After division, cells need to respond to external cues from the surrounding tissue and decide whether to continue dividing or to halt the cell cycle to become specialised in a task required for the proper function of the tissue/organ where they reside. (europa.eu)
Focusing in particular on skin, Ben Simons (University of Cambridge, UK) talked about his inquiry into the mechanisms by which skin stem cells maintain their tissue. (biologists.com)

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. (nih.gov)
The long-term goal of our laboratory is to understand how the cell-cycle events of meiosis are coordinated with the developmental and metabolic events of gametogenesis. (nih.gov)

Recently, evidence has been accumulating on the molecular mechanism underlying self-renewal of stem cells. (karger.com)
Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)

To investigate the function of Cdh1 in vertebrate cells, we generated clones of chicken DT40 cells disrupted in their Cdh1 loci. (elsevierpure.com)

RHEB is vital in the regulation of growth and cell cycle progression. (signalchem.com)

Furthermore these cycles possess a G1 and a G2 stage and so are endowed with DNA harm and spindle checkpoints (find for example personal references 13 18 and 46). (bioerc-iend.org)

Conversely, genetically promoting lactate production in HFSCs through mitochondrial pyruvate carrier 1 (Mpc1) deletion accelerated their activation and the hair cycle. (nature.com)
Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)

Temperature-Induced uncoupling of cell cycle regulators. (nih.gov)
TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. (nih.gov)

He presented fascinating live imaging data demonstrating that several molecules of the NFkB pathway periodically change location within the cell at distinct rates. (biologists.com)

To understand the regulatory inputs that control early meiotic progression, we are working to determine how the oocyte initiates and then maintains the meiotic cycle within the challenging environment of the ovarian cyst. (nih.gov)

1,100 muscle-targeted RNAi interventions to comprehensively assess the function of 447 transcription factors in the developmental growth of body wall skeletal muscles in Drosophila. (sdbonline.org)
As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

To alter the expression of Buffy in the dopaminergic neurons of Drosophila. (sdbonline.org)
The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
It is concluded that the inhibition of Buffy in DA neurons produces a novel model of PD in Drosophila. (sdbonline.org)
Neurons are remarkably long-lived, non-dividing cells that must maintain their functional features (e.g., electrical properties, chemical signaling) for extended periods of time - decades in humans. (bvsalud.org)

The canonical watch about the control of the cell routine is in fact getting challenged by in vivo research. (bioerc-iend.org)

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells. (unibas.ch)

An intrinsic mechanism that through the secretion of a specific molecule called Wingless by the neighbouring cells, instruct the receiving cells to keep their proliferative state. (europa.eu)

Overexpression of DEAF-1 by using a maternal driver inhibits germ-band retraction and causes defects in dorsal closure, whereas overexpression at later stages causes cell death (Reed, 2008). (sdbonline.org)

Depending on the species, DAZL is expressed in primordial germ cells (PGCs) and/or pre-meiotic and meiotic germ cells of both sexes. (ijbs.com)
1. The presence of nerve fibers in contact with touch, the "emotional touch", which is vital for the the skin surface skin cells (keratinocytes) survival and maintenance of our species. (bvsalud.org)

Drosophila adult muscle development and regeneration. (unibas.ch)

Structure and development of the subesophageal zone of the Drosophila brain. (unibas.ch)
Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking. (unibas.ch)
Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. (mpg.de)

These results indicate that unlike K69 and K285, K34 does not control nuclear localization of DVL-1 across multiple cell line models. (oncotarget.com)
A ) MDA MB-231 cells were seeded onto 96 well plates and grown in the presence of nuclear stain NucLight Rapid Red Reagent (Essen Biosciences). (oncotarget.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Alternatively, all the cells may become specialised and stop producing new cells, which accelerates the degeneration of tissues or the ageing process. (europa.eu)
Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
Periapical lesions are diseases resulting from contamination and necrosis of dental pulp and the progression of this infection toward the periapical tissues. (bvsalud.org)
Gram-negative bacteria not only have different factors of virulence and generate products and sub-products that are toxic to apical and periapical tissues, but also contain endotoxin in the outer membrane of their cell wall. (bvsalud.org)

Identification and functional characterization of muscle satellite cells in Drosophila. (unibas.ch)

Anatomy24

Organisms13

Diseases4

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes82

Disciplines and Occupations1

Information Science3

Health Care1

Melanogaster8

Proliferation16

Differentiation12

Mitotic14

Proteins14

Gene10

Model organism1

Mitosis5

Maintained in many1

Homolog2

Embryos7

Tumor3

Genes6

Biology8

Regulator5

Elegans3

Highly conserved2

Embryonic5

Embryo1

Mammalian2

Protein9

Epithelial3

Kinase1

Biol5

Feeding behavior1

Genetic3

Eukaryotic cells2

Histone3

Replication2

Neural2

Progenitor4

Genome3

Stem Cell3

Organisms6

Yeast2

Metabolism1

Tissue4

Meiosis2

Molecular2

Vertebrate1

Regulation1

Checkpoints1

Activation2

Regulators2

Pathway1

Oocyte1

Transcription2

Neurons4

Vivo1

Malignant1

Mechanism1

Inhibits1

Species2

Regeneration1

Development3

Nuclear2

Tissues6

Functional1