Drosophila asp protein cell division mutants in drosophila. Medical search. Frequent questions

Drosophila melanogaster for example has only 2 genes, whereas Caenorhabditis elegans has only one. (wikipedia.org)
To understand the role of autophagy in the pathogenesis of glial tumors in vivo, an established Drosophila melanogaster model of glioma was used based on overexpression in larval glial cells of an active human EGFR and of the PI3K homolog Pi3K92E /Dp110. (sdbonline.org)
Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)

Further, we review the corresponding genes and the proteins encoded by these genes, their possible role in the developing brain and reported mutations of these genes. (biomedcentral.com)
With 35,000 genes and hundreds of thousands of protein states to identify, correlate, and understand, it no longer suffices to rely on studies of one gene, gene product, or process at a time. (genomicglossaries.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
NF-κB is a transcription factor that plays a pivotal role in the highly specific pattern of gene expression observed for immune, inflammatory and acute phase response genes, including interleukin 1, interleukin 8, tumor necrosis factor and certain cell adhesion molecules. (justia.com)
Specifically, YTHDC2 deficiency causes microtubule-dependent telomere clustering and apoptosis at the pachytene stage of prophase I. Depletion of YTHDC2 results in a massively dysregulated transcriptome in pachytene cells, with a tendency toward upregulation of genes normally expressed in mitotic germ cells and downregulation of meiotic transcripts. (bvsalud.org)
Dysregulation does not correlate with m6A status, and YTHDC2-bound mRNAs are enriched in genes upregulated in mutant germ cells, revealing that YTHDC2 primarily targets mRNAs for degradation. (bvsalud.org)

J Cell Biol (2001) 155 (6): 937-948. (rupress.org)
2002) J Cell Biol, 158: 529-539). (justia.com)

The master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. (sdbonline.org)
Hamilton: B. C. Decker Inc.). A number of anti-angiogenic activities have been reported for this protein, such as inhibition of endothelial cell proliferation, migration, and tube formation. (justia.com)
Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. (lookformedical.com)
We decellularized the metastatic lung sections, measured the micromechanics of the tumor ECM, and stained the sections for ECM proteins, proliferation, and cell death markers. (ibecbarcelona.eu)

Once this complex is activated, the cell is forced into mitosis, by the subsequent activation and regulation of other protein kinases or by direct phosphorylation of structural proteins involved in this cellular reorganisation. (wikipedia.org)
Activation of AMPK by low energy supply and phosphorylation of LKB1 results in an inhibition of mTOR , thus decreasing energy-consuming processes, in particular translation and, thus, cell growth. (sdbonline.org)
Endostatin inhibits endothelial cell migration by inhibiting phosphorylation of focal adhesion kinase via binding to α5β1 integrin (Wickstrom et al. (justia.com)
It undergoes tyrosine phosphorylation by C-SRC PROTEIN PP60 and plays a regulatory role in CAVEOLAE formation. (lookformedical.com)
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)

It is predicted that MCPH gene mutations may lead to the disease phenotype due to a disturbed mitotic spindle orientation, premature chromosomal condensation, signalling response as a result of damaged DNA, microtubule dynamics, transcriptional control or a few other hidden centrosomal mechanisms that can regulate the number of neurons produced by neuronal precursor cells. (biomedcentral.com)
MCPH is inherited in an autosomal recessive pattern in which both copies of the gene in each cell have mutations. (biomedcentral.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)

In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
While the recombinant wild type MsmNDK showed the NTPase, NTP synthesising, and autophosphorylation activities, the H117Q mutation abolished the biochemical activities of the recombinant MsmNDK-H117Q mutant protein in vitro . (openbiochemistryjournal.com)

It is composed of intermediate filaments and membrane associated proteins. (wikipedia.org)

The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
Vertebrate protein kinases LIMK-1 and LIMK-2. (embl.de)

These different disassembly events are initiated by the cyclin B/Cdk1 protein kinase complex (MPF). (wikipedia.org)
Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)

Rapid and comprehensive analysis of putative proteinous allergens ( allergenome ) by applying such a proteomic strategy … With allergenomics, we can not only detect and assign the putative allergens (proteins specifically interacting with IgE antibodies in a patient's blood) in a short time, but also analyze the quantitative and qualitative change of the antigens, depending on the surroundings and environmental conditions of an allergenic causative. (genomicglossaries.com)
Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins. (justia.com)
B cells use unconventional strategies for the production of a seemingly unlimited number of antibodies from a very limited amount of DNA. (cipsm.de)
Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)

A variety of extracellular stimuli including mitogens, cytokines, antigens, stress inducing agents, UV light and viral proteins initiate a signal transduction pathway that ultimately leads to NF-κB release and activation. (justia.com)

Next to providing mechanical support to the nucleus, the nuclear lamina plays an essential role in chromatin organization, cell cycle regulation, DNA replication, DNA repair, cell differentiation and apoptosis. (wikipedia.org)
a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
LncRNAs fulfill important functions in a variety of biological processes, including genome imprinting, cell differentiation, apoptosis, stem cell pluripotency, X chromosome inactivation and nuclear transport. (bvsalud.org)
As high throughput sequencing technology develops, a substantial number of lncRNAs have been found to be related to a variety of biological processes, such as development of the testes, maintaining the self-renewal and differentiation of spermatogonial stem cells, and regulating spermatocyte meiosis. (bvsalud.org)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
Alternate forms of the PolII transcription initiation machinery have been proposed to play a role in selective activation of cell-type-specific gene expression programs during cellular differentiation. (silverchair.com)

Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)
Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)

Cell 75:495, 1993), and a series of unique E6-AP homologous proteins have been identified (Huibregtse et al. (justia.com)

Saccharomyces cerevisiae (Baker's yeast) rho-type GTPase activating protein RGA1/DBM1. (embl.de)
Several major species of E2 enzymes have been characterized in mammalian cells, plants, and yeast. (justia.com)

Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)

The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
A lot of these proteins relate to metabolic processes like respiration, mitochondrial function, signaling and homeostasis. (regenerativemedicine.net)

Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
1. Chimerical peptides, characterized by having a primary structure comprising at least one segment inhibitor of the activation of the NS3pro protease from a virus of the Flaviviridae family and a cell penetrating segment and these peptides are able to inhibit or attenuate the infection by the virus. (patentsencyclopedia.com)
3. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease, this segment is a peptide able to bind to NS3pro and contact at least one residue comprised in the region Gly21-Lys28 of the N-terminal domain of the NS3pro protein from DV2 or structurally equivalent residues of the NS3pro protein from other Flavivirus. (patentsencyclopedia.com)
5. Chimerical peptides according to the claim 1, where the mentioned segment inhibitor of the activation of the NS3pro protease contact at least one residue comprised in the region Glu32-Thr38 of the N-terminal domain of the NS3pro protein from HCV or structurally equivalent residues of the NS3pro protein from other Hepacivirus. (patentsencyclopedia.com)
6. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Asp50-Glu62 of the NS2B protein from DV2 or the structurally equivalent segment of the protein NS2B from other Flavivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)
8. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Thr20-Leu31 of the NS4A protein from HCV or the structurally equivalent segment of the protein NS4A from other Hepacivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)

They consist of two zinc-binding motifs that resemble GATA-like Znf's, however the residues holding the zinc atom(s) are variable, involving Cys, His, Asp or Glu residues. (embl.de)
It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues. (lookformedical.com)

Receives Zn 2+ from the secreted, extracellular zincophore protein, Pra1 for uptake of the metal. (tcdb.org)
This study presents an in-silico model replicating a microfluidic assay where endothelial cells sprout into a biomimetic extracellular matrix, specifically, a large-pore, low-concentration fibrin-based porous hydrogel, influenced by chemotactic factors. (ibecbarcelona.eu)
Extracellular vesicles (EVs) -- nanometer sized messengers that travel between cells to deliver cues and cargo -- are promising tools for the next generation of therapies for everything from autoimmune and neurodegenerative diseases to cancer and tissue injury. (regenerativemedicine.net)

During spermatogenesis, the process in which sperm for fertilization are produced from germline cells, gene expression is spatiotemporally highly regulated. (bvsalud.org)

Endocytic/exocytic CELL MEMBRANE STRUCTURES rich in glycosphingolipids, cholesterol, and lipid-anchored membrane proteins that function in ENDOCYTOSIS (potocytosis), transcytosis, and SIGNAL TRANSDUCTION. (lookformedical.com)
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. (lookformedical.com)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
This activates cascade of events which, in the end, affects oxidative status of the cells and provides robust protection against oxidative challenge. (springer.com)

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
Proteins which are found in membranes including cellular and intracellular membranes. (lookformedical.com)
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)

The nuclear lamin-associated membrane proteins are either integral or peripheral membrane proteins. (wikipedia.org)
They consist of two types, peripheral and integral proteins. (lookformedical.com)

Eukaryotic cells rely on de novo nucleation mechanisms to generate actin filaments in order to elicit spatial and temporal remodeling of their actin cytoskeleton. (biomedcentral.com)
A single-stranded DNA-binding protein that is found in EUKARYOTIC CELLS. (lookformedical.com)

Besides providing mechanical support, the nuclear lamina regulates important cellular events such as DNA replication and cell division. (wikipedia.org)

The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B1, B2) according to homology of their DNA sequences, biochemical properties and cellular localization during the cell cycle. (wikipedia.org)

Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)

The team also demonstrated that these intercellular travelers could be derived from endothelial cells, which line the surface of blood vessels and are more abundant and easier to maintain than stem cells. (regenerativemedicine.net)

Degradation of a protein via the ubiquitin pathway proceeds by two discrete and successive steps: (a) covalent attachment of multiple ubiquitin molecules to the protein substrate, and (b) degradation of the targeted protein by the 26S proteasome complex. (justia.com)
So, rather than one molecule that is therapeutic, we think that the exosomes contain a cocktail of molecules and proteins that can, all together, help the cell maintain homeostasis, deal with the stress, modify metabolic action and reduce the amount of injury. (regenerativemedicine.net)
Our findings indicate that EEVs could protect cardiac tissue from reoxygenation injury in part by supplementing the injured cells with proteins and signaling molecules that support different metabolic processes, paving the way for new therapeutic approaches," said Andr G. Kl ber, a Visiting Professor of Pathology at Harvard Medical School and co-author of the study. (regenerativemedicine.net)

Active in zinc-replete cells and is time-, temperature- and concentration-dependent. (tcdb.org)
Zinc/ Iron/Cadmium ion transporter protein IRT1 of 355 aas and 9 TMSs. (tcdb.org)
LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
S-palmitoylation is one type of protein modifications catalyzed by zinc finger Asp-His-His-Cys (ZDHHC)-family palmitoyl S-acyltransferases. (bvsalud.org)

Formins are multidomain proteins conserved from plants to fungi and vertebrates. (biomedcentral.com)

It also has been shown that cell surface glypicans are low-affinity endostatin receptors (Karumanchi et al. (justia.com)

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. (lookformedical.com)

The main structural proteins of CAVEOLAE. (lookformedical.com)

By alternative splicing, at least seven different polypeptides (splice variants) are obtained, some of which are specific for germ cells and play an important role in the chromatin reorganisation during meiosis. (wikipedia.org)
Spermatogenesis was not disrupted in Zdhhc19 knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules. (bvsalud.org)

a protein required for the asymmetric division of vulval blast cells. (embl.de)

The researchers mapped the entire set of EEV proteins that are, or can be, expressed by the vesicles. (regenerativemedicine.net)
Surprisingly, even though these vesicles are only a hundred and fifty nanometers in diameter, they contain almost 2,000 different proteins," said Yadid. (regenerativemedicine.net)

A collection of different allotypes or allelic protein variants, a new type of protein library. (genomicglossaries.com)

Helianthus annuus (Common sunflower) pollen specific protein SF3. (embl.de)

A partitioning within cells due to the selectively permeable membranes which enclose each of the separate parts, e.g., mitochondria, lysosomes, etc. (lookformedical.com)

We propose that quantitative experimental embryology offers essential ways to explore the reaction of cells and tissues to targeted cell addition, removal, and confinement. (mdpi.com)
Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)

Like other members of the Rel family of transcriptional activators, NF-κB is sequestered in an inactive form in the cytoplasm of most cell types. (justia.com)
NF-κB in the cytoplasm of nonstimulated cells. (justia.com)

S. cerevisiae hypothetical protein YKR090w. (embl.de)

Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)

The post-translational modifications of proteins play important roles in this biological process. (bvsalud.org)
Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)

Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. (patentsencyclopedia.com)
In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)

The binding site in Pra1 is in the C-terminal region of this 299 aa protein ( Łoboda and Rowińska-Żyrek 2017 ). (tcdb.org)

2001) Mol Cell, 7: 811-822). (justia.com)

Zyxin is a low-abundance adhesion plaque protein which has been shown to interact with CRP. (embl.de)

a beta-cell-specific transcriptional enhancer found in the insulin gene. (embl.de)
The team also found that injured cardiomyocytes that had been treated with EEVs exhibited a set of proteins that was more similar to the uninjured ones compared with untreated cells. (regenerativemedicine.net)

Anatomy52

Organisms10

Diseases1

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology4

Phenomena and Processes106

Disciplines and Occupations1

Information Science4

Health Care2

Melanogaster3

Genes8

Biol2

Proliferation4

Phosphorylation5

Mutations2

Cysteine-rich protein2

Vitro3

Membrane associated1

Kinases2

Kinase3

Antibodies4

Signal transdu1

Differentiation7

Cytoskeletal2

Homologous1

Yeast2

Lymphoid1

Mitochondrial2

Inhibitor6

Residues2

Extracellular3

Gene expression1

Lipid2

Oxidative3

Intracellular4

Peripheral2

Eukaryotic2

Regulates1

Cellular1

Secretion1

Escherichia1

Endothelial cells1

Molecules3

Zinc5

Fungi1

Affinity1

Regulate1

Structural1

Germ cells2

Asymmetric1

VESICLES2

Type of protein1

Specific protein1

Mitochondria1

Tissues2

Cytoplasm2

Hypothetical1

Actin1

Roles2

Activation3

Regulatory1

20171

20011

Adhesion1

Found2