• Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed ends. (reed.edu)
  • Yes-associated protein (Yap), a transcriptional cofactor in the Hippo signaling pathway, promotes proliferation of embryonic cardiomyocytes by activating the insulin-like growth factor and Wnt signaling pathways. (pnas.org)
  • Harvey KF, Pfleger CM, Hariharan IK (2003) The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. (springer.com)
  • Pantalacci S, Tapon N, Léopold P (2003) The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. (springer.com)
  • In addition to its role in many cellular processes, Capping Protein acts as a main tumor suppressor module in Drosophila and in humans, in part, by restricting the activity of Yorkie/YAP/TAZ oncogenes. (plos.org)
  • have shown that capping protein is essential for various actin-mediated processes. (biologists.org)
  • Additionally, protein tyrosine kinases, found only in multicellular eukaryotes, provide links between extracellular signals and F-actin-dependent cellular processes. (biologists.org)
  • In situ hybridization analysis in Drosophila embryos detected the uniformly distributed DLIMK mRNA in stages 2 to 5. (sdbonline.org)
  • The actin bundles in Drosophila bristle cells represent one of the best places to study this process. (rupress.org)
  • Here, we used confocal and electron microscopy to examine bundle formation at the growing bristle tip and find that linear arrays of modules morph into continuous actin bundles by overlap and smoothing resulting in a stiff and continuous bundle. (rupress.org)
  • Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis. (sdbonline.org)
  • The Abl effector, Enabled (Ena), selectively labels the cis-Golgi in developing PRs.Finally, we demonstrate that the effects of Abl signaling on Golgi are mediated via regulation of the actin cytoskeleton.Moreover, they raise the possibility that some of the effects of Abl signaling may arise, in part, from alterations of protein trafficking and secretion. (nih.gov)
  • Genetic and pharmacological experiments suggest that Abl/Ena signaling controls Golgi distribution through its regulation of the actin cytoskeleton. (nih.gov)
  • Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. (koreascience.or.kr)
  • In addition, we discuss actin-mediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. (koreascience.or.kr)
  • Yu FX, Zhao B, Panupinthu N et al (2012) Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. (koreascience.or.kr)
  • Matsui Y and Lai ZC (2013) Mutual regulation between Hippo signaling and actin cytoskeleton. (koreascience.or.kr)
  • Aragona M, Panciera T, Manfrin A et al (2013) A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. (koreascience.or.kr)
  • The conserved Hippo (Hpo) signal transduction pathway has emerged as a crucial regulator of tissue size in both Drosophila and mammals ( Edgar, 2006 ). (biologists.org)
  • The Hippo signaling pathway is an evolutionarily ancient cascade of kinases and effector proteins that control cell proliferation and organ size ( 20 , 21 ). (pnas.org)
  • The Hippo pathway was originally identified as the signaling that controls organ size in Drosophila , with the core architecture conserved in mammals. (springer.com)
  • I show that Basigin exhibits genetic interaction with Tropomodulin, an actin-capping protein, suggesting that they function in the same molecular pathway in regulating dendrite development. (columbia.edu)
  • Much of our current work is aimed at identifying molecules that cooperate with actin capping protein and myosin VI in a variety of cellular contexts to modulate actin structure formation and function. (wustl.edu)
  • On the basis that RPGRIP exhibited a stronger association with the ciliary axoneme and that the CC localization of RPGRIP remained unchanged in mice lacking RPGR, it was proposed that RPGRIP was likely the primary resident protein in the CC, whereas RPGR localized in this cellular compartment via binding to RPGRIP ( 5 , 6 ). (pnas.org)
  • Many essential cellular functions are linked to alterations in the F-actin cytoskeleton. (biologists.org)
  • A homozygous disruption or genetic mutation of the bag3 gene, a member of the Bcl-2-associated athanogene (BAG) family proteins, causes cardiomyopathy and myofibrillar myopathy that is characterized by myofibril and Z-disc disruption. (genes2cognition.org)
  • This entry represent the alpha subunit (CAPZA), which is a protein of about 268 to 286 amino acid residues whose sequence is well conserved in eukaryotic species [ PMID: 1711931 ]. (ebi.ac.uk)
  • This fundamental question in axon guidance led researchers to Robo, which was identified in a large-scale screening of Drosophila mutants in the early 1990s. (wikipedia.org)
  • The CC localization of these two proteins provides clues about their in vivo functions. (pnas.org)
  • Among the tyrosine kinases, c-Abl and its relative Arg are unique in binding directly to F-actin. (biologists.org)