• Heroin self-administration and relapse in Drd1-Cre + and Drd2-Cre + transgenic LE rats. (jneurosci.org)
  • C , The average number of heroin infusions received did not differ significantly between Drd1-Cre + and Drd2-Cre + rats. (jneurosci.org)
  • D , Postabstinence cue-induced relapse test: Average number of active lever presses during the first 30 min of the last 3 SA sessions for Drd1-Cre + (red triangles) and Drd2-Cre + (blue triangles) rats (left). (jneurosci.org)
  • low Mn, less soluble) resulted in deposition of Mn in the olfactory bulb and striatum, altered the expression of divalent metal transporter 1 (Dmt1), dopamine D1 (Drd1) and D2 (Drd2) receptors, and induced a subtle neuroinflammatory response in the striatum and midbrain. (cdc.gov)
  • In addition, both fumes down-regulated Drd1, Drd2 and Vmat2 mRNAs in the midbrain. (cdc.gov)
  • A downregulation of DRD1 but not DRD2 expression was seen in alcoholics. (diva-portal.org)
  • Expression of DRD1 and DRD2 strongly correlated with that of PDYN and OPRK1 suggesting high levels of transcriptional coordination between these gene clusters. (diva-portal.org)
  • Dopamine and FP exerted antitumor effects through the dopamine receptors DRD1 and DRD2, respectively. (iupui.edu)
  • Using RNAscope, we further demonstrate that ~ 40% of Olig2 + /Pdfgra + cells and ~ 20% of Olig2 + /Pdgfra- cells in the anterior corpus callosum express Drd1 and Drd2 transcripts. (nih.gov)
  • It is a protein that in humans is encoded by the DRD1 gene. (wikipedia.org)
  • The DRD1 gene expresses primarily in the caudate putamen in humans, and in the caudate putamen, the nucleus accumbens and the olfactory tubercle in mouse. (wikipedia.org)
  • Dysregulation of DYN/KOR system and dopamine signaling through both alterations in co-expression patterns of opioid genes and decreased DRD1 gene expression may contribute to imbalance in the activity of D1- and D2-containing pathways which may lead to the negative affective state in human alcoholics. (diva-portal.org)
  • We drew comparisons with a single nucleotide polymorphism in the dopamine D1 receptor (DRD1) gene, which was associated with ADHD within our cohort, and a polymorphism within the dopamine transporter (DAT1) gene, reported to have additive effects with the DRD4 7-repeat allele. (ox.ac.uk)
  • 113 disease terms (MeSH) has been reported with DRD1 gene. (cdc.gov)
  • Rabbit Anti Dopamine D1 Receptors Drd1 Antibody, supplied by Abcam, used in various techniques. (bioz.com)
  • Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (snpedia.com)
  • Northern blot and in situ hybridization show that the mRNA expression of DRD1 is highest in the dorsal striatum (caudate and putamen) and ventral striatum (nucleus accumbens and olfactory tubercle). (wikipedia.org)
  • By contrast, there were no significant effects of the DRD1 or DAT1 polymorphisms on clinical outcome or cortical development. (ox.ac.uk)
  • Participants were genotyped for 3 functional single nucleotide polymorphisms (SNPs): dopamine receptor D1 (DRD1) rs686, dopamine receptor D2 (DRD2) rs4648317, and catechol-O-methyltransferase (COMT) Val158Met. (ox.ac.uk)
  • RESULTS: Our data showed that carriers of more transcriptionally active DRD1 alleles compared to noncarriers demonstrated greater aggression levels due to medial prefrontal cortex lesions but reduced aggression levels due to lateral prefrontal cortex lesions independently of DRD2 rs4648317 or COMT Val158Met genotypes. (ox.ac.uk)
  • We used immunohistochemistry and in situ hybridization to measure the neuronal activity marker Fos in the NAc, and cell-type-specific colocalization of Fos with Drd1- and Drd2-expressing neurons. (nih.gov)
  • To test the causal role of Drd1- and Drd2-expressing neurons, we validated a transgenic hybrid breeding strategy crossing inbred Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD (hM4Di) to inhibit NAc Drd1- and Drd2-expressing neuron activity. (nih.gov)
  • We found that aggression self-administration and aggression seeking induced higher Fos expression in NAc shell than in core, that Fos colocalized with Drd1 and Drd2 in both subregions, and that chemogenetic inhibition of Drd1-, but not Drd2-, expressing neurons decreased aggression self-administration and aggression seeking. (nih.gov)
  • low Mn, less soluble) resulted in deposition of Mn in the olfactory bulb and striatum, altered the expression of divalent metal transporter 1 (Dmt1), dopamine D1 (Drd1) and D2 (Drd2) receptors, and induced a subtle neuroinflammatory response in the striatum and midbrain. (cdc.gov)
  • In addition, both fumes down-regulated Drd1, Drd2 and Vmat2 mRNAs in the midbrain. (cdc.gov)
  • We examined the influence of haplotypes in three dopamine receptors (DRD1, DRD2 and DRD3) and the Brain Derived Neurotrophic Factor (BDNF) on dyskinesia.Patient data were drawn from a population-based case-control study. (nih.gov)
  • Using RNAscope, we further demonstrate that ~ 40% of Olig2 + /Pdfgra + cells and ~ 20% of Olig2 + /Pdgfra- cells in the anterior corpus callosum express Drd1 and Drd2 transcripts. (nih.gov)
  • The dopamine receptor family, which belongs to the G-protein-coupled receptor (GPCR) superfamily, can be divided into two subfamilies, namely the D1-like subfamily (including dopamine receptor D1 (DRD1) and DRD5), and the D2-like subfamily (including DRD2, DRD3, and DRD4). (elifesciences.org)
  • High doses of theacrine also activate dopamine D1 and D2 receptors in rats ( DRD1 , DRD2 ). (selfdecode.com)
  • Much of the processing that occurs in the PFC depends on the chemical dopamine, and the way neurons in the PFC utilize dopamine is affected by variation in the COMT , DRD1 , and DRD2 genes. (nih.gov)
  • Similarly, forms of the DRD1 and DRD2 genes that were associated with greater PFC efficiency in town- or rural-raised participants were instead associated with lower efficiency in urban-raised individuals. (nih.gov)
  • Stains human Dopamine D1 R/DRD1 transfected cells but not irrelevant transfectants in flow cytometry. (rndsystems.com)
  • Detection of Dopamine D1 R/DRD1 in HEK293 Human Cell Line Transfected with Human Dopamine D1/DRD1 and eGFP by Flow Cytometry. (rndsystems.com)
  • HEK293 human embryonic kidney cell line transfected with human Dopamine D1/DRD1 and eGFP was stained with either (A) Mouse Anti-Human Dopamine D1 R/DRD1 Monoclonal Antibody (Catalog # MAB8276) or (B) Mouse IgG 2A Isotype Control (Catalog # MAB003 ) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B ). (rndsystems.com)
  • Dopamine D1 R/DRD1 in Human Brain. (rndsystems.com)
  • Aggression, DRD1 polymorphism, and lesion location in penetrating traumatic brain injury. (ox.ac.uk)
  • 16. A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood. (nih.gov)
  • Dopamine Receptor D1 (DRD1) is a 50 kDa member of class 1 GPCR superfamily and is the most abundant dopamine receptor in the central nervous system. (rndsystems.com)
  • Dopamine receptor D1, also known as DRD1. (wikipedia.org)
  • The DRD1 receptor appears to drive the hyperactivity. (neurosciencenews.com)
  • Dopamine DRD1 receptor regulates renal function and vascular resistance. (unisa.it)
  • two SNPs (rs2424908 and rs6119954) within DNMT3B and five SNPs (rs4532, rs5326, rs2168631, rs6882300 and rs267418) within DRD1 were genotyped in 365 schizophrenic patients and 365 healthy controls. (nih.gov)
  • Our group discovered a 3' UTR SNP in DRD1 and lower risk of developing lung cancer in individuals exposed to secondhand smoke during childhood. (nih.gov)
  • We generated stable lung cancer cell lines harboring shRNA-mediated knockdown of DRD1, and cell lines with stable DRD1 overexpression which display increased and decreased growth, respectively. (nih.gov)
  • This data infers a tumor suppressive role for DRD1 in lung cancer. (nih.gov)
  • Our western blot analysis shows that over expression of DRD1 in H1299 lung cancer cell line decreases ERK1/2 activation. (nih.gov)
  • To understand the mechanistic basis for tumor suppressive role of DRD1, we aimed to determine which signaling pathways are modulated by DRD1 activation/reduction. (nih.gov)
  • Therefore, understanding the molecular and cellular basis of DRD1 and EGFR and MAPK signaling interaction is important to develop potentially more effective molecular therapeutic approaches that involve simultaneously targeting both DRD1 and EGFR. (nih.gov)
  • We calculated risk ratios using Poisson regression with robust error variance.There was no difference in dyskinesia prevalence among carriers of various haplotypes in DRD1. (nih.gov)
  • Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice. (nih.gov)
  • Results indicate a cell-type-specific role of Drd1-expressing neurons that is critical for both aggression self-administration and aggression seeking. (nih.gov)
  • Our preliminary data confirms the role of DRD1 in MAPK signaling. (nih.gov)
  • Kinome and Transcriptional profiling analysis results collectively suggest that DRD1 reduction is associated with EGFR and MAPK signaling activation. (nih.gov)
  • In particular, DRD1 and DRD5 are found exclusively in postsynaptic sites of dopamine-receptive neurons. (elifesciences.org)
  • Therefore, we analyzed global phosphorylation levels of up to 100 proteins on our in-house DRD1 cell line models by high-throughput Kinome profiling. (nih.gov)