• The aim of this study was to examine the distribution of HLA Class II DRB1* alleles in a homogeneous cohort of individuals who were infected with HCV-contaminated anti-D immunoglobulin, and to compare frequencies of alleles in individuals with spontaneous viral clearance to those with chronic HCV infection. (nih.gov)
  • RESULTS: The alleles HLA-DRB1*01 (pc= 0.00083) and HLA-DRB1*04 (pc=0.0049) were strongly associated with systemic JIA, while HLA-DRB1*11 and HLA-DRB1*14 were found to have decreased frequencies in the patients with systemic JIA compared to the controls. (anthropogeny.org)
  • Two alleles were found to have increased frequencies with JIA oligoarthritis subgroup, HLA-DRB1*11 (p=0.01, pc=NS) and HLA-DRB1*13 (p=0.01, pc=NS). (anthropogeny.org)
  • The HLA-DRB1*04 was found increased frequencies with susceptibility for RF negative and RF positive polyarthritis JIA subgroups (p correction resulted in loss of significance). (anthropogeny.org)
  • In contrast two alleles HLA-DRB1*07 and HLA-DRB1*14 were found decreased frequencies only patients RF positive polyarthritis JIA subgroup compared to the controls (pc=NS). (anthropogeny.org)
  • We established a genetic database by investigating human leukocyte antigen (HLA)-DRB1 allelic frequencies in a disease-association study in the Tujia population in Wufang, Hubei, China. (geneticsmr.com)
  • The allele frequencies of the HLA-DRB1 locus in 262 healthy, unrelated Tujia individuals living in the Wufeng region of the Hubei Province were analyzed using the Luminex HLA sequence-specific oligonucleotide method with a WAKFlow HLA typing kit. (geneticsmr.com)
  • HLA-DRB1 allele frequencies were compared between alloantibody-positive and -negative groups through the chi(2) test. (ac.ir)
  • Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions. (allelefrequencies.net)
  • 2022 Allele Frequencies Website. (allelefrequencies.net)
  • The frequencies of HLA class I and class II alleles and haplotypes of 104 healthy unrelated Tunisians were analyzed by high-resolution PCR-reverse dot blot hybridization, and was compared with other Mediterranean and Sub-Saharan Africans using genetic distances measurements, Neighbor-joining dendrograms, correspondence, and extended haplotypes analysis. (nih.gov)
  • 4-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from African-Caribbean descent. (anthonynolan.org)
  • 4-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from Guanacaste. (anthonynolan.org)
  • 4-Locus high-resolution HLA allele and haplotype frequencies in admixed population from Nicaragua. (anthonynolan.org)
  • 5-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from the Central Valley. (anthonynolan.org)
  • BACKGROUND: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles. (ox.ac.uk)
  • Objectives To determine the association between the amount of smoking and risk of RA in the context of different HLA-DRB1 shared epitope (SE) alleles, and to estimate proportions of RA cases attributed to smoking. (bmj.com)
  • We evaluated whether RA-ILD is associated with these genetic variants and HLA-DRB1 shared epitope (SE) alleles in a large RA cohort stratified by race and smoking history. (cdc.gov)
  • Dr. Scher expressed his surprise with two findings, "First, that P. copri abundance in the gut correlates inversely with presence of shared epitope alleles. (the-rheumatologist.org)
  • These results reveal how DRB1 alleles with the shared epitope could initiate an autoimmune response to citrullinated self-Ags in RA patients. (uwo.ca)
  • HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. (wikipedia.org)
  • DR17 recognizes the DRB1*0301, *0304 alleles. (wikipedia.org)
  • DRB1*0301: diabetes mellitus type 1, myositis, early onset Graves disease, type 1 autoimmune hepatitis, inflammatory inclusion body myositis. (wikipedia.org)
  • In autoimmune hepatitis, DRB1*0301 correlates with more severe and difficult to treat disease. (wikipedia.org)
  • DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1, ovarian cancer, non-thymomic myasthenia gravis, idiopathic inflammatory myopathies, non-cancer associated Lambert-Eaton myasthenic syndrome and sarcoidosis The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. (wikipedia.org)
  • DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype: A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201 This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1" derived from IMGT/HLA Berlin M, Fogdell-Hahn A, Olerup O, Eklund A, Grunewald J (1997). (wikipedia.org)
  • We have previously shown that Scandinavian sarcoidosis patients expressing the HLA-DR allele DRB1*0301 are characterized by large accumulations in the lungs of CD4+ T cells expressing the TCR AV2S3 gene segment. (jci.org)
  • Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. (cdc.gov)
  • In all three populations studied (Estonian, Latvian, and Russian), DQB1*0302 haplotypes most frequently carried DRB1*0401 or DRB1*0404. (diabetesjournals.org)
  • These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. (wikipedia.org)
  • In contrast, strong dominant protection from the disease is associated with the expression of DRB1*0701, such that the risk of disease is the same in individuals inheriting DRB1*1501 and DRB1*0701 and in the general population. (medscape.com)
  • DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. (thermofisher.com)
  • In addition, anti-GBM disease has a strong positive association with the human leukocyte antigen (HLA)-DR15 haplotype, particularly the DRB1*1501 allele, which is found in more that 80% of patients with anti-GBM disease. (medscape.com)
  • Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles. (ox.ac.uk)
  • In this study we analyzed at the population level the effect of DR4 subtypes and class I, HLA-B alleles, on IDDM risk when the influence of the DQ locus was stratified. (diabetesjournals.org)
  • When HLA-B alleles were analyzed, strong associations between the presence of specific B alleles and DRB1*04 subtypes were detected. (diabetesjournals.org)
  • According to em DRB1*04 /em subtypes, ( em DRB1* 0405 /em ) was present in of 80% them. (exposed-skin-care.net)
  • Subtypes There are three main subclades of DR1: - DRB1*01:01 : the vast. (eupedia.com)
  • Here is a map showing the allele frequency of HLA-A3, which is divided in two subtypes : A3:01 and A3:02. (eupedia.com)
  • The DRB1*01 allele was found significantly more frequently in individuals with viral clearance compared to those with chronic infection (27.4% vs. 7.1% p = 0.001, odds ratio OR = 4.9, pc = 0.01). (nih.gov)
  • RESULTS: HLA-DRB1*15:03 allele frequency was significantly different between groups (P = 0.000, odds ratio (OR) = 4.193). (ac.ir)
  • In one study, HLA-DRB1*03011 was reported to be found at a significantly higher frequency in 32 unrelated patients with APSGN as compared to 380 healthy individuals. (medscape.com)
  • HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. (cdc.gov)
  • A total of 13 alleles were detected at the HLA-DRB1 locus. (geneticsmr.com)
  • The results showed that the Tujia population has a close genetic relationship with the Middle Han population at the HLA-DRB1 locus. (geneticsmr.com)
  • Three-locus haplotype analysis revealed that A*03-B*07-DRB1*1503 and A*02-B*44-DRB1*0402 were the most common HLA class I and II haplotypes in this population. (nih.gov)
  • Certain alleles with the major histocompatibility (MHC) class II locus, specifically DRB1, confer a higher risk for disease. (the-rheumatologist.org)
  • are in linkage disequilibria with the HLA-drb1 locus in a japanese population. (lu.se)
  • CONCLUSIONS: According to our results, detecting HLA-DRB1*15:03 and HLA-DRB1*11 alleles are useful in the pre-transfusion test and could determine responder patients and improve transfusion safety. (ac.ir)
  • Genetic studies have exhibited multiple HLA- em DRB1 /em alleles encoding a conserved sequence at amino acid positions 70C74 are associated with susceptibility and severity of RA. (exposed-skin-care.net)
  • 2007). The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population . (up.pt)
  • HLA-DRB1* genes do not appear to influence severity of liver disease. (nih.gov)
  • The goals of this program are to standardize typing of KIR genes and alleles, and to identify new alleles. (uclahealth.org)
  • The present study is usually a cross-sectional analysis aimed to evaluate the significance of the presence of SE genes, defined as em DRB1*01 /em or em DRB1*04 /em , in relation to anti-CCP antibodies, antikeratin antibody (AKA) and RF in individuals who developed RA. (exposed-skin-care.net)
  • 12 - 15 These studies focused mainly on major histocompatibility complex (MHC) class II genes, and found evidence that class II alleles such as HLA-DRB1*03:01 are associated with auto-antibody production. (cdc.gov)
  • The DRB1*0101 allele offers relatively weak protection. (medscape.com)
  • DRB1*0401 was the most prevalent subtype in IDDM patients, whereas DRB 1*0404 was decreased in frequency. (diabetesjournals.org)
  • Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format. (allelefrequencies.net)
  • Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n). (allelefrequencies.net)
  • Frequency given under DRB1*1103. (allelefrequencies.net)
  • Here is a map showing the allele frequency of HLA-DR14. (eupedia.com)
  • Here is a map showing the allele frequency of HLA-DR10. (eupedia.com)
  • To understand how citrulline might evoke an autoimmune reaction, we have studied T cell responses to citrulline-containing peptides in HLA-DRB1*0401 transgenic (DR4-IE tg) mice. (uwo.ca)
  • We have therefore used our population-based study, the Epidemiological Investigation of Rheumatoid Arthritis (EIRA), to estimate the relative risk of RA conferred by different amounts of smoking in the context of different HLA-DRB1 genotypes, and to estimate the excess fraction (EF) of RA cases attributed to smoking. (bmj.com)
  • The researchers also obtained blood samples from those in the study to check if they were carriers of HLA-DRB1, a gene believed to raise the risk for rheumatoid arthritis, and whether their arthritis was characterized by the elevated presence of autoantibodies known as antibodies to citrullinated peptide, or ACPA. (dotmed.com)
  • PATIENTS AND METHODS: We typed 120 patients with JIA and 99 healthy controls for HLA class II alleles were performed by PCR-SSO. (anthropogeny.org)
  • MATERIALS AND METHODS: Antibody screening tests were performed by tube method, and HLA-DRB1 genotyping was determined by Sequence-Specific Primers (SSP-PCR) in 59 alloimmunised and 205 non-alloimmunised patients. (ac.ir)
  • The CYP2D6 gene in DNA from 179 cell lines including rare and/or difficult to analyze alleles and/or diplotypes were characterized by the GeT-RM using a variety of methods ( J Mol Diag 2019 21:1034-1052 ). (cdc.gov)
  • Methods: HLA-DRB1 SE alleles and MUC5B rs35705950 and TOLLIP rs5743890 SNPs were genotyped in U.S. veterans with RA. (cdc.gov)
  • OBJECTIVE: To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their association with genetic variants within HLA-DRB1 SE alleles. (ox.ac.uk)
  • AIH usually develops in individuals with a genetic background mainly consisting of some risk alleles of the major histocompatibility complex (HLA). (wjgnet.com)
  • Anti-CCP and anti-citrullinated protein antibodies were associated with HLA-DRB1*04 rather than with HLA-DRB1*01 alleles. (ox.ac.uk)
  • The combination of em DRB1*04 /em + anti-CCP antibodies gave increase in the specificity and positive predictive value to 92% and 90 respectively. (exposed-skin-care.net)
  • CONCLUSION: The profile of HLA-DRB1 alleles associations in Mexican with JIA were somewhat distinct from association typically found in Caucasians. (anthropogeny.org)
  • Cells with rare alleles and unusual DR-DQ associations are studied. (uclahealth.org)
  • Associations between sarcoid and HLA-DRB1 [3] and M. tuberculosis DNA [4] are currently being evaluated. (aao.org)
  • We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)
  • HLA- em DRB1 /em genotypes, high disease activity, high disability scores, and high levels of acute phase proteins [2]. (exposed-skin-care.net)
  • 13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)
  • DRB1*01 is associated with spontaneous viral clearance in an Irish cohort infected with HCV via contaminated anti-D immunoglobulin. (nih.gov)
  • To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (jci.org)
  • All specific reactivities were primarily associated with the HLA-DRB1*04 alleles, suggesting common pathways of anti-citrulline immunity. (ox.ac.uk)
  • HLA DRB1* typing was performed on whole blood or serum from 157 females. (nih.gov)
  • In 1997, DNA extracts from cells with unusual class I alleles were provided to participating laboratories. (uclahealth.org)
  • Association of HLA DRB1 alleles with juvenile idiopathic arthritis in Mexicans. (anthropogeny.org)
  • OBJECTIVE: The aim of the study was to investigate association between HLA class II alleles and juvenile idiopathic arthritis (JIA) in Mexican patients. (anthropogeny.org)
  • The list below shows all populations in AFND that contains the allele. (allelefrequencies.net)
  • Many of these extracts were from the reference cells sequenced for rare alleles, thus giving laboratories the opportunity to type them, whereas they may not detect them in routine typing them in their local populations. (uclahealth.org)
  • The aim of the present study was to determine the relationship between HLA-DRB1*15:03, HLA-DRB1*11 and HLA-DRB1*09:01 alleles and alloimmunisation in Iranian thalassemia patients. (ac.ir)
  • In addition, our immunogenetic analysis showed a possible association between HLA-DRB1*1502 allele and the patients positive for anti-NF-L autoantibodies. (elsevierpure.com)
  • was found in 45% of patients and 35% of them had one or two HLA- em DRB1*04 /em alleles. (exposed-skin-care.net)
  • We retrospectively examined the effect of HLA-DRB1 matching at the DNA level compared with serological HLA-DR matching on acute rejection and graft survival in patients who underwent primary cadaveric renal transplantation. (lww.com)
  • 48%). Five-year graft survival in patients with zero DRB1 mismatch was 100%, whereas that in those with one or two DRB1 mismatches was 76%, although the difference was not statistically significant. (lww.com)
  • Phenotypic and HLA-DRB1 allele characterization of Swedish cardiac sarcoidosis patients. (cdc.gov)
  • Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus. (medscape.com)
  • In 1994, the Cell Exchange initiated offering the same cells for molecular typing as for serologic typing for Class I. The data from the parallel typings is instrumental in identifying serologic equivalents for Class I and Class II alleles that previously had little or no serologic information. (uclahealth.org)
  • In the MHC, one allele in the class II region, and one SNP in the class III region, have been associated with risk of developing lupus . (snpedia.com)
  • The most frequent HLA class I A alleles were A*02, A*24, and A*30, while the most frequent B alleles were B*44, followed by B*50, B*51, and B*07. (nih.gov)
  • We used a novel in vitro degradation assay involving cytosolic extracts as well as endogenous intracellular processing assays to examine 2 well-characterized HIV-1 Gag overlapping epitopes presented by the same HLA class I allele, one of which is consistently immunodominant and the other subdominant in infected persons. (jci.org)
  • The most well-known risk factor for autoimmune Addison disease is a variant of the HLA-DRB1 gene called HLA-DRB1*04:04 . (medlineplus.gov)
  • The goals are to standardize typing of MICA alleles and MICA antibody identification, as well as to identify new alleles. (uclahealth.org)
  • Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies. (cdc.gov)
  • The fact that HLA-DRB1 matching at the DNA level influenced incidence of graft rejection after cadaveric renal transplantation is analogous to results in living-related renal transplantation. (lww.com)
  • No significant association was shown between severity of liver disease and DRB1* alleles. (nih.gov)
  • These results suggest that host HLA-DRB1* alleles are important contributors to disease outcome. (nih.gov)
  • This information will be useful for HLA-DRB1-linked disease-association studies. (geneticsmr.com)
  • In addition, no increased risk for the disease was found among those getting a vaccine who were carriers of HLA-DRB1 alleles or smokers. (dotmed.com)
  • In individuals carrying two copies of the HLA-DRB1 SE, 55% of ACPA-positive RA was attributable to smoking. (bmj.com)
  • There was a correlation between HLA-DRB1*11 and anti-K (P = 0.000, OR = 6.643). (ac.ir)
  • There was no association between HLA-DRB1*09:01 and alloimmunisation (P = 0.350). (ac.ir)
  • It is suggested that avoidance of mismatching for DRB1 alleles at the DNA level in recipient selection of cadaveric renal transplantation leads to an improvement of graft outcome. (lww.com)
  • The assays used and alleles tested in this study can be viewed with this link . (cdc.gov)
  • Identification of a new allele, HLA-DRB1*01:01:01:02 discovered using third-generation sequencing. (anthonynolan.org)
  • For prediction of grade of activity, the impartial predictors were anti-CCP (OR 19.6), and em DRB1*04 /em positive allele (OR 5.1). (exposed-skin-care.net)
  • The data from each test method and consensus diplotypes for each sample, assays used, and alleles tested can be viewed here . (cdc.gov)