In this study our aim was to evaluate the susceptibility of the pegylated liposomal formulation of doxorubicin (PLD/Doxil(R)/Caelyx(R)) to MDR. (mtak.hu)
Liposomal doxorubicin is an anthracycline-type chemotherapy drug that is used to treat certain types of cancer (such as ovarian cancer , AIDS-related Kaposi's sarcoma , multiple myeloma ). (webmd.com)
Drugs used in chemotherapy, such as pegylated liposomal doxorubicin hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (clinicaltrialsgps.com)
Liposomal drug delivery systems are used as targeted therapy for cancer treatment in radiation therapy, chemotherapy, and surgical resection. (yahoo.com)
For their study, they assigned patients with early-stage (T0) KS to combined antiretroviral (cART) therapy alone, and those with advanced-stage (T1) KS to cART plus liposomal anthracycline chemotherapy. (medscape.com)
Of those with advanced-stage KS, 140 (84%) were treated with cART plus liposomal anthracycline chemotherapy, 14 (8%) were treated with cART alone, 9 (5%) were treated with cART and radiotherapy for localized ulcerating tumors, and 3 (2%) were treated with cART plus complete excision. (medscape.com)
Gemcitabine3
Scholars@Duke publication: Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcγRIIIa-158 V/F polymorphism. (duke.edu)
BACKGROUND: Based on in vitro synergistic cytotoxicity when anti-CD30 antibodies are combined with gemcitabine, the Cancer and Leukemia Group B conducted a double-blind, randomized, phase II trial of SGN-30 with gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD) in patients with relapsed Hodgkin's lymphoma. (duke.edu)
Methods Patients with platinum-sensitive recurrent ovarian cancer received intravenous (IV) paclitaxel at 60 mg/m 2 followed by IV carboplatin at an area under the curve of 6 and IV pegylated liposomal doxorubicin at 30 mg/m 2 on day 1 in a 28-day cycle (DC-LOP) or IV gemcitabine at 1000 mg/m 2 on days 1 and 8 in a 21-day cycle (GC-LOP). (bmj.com)
I. To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/ carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the event-free survival (EFS) of patients with newly diagnosed stage 4 diffuse anaplastic Wilms tumor (DAWT) as compared to historical controls. (clinicaltrials.gov)
To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the EFS of patients with standard-risk relapsed favorable histology Wilms tumor (SRrFHWT) as compared to historical controls. (clinicaltrials.gov)
I. To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the overall survival (OS) of patients with newly diagnosed stage 4 DAWT as compared to historical controls. (clinicaltrials.gov)
Liposomes3
Doxorubicin liposomal is a pegylated formulation that protects the liposomes and, thereby, increases blood circulation time. (medscape.com)
Materials and Methods: In-111-labeled temperature-sensitive liposomes encapsulating doxorubicin and [Gd(HPDO3A) (H2O)] were injected intravenously in the tail vein of rats (n = 12) bearing a subcutaneous rhabdomyosarcoma tumor on the hind leg. (maastrichtuniversity.nl)
The compact size of STDO precisely fits inside a stealthy liposome of about 150 nm and could efficiently remotely load doxorubicin in liposomes (LSTDO) without a pH driven gradient. (unive.it)
Daunorubicin1
Liposomal formulations of daunorubicin and doxorubicin have been approved that appear to be somewhat less toxic to cardiac tissue. (wikidoc.org)
Doxorubicin hydrochloride Pegylated Liposomal Injection inhibits DNA and RNA synthesis by intercalating between DNA base pairs causing steric obstruction and inhibits topoisomerase-II at the point of DNA cleavage. (magicinepharma.com)
This randomized phase II/III trial studies how well pegylated liposomal doxorubicin hydrochloride with atezolizumab and/or bevacizumab work in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has come back. (clinicaltrialsgps.com)
I. Estimate the probability of a dose limiting toxicity (DLT) following cycle 1 of experimental regimens (pegylated liposomal doxorubicin hydrochloride [pegylated liposomal doxorubicin] [PLD] and atezolizumab and PLD/bevacizumab and atezolizumab). (clinicaltrialsgps.com)
ARM II: Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1, bevacizumab IV over 30-90 minutes on days 1 and 15, and atezolizumab IV over 30-60 minutes on days 1 and 15. (clinicaltrialsgps.com)
Injection2
The presence of the liposomal carriers and the intratumoral distribution of doxorubicin were imaged ex vivo with autoradiography and fluorescence microscopy, respectively, for 2 different time points after injection (90 minutes and 48 hours). (maastrichtuniversity.nl)
At 48 hours after injection, the liposomal accumulation in the tumor was enhanced in the hyperthermia group in comparison with the controls. (maastrichtuniversity.nl)
Ovarian cancer3
Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
Strother, R & Matei, D 2009, ' Pegylated liposomal doxorubicin in ovarian cancer ', Therapeutics and Clinical Risk Management , vol. 5, no. 1, pp. 639-650. (northwestern.edu)
This study evaluated the safety and efficacy of canfosfamide in combination with pegylated liposomal doxorubicin (PLD) in patients with platinum resistant ovarian cancer. (houstonmethodist.org)
Epirubicin1
Epirubicin has similar activity to doxorubicin, however has reduced cardiotoxic side effects. (wikipedia.org)
Formulation2
The liposomal formulation leads to improved delivery to the target tumor tissue, allowing enhanced uptake by cancer cells. (northwestern.edu)
Pegylated liposomal formulation of doxorubicin overcomes drug resistance in a genetically engineered mouse model of breast cancer. (mtak.hu)
A favorable toxicity profile renders liposomal doxorubicin an ideal partner for combination regimens with other cytotoxics, and more recently with biological agents. (northwestern.edu)
Intracellular1
Compared with direct infusion over a 2-hour period, thermosensitive liposome delivery leads to a much higher peak intracellular concentration of doxorubicin, which may increase cell killing in tumour thereby enhancing the therapeutic effect of the drug. (elsevierpure.com)
Toxicity3
The encapsulation of doxorubicin in a pegylated liposomal matrix led to a reformulated agent with a different toxicity profile and improved clinical utility. (northwestern.edu)
Liposomal doxorubicin is devoid of the cardiac toxicity associated with doxorubicin, but is associated with predictable muco-cutaneous toxicity. (northwestern.edu)
We investigated the efficacy and safety of single-agent pegylated liposomal doxorubicin (PLD) as first-line treatment for elderly women with advanced breast cancer and evaluated predictive markers for response and toxicity. (scilifelab.se)
Patients2
Doxorubicin (DOX) is recognized by Pgp and therefore it can induce therapy resistance in breast cancer patients. (mtak.hu)
The high cost of devices makes liposomal treatment more expensive and unaffordable for patients, thereby hindering the growth of the market. (yahoo.com)
Growth3
The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
The rise in the number of cancer cases across the globe is likely to contribute to the growth of the liposomal drug delivery devices market during the forecast period. (yahoo.com)
The high cost of liposomal drug delivery devices is expected to limit the growth of the market during the forecast period. (yahoo.com)
Tumor1
Fluorescence images showed perivascular doxorubicin in control tumors, whereas in the HIFU-treated tumors, the delivered drug was spread over a much larger area and also taken up by tumor cells at a larger distance from blood vessels. (maastrichtuniversity.nl)
Additionally1
Additionally, the effect of the targeted liposomal combinations was evaluated on the percentage of ALDH+/high putative triple-negative breast CSC population and phenotype, including mammosphere-forming capacity and live single-cell tracking. (uc.pt)
Tumors1
Consistent with the higher Pgp levels needed to confer resistance, PLD administration was able to overcome doxorubicin insensitivity of the mouse mammary tumors. (mtak.hu)
Treatment4
Pegylated liposomal doxorubicin, an effective, well-tolerated treatment for refractory aggressive fibromatosis. (dtrf.org)
Conclusions: Treatment with HIFU hyperthermia not only improved the immediate drug delivery, bioavailability, and intratumoral distribution but also enhanced liposomal accumulation over time. (maastrichtuniversity.nl)
Pegylated liposomal doxorubicin as first-line monotherapy in elderly women with locally advanced or metastatic breast cancer: novel treatment predictive factors identified. (scilifelab.se)
Furthermore, according to the ScienceDirect Journal, liposomal drug delivery is the most expensive treatment for topical disorders such as psoriasis, atopic dermatitis, and skin cancer. (yahoo.com)
Decrease3
Depending on how severe your hand-foot syndrome is, your doctor may give you something to reduce the symptoms, or decrease or delay your next dose of liposomal doxorubicin . (webmd.com)
apalutamide will decrease the level or effect of doxorubicin liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
doxorubicin liposomal will decrease the level or effect of dabigatran by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
Evaluate1
alone and evaluate its activity in combinatio n with pegylated liposomal doxorubicin (PLD). (researchgate.net)
Therapy2
Heart problems may occur during liposomal doxorubicin therapy or months to years after receiving this medication . (webmd.com)
Doxorubicin is part of VAD therapy. (medscape.com)
Therefore, the rise in cancer incidence rate globally is anticipated to boost the demand for the liposomal drug delivery devices market over the forthcoming years. (yahoo.com)
Contrast1
Objectives: The aim of this study was to investigate the intratumoral distribution of a temperature-sensitive liposomal carrier and its encapsulated compounds, doxorubicin, and a magnetic resonance (MR) imaging contrast agent after high-intensity focused ultrasound (HIFU)-mediated hyperthermia-induced local drug release. (maastrichtuniversity.nl)
Cell4
The iron-doxorubicin complex can bind DNA and cell membranes, producing free hydroxyl (OH) radicals that cleave DNA and cell membranes. (magicinepharma.com)
The targeted liposomal combinations of DXR/C6- or C18-ceramide, at a 1:1 molar ratio, at death fractions of either 0.5 (IC50) or 0.9 (IC90), at 4 or 24 h incubation, enabled a synergistic drug interaction in all (bulk) TNBC cell lines tested (MDA-MB-231, MDA-MB-468 and Hs578T). (uc.pt)
Initial studies show it seems to work as well as liposomal doxorubicin and its main side effect is a low white blood cell count. (cancer.org)
We show that cells selected to be resistant to DOX are cross-resistant to PLD and PLD is also ineffective in an allograft model of doxorubicin-resistant mouse B-cell leukemia. (mtak.hu)
Global1
Dublin, Aug. 01, 2022 (GLOBE NEWSWIRE) -- The "Liposomal Drug Delivery Devices Global Market Report 2022" report has been added to ResearchAndMarkets.com's offering. (yahoo.com)
Delivery7
The model has been applied to idealized tumour geometry, and comparisons are made between continuous infusion of doxorubicin and thermosensitive liposome-mediated delivery. (elsevierpure.com)
Zhan, W & Xu, XY 2013, ' A Mathematical Model for Thermosensitive Liposomal Delivery of Doxorubicin to Solid Tumour ', Journal of Drug Delivery , vol. 2013, 172529. (elsevierpure.com)
Moreover, co-encapsulation and delivery of doxorubicin (DXR) and ceramides have the potential to circumvent one of the resistance mechanisms to DXR - the overexpression of glucosylceramide synthase, an enzyme described to metabolize ceramides. (uc.pt)
North America was the largest region in the liposomal drug delivery devices market in 2021. (yahoo.com)
Asia Pacific was the second-largest region in the liposomal drug delivery devices market. (yahoo.com)
For instance, according to the Journal of Biotechnology & Biomaterials, lipid/liposomal drug delivery systems are expensive to produce attributing to their high production cost. (yahoo.com)
Several big companies are undertaking various strategic initiatives such as collaborations and new product development, which is likely to become a major trend in the liposomal drug delivery devices market. (yahoo.com)
Study1
cutánea maligna de células T. Luego se realizó el frotis de médula ósea, en el que se identificaron células «cerebriformes» study conception, manuscript que confirmaron el diagnóstico de síndrome de Sézary. (bvsalud.org)