• Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. (foodforbreastcancer.com)
  • The usefulness of Adriamycin, an anthracycline chemotherapy drug with powerful antitumor activity, is limited by Adriamycin-induced cardiotoxicity, which can lead to heart failure in susceptible breast cancer patients. (foodforbreastcancer.com)
  • Cell studies also found that kaempferol appeared to use the mitochondrion-dependent pathway to inhibit the Adriamycin-induced cardiotoxicity. (foodforbreastcancer.com)
  • The authors conclude that kaempferol protected against Adriamycin-induced cardiotoxicity. (foodforbreastcancer.com)
  • They further comment that kaempferol might be a promising reagent for treating Adriamycin-induced cardiotoxicity, and may have implications in the long-term clinical usefulness of Adriamycin. (foodforbreastcancer.com)
  • Alkreathy H, Damanhouri ZA, Ahmed N, Slevin M, Ali SS, Osman AM. Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats. (foodforbreastcancer.com)
  • The efficacy of an anthracycline antibiotic doxorubicin (DOX) as a chemotherapeutic agent is limited by dose-dependent cardiotoxicity. (northwestern.edu)
  • p38δ plays a crucial role in promoting DOX-induced cardiotoxicity in female mice by inhibiting autophagy. (northwestern.edu)
  • New & Noteworthy: This study for the first time identifies the sex-specific roles of the alternative p38γ and p38δ MAPK isoforms in promoting doxorubicin (DOX) cardiotoxicity. (northwestern.edu)
  • Use of Milk Thistle active Silymarin along with Doxorubicin benefits children with leukemia by reducing the Doxorubicin-induced cardiotoxicity as demonstrated in a clinical study with children with acute lymphoblastic leukemia. (addon.life)
  • However, this impact of Doxorubicin also results in severe collateral damage to the healthy cells, with cardiotoxicity as one of the most severe side-effects having a probability of fatal congestive heart failure, that could occur either during treatment or months or years after the therapy. (addon.life)
  • Increased probability of cardiotoxicity, as assessed by various signs and symptoms including decline in heart function or change in levels of key enzyme markers of cardiotoxicity, increases with increasing the total cumulative dose of Doxorubicin. (addon.life)
  • Researchers have studied the effect of different natural plant derived supplements when taken along with Doxorubicin on the cardiotoxicity endpoints in cancer cells and animal disease models, similar ones as used in the drug development process for approved drugs. (addon.life)
  • Silymarin has been shown experimentally to have cardioprotective effects when given along with Doxorubicin (reducing Doxorubicin-induced cardiotoxicity). (addon.life)
  • They found that in the Silymarin group, there was 'decreased early Doxorubicin-induced left ventricular systolic function disturbances (cardiotoxicity)' over the placebo group. (addon.life)
  • Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes. (oncotarget.com)
  • Notably, tumour EVP education enhanced side effects of chemotherapy, including bone marrow suppression and cardiotoxicity, suggesting that metabolic reprogramming of the liver by tumour-derived EVPs may limit chemotherapy tolerance in patients with cancer. (nature.com)
  • In addition, reactive oxygen species have an important role in DXR-induced cardiotoxicity. (fusabil.org)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • Two studies, HEC1 and HEC2, evaluated rolapitant in patients receiving cisplatin-based highly emetogenic chemotherapy (HEC), the other looked at rolapitant in patients receiving moderately emetogenic chemotherapy (MEC). (pharmacytimes.com)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • In a study of 136 patients with advanced non-small cell lung cancer, three cycles of treatment with injectable astragalus polysaccharide (250 mg/d concurrent with chemotherapy cycle) combined with vinorelbine and cisplatin yielded significant improvements in overall quality of life ( P = .003) compared with the control group receiving chemotherapy alone. (ascopost.com)
  • Palonosetron did not inhibit the antitumor activity of cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C in murine tumor models. (com.bd)
  • Compared with the corresponding parental cells, the SP cells of SWCNT-transformed and H460 cells acquired apoptosis resistance to various chemotherapy including antimycin A, cisplatin, doxorubicin and etoposide. (cdc.gov)
  • One of the main objectives of these studies is the development of a new quinone derived compound that produces anti-neoplastic activity while maintaining low toxicity at therapeutic doses. (wikipedia.org)
  • Cardiovascular toxicity in cancer patients receiving chemotherapy remains one of the most undesirable side effects, limiting the choice of the most efficient therapeutic regimen, including combinations of different anticancer agents. (uninsubria.it)
  • Dox-induced over-production of reactive oxygen and nitrogen species (ROS and RNS) such as superoxide, hydrogen peroxide, hydroxyl radical and peroxynitrite has been proposed to be the main cause of Dox-induced acute cardiomyocyte toxicity and cell death by damaging various molecular constituents and organelles [ 9 - 12 ]. (oncotarget.com)
  • In two studies conducted in women undergoing treatment for breast cancer, levels of a protein known as hemopexin circulating in the blood were associated with increased cardiac toxicity. (appliedradiationoncology.com)
  • These findings, published in Science Advances, suggest the body produces the protein as a protective measure against the therapy-induced cardiac toxicity. (appliedradiationoncology.com)
  • Having established a clear link between anthracycline-induced cardiac toxicity and increased hemopexin levels, the scientists sought to determine hemopexin's functional role. (appliedradiationoncology.com)
  • However, when they performed a similar experiment in genetically altered mice that lack the naturally occurring hemopexin protein, the hemopexin-deficient mice demonstrated increased doxorubicin cardiac toxicity compared to wild type mice. (appliedradiationoncology.com)
  • These findings serve as the basis for future investigations to develop hemopexin as both a biomarker and a protective therapy for patients at risk of chemotherapy-related heart toxicity," said Dr Asnani, who is also an associate member of the Cancer Research Institute at BIDMC. (appliedradiationoncology.com)
  • 7 While several cardiovascular toxicity studies have been conducted in adult cancer patients, far fewer have been conducted in pediatric cancer patients. (ajmc.com)
  • Further, the utility of the first-line cytostatic doxorubicin is limited by dose-related and cumulative myocardial toxicity, especially in elderly patients with pre-existing cardiac disease ( 14 ). (spandidos-publications.com)
  • Based on the above studies, when anthracycline is used as a chemotherapeutic agent, cardiac toxicity has become the main limiting factor, and the discovery, prevention, and treatment of it will be an important issue. (frontiersin.org)
  • This study investigated the effect of nasturtium officinale extract on the ovarian function following the toxicity induced by doxorubicin in female rats. (ac.ir)
  • Besides the superiority of its relatively wide spectrum and powerful effect, it also has a disadvantage of strong toxicity, as doxorubicin has an irreversible cardiotoxic effect. (fusabil.org)
  • Thus, while doxorubicin and other anthraquinones act through many mechanisms such as apoptosis, abrogation of the cell cycle cell, activation of caspases, generation of ROS, inhibition of both topoisomerases, activation of intracellular secondary messengers, etc. (wikipedia.org)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • In this study, it was found that oxidative stress inhibited apoptosis by depleting cells of their energy source, which is called adenosine triphosphate (ATP). (pinestreetfoundation.org)
  • Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. (cancerindex.org)
  • ABCG2 inhibitor verapamil, downregulate ABCG2, induce ER stress markers and induces apoptosis. (pka-signal.com)
  • Previous evidence has shown that PKC is involved in the control of human medullary thyroid carcinoma (MTC) proliferation and survival by modulating apoptosis, with a mechanism that implicates PKCβII isoform and translocation in different subcellular compartments.In this study, we investigated the role of PKCδ. (endocrine-abstracts.org)
  • Doxorubicin, like other anticancer quinones, was used for chemotherapy in human cancers for many years. (wikipedia.org)
  • Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
  • The cardiovascular side effects associated with doxorubicin (DOX), a wide spectrum anticancer drug, have limited its clinical application. (isciii.es)
  • With this line it has been demonstrated that pre-incubation with LD doxorubicin (LDDOX) protects normal cells against tubulin poisons.4 5 Similarly a LD of actinomycin?D (LDactD) another clinically approved anticancer drug has been used like a chemoprotectant in combination with the Aurora kinase inhibitor VX680.6 Unfortunately both LDDOX and LDactD also protected p53-deficient malignancy cell lines to a small degree. (immune-source.com)
  • Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
  • Varubi indicated for use in combination with other antiemetic agents to treat delayed chemotherapy-induced nausea and vomiting in adults. (pharmacytimes.com)
  • The FDA has approved intravenous (IV) rolapitant (Varubi) for use in combination with other antiemetic agents to treat delayed chemotherapy-induced nausea and vomiting (CINV) in adults, according to Tesaro, the manufacturer of the agent. (pharmacytimes.com)
  • Delayed nausea and vomiting occurs between 25 and 120 hours after chemotherapy. (pharmacytimes.com)
  • Patients assigned to rolapitant also reported experiencing less nausea that interfered with normal daily life and fewer episodes of vomiting over multiple cycles of chemotherapy. (pharmacytimes.com)
  • We will continue our efforts to expand awareness of delayed chemotherapy-induced nausea and vomiting, and plan to make this important medicine available next month. (pharmacytimes.com)
  • Ginger (Zingiber officinale) can be helpful in alleviating nausea and vomiting caused by chemotherapy. (peacehealth.org)
  • A systematic review (4 trials, n = 342) showed that it helped stimulate immunocompetent lymphocytes and decrease nausea and vomiting in patients with colorectal cancer who were undergoing chemotherapy. (ascopost.com)
  • A meta-analysis (27 trials, 1,843 patients with colorectal cancer) also found reductions in chemotherapy-induced nausea and vomiting (risk ratio = 0.65 [0.59-0.71], I(2) = 28%) following concurrent use of astragalus with chemotherapy compared with chemotherapy alone. (ascopost.com)
  • nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy. (nih.gov)
  • prevention of radiation-induced nausea and vomiting (greater than or equal to 2%) are: headache, constipation, and diarrhea. (nih.gov)
  • Prevention of chemotherapy-induced nausea and vomiting (CINV) is crucial in maximizing patients' quality of life and optimizing outcomes of cancer therapy, and can be done more effectively than ever before. (medscape.com)
  • Similar to realtors' mantra of "location, location, location," oncology nurses should have the mantra "prevention, prevention, prevention" foremost on their minds when assessing and developing a plan of care for controlling chemotherapy-induced nausea and vomiting (CINV). (medscape.com)
  • Poorly controlled nausea or vomiting associated with chemotherapy increases risk of developing anticipatory nausea and vomiting, which ranges from 18%-57% in incidence (NCCN, 2012a). (medscape.com)
  • A study of patients with breast cancer who received aggressive antiemetics demonstrated improved appetite, better control of nausea and vomiting, and subsequent improved quality of life (Roldán et al. (medscape.com)
  • The study enrolled 60 breast cancer patients who had undergone surgical resection of the tumor and lymph nodes and received adjuvant chemotherapy. (naturalmedicinejournal.com)
  • Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. (oncotarget.com)
  • We previously demonstrated that GH protects breast cancer cells towards the cytotoxic effects of doxorubicin, inducing chemoresistance. (endocrine-abstracts.org)
  • BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
  • Using cytotoxic and antioxidant studies, the study attempted to assess some of the commonly used medicinal plants used to cure cancer among Yoruba people in Ogun, Oyo, Osun, and Lagos (South-West, Nigeria). (who.int)
  • In the mortality meta-analysis for all cancers, the pooled OR was higher for studies conducted in Asia than studies conducted in Europe or North America. (elifesciences.org)
  • Doxorubicin is a chemotherapy drug that has been approved for use as standard of care treatment in many cancer indications including acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML), neuroblastoma, sarcomas, breast, ovarian, bladder, thyroid, gastric and many other cancers. (addon.life)
  • Doxorubicin (Dox), a non-selective class I anthracycline antibiotic, is a potent chemotherapeutic agent which is used for the treatment of numerous cancers [ 1 ]. (oncotarget.com)
  • Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)
  • Keywords: actinomycin D chemoprotection cyclotherapy leptomycin B Nutlin-3 p53 tenovin-6 Launch Chemotherapy approaches purpose at developing remedies that eradicate cancers cells effectively and selectively. (immune-source.com)
  • Obtaining vitamin B6 through diet may help to reduce the risk of certain cancers, but using B6 supplements does not prevent cancer or reduce chemotherapy side effects. (mskcc.org)
  • Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)
  • Whether the elevated TIGAR expression protects DNA damage induced by chemotherapeutic agents or hypoxia has not been explored. (nature.com)
  • Doxorubicin, which has been the most frequently used chemotherapeutic agent in the treatment of soft tissue sarcomas, demonstrates response rates of 20-30% in disseminated disease ( 9 , 10 ). (spandidos-publications.com)
  • Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). (endocrine-abstracts.org)
  • The aim of the present study was to determine the effects of CoQ 10 and vitamin E on lipid peroxidation and antioxidant profile in rats treated with the chemotherapeutic agent doxorubicin, along with the biochemical parameters of albumin, globulin, total protein, alanine aminotransferase (ALT) and glucose levels. (fusabil.org)
  • The nasturtium officinale extract attenuated the toxic effect of doxorubicin on the rat ovaries and protected the cell division in the follicles and the oocytes maturation. (ac.ir)
  • apalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • darolutamide will increase the level or effect of doxorubicin by Other (see comment). (medscape.com)
  • enzalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • erdafitinib will increase the level or effect of doxorubicin by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • To determine in a randomized study design whether the incidence and/or severity of acute vincristine-induced peripheral neuropathy can be reduced by decreasing the dosage of vincristine in patients with the high-risk CEP72 TT genotype or by shortening the duration of vincristine therapy in standard/high-risk patients with the CEP72 CC or CT genotype. (centerwatch.com)
  • The eligible studies for inclusion in our analysis were limited to RCTs of HER2-targeted ADCs that were approved by the US Food and Drug Administration and examined on cancer patients with available data on fatal adverse events. (bvsalud.org)
  • Previous studies have reported that the cytotoxicity of doxorubicin against cancer cells is not reduced by exposure of the cells to kaempferol. (foodforbreastcancer.com)
  • Please see our article on breast cancer diet during Adriamycin chemotherapy for more information on how to optimize treatment with Adriamycin and minimize its side effects. (foodforbreastcancer.com)
  • Anthracyclines (doxorubicin) and antimetabolites (5-fluorouracil (5-FU), capecitabine) are among the most known agents used in breast cancer and other neoplasms and are associated with cardiotoxic effects. (uninsubria.it)
  • In this study, we investigated the activities of polyphenol-rich extract from OMWW, A009, in cooperation with chemotherapy on two breast cancer cell lines, namely, BT459 and MDA-MB-231, in a cardio-oncology perspective. (uninsubria.it)
  • For in vivo studies, the murine sponge assay of angiogenesis was used as a model of breast cancer-associated vascularization. (uninsubria.it)
  • We found that the A009 extract exhibited antiangiogenic activities induced by breast cancer cell supernatants and increased T-cell recruitment in vivo. (uninsubria.it)
  • Our study demonstrates that the polyphenol-rich purified OMWW extract A009 combined with cancer chemotherapy could represent a potential candidate for cardiovascular protection in breast cancer patients, while increasing the effects of breast cancer chemotherapy. (uninsubria.it)
  • It has long been known that oxidative stress is an essential mechanism by which chemotherapy works to treat cancer. (pinestreetfoundation.org)
  • To carry out a systematic review of the studies comparing the outcome of unvaccinated COVID-19 patients with and without cancer, a search string was devised which was used to identify relevant publications in PubMed up to December 31, 2020. (elifesciences.org)
  • For all cancer combined, the pooled odds ratio (OR) for mortality was 2.32 (95% confidence interval [CI] 1.82-2.94, I 2 for heterogeneity 90.1%, 24 studies), that for ICU admission was 2.39 (95% CI 1.90-3.02, I 2 0.0%, 5 studies), that for disease severity or hospitalization was 2.08 (95% CI 1.60-2.72, I 2 92.1%, 15 studies). (elifesciences.org)
  • The authors conducted a systematic review and baseline meta-analysis of studies on the impact of SARS-Cov-2 infection on morbidity and mortality among cancer patients not previously vaccinated against the virus. (elifesciences.org)
  • Doxorubicin is able to kill the abnormally fast growing cancer cells by causing excessive DNA damage and increasing oxidative stress that also induces cell death. (addon.life)
  • Dr Asnani and colleagues studied 30 women diagnosed with breast cancer and scheduled to undergo treatment with anthracycline chemotherapies. (appliedradiationoncology.com)
  • We identified tumour-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumour EVP secretion via depletion of Rab27a . (nature.com)
  • Since pycnogenol is a naturally occurring compound that is very well-tolerated with a high oral bioavailability, it has been highly studied for the treatment of many diseases including cancer ( 17 , 18 ). (spandidos-publications.com)
  • Oxaliplatin (OXA), is a third generation platinum drug used as first-line chemotherapy in colorectal cancer (CRC). (pka-signal.com)
  • Role of ABCG2 and plausible molecular signaling pathways involved in Oxaliplatin-Resistant (OXA-R) colon cancer cells was evaluated in the present study. (pka-signal.com)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
  • Pharmacological activation of wild-type p53 has been found to protect normal cells in culture from cytotoxicity and nuclear aberrations caused by standard cancer therapeutics. (immune-source.com)
  • 2,3] The majority employ them as adjuncts to chemotherapy or other cancer treatments to alleviate symptoms and to prevent recurrence. (cancernetwork.com)
  • Getting B6 through diet along with other nutrients is associated with cancer-preventive effects, but it cannot reduce side effects from chemotherapy. (mskcc.org)
  • BOSTON, Aug. 01, 2022 (GLOBE NEWSWIRE) -- Aileron Therapeutics (Nasdaq: ALRN), a chemoprotection oncology company that aspires to make chemotherapy safer and thereby more effective to save more patients' lives, today outlined its strategy to strengthen the company's Phase 1b chemoprotection trial of ALRN-6924 in patients with p53-mutated breast cancer. (aileronrx.com)
  • The evidence-based modifications we are implementing reflect key, collective learnings from our healthy volunteer study, as well as our non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) clinical trials. (aileronrx.com)
  • Protecting cancer patients from chemotherapy-induced toxicities remains a critical unmet need. (aileronrx.com)
  • We look forward to the continued clinical investigation of this potentially transformative therapy to prevent multiple chemotherapy-induced side effects and help patients fight cancer more effectively. (aileronrx.com)
  • Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. (oaepublish.com)
  • Telomeric DNA damage response induced by some cancer treatments can persist for months, possibly accounting for long-term sequelae of cancer treatments. (oaepublish.com)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • initial and repeat courses of moderately emetogenic cancer chemotherapy. (nih.gov)
  • Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. (cdc.gov)
  • This study presented an artificial intelligence pipeline of miRNA-based discovery of biomarkers, therapeutic targets, and repositioning drugs that can be applied to many cancer types. (cdc.gov)
  • Patients with cancer often approach chemotherapy treatment with preconceived ideas about what their experience will entail. (medscape.com)
  • Some additional studies were also performed: measurement of fullerenol nanoparticle size, zeta potential, and the influence of fullerenol on the ionizing radiation-induced damage to PMBCs. (biofullerene.com)
  • A new study has reported that kaempferol , a flavonol found in foods such as kale, chives and mustard greens, reduces the cardiotoxic effects of Adriamycin (doxorubicin) in rats. (foodforbreastcancer.com)
  • On the other hand, kaempferol pretreatment was found to reduce the Adriamycin-induced damage in heart tissues. (foodforbreastcancer.com)
  • Note that while black and green tea are also good sources of kaempferol, they might reduce the effectiveness of Adriamycin and other anthracycline chemotherapy through their caffeine content. (foodforbreastcancer.com)
  • Doxorubicin (Adriamycin, DXR), is an anthracycline derived from Streptomyces peucetius variete caesius cultures. (fusabil.org)
  • ABSTRACT In Bahrain, adequate epidemiological information is lacking concerning the rate of EBV infection, which could be helpful in order to develop measures to protect against EBV infections. (who.int)
  • TACE induced a reduction in tumor size mainly due to ischemia resulting from embolization 11 which expose tumor to acute hypoxia. (nature.com)
  • The overarching objective of this study is to use novel precision medicine strategies based on inherited and acquired leukemia-specific genomic features and targeted treatment approaches to improve the cure rate and quality of life of children with acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (LLy). (centerwatch.com)
  • The risk of developing secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) is increased following treatment with doxorubicin hydrochloride. (medscape.com)
  • The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
  • Many healthcare providers tend to believe that CINV is no longer an unmet need but the reality is that more than half of patients treated with emetogenic chemotherapy experience delayed CINV, even when prescribed standard preventative therapies, such as a 5-HT3 receptor antagonist and dexamethasone," Lee Schwartzberg, MD, professor of Medicine at University of Tennessee Health Science Center, said in a statement. (pharmacytimes.com)
  • This column reviews the history and pathophysiology of treatments for CINV, as well as patient- and chemotherapy-specific risk factors that should be considered to optimize treatment outcomes in patients with CINV. (medscape.com)
  • However, when one looks more closely at the existing published science on how antioxidants and chemotherapy combine, the true answer is not so definitive. (pinestreetfoundation.org)
  • A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
  • Participants had bloodwork and other data collected at baseline before receiving the doxorubicin regimen. (appliedradiationoncology.com)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • To conduct the study, the authors divided rats into two groups. (foodforbreastcancer.com)
  • In this study, proteomics and metabonomics techniques were used to analyze the tissue and plasma of DOX-induced heart failure (HF) in rats and to clarify the molecular mechanism of the harmful effects of DOX on cardiac metabolism and function in rats from a new point of view. (frontiersin.org)
  • Here, we used ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) to analyze DOX-induced HF in rats, to explain the toxicological pathways of DOX to the heart, especially the combined proteomic technology, to provide more information for the study of its pathogenesis. (frontiersin.org)
  • This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
  • Moreover, NPM is crucial for inflammatory gene expression induced by tumor necrosis factor alpha (TNF-α) and lipopolysaccharides (LPS) in fibroblasts and macrophages ( 6 ). (frontiersin.org)
  • Cyclotherapy strategies purpose at improving the therapeutic windows of standard chemotherapy by protecting healthy cells.1-3 For instance if transient cell cycle arrest ARRY334543 (Varlitinib) in G1 or G2 was induced in normal tissues only their level of sensitivity to S- and M-phase poisons would be decreased while leaving the tumor vulnerable to the treatment. (immune-source.com)
  • Several small-molecule activators of the p53 tumor suppressor have been shown to induce a slight cytostatic response in normal cells in tradition. (immune-source.com)
  • 2008). Patients receiving chemotherapy with a goal of cure must receive full doses of standard chemotherapy on schedule to achieve optimal outcomes (Bonadonna et al. (medscape.com)
  • Dox is a mitochondrial toxin, and mitochondrial damage is central to Dox-induced cardiac dysfunction and cell death [ 8 ]. (oncotarget.com)
  • When researchers treated wild type (normal) lab mice with doxorubicin, they found that administering hemopexin prevented the development of cardiac dysfunction. (appliedradiationoncology.com)
  • Fig. 1: Remote primary tumours induce metabolic dysfunction in the liver. (nature.com)
  • Fig. 2: Tumour-derived EVPs induce liver metabolic dysfunction. (nature.com)
  • Chemotherapy agents can cause ovarian dysfunction and eventually lead to infertility. (ac.ir)
  • Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. (oaepublish.com)
  • Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. (oaepublish.com)
  • Similar improvements in global quality of life were reported in another study of 23 patients with metastatic disease following adjunctive use of both high (500 mg, P = .012) and low (250 mg, P = .02) doses of injectable astragalus polysaccharide, administered 3 times/week/cycle of 4 weeks. (ascopost.com)
  • as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
  • The doxorubicin damages DNA by intercalation, the generation of reactive oxygen species and inhibition of DNA topoisomerase I and II. (wikipedia.org)
  • It is an antioxidant and able to reduce damage to the membranes and proteins by the reactive species, that are created as part of Doxorubicin mechanism of action, by preventing depletion of the inherent antioxidant machinery of healthy cells (Roskovic A et al, Molecules 2011). (addon.life)
  • Development of multi drug resistance in OXA-R cells was confirmed by exposing the resistance cells to oxaliplatin, 5-FU and doxorubicin. (pka-signal.com)
  • Oxaliplatin (OXA), a first-line chemotherapy in CRC, acts as a bifunctional alkylating agent, covalently binding DNA and forming platinum-DNA adducts to inhibit DNA replication and transcription (Kelland, 2007). (pka-signal.com)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • The immunomodulatory effects of astragalus were found to be exerted through Toll-like receptor 4-mediated activation of mitogen-activated protein kinases and nuclear factor-kappa B. 18 In another study, a sublingual astragalus root extract resulted in increases in monocyte, neutrophil, lymphocyte, and platelet counts, as well as circulating cytokine levels, in healthy adults. (ascopost.com)
  • Other than infusion-site reactions with IV rolapitant, the safety profile in the study was consistent to previous trial findings with the oral formulation. (pharmacytimes.com)
  • RNA-seq raw data and associated processed data files that support the findings of this study have been deposited in the Gene Expression Omnibus under accession codes GSE199863 and GSE220446 . (nature.com)
  • [ 3 ] These long-term follow-up studies are augmented well by the findings of effect-specific investigations. (medscape.com)
  • [ 5 ] Studies in both adults and children have shown abnormal echocardiographic findings to be more frequent in patients monitored for more than 10 years than in those monitored for less than 10 years. (medscape.com)
  • Since the emergence of SARS-CoV-2, many studies have been conducted on the outcomes of COVID-19, in order to identify factors associated with a higher death rate and a more severe infection course. (elifesciences.org)
  • Hence, there are continuous efforts to find approaches that can help alleviate or protect the patient from the severe side-effects. (addon.life)
  • The combination of doxorubicin with ifosfamide is more effective, exhibiting higher response rates than doxorubicin alone, but is associated with severe short- and long-term toxicities, including cardiomyopathy and bone marrow suppression ( 11 - 13 ). (spandidos-publications.com)
  • The recently published EORTC 62012 trial which involved 455 patients with locally advanced, unresectable or metastatic high-grade soft tissue sarcomas concluded that an intensified therapy with doxorubicin and ifosfamide is not suitable for palliation of advanced soft tissue sarcomas because of the severe side-effects and should only be used when the specific goal is tumour shrinkage ( 13 ). (spandidos-publications.com)
  • In adults, the incidence of CHF was 3% at a cumulative doxorubicin dose of 400 mg/m 2 , 7% at a cumulative dose of 550 mg/m 2 , and 18% at cumulative doses higher than 700 mg/m 2 . (medscape.com)
  • In a review of 6493 children on Pediatric Oncology Group studies, the risk of developing CHF was 5 times higher with cumulative doses higher than 550 mg/m 2 than with lower doses. (medscape.com)
  • The combination of the OMWW extracts with doxorubicin or 5-FU limited BT459 and MDA-MB-231 cell viability and the diameter of 3D spheroids, while mitigating their toxic effects on the rat H9C2 cardiomyocytes. (uninsubria.it)
  • On the other hand, the decreased levels of antioxidants (or oxidative stress) that are caused by many chemotherapy treatments correlates with increased side effects. (pinestreetfoundation.org)
  • The FDA approval of Varubi IV gives doctors and nurses a new option to help protect their patients from these often preventable side effects. (pharmacytimes.com)
  • Based on these human findings, we used a mouse model that closely mirrored the heart issues observed in patients treated with doxorubicin," said first author Jing Liu, MD, PhD, a post-doctoral researcher in the Division of Cardiovascular Medicine at BIDMC. (appliedradiationoncology.com)
  • Our results reveal how tumour-derived EVPs dysregulate hepatic function and their targetable potential, alongside TNF inhibition, for preventing fatty liver formation and enhancing the efficacy of chemotherapy. (nature.com)
  • Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
  • In mice, ghrelin administration has been demonstrated to prevent the doxorubicin-induced GI mucosal damage. (naturalmedicinejournal.com)
  • Follow up studies in mice revealed the protein has heart-protective properties. (appliedradiationoncology.com)
  • As we saw in patients, plasma hemopexin was elevated in mice within 24 hours after completion of chemotherapy and was strongly associated with subsequent cardiac function. (appliedradiationoncology.com)
  • This compound has been shown to selectively shield normal cells against S-phase poisons 8 tubulin poisons 9 10 a Polo-like kinase 1 inhibitor (PLK1I)12 and an Aurora kinase inhibitor.7 Most importantly oral administration of nutlin-3 protects mice against PLK1I-induced neutropenia.12 Table?1. (immune-source.com)
  • Doxorubicin (DOX) is a commonly used anthracycline broad-spectrum antitumor antibiotic with strong antitumor effect and definite curative effect. (frontiersin.org)
  • Both the innate stimuli, such as lipopolysaccharides and Poly inositol-cytosine and adaptive stimuli, that is, cytokine mix, were able to induce the extracellular release of NPM in immortalized keratinocytes and human skin fibroblasts in the absence of cytotoxicity. (frontiersin.org)
  • Ghrelin, which is produced by GI enteroendocrine cells, is "involved in the control of the mucosal barrier and is considered a potential protective agent against chemotherapy complications. (naturalmedicinejournal.com)
  • Many studies demonstrated that somatic BRAF gene mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma (PTC), even from very small samples. (endocrine-abstracts.org)
  • Finally, in human cardio myocytes, we observed 5-FU-induced upregulation of the inflammatory, senescence-associated cytokine IL6 and p16 genes, which expression was reduced by OMWW treatment. (uninsubria.it)
  • One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
  • 2003) As seen in this study, higher levels of natural antioxidants can help treatment outcomes. (pinestreetfoundation.org)
  • To date, there are no effective and well-tolerated cytostatics for the palliative treatment of patients who are not suitable for aggressive anthracycline-based chemotherapy. (spandidos-publications.com)
  • Therefore, we think that PTP1B may play an important role in the development of heart failure induced by doxorubicin and can be used as a potential target for the treatment of heart failure. (frontiersin.org)
  • ALRN-6924 will be administered at 1.2 mg/kg on 3 consecutive days in each treatment cycle, Days 0, 1 and 2, while chemotherapy will be administered on Day 1. (aileronrx.com)
  • 0000005219 00000 n Many studies suggest several agents in the treatment and prevention of OM with varying results. (jonnevandermeijden.nl)
  • Confirm with patients who have received chemotherapy that their blood tests are normal prior to providing invasive dental treatment. (jonnevandermeijden.nl)
  • Long-term studies of this population have brought to light specific adverse effects of treatment, which are often present years after treatment and thus are termed late effects. (medscape.com)
  • The aggressive nature of ATC makes treatment studies difficult to perform. (medscape.com)
  • Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. (jonnevandermeijden.nl)
  • We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
  • The majority of NK-1 receptor antagonist doses are administered intravenously in the United States, and with the introduction of Varubi IV, we now offer healthcare providers a unique, easy-to-use option that fits well into standard operating practices of a chemotherapy clinic or hospital," Mary Lynne Hedley, PhD, president and COO of Tesaro, said in a press release. (pharmacytimes.com)
  • The 1st studies used low doses (LD) of DNA damaging providers to induce p53-dependent cell cycle arrest. (immune-source.com)
  • It is worth noting that we have found the key upstream target of DOX-induced HF, PTP1B, which inhibits the expression of HIF-1α by inhibiting the phosphorylation of IRS, leading to disorders of fatty acid metabolism and glycolysis, which together with the decrease of Nrf2, SOD, Cytc, and AK4 proteins lead to oxidative stress. (frontiersin.org)