• Two studies, HEC1 and HEC2, evaluated rolapitant in patients receiving cisplatin-based highly emetogenic chemotherapy (HEC), the other looked at rolapitant in patients receiving moderately emetogenic chemotherapy (MEC). (pharmacytimes.com)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • In a study of 136 patients with advanced non-small cell lung cancer, three cycles of treatment with injectable astragalus polysaccharide (250 mg/d concurrent with chemotherapy cycle) combined with vinorelbine and cisplatin yielded significant improvements in overall quality of life ( P = .003) compared with the control group receiving chemotherapy alone. (ascopost.com)
  • Palonosetron did not inhibit the antitumor activity of cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C in murine tumor models. (com.bd)
  • Compared with the corresponding parental cells, the SP cells of SWCNT-transformed and H460 cells acquired apoptosis resistance to various chemotherapy including antimycin A, cisplatin, doxorubicin and etoposide. (cdc.gov)
  • Prompt recognition and management of cardiotoxicity during chemotherapy is critical in order to ensure that patients can continue to receive these important treatments. (ajmc.com)
  • Use of Milk Thistle active Silymarin along with Doxorubicin benefits children with leukemia by reducing the Doxorubicin-induced cardiotoxicity as demonstrated in a clinical study with children with acute lymphoblastic leukemia. (addon.life)
  • However, this impact of Doxorubicin also results in severe collateral damage to the healthy cells, with cardiotoxicity as one of the most severe side-effects having a probability of fatal congestive heart failure, that could occur either during treatment or months or years after the therapy. (addon.life)
  • Increased probability of cardiotoxicity, as assessed by various signs and symptoms including decline in heart function or change in levels of key enzyme markers of cardiotoxicity, increases with increasing the total cumulative dose of Doxorubicin. (addon.life)
  • Researchers have studied the effect of different natural plant derived supplements when taken along with Doxorubicin on the cardiotoxicity endpoints in cancer cells and animal disease models, similar ones as used in the drug development process for approved drugs. (addon.life)
  • Silymarin has been shown experimentally to have cardioprotective effects when given along with Doxorubicin (reducing Doxorubicin-induced cardiotoxicity). (addon.life)
  • They found that in the Silymarin group, there was 'decreased early Doxorubicin-induced left ventricular systolic function disturbances (cardiotoxicity)' over the placebo group. (addon.life)
  • It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been proposed that doxorubicin-associated cardiomyopathy develops as the result of reactive oxygen species (ROS) production and iron accumulation. (medindia.net)
  • In a mouse model of doxorubicin-associated cardiotoxicity, overexpression of a protein that enhances mitochondrial iron transport reduced mitochondrial iron, ROS, and protected animals from doxorubicin-induced cardiomyopathy. (medindia.net)
  • Treatment of animals with dexrazoxane, which attenuates doxorubicin-induced cardiotoxicity, decreased mitochondrial iron levels and reversed doxorubicin-induced cardiac damage. (medindia.net)
  • These data suggest that therapies that limit mitochondrial iron accumulation have potential to limit doxorubicin-associated cardiotoxicity. (medindia.net)
  • In addition, reactive oxygen species have an important role in DXR-induced cardiotoxicity. (fusabil.org)
  • Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes. (oncotarget.com)
  • In our publication, we provide molecular mechanisms by which a genetic variant previously identified by our group may lead to the clinical development of anthracycline-induced cardiotoxicity in patients. (iu.edu)
  • Previous research by the Schneider laboratory suggested that people may be more likely to experience serious heart damage, known as cardiotoxicity, after getting chemotherapy with anthracyclines based on their genetics, but there has not been enough information to determine which specific genes are independent of other cardiac risk factors. (iu.edu)
  • This drug, or perhaps other drugs that work in a similar way, may be a key strategy for minimizing cardiotoxicity as a side effect to chemotherapy. (iu.edu)
  • Doxorubicin (Adriamycin, DXR), is an anthracycline derived from Streptomyces peucetius variete caesius cultures. (fusabil.org)
  • In patients with renal failure or highly aggressive disease, therapy with vincristine, Adriamycin (doxorubicin), and dexamethasone (VAD) may be preferred. (medscape.com)
  • To determine in a randomized study design whether the incidence and/or severity of acute vincristine-induced peripheral neuropathy can be reduced by decreasing the dosage of vincristine in patients with the high-risk CEP72 TT genotype or by shortening the duration of vincristine therapy in standard/high-risk patients with the CEP72 CC or CT genotype. (centerwatch.com)
  • The Phase 1b, open-label, single-arm i , multicenter trial is designed to evaluate the safety, tolerability and chemoprotective effect of ALRN-6924 in up to 24 patients with p53-mutated breast cancer undergoing either neoadjuvant or adjuvant treatment with docetaxel, doxorubicin and cyclophosphamide, also known as TAC. (aileronrx.com)
  • Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
  • Chemotherapy refers to the use of cytotoxic drugs in the treatment of cancer. (medindia.net)
  • Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. (oncotarget.com)
  • We previously demonstrated that GH protects breast cancer cells towards the cytotoxic effects of doxorubicin, inducing chemoresistance. (endocrine-abstracts.org)
  • The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. (biomedcentral.com)
  • The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
  • Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
  • BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
  • 1,2 Similarly, there are increased risks of congestive heart failure in adults treated with anthracycline-based chemotherapy regimens, which in current practice includes patients with breast cancer, leukemia, lymphoma, sarcoma, and other cancer types. (ajmc.com)
  • All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • The aim of the present study was to determine the effects of CoQ 10 and vitamin E on lipid peroxidation and antioxidant profile in rats treated with the chemotherapeutic agent doxorubicin, along with the biochemical parameters of albumin, globulin, total protein, alanine aminotransferase (ALT) and glucose levels. (fusabil.org)
  • Doxorubicin (Dox), a non-selective class I anthracycline antibiotic, is a potent chemotherapeutic agent which is used for the treatment of numerous cancers [ 1 ]. (oncotarget.com)
  • Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). (endocrine-abstracts.org)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
  • It also has severe limitations on the dosage of chemotherapeutic agents that can be administered to a patient, thus, limiting the effective range of chemotherapy. (justia.com)
  • By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
  • Besides the superiority of its relatively wide spectrum and powerful effect, it also has a disadvantage of strong toxicity, as doxorubicin has an irreversible cardiotoxic effect. (fusabil.org)
  • Dox-induced over-production of reactive oxygen and nitrogen species (ROS and RNS) such as superoxide, hydrogen peroxide, hydroxyl radical and peroxynitrite has been proposed to be the main cause of Dox-induced acute cardiomyocyte toxicity and cell death by damaging various molecular constituents and organelles [ 9 - 12 ]. (oncotarget.com)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • We know it is tricky to balance the toxicity needed to kill cancer cells, while also protecting the rest of a patient's healthy body," said Bryan P. Schneider, MD , Vera Bradley Professor of Oncology at IU School of Medicine, who is the senior author of the publication. (iu.edu)
  • Varubi indicated for use in combination with other antiemetic agents to treat delayed chemotherapy-induced nausea and vomiting in adults. (pharmacytimes.com)
  • The FDA has approved intravenous (IV) rolapitant (Varubi) for use in combination with other antiemetic agents to treat delayed chemotherapy-induced nausea and vomiting (CINV) in adults, according to Tesaro, the manufacturer of the agent. (pharmacytimes.com)
  • Delayed nausea and vomiting occurs between 25 and 120 hours after chemotherapy. (pharmacytimes.com)
  • Patients assigned to rolapitant also reported experiencing less nausea that interfered with normal daily life and fewer episodes of vomiting over multiple cycles of chemotherapy. (pharmacytimes.com)
  • We will continue our efforts to expand awareness of delayed chemotherapy-induced nausea and vomiting, and plan to make this important medicine available next month. (pharmacytimes.com)
  • Ginger (Zingiber officinale) can be helpful in alleviating nausea and vomiting caused by chemotherapy. (peacehealth.org)
  • A systematic review (4 trials, n = 342) showed that it helped stimulate immunocompetent lymphocytes and decrease nausea and vomiting in patients with colorectal cancer who were undergoing chemotherapy. (ascopost.com)
  • A meta-analysis (27 trials, 1,843 patients with colorectal cancer) also found reductions in chemotherapy-induced nausea and vomiting (risk ratio = 0.65 [0.59-0.71], I(2) = 28%) following concurrent use of astragalus with chemotherapy compared with chemotherapy alone. (ascopost.com)
  • nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy. (nih.gov)
  • prevention of radiation-induced nausea and vomiting (greater than or equal to 2%) are: headache, constipation, and diarrhea. (nih.gov)
  • Prevention of chemotherapy-induced nausea and vomiting (CINV) is crucial in maximizing patients' quality of life and optimizing outcomes of cancer therapy, and can be done more effectively than ever before. (medscape.com)
  • Similar to realtors' mantra of "location, location, location," oncology nurses should have the mantra "prevention, prevention, prevention" foremost on their minds when assessing and developing a plan of care for controlling chemotherapy-induced nausea and vomiting (CINV). (medscape.com)
  • Poorly controlled nausea or vomiting associated with chemotherapy increases risk of developing anticipatory nausea and vomiting, which ranges from 18%-57% in incidence (NCCN, 2012a). (medscape.com)
  • A study of patients with breast cancer who received aggressive antiemetics demonstrated improved appetite, better control of nausea and vomiting, and subsequent improved quality of life (RoldĆ”n et al. (medscape.com)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • Given the fact that ALK+ ALCL exhibits high levels of apoptosis and is typically responsive to conventional chemotherapy, we examined whether GzB expression might play a role in sensitizing ALK+ ALCL tumour cells to apoptosis. (biomedcentral.com)
  • Both spontaneous apoptosis and apoptosis in response to treatment with staurosporine or doxorubicin were investigated. (biomedcentral.com)
  • While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation. (biomedcentral.com)
  • Our findings are the first to demonstrate that GzB expression sensitizes ALK+ ALCL cell lines to drug-induced apoptosis. (biomedcentral.com)
  • Some types of chemotherapy are more likely than others to cause hair loss. (cancare.my)
  • Many healthcare providers tend to believe that CINV is no longer an unmet need but the reality is that more than half of patients treated with emetogenic chemotherapy experience delayed CINV, even when prescribed standard preventative therapies, such as a 5-HT3 receptor antagonist and dexamethasone," Lee Schwartzberg, MD, professor of Medicine at University of Tennessee Health Science Center, said in a statement. (pharmacytimes.com)
  • The FDA approval of Varubi IV gives doctors and nurses a new option to help protect their patients from these often preventable side effects. (pharmacytimes.com)
  • One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
  • Using antioxidants during chemotherapy is an important and controversial question among health care providers, patients, and their support teams. (pinestreetfoundation.org)
  • Furthermore, heart samples from patients undergoing doxorubicin therapy revealed higher levels of mitochondrial iron in patients with cardiomyopathies compared to patients without cardiac complications. (medindia.net)
  • In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
  • Similar improvements in global quality of life were reported in another study of 23 patients with metastatic disease following adjunctive use of both high (500 mg, P = .012) and low (250 mg, P = .02) doses of injectable astragalus polysaccharide, administered 3 times/week/cycle of 4 weeks. (ascopost.com)
  • BOSTON, Aug. 01, 2022 (GLOBE NEWSWIRE) -- Aileron Therapeutics (Nasdaq: ALRN), a chemoprotection oncology company that aspires to make chemotherapy safer and thereby more effective to save more patients' lives, today outlined its strategy to strengthen the company's Phase 1b chemoprotection trial of ALRN-6924 in patients with p53-mutated breast cancer. (aileronrx.com)
  • Protecting cancer patients from chemotherapy-induced toxicities remains a critical unmet need. (aileronrx.com)
  • We look forward to the continued clinical investigation of this potentially transformative therapy to prevent multiple chemotherapy-induced side effects and help patients fight cancer more effectively. (aileronrx.com)
  • For cancer patients who need to undergo chemotherapy, this is a real concern. (cancare.my)
  • Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
  • Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
  • The aim of this study was a retrospective evaluation of the clinicopathological characteristics of pNEN patients receiving STZ-based chemotherapies and to identify predictive and prognostic markers. (cancerindex.org)
  • STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
  • The aim of the present study was to determine the status of STZ usage in Japan and to evaluate the effectiveness and safety of STZ chemotherapy in Japanese NET patients. (cancerindex.org)
  • The main recipients of STZ chemotherapy were middle-aged patients with pancreatic NET and unresectable liver metastases. (cancerindex.org)
  • INDIANAPOLIS-Researchers at Indiana University School of Medicine are learning more about ways to prevent serious side effects from chemotherapy used to treat breast cancer patients. (iu.edu)
  • Anthracyclines belong to a class of chemotherapy agents used to treat a variety of cancers and remain an important part of therapy for patients with high-risk breast cancer. (iu.edu)
  • As pegylated liposomal formulation: In patients who failed 1st-line platinum-based chemotherapy regimen: 50 mg/m 2 via infusion over 60 minutes once every 4 weeks. (azurewebsites.net)
  • As pegylated liposomal formulation: In patients with low CD4 counts and extensive visceral or mucocutaneous disease, or after failure of or intolerance to previous systemic chemotherapy: 20 mg/m 2 via infusion over 30 or 60 minutes once every 2-3 weeks. (azurewebsites.net)
  • Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
  • This column reviews the history and pathophysiology of treatments for CINV, as well as patient- and chemotherapy-specific risk factors that should be considered to optimize treatment outcomes in patients with CINV. (medscape.com)
  • Patients with cancer often approach chemotherapy treatment with preconceived ideas about what their experience will entail. (medscape.com)
  • Despite advances in oncology care, many people still believe that all patients who receive chemotherapy will experience intractable vomiting. (medscape.com)
  • 2008). Patients receiving chemotherapy with a goal of cure must receive full doses of standard chemotherapy on schedule to achieve optimal outcomes (Bonadonna et al. (medscape.com)
  • 42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). (wikipedia.org)
  • These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells. (wikipedia.org)
  • Doxorubicin is a chemotherapy drug that has been approved for use as standard of care treatment in many cancer indications including acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML), neuroblastoma, sarcomas, breast, ovarian, bladder, thyroid, gastric and many other cancers. (addon.life)
  • The overarching objective of this study is to use novel precision medicine strategies based on inherited and acquired leukemia-specific genomic features and targeted treatment approaches to improve the cure rate and quality of life of children with acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (LLy). (centerwatch.com)
  • It is used with other antineoplastics to induce remissions in acute leukaemias (acute lymphoblastic leukaemia and acute myeloid leukaemias) and in some other malignancies. (e-lactancia.org)
  • Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. (curehunter.com)
  • The risk of developing secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) is increased following treatment with doxorubicin hydrochloride. (medscape.com)
  • When it is possible to do so, milk detections of each patient to determine the total elimination of the drug would be the best indicator to resume breastfeeding between two cycles of chemotherapy. (e-lactancia.org)
  • initial and repeat courses of moderately emetogenic cancer chemotherapy. (nih.gov)
  • The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
  • Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. (cdc.gov)
  • Glutamine has successfully reduced chemotherapy-induced mouth sores. (peacehealth.org)
  • Mouth sores are a common side effect of radiation and certain chemotherapy drugs. (vacancer.com)
  • Symptoms of mouth sores commonly occur three to ten days following your treatment with chemotherapy. (vacancer.com)
  • Furthermore, the lining of your mouth serves to protect you against infection, so mouth sores may make you more susceptible to bacterial, fungal, or viral infections in the mouth. (vacancer.com)
  • 55-59 : 17-18 Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. (wikipedia.org)
  • 2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
  • Secondary endpoints include the chemoprotective effect of ALRN-6924 on chemotherapy-induced alopecia, as well as other hematologic and non-hematologic toxicities. (aileronrx.com)
  • Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. (medscape.com)
  • Performance status is often used as a measure to determine whether a person can receive chemotherapy, or whether dose reduction is required. (worldsbest.rehab)
  • We assume bacteria translocated through the distended colonic wall during chemotherapy-induced neutropenia and believe that the blood culture isolate was not a contaminant because it was isolated from 2 samples taken in a 30-min span. (cdc.gov)
  • Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo . (frontiersin.org)
  • There are data suggesting that early recognition of chemotherapy-induced cardiomyopathy and prompt initiation of medical therapy can promote recovery of cardiac function. (ajmc.com)
  • Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. (mdpi.com)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • Chemotherapy-induced alopecia management: clinical experience and practical advice. (cancare.my)
  • Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial. (cancare.my)
  • ABSTRACT In Bahrain, adequate epidemiological information is lacking concerning the rate of EBV infection, which could be helpful in order to develop measures to protect against EBV infections. (who.int)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • 55-59 Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or hyperthermia therapy. (wikipedia.org)
  • 55-59 Combination chemotherapy involves treating a person with a number of different drugs simultaneously. (wikipedia.org)
  • Herbs, however, contain biologically active compounds and can potentially interact with prescription medications, including chemotherapy drugs. (cancernetwork.com)
  • Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body. (medindia.net)
  • It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including chemotherapy. (worldsbest.rehab)
  • It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
  • This way, the chemotherapy drugs are less likely to impact your hair, protecting your hair follicle from being damaged. (cancare.my)
  • Most chemotherapy drugs can cause mucositis, but this side effect is more frequent with some treatments. (vacancer.com)
  • Doxorubicin liposomal is a pegylated formulation that protects the liposomes and, thereby, increases blood circulation time. (medscape.com)
  • Hence, there are continuous efforts to find approaches that can help alleviate or protect the patient from the severe side-effects. (addon.life)
  • Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. (cancerindex.org)
  • 55-59 Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
  • In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
  • The patient demographics, tumor characteristics, context of STZ chemotherapy, and patient outcome were collected and assessed. (cancerindex.org)
  • Chemotherapy- or radiation-induced damage to the cells lining the mouth, throat and gastrointestinal (GI) tract is called mucositis. (vacancer.com)
  • Along with the traditional approaches of chemotherapy, a revolution in the understanding of the molecular mechanisms that underlie many common cancers has led to the development of targeted pathway inhibitors, many of which inhibit tyrosine kinases. (ajmc.com)
  • Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)
  • Chemotherapy and radiation kill rapidly dividing cells, a hallmark characteristic of some cancers. (vacancer.com)
  • Dox is a mitochondrial toxin, and mitochondrial damage is central to Dox-induced cardiac dysfunction and cell death [ 8 ]. (oncotarget.com)
  • It is an antioxidant and able to reduce damage to the membranes and proteins by the reactive species, that are created as part of Doxorubicin mechanism of action, by preventing depletion of the inherent antioxidant machinery of healthy cells (Roskovic A et al, Molecules 2011). (addon.life)
  • On the other hand, the decreased levels of antioxidants (or oxidative stress) that are caused by many chemotherapy treatments correlates with increased side effects. (pinestreetfoundation.org)
  • 2,3] The majority employ them as adjuncts to chemotherapy or other cancer treatments to alleviate symptoms and to prevent recurrence. (cancernetwork.com)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (wikipedia.org)
  • Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. (wikipedia.org)
  • Chemotherapy does not affect milk production during or after treatment. (e-lactancia.org)
  • Given the strong evidence that exists regarding the benefits of breastfeeding for the development of babies and the health of mothers, it is advisable to evaluate the risk-benefit of any maternal treatment, including chemotherapy, individually advising each mother who wishes to continue with breastfeeding (Koren 2013). (e-lactancia.org)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • ALRN-6924 will be administered at 1.2 mg/kg on 3 consecutive days in each treatment cycle, Days 0, 1 and 2, while chemotherapy will be administered on Day 1. (aileronrx.com)
  • There is no simple answer to this as it is highly dependent on the chemotherapy recommended for your treatment. (cancare.my)
  • If this is a major concern to you, it is best for you to speak to your doctor to learn more about the chemotherapy prescribed for your treatment. (cancare.my)
  • This side effect of cancer treatment can significantly affect patient quality of life and may cause delays in treatment. (vacancer.com)
  • For this reason, the GI tract is particularly susceptible to damage by chemotherapy and radiation treatment. (vacancer.com)
  • A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
  • In this issue of the Journal of Clinical Investigation , Hossein Ardehali and colleagues at Northwestern University determined that doxorubicin accumulates within the mitochondria of cardiomyocytes and this accumulation promotes mitochondrial ROS production and iron accumulation. (medindia.net)
  • However, when one looks more closely at the existing published science on how antioxidants and chemotherapy combine, the true answer is not so definitive. (pinestreetfoundation.org)
  • Many research studies, encompassing cell culture tests in the laboratory and also animal and some human studies, are coming to a conclusion often very different from the conventional perspective that chemotherapy and antioxidants should never be combined. (pinestreetfoundation.org)
  • In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)
  • In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
  • Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
  • They are believed to function as antioxidants that protects your body against damage which can place an individual at a high risk for diseases like heart disease and cancer. (scienceherb.com)
  • In adults, the incidence of CHF was 3% at a cumulative doxorubicin dose of 400 mg/m 2 , 7% at a cumulative dose of 550 mg/m 2 , and 18% at cumulative doses higher than 700 mg/m 2 . (medscape.com)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • People taking it also experienced stabilized body weight and a reduction in the fatigue and inertia that usually accompany this combination of chemotherapy agents. (peacehealth.org)
  • Together, our results indicate the ability of SWCNT to transform human lung epithelial cells and induce CSCs which could represent a novel mechanism of carcinogenesis induced by CNTs. (cdc.gov)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • The majority of NK-1 receptor antagonist doses are administered intravenously in the United States, and with the introduction of Varubi IV, we now offer healthcare providers a unique, easy-to-use option that fits well into standard operating practices of a chemotherapy clinic or hospital," Mary Lynne Hedley, PhD, president and COO of Tesaro, said in a press release. (pharmacytimes.com)
  • Women undergoing chemotherapy during pregnancy have lower rates of breastfeeding because they experience difficulties in breastfeeding (Stopenski 2017), needing more support to achieve it. (e-lactancia.org)
  • doxorubicin decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
  • It has long been known that oxidative stress is an essential mechanism by which chemotherapy works to treat cancer. (pinestreetfoundation.org)
  • Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
  • Doxorubicin is able to kill the abnormally fast growing cancer cells by causing excessive DNA damage and increasing oxidative stress that also induces cell death. (addon.life)
  • Our previous studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNTs) induces malignant transformation of human lung epithelial cells. (cdc.gov)
  • The key reason for this is because chemotherapy is a potent drug that attack your body's rapidly growing cells. (cancare.my)
  • Furthermore, by adding various kinase inhibitors, we confirmed that the phosphorylation status of rpS3 was regulated by both Lyn and doxorubicin, and the phosphorylation of rpS3 by Lyn increased drug resistance in cells by upregulating p-glycoprotein translation. (bmbreports.org)
  • Wu and her colleagues used pluripotent stem cell-derived cardiomyocytes, which are the cells responsible for contracting the muscles of the heart, to show that an inherited genetic variant decreased the cell's ability to contract heart muscles after being exposed to doxorubicin, an anthracycline chemotherapy drug. (iu.edu)
  • However, a new biological therapy called Kepivanceā„¢, which is the recombinant form of human keratinocyte growth factor, appears to reduce mouth and throat soreness and improve function by stimulating cells that protect the lining of the mouth and GI tract. (vacancer.com)
  • In addition, it is an important fat-soluble antioxidant tasked with protecting lipoproteins and cell membranes against oxidative damage. (fusabil.org)
  • It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)