Doxorubicin could be an inexpensive alternative to other evidenced-based chemotherapeutic agents for single immediate intravesical chemotherapy. (medscape.com)
A study has shown an intravesical sustained-release chemotherapy device demonstrated effectiveness in advanced bladder cancer. (europeanpharmaceuticalreview.com)
Currently receiving other intravesical chemotherapy. (keckmedicine.org)
Valrubicin intravesical10
These highlights do not include all the information needed to use VALRUBICIN INTRAVESICAL SOLUTION safely and effectively. (nih.gov)
See full prescribing information for VALRUBICIN INTRAVESICAL SOLUTION. (nih.gov)
Valrubicin intravesical solution is an anthracycline topoisomerase inhibitor indicated for intravesical therapy of BCG-refractory carcinoma in situ (CIS) of the urinary bladder in patients for whom immediate cystectomy would be associated with unacceptable morbidity or mortality. (nih.gov)
Valrubicin intravesical solution is recommended at a dose of 800 mg administered intravesically once a week for six weeks. (nih.gov)
Warm valrubicin intravesical solution slowly to room temperature, but do not heat. (nih.gov)
Use caution when handling and preparing the solution of valrubicin intravesical solution. (nih.gov)
Evaluate the status of the bladder before the intravesical instillation of valrubicin intravesical solution. (nih.gov)
Embryo-Fetal Toxicity: Valrubicin intravesical solution can cause fetal harm. (nih.gov)
Handle and dispose of valrubicin intravesical solution in a manner consistent with other cytotoxic drugs. (nih.gov)
Valrubicin intravesical solution contains polyoxyl castor oil, which has been known to cause leaching of di(2-ethylhexyl) phthalate (DEHP) a hepatotoxic plasticizer, from polyvinyl chloride (PVC) bags and intravenous tubing. (nih.gov)
Gemcitabine1
Phase IIb study results show evidence of sustained, durable complete responses beyond one year with an intravesical gemcitabine delivery system for a high-risk bladder cancer. (europeanpharmaceuticalreview.com)
Carcinoma in s1
Bacillus Calmette-Guérin (BCG) is the most common intravesical agent used to treat carcinoma in situ (CIS). (medscape.com)
Instillation2
BACKGROUND: The purpose of this study was to investigate whether adding single immediate postoperative intravesical instillation of doxorubicin (SID) to transurethral resection of bladder tumor (TURBT) significantly reduced the risk of recurrence in patients with non-muscle-invasive bladder cancer (NMIBC). (medscape.com)
Local bladder irritation, the main toxicity associated with intravesical administration of AD 32, persisted for several days after each instillation. (nih.gov)
Transurethral resection1
Delay administration at least two weeks after transurethral resection and/or fulguration. (nih.gov)
Bladder Cancer3
Effectiveness of Intravesical Doxorubicin Immediately Following Resection of Primary Non-muscle-invasive Bladder Cancer: A Propensity Score-matched Analysis. (medscape.com)
12. Potential therapeutic strategies for non - muscle invasive bladder cancer based on association of intravesical immunotherapy with p - mapa and systemic administration of cisplatin and doxorubicin. (nih.gov)
The first gene therapy for high-risk non-muscle-invasive bladder cancer has been approved by The US Food and Drug Administration (FDA). (europeanpharmaceuticalreview.com)
Toxicity1
If the proof-of concept trial of AVA6000 Pro-doxorubicin is successful, it could lead to a pipeline of pro-drug chemotherapies with limited toxicity, say the drug's developers. (europeanpharmaceuticalreview.com)
Effectiveness1
Due to the advantages of directly targeting the bladder, as well as the effectiveness of permeability enhancers, advances in intravesical drug carriers, and mucoadhesive, intravesical drug delivery is becoming more effective and of increased interest in the medical community. (wikipedia.org)
Topoisomerase1
Doxorubicin is an anthracycline antineoplastic that causes DNA strand breakage through effects on topoisomerase II and direct intercalation into DNA, which causes DNA polymerase inhibition. (medscape.com)
Antineoplastic Agents1
Comment: Palifermin should not be administered within 24 hr before, during infusion of, or within 24 hr after administration of antineoplastic agents. (medscape.com)
Systemic2
The bladder's impermeability means that any drug delivered intravesical will not absorb into the bloodstream well through the bladder wall, causing fewer systemic effects. (wikipedia.org)
While intravesical delivery shows distinct advantages over systemic drug delivery it has several problems to overcome. (wikipedia.org)
Recurrence1
Outcome measurements of cancer-specific survival (CSS), overall survival (OS), intravesical recurrence-free survival (IVRFS), and recurrence-free survival (RFS), including hazard ratios (HRs) and 95% confidence intervals (CIs), were extracted and pooled. (biomedcentral.com)
Therapy2
Caution if coadministered because of additive immunosuppressive effects during such therapy and in the weeks following administration. (medscape.com)
Intravesical therapy may reduce or delay the progression of cancer to a higher stage. (medscape.com)
Slowly1
In ovarian cancer, the doxorubicin metabolites accumulated in the ascites and cleared more slowly from the peritoneal compartment than from the serum. (ijpsr.com)
Urinary3
Intravesical drug delivery is the delivery of medications directly into the bladder by urinary catheter. (wikipedia.org)
Intravesical drug delivery has been identified as an ideal way to treat most urinary disorders, including bladder tumors and bladder cancers, interstitial cystitis, and urinary incontinence. (wikipedia.org)
There is currently a lack of interest in treating urinary tract infections using intravesical delivery. (wikipedia.org)
Drug5
Serum drug levels were measured during the 6-hour period after administration of the first, third, and sixth doses. (nih.gov)
Intravesical drug dilution occurs as urine accumulates in the bladder, lowering the concentration of drug in the bladder as overall volume increases. (wikipedia.org)
When modifying drug formulations for intravesical delivery gels or viscosity increasing formulations are sometimes used to increase retention, though this can cause issues with urethra obstruction, an additional hurdle in intravesical drug delivery. (wikipedia.org)
Overcoming the impermeability of the mucin layer and the urothelium is a large focus of many intravesical drug formulations, and is key to an efficacious intravesical treatment The main ways researchers are currently overcoming the problems in intravesical drug delivery are through developing formulations using mucoadhesives, nanoparticles, liposomes, polymeric hydrogel, expandable delivery devices, and electromotive drug administration. (wikipedia.org)
1 The use of goggles, gloves, and protective gowns is recommended during preparation and administration of the drug. (nih.gov)
Treatment1
Six weekly doses of AD 32 (200 to 900 mg) were administered to 32 patients with superficial TCC who were candidates for intravesical treatment. (nih.gov)
Patients2
An ongoing shortage of BCG in the United States has necessitated the development of strategies to prioritize use of intravesical BCG and identify alternatives for some patients. (medscape.com)
Administration of live or live-attenuated vaccines in patients immunocompromised by chemotherapeutic agents including epirubicin hydrochloride injection, may result in serious or fatal infections ( 5.8 ). (nih.gov)
Cancer1
In lungs cancer, the aggregate results of the present series of studies demonstrate that RLIP76 is the predominant doxorubicin transporter in the lung cancer cell. (ijpsr.com)