• The rate of this side effect limits the dose of this formulation that can be given as compared with plain doxorubicin in the same treatment regimen, thereby limiting potential substitution. (wikipedia.org)
  • No "lifetime maximum dose" has been established for doxorubicin (liposomal). (chemocare.com)
  • Consider alternate therapy or monitor for therapeutic/adverse effects of Doxorubicin if Terbinafine is initiated, discontinued or dose changed. (nextbio.com)
  • OBJECTIVES: I. Estimate the maximum tolerated dose of weekly intravenous doxorubicin (DOX) that can be given in combination with oral estramustine (EM) in patients with metastatic prostate cancer refractory to treatment with hormonal agents. (bioportfolio.com)
  • Our previous studies have shown that lowering the dose of pegylated liposomal doxorubicin (PLD) and bortezomib in combination with intravenous dexamethasone on a longer 4-week cycle maintained efficacy and improved tolerability in both previously untreated and relapsed/refractory (R/R) multiple myeloma (MM) patients. (nature.com)
  • Each single-dose vial of sterile, lyophilized red powder, contains doxorubicin HCl 10 mg. (medbroadcast.com)
  • The recommended dose of doxorubicin varies according to the specific condition being treated, the response to therapy, the other medications being used, and body size. (medbroadcast.com)
  • In the clinical trial 3-6 patients will be assigned to L19TNFalfa at one of the following sequential dose levels (10.4 µg/kg, 13 µg/kg and 17 µg/kg) in combination with a fixed dose of doxorubicin. (clinicaltrials.gov)
  • To determine the maximum tolerated dose and safety of intravenous doxorubicin hydrochloride and intraperitoneal carboplatin in patients with platinum-sensitive recurrent ovarian cancer. (knowcancer.com)
  • In phase 1, advanced HCC patients received PTK at escalating doses together with doxorubicin 60 mg/m 2 given as an intravenous bolus every 3 weeks to establish the maximum tolerated dose (MTD). (wiley.com)
  • The probability of incurring doxorubicin-induced congestive heart failure was related to the total dose of doxorubicin administered. (annals.org)
  • A weekly dose schedule of doxorubicin was associated with a significantly lower incidence of congestive heart failure than was the usually employed every 3-week schedule. (annals.org)
  • Doxorubicin (DXR) is a 14-hydroxylated version of daunorubicin, the immediate precursor of DXR in its biosynthetic pathway. (bionity.com)
  • Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. (nextbio.com)
  • The dps genes of Streptomyces peucetius, encoding daunorubicin (DNR)-doxorubicin (DXR) polyketide synthase (PKS), are largely within an 8.7-kb region of DNA that has been characterized by Southern analysis, and gene sequencing, mutagenesis and expression experiments. (nih.gov)
  • Epirubicin and idarubicin have similar profiles of activity and adverse events as doxorubicin, but have been less commonly used and their potential for causing liver injury has been less well defined. (nih.gov)
  • Doxorubicin (dox" oh roo' bi sin), epirubicin (ep" i roo' bi sin), idarubicin (eye" da roo' bi sin) and valrubicin (val roo' bi sin) are cytotoxic, anthracycline antibiotics which are believed to act by intercalating between DNA base pairs and uncoiling the DNA helix, which results in inhibition of DNA synthesis and the normal DNA breaking and resealing action of DNA toposiomerase II. (nih.gov)
  • Epirubicin is an analogue of doxorubicin that has activity against many forms of cancer, but is used largely in the treatment of advanced breast cancer. (nih.gov)
  • occasionally happen with prolonged usage of some chemotherapy drugs, especially doxorubicin and epirubicin. (evidence.nhs.uk)
  • Gouazè V, Mirault ME, Carpentier S, Salvayre R, Levade T, Andrieu-Abadie N: Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells. (springer.com)
  • These results led the researchers to hypothesize that inhibition of apoptosis in Doxorubicin-treated cardiomyocytes was due to Bcl-2 acting as an antioxidant enzyme to decrease the amount of ROS, therefore inhibiting the ability of p53 to induce apoptosis. (wikipedia.org)
  • What are the possible side effects of doxorubicin? (cigna.com)
  • Substitution would be desirable because liposome-encapsulated doxorubicin is less cardiotoxic than unencapsulated doxorubicin. (wikipedia.org)
  • We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. (mdpi.com)
  • Further studies are being undertaken to determine the cellular mechanism via which Doxorubicin mediates increased myocardial injury in conditions of ischaemia-reperfusion. (bmj.com)
  • Doxorubicin was originally made from the bacteria Streptomyces peucetius. (wikipedia.org)
  • Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius. (nih.gov)
  • In contrast, only one known non- wild type species, streptomyces peucetius subspecies cesius ATCC 27952, was initially found to be capable of producing the more widely used doxorubicin. (bionity.com)
  • Subsequently, Hutchinson's group showed that under special environmental conditions, or by the introduction of genetic modifications, other strains of streptomyces can produce doxorubicin. (bionity.com)
  • The anthracycline skeleton of doxorubicin (DXR) is produced by a Type II polyketide synthase (PKS) in streptomyces peucetius . (bionity.com)
  • Doxorubicin is produced by the soil fungus belonging to genus Streptomyces. (sbwire.com)
  • Doxorubicin is associated with a high rate of transient serum enzyme during therapy and to rare instances of clinically apparent acute liver injury with jaundice that can be severe and even fatal. (nih.gov)
  • Doxorubicin has potent activity in several forms of cancer, including acute leukemia, lymphomas, sarcomas and solid tumors. (nih.gov)
  • Idarubicin is an analogue of doxorubicin that has activity against many forms of cancer, but most convincingly in acute myeloid leukemia (AML). (nih.gov)
  • The amount of doxorubicin (liposomal) you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. (chemocare.com)
  • Therefore, there is a lifetime maximum on the amount of doxorubicin you can receive. (chemocare.com)
  • Fractions were measured for fluorescence using a fluorometer to determine the amount of doxorubicin that diffused across the sclera. (arvojournals.org)
  • Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisom. (nextbio.com)
  • Our goal is to develop a model for the binding, internalization, and tumor-killing dynamics of liposome-enclosed doxorubicin targeted to cancer cells and develop design principles for creating more effective therapeutics. (mit.edu)
  • Tumor cell apoptosis in the combination therapy-treated mice was 113.3 ± 20% greater than that in TM-treated mice and 52.4 ± 14.3% greater than that in doxorubicin-treated mice. (aacrjournals.org)
  • In this study, the combination therapy of TM and doxorubicin was more effective at inducing apoptosis and suppressing tumor growth in NF-κB-overexpressing SUM149 cells than either agent administered alone. (aacrjournals.org)
  • The amount of amino acids after interaction with doxorubicin was significantly reduced ( p = 0.05). (mdpi.com)
  • Confocal laser scanning microscopy and quantitative flow cytometry studies both verified that, for equivalent doxorubicin concentrations, composite doxorubicin-loaded micelles significantly enhanced cellular doxorubicin accumulation and inhibited doxorubicin release. (dovepress.com)
  • Colony-forming assays demonstrated that composite doxorubicin-loaded micelles are radiosensitive, as shown by significantly reduced survival of cells treated by radiation + composite micelles compared with those treated with radiation + free doxorubicin or radiation alone. (dovepress.com)
  • Doxorubicin also significantly increased apoptosis and decreased cell viability after reoxygenation compared to control. (bmj.com)
  • The multicellular spheroid migration area and growth ability verified higher radiosensitivity for the composite micelles loaded with doxorubicin than for free doxorubicin. (dovepress.com)
  • Do not administer doxorubicin HCl in combination with trastuzumab due to increased risk of cardiac dysfunction ( 5.1 , 7.2 ). (nih.gov)
  • Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction. (greenmedinfo.com)
  • In conclusion, data from this study suggest that the reduction of antioxidant defense during doxorubicin administration resulted in hepatic injury could be prevented by L-carnitine supplementation by decreasing the oxidative stress and preserving both the activity and gene expression level of antioxidant enzymes. (hindawi.com)