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  • ovarian cancer
  • Zoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others. (drugbank.ca)
  • efficacy
  • The minimization of this side effect may allow for one-for-one (1:1) substitution with doxorubicin in the same treatment regimen, thereby improving safety with no loss of efficacy. (wikipedia.org)
  • cancer cells
  • The proposed method of action is that upon administration zoptarelin doxorubicin binds to the LHRH receptor and is subsequently internalized, concentrating the toxic doxorubicin within cancer cells and the small subset of normal tissues, as opposed to the completely systemic distribution observed with untargeted chemotherapeutics. (wikipedia.org)
  • Doxorubicin works by stopping the cancer cells from dividing and multiplying. (netdoctor.co.uk)
  • administration
  • Ved i.v. administration skal doxorubicin på grund af den lokalirriterende effekt altid doseres i løbende drop. (medicin.dk)
  • Doxorubicin er substrat for P-glykoprotein (P-gp), og derfor kan samtidig administration af P-gp-hæmmere (fx ciclosporin og verapamil) øge plasmakoncentrationen og dermed den cytostatiske effekt af doxorubicin, se Farmakodynamiske interaktioner . (medicin.dk)
  • originally
  • CARP was originally identified as a YB-1-associating, cardiac-restricted transcription co-repressor in the homeobox NKX2-5 pathway that is involved in cardiac ventricular chamber specification, maturation and morphogenesis, and whose mRNA levels are exquisitely sensitive to Doxorubicin, mediated through a hydrogen peroxide/ERK/p38MAP kinase-dependent as well as M-CAT cis-element-dependent mechanism. (wikipedia.org)