Double blind randomized study assessing bupivacaine. Medical search. Frequent questions

Pacira Pharmaceuticals, an emerging specialty pharmaceutical company currently focused on the development of non-opioid products for postsurgical pain control, has announced negative results from its second pivotal Phase 3 clinical trial assessing the safety and efficacy of Exparel® (bupivacaine liposome injectable suspension) in intercostal nerve block for posterolateral thoracotomy. (arjournals.com)
This double-blind, randomized clinical trial included 60 children aged 6-72 months undergoing unilateral herniorrhaphy at selected hospitals in Shiraz, Iran, randomly allocated into two groups, 30 in each group. (ekja.org)
Alkhamesi N, Peck D, Lomax D, Darzi A. Intraperitoneal aerosolization of bupivacaine reduces postoperative pain in laparoscopic surgery: a randomized prospective controlled double-blinded clinical trial. (ijsurgery.com)
A randomised, double-blind clinical trial will be performed in a large hospital located in the southern region of Ceará, Brazil and at the HUJB in Cajazeiras, Paraíba. (bvsalud.org)
In this double-blind randomized clinical trial, 63 patients who were candidates for gynecologic laparoscopy were included. (ijfs.ir)
Supplemental reflective blankets and wool socks help maintain body temperature in dogs undergoing celiotomy procedures: A prospective randomized controlled clinical trial. (awionline.org)
This test is a double-blind, saline-controlled, randomized clinical trial being carried out by BioRestorative Therapies. (reportsanddata.com)
an interventional, randomized clinical trial. (bvsalud.org)
Multimodal periarticular injection vs continuous femoral nerve block after total knee arthroplasty: a prospective, crossover, randomized clinical trial. (ijoro.org)
Braz J Anesthesiol, Ahead of Print, 2023 Posterior transversus abdominis plane block versus lateral quadratus lumborum block in children undergoing open orchiopexy: a randomized clinical trial Özgecan P. Zanbak Mutlu, Ayşe Ç. (bjan-sba.org)

However, there are not many studies on the safety and efficacy of spinal anesthesia in patients who have undergone long segment stabilization surgery. (bvsalud.org)
Despite this widespread use, for many years, the lack of randomized controlled trials resulted in questions about the efficacy of steroid injections, and the result of one study suggested that there was no difference between saline and steroids in relieving pain in the facet joint. (medscape.com)
Manchikanti et al performed randomized, double-blind, controlled trials to assess the efficacy of medial branch blocks for treating managing chronic neck or thoracic pain of facet joint origin. (medscape.com)
This study did not find efficacy of the study drug against placebo. (medscape.com)
This study demonstrated the drug's efficacy compared with placebo but did not demonstrate the duration of the nerve block (only the first 72 hours) or adequately report cardiac safety data. (medscape.com)
The FDA requested that the applicant demonstrate efficacy from an adequate and well-controlled trial in one or more additional clinical settings and to adequately characterize safety for femoral block with the study drug. (medscape.com)
The aim of this study was to evaluate the efficacy of different concentrations of ropivacaine 0.5% and 0.75% as compared to bupivacaine 0.5% in supraclavicular brachial plexus block in upper limb surgeries. (oaji.net)
Pacira plans to submit data from the ongoing femoral nerve block study to demonstrate efficacy and safety, as well as safety data from the intercostal nerve block study with Exparel® that also has broad applications across a range of surgical specialties and is currently indicated for single-dose administration into the surgical site to produce postsurgical analgesia. (arjournals.com)
Thus, researchers have investigated the efficacy of various analgesics, including bupivacaine, levobupivacaine, clonidine and naloxone, on post-herniorrhaphy pain in children administered at different times through various routes [ 6 , 7 ] such as caudal analgesia, inguinal nerve block, or local infiltration combined with a general anesthetic [ 8 ]. (ekja.org)
The aim of this study was to determine the local anesthetic-sparing efficacy of epidural epinephrine by its effect on the MLAC of bupivacaine. (silverchair.com)
Analgesic efficacy was assessed using 100-mm visual analog pain scores, with 10 mm or less within 30 min defined as effective. (silverchair.com)
SPG blockade efficacy is supported by randomized controlled studies but SPG RFA is not. (ochsnerjournal.org)
RFA and neuromodulation have the potential to offer long-term significant pain relief, but more randomized studies are needed to demonstrate their efficacy. (ochsnerjournal.org)
In this prospective, randomized, double- blind study, we investigated the postoperative analgesic efficacy of intrathecal midazolam 2.5mg as an adjunct to bupivacaine for spinal anesthesia in 80 patients undergoing lower limb orthopedic surgery. (ispub.com)
10 In this prospective, randomized, double-blind study, we evaluated the analgesic efficacy of a combination of intrathecal midazolam and bupivacaine and compared it with bupivacaine alone in patients undergoing lower limb orthopedic surgery. (ispub.com)
All randomized trials comparing the efficacy of wound infiltration for postoperative pain management after cesarean section will be included. (researchsquare.com)
Doses of ≤50 mg bupivacaine equivalents (20 ml 0.25% bupivacaine on each side, for example) are recommended on each side to balance analgesia efficacy with risk of local anesthetic systemic toxicity (LAST). (asra.com)
Because of the limited efficacy or questionable toxicity of the previously studied drugs, some investigators evaluated glucocorticoids as adjuvants for regional anesthesia. (springeropen.com)
In this study, we tried to show the efficacy of Intraperitoneal dexamethasone on relieving shoulder pain after gynecologic laparoscopy. (ijfs.ir)
Future studies are necessary to evaluate the efficacy of our recommendations. (springer.com)
The purpose of this study was to evaluate the efficacy of continuous subacromial bupivacaine infusion to relieve pain after arthroscopic rotator cuff repair. (unboundmedicine.com)
TY - JOUR T1 - Efficacy of continuous subacromial bupivacaine infusion for pain control after arthroscopic rotator cuff repair. (unboundmedicine.com)
Busch CA, Shore BJ, Bhandari R. Efficacy of periarticular multimodal drug injection in total knee arthroplasty: a randomized trial. (ijoro.org)

Group I and group II received 30 ml of 0.5% and 0.75% ropivacaine respectively and group III received 0.5% bupivacaine in supraclavicular brachial plexus block. (oaji.net)
In this study, we have hypothesized that perineural dexamethasone added to bupivacaine in ultrasound-guided interscalene brachial plexus block would prolong the duration of sensory analgesia and delay the need for postoperative rescue analgesia. (springeropen.com)

The goal of this study was to measure the relationship between increasing body mass index (BMI) in patients undergoing total hip arthroplasty (THA) with different components of operating room (OR) time. (stanford.edu)
1,332 patients were included in the study. (stanford.edu)
It was hypothesized that patients who received an interscalene block with both bupivacaine and liposomal bupivacaine would have a decreased diaphragmatic excursion when compared to bupivacaine alone at 24 h. (umn.edu)
METHODS: This was a double-blinded study of adult patients who were randomized to receive an interscalene block with either 20 ml 0.5% bupivacaine (bupivacaine group) or 10 ml 0.5% bupivacaine plus 10 ml liposomal bupivacaine (liposomal bupivacaine group). (umn.edu)
Twenty-six patients were randomized with 22 included in the analysis. (umn.edu)
Five patients in the liposomal bupivacaine group had a greater than 25% reduction in diaphragmatic excursion at 24 h versus zero in the bupivacaine group. (umn.edu)
Patients who underwent lumbar and lower thoracic spinal instrumentation operations with general anesthesia (GA) or spinal anesthesia were included in the study. (bvsalud.org)
572 patients with SA and 598 patients with GA were included in the study, 352 / 347 had only-lumbar region and 220 / 251 had thoracolumbar region operations, respectively. (bvsalud.org)
One prospective, randomized, controlled, double-blind study by Riew et al was performed in patients who were surgical candidates and who initially wished to undergo surgery to relieve radiculopathy from nerve root compression. (medscape.com)
A subsequent follow-up study in this cohort found that most of the patients who avoided surgery for at least 1 year after undergoing SNRB with bupivacaine, with or without betamethasone, continued to avoid operative intervention for a minimum of 5 years. (medscape.com)
[ 5 ] Most studies report an average time of pain relief as 1-3 months in those patients that have initial improvement, although some studies have described longer relief in a high percentage of patients. (medscape.com)
[ 6 , 7 ] Results were similar in patients treated with bupivacaine alone and those who received bupivacaine plus steroid: at 1 year, over 83% of patients with neck pain and 79% of patients with thoracic pain showed significant pain relief and functional improvement. (medscape.com)
Secondary endpoints for both studies were total opioid use, percentage of patients who were opioid-free, and time to first opioid. (medscape.com)
In study 322, researchers randomly assigned 185 patients in the United States and Eastern Europe undergoing posterolateral thoracotomy in a 1:1 ratio to receive an intercostal nerve block or placebo. (medscape.com)
In study 323, researchers randomly assigned 183 patients in the United States undergoing total knee arthroplasty in a 1:1 ratio to receive a femoral nerve block or placebo via an epidural catheter using ultrasound guidance. (medscape.com)
For both studies, different patients underwent both partial and full pharmacokinetics (PK) sampling through 120 hours. (medscape.com)
MATERIALS& METHODS 50 ASA class-I and II adult patients of either sex, aged 20-60 years undergoing lower limb surgeries under spinal anaesthesia were selected and randomly allocated in 2 groups (n=25) in a randomized, double-blinded manner. (researchbib.com)
Patients in Group A received 3 ml of bupivacaine 0.5 % with 0.5ml (25g) of fentanyl and patients in Group B received 3 ml of bupivacaine 0.5 % with 0.5ml of saline intrathecally. (researchbib.com)
In a double-blind, randomized, placebo-controlled clinical trials, 80 patients scheduled for elective CABG were randomly assigned into 2 groups. (longdom.org)
The administration of intrathecal sufentanil plus bupivacaine seems to keep the hemodynamic status of the patients more stable than intrathecal sufentanil alone. (longdom.org)
Material and Methods: A randomized double blind study was conducted on 60 adult patients of ASA grade I and II, were randomly allocated into three groups of 20 each. (oaji.net)
Material and Methods: After institutional ethical committee approval and patient consent, eighty ASA I/II patients, aged 18 to 60 years, with normal airway, who underwent elective surgeries under general anaesthesia were included in the study. (oaji.net)
The double-blind study that randomized 180 patients with either 266mg of Exparel or placebo failed to meet primary endpoint, which is reduction of cumulative pain scores over 72 hours. (arjournals.com)
Evaluation of the effect of periportal infiltration of ropivacaine in laparoscopic cholecystectomy patients: a randomized double-blind, placebo-controlled study in a tertiary-care teaching hospital. (ijsurgery.com)
Patients were randomized to receive either 0. (druglib.com)
When patients met criteria for PACU discharge, diaphragm function was again assessed using ultrasound and room air SpO2 was recorded. (druglib.com)
After approval by the hospital ethics committee and obtaining written informed consent, 80 patients (ASA class I and II), aged 20 to 50 years, scheduled to undergo elective lower limb orthopedic surgery (internal fixation of femur) were included in this prospective, randomized, double-blind trial. (ispub.com)
Patients were excluded from the study if there was a contraindication to regional anesthesia, known sensitivity to study drugs, or were on chronic analgesic therapy. (ispub.com)
The patients were immediately placed in the supine position after intrathecal administration of the study drugs. (ispub.com)
Patients were divided into two groups: one group received Bupivacaine with clonidine, and the other group received only bupivacaine at a dose of 15 mg. (bvsalud.org)
this prospective randomized double blind study was done on 60 patients with ASA grade I/II undergoing lower abdominal surgeries under bupivacaine spinal anaesthesia. (panafrican-med-journal.com)
The aim of the work was to determine whether the addition of perineural dexamethasone to bupivacaine in-ultrasound guided interscalene block would prolong the duration of sensory analgesia in patients undergoing shoulder surgery. (springeropen.com)
This prospective, randomized, double-blinded study comprised 50 patients. (springeropen.com)
59 patients with knee osteoarthritis, undergoing a meniscectomy procedure, were randomized to receive postoperative treatment with either an injection of corticosteroids and lidocaine or saline and lidocaine. (myorthoevidence.com)
[9] We therefore undertook a prospective, randomized, doubleblind, placebo-controlled study to investigate the possible antipruritic properties of ondansetron in patients who received epidurally or intrathecally administered morphine. (asahq.org)
All patients underwent regional anesthesia with plain bupivacaine (0.5%, given epidurally) or hyperbaric bupivacaine (0.5%, given spinally) without any other additives. (asahq.org)
Inclusion criteria were randomised control trials (RCTs) or systematic reviews of analgesic, anaesthetic and operative interventions, published in the English language assessing pain management for patients undergoing up to two-level lumbar laminectomy. (springer.com)
Aims and objectives: To compare the ease of insertion of LMA in patients given propofol alone versus thiopentone with lignocaine, as well as assessing the cost effectiveness of these agents in our hospital setting. (bvsalud.org)
Sixty-four ASA I and II patients equally randomized into 2 groups scheduled for short (not lasting more than one hour) elective gynaecological, orthopaedic, urological and general surgical procedures were recruited into this study. (bvsalud.org)
This study was aimed to evaluate the correlation of PaO2, PaCO2, pH, and HCO3 values between ABG and saliva gas in traumatic patients under mechanical ventilation. (magiran.com)
This was a retrospective cross-sectional study of 18-85-year-old traumatic patients under mechanical ventilation conducted in an academic medical hospital. (magiran.com)
This trial aims to assess whether dexmedetomidine can reduce the incidence of postoperative cognitive dysfunction in elderly orthopaedic patients and explore the specific mechanism. (biomedcentral.com)
Ninety-six elderly patients who undergo total hip or knee replacement will be studied in this trial and randomly divided into two groups. (biomedcentral.com)
Another study reported that the Th17/Treg balance shifting to the Th17 cell played a role in the development of cognitive impairment in traumatic brain injury patients [ 19 ]. (biomedcentral.com)
We hypothesized that patients receiving continuous subacromial bupivacaine infusions after arthroscopic rotator cuff repair will have less postoperative pain in the early postoperative period than placebo and control groups. (unboundmedicine.com)
Eighty-eight patients undergoing arthroscopic rotator cuff repair were randomized in a blinded fashion into 1 of 3 groups. (unboundmedicine.com)
Patients were randomized into Group I (wound site infiltration, n=35) and Group T (TAP block, n=35). (hippokratia.gr)
Patients' numeric pain scale (NPS) levels at 2, 6, 12 and 24th hours, after the operation (NPS 0 ) and during mobilization were assessed. (hippokratia.gr)
After obtaining the approval of the ethics committee and the informed consent of the patients, a prospective randomized, double blinded study was undertaken of patients over 18 years old scheduled to caesarean section in Bagcılar Training and Research Hospital. (hippokratia.gr)
A total of 75 patients with symptomatic knee OA (Kellgren-Lawrence grade 3 to 4) were enrolled in this study between August 2013 and July 2014. (sogacot.org)
Patients were randomized to treatment either with a single leukocyte-reduced PRP or corticosteroid intra-articular injection. (sogacot.org)
Educating Surgical Patients About Safe Use of Opioids: A Randomized Controlled Trial. (stopbang.ca)
Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Amisulpride as Treatment of Established Postoperative Nausea and Vomiting in Patients Who Have Had No Prior Prophylaxis. (stopbang.ca)
Amisulpride for the Rescue Treatment of Postoperative Nausea or Vomiting in Patients Failing Prophylaxis: A Randomized, Placebo-controlled Phase III Trial. (stopbang.ca)
Optimal Propofol Induction Dose in Morbidly Obese Patients: A Randomized Controlled Trial Comparing the Bispectral Index and Lean Body Weight Scalar. (stopbang.ca)
Material and Methods: The study was conducted on 85 patients at Gynae-unit I, SPH/ Bolan Medical Complex Hospital, Quetta, Pakistan. (edu.pk)
300 TKR patients and 300 THR patients are being recruited into this single-centre double-blind RCT. (biomedcentral.com)
A nested qualitative study within the RCT will examine the acceptability and feasibility of the intervention for both patients and healthcare professionals. (biomedcentral.com)
In a recent study at the Avon Orthopaedic Centre, 58% of TKR patients and 47% of THR patients reported moderate or severe pain on the first post-operative day[ 12 ]. (biomedcentral.com)

METHODS: In this observational study, 13 infants undergoing lower abdominal surgery received spinal anesthesia (0.5% bupivacaine with clonidine). (bvsalud.org)
In the literature we find data evaluating the installation of sympathetic block through HRV using linear methods however, there is a lack of studies using methods based on the domain of chaos. (bvsalud.org)
Some studies address the value of HRV as a predictor of hypotension following subarachnoid anesthesia, mainly using linear methods in the frequency domain. (bvsalud.org)
One of such methods is the intra abdominal injection of analgesics such as lidocaine and bupivacaine ( 8 - 13 ). (ijfs.ir)
Methods: This is arandomised single blind prospectivestudy carried out in a Public Tertiary Academic Health Institution. (bvsalud.org)
2023. Evaluation of different methods of environmental enrichment to control anxiety in dogs undergoing hemilaminectomy after acute intervertebral disc extrusion: A randomized double-blinded study. (awionline.org)
Material and Methods: This was a randomized experimental study. (edu.pk)
Materials and Methods: This community‑based cross‑sectional study was conducted among 378 tribal under‑five children residing in 21 villages of Mohammad Bazar Block during September 2018-August 2020 using Lot Quality Assurance Sampling (LQAS) technique. (who.int)

Clinical studies of anesthesia for thoracic surgery including provision and maintenance of safe one-lung ventilation and postthoracotomy analgesia. (stanford.edu)
In this study, we examined the hypothesis that, in the presence of epidural bupivacaine, continuous infusions of epidural fentanyl elicit analgesia by a spinal mechanism. (stanford.edu)
Women received lumbar epidural analgesia with 20-30 mL bupivacaine 0.125% until pain free. (stanford.edu)
Unlike previous studies that assessed the minimum local analgesic concentration (MLAC) for bolus administration at the initiation of analgesia, this study assessed MLAC(infusion) for the maintenance of analgesia throughout the first stage of labor. (stanford.edu)
This marked increase in potency for the epidural route is highly suggestive for a predominantly spinal mechanism of action for infused epidural fentanyl under the conditions of this study.This study determined the median effective concentration for epidural infusions of bupivacaine during labor analgesia. (stanford.edu)
As reported by Medscape Medical News , the FDA approved bupivacaine liposomal injectable suspension in 2011 for "administration into the surgical site to produce postsurgical analgesia. (medscape.com)
Onset and duration of sensory and motor block, sparing of dermatomes and duration of analgesia were studied as primary outcome. (oaji.net)
Postoperatively although the duration of analgesia was comparable among all the three groups but the total dose of rescue analgesia required was significantly lesser in 0.75% ropivacaine than 0.5% ropivacaine and 0.5% bupivacaine. (oaji.net)
In this double-blind, randomized, prospective study, 70 parturients who were at 7 cm or less cervical dilation and who requested epidural analgesia were allocated to one of two groups. (silverchair.com)
We conclude that intrathecal midazolam 2.5mg provided moderate prolongation of postoperative analgesia when used as an adjunct to bupivacaine. (ispub.com)
Spinal anesthesia with bupivacaine is administered routinely for lower limb surgery 1 and provides effective analgesia in the early postoperative period. (ispub.com)
Morphine consumption was the primary end point to assess postoperative analgesia. (bmj.com)
21 The role of liposomal bupivacaine, which provides longer duration of analgesia, shows some promise in the CD setting. (asra.com)
We concluded that the addition of 8 mg of perineural dexamethasone to 30 ml of 0.5% bupivacaine showed improvement in the postoperative analgesia in shoulder surgery without obvious complications. (springeropen.com)
Additional studies are needed to assess multimodal analgesia techniques. (podiatryarena.com)
This month the Journal of the American Medical Association Pediatrics (JAMA Pediatrics ) released an online study "Association Between Epidural Analgesia During Labor and Risk of Autism Spectrum Disorders in Offspring," authored by Qiu et al. (theanesthesiaconsultant.com)

This study assesses the effect of intrathecal adjuvant bupivacaine plus sufentanil on intraoperative hemodynamic changes in elective coronary artery bypass surgery. (longdom.org)

The aim of this study was to compare the analgesic efficiency of ultrasound (USG)-guided transversus abdominis plane (TAP) block with local anesthetic infiltration on a wound site. (hippokratia.gr)
The local anesthetic is usually bupivacaine or ropivacaine. (theanesthesiaconsultant.com)

This exploratory study has highlighted the potential for expanding awake infant spinal anesthesia to a broader range of procedures and the utility of surface electromyography in studying regional anesthesia techniques. (bvsalud.org)
Several drugs have been studied as adjuvants for regional anesthesia such as epinephrine, clonidine, opioids, and ketamine. (springeropen.com)

Liposomal bupivacaine is approved for use in interscalene blocks with the potential to provide longer pain control. (umn.edu)
However, the impact of liposomal bupivacaine on the phrenic nerve has not been evaluated. (umn.edu)
CONCLUSIONS: The addition of liposomal bupivacaine to bupivacaine in an interscalene block results in statistically significant reductions in diaphragm excursion and pulmonary function testing 24 h after block placement when compared to bupivacaine alone. (umn.edu)

Five minutes after premedication, subarachnoid block (SAB) was given with 3 ml of 0.5% hyperbaric bupivacaine following which sensory and motor blockade, hemodynamic changes, sedation, and complications of the surgery were recorded and this data was analyzed statistically using χ 2 test, corrected χ 2 test, Fisher´s exact test, and test of proportion (Z-test). (panafrican-med-journal.com)

Prior studies investigating infant spinal anesthesia are open to interpretation and may not have accurately characterized block onset or density. (bvsalud.org)
The recovery of spinal anesthesia is assessed through a scale defined in 1979 by Bromage and is based exclusively on the return of motor function and does not take into account the recovery of ANS activity. (bvsalud.org)
To assess cardiac autonomic modulation during perioperative hypotension caused by subarachnoid anesthesia. (bvsalud.org)
At the end of the procedure performed under general anesthesia, nerve blocks using 2 mg/kg of 0.375% bupivacaine and 2 μg/kg of clonidine were performed in the FNB (n = 16) and PCB (n = 15) groups. (bmj.com)
Short Duration of Action and Low Potency Benzocaine Procaine Chloroprocaine Medium Duration of Action and Medium Potency Lidocaine Prilocaine High Duration and High Potency Tetracaine Bupivacaine Cinchocaine Ropivacaine Local anesthetics may be used to prevent and/or treat acute pain, to treat chronic pain, and as a supplement to general anesthesia. (wikipedia.org)
This study examined the issue of autism and epidural anesthesia for childbirth. (theanesthesiaconsultant.com)
The study did find an increased incidence of autism in children of mothers who had labor epidural anesthesia, and that's an important story. (theanesthesiaconsultant.com)

All women received an epidural infusion of bupivacaine at a rate of 20 mL/h, the concentration of which was determined by the response of the previous woman in the same group to the analgesic regimen used. (stanford.edu)
The US Food and Drug Administration's (FDA's) Anesthetic and Analgesic Drug Products Advisory Committee voted 6 to 4 against recommending bupivacaine liposomal injectable suspension ( Exparel , Pacira Pharmaceuticals Inc) as a nerve block to treat regional postsurgical pain. (medscape.com)
Analgesic requirements, emergence time, and nausea/vomiting, postoperative pain and sedation scores were assessed for 4 h after the operation. (ekja.org)
Background The authors compared the analgesic effects and quality of rehabilitation of three analgesic techniques after total-hip arthroplasty in a double-blind, randomized trial. (bmj.com)
Randomised controlled trials (RCTs) published in the English language from 1 January 2008 until 31 March 2020-assessing post-operative pain using analgesic, anaesthetic and surgical interventions-were identified from MEDLINE, EMBASE and Cochrane Databases. (springer.com)
Post-operative pain outcomes (pain scores and analgesic requirements) were the primary focus, but other recovery outcomes-including adverse effects-were also assessed, when reported, and the limitations of the data were critically reviewed. (springer.com)

The concentration of bupivacaine was determined by the response of the previous patient in that group to a higher or lower concentration using up-down sequential allocation. (silverchair.com)
The investigators hypothesized that a lower concentration of bupivacaine would cause less weakness of the diaphragm but still provide good pain relief. (druglib.com)

The intervention consists of an intra-operative local anaesthetic wound infiltration, consisting of 60 mls of 0.25% bupivacaine with 1 in 200,000 adrenaline. (biomedcentral.com)

We studied the effect of intrathecal fentanyl on the incidence of shivering following spinal anaesthesia. (researchbib.com)

For the initial sNDA, the company submitted results from two multicenter, randomized, placebo-controlled clinical trials: 402-C-322 (study 322) and 302-C-323 (study 323). (medscape.com)

Postoperative pain was assessed using Wong Baker facial pain scale at 6, 12 and 18 hours and use of rescue analgesics were noted. (ijsurgery.com)

We performed a systematic review of randomized controlled trials assessing postoperative pain after foot and ankle surgery, because the surgery will lead to moderate-to-severe postoperative pain, but the optimal pain therapy has been controversial. (podiatryarena.com)
A systematic review of randomized controlled trials in English reporting on pain after foot and ankle surgery in adults published from January 1946 to February 2013 was performed. (podiatryarena.com)

This study aimed to compare the effect of dexmedetomidine added to local infiltration of bupivacaine for postoperative pain relief in children undergoing inguinal herniorrhaphy. (ekja.org)
One group received 1 µg/kg dexmedetomidine plus local infiltration of 0.2 ml/kg bupivacaine 0.5% at the incision site before surgery (BD), and the other group received bupivacaine and normal saline (BO). (ekja.org)
Addition of dexmedetomidine to local infiltration of bupivacaine in children undergoing herniorrhaphy significantly reduced postoperative pain and increased sedation. (ekja.org)
to evaluate the effects of intravenous (IV) dexmedetomidine as a pre-medication on clinical profile of bupivacaine spinal anaesthesia in lower abdominal surgeries. (panafrican-med-journal.com)
Group-1 (control group) received normal saline and group-2 (study group) received IV dexmedetomidine 1 g/kg over 10 min as premedication. (panafrican-med-journal.com)
Dexmedetomidine has been confirmed as a drug that can improve postoperative cognitive dysfunction in some studies. (biomedcentral.com)

The actual study expanded this kind of to assess the effectiveness over two-weeks. (invitroscreeningblog.com)
So far, according to available information, there is not a published study with high quality methodology about effectiveness of intraperitoneal dexamethasone. (ijfs.ir)
This study aims to investigate the effectiveness of ondansetron to treat this side effect. (asahq.org)
However, current studies have changed the prescribing pattern, using IAI as a first-line treatment because it has proven effectiveness for pain with fewer side effects than some oral medications. (sogacot.org)
Objective: The study is conducted to access the effectiveness of Isometric Handgrip (IHG) Exercise in pre-eclamptic females. (edu.pk)
Large-scale RCTs assessing the effectiveness of a surgical intervention are uncommon, particulary in orthopaedics. (biomedcentral.com)

Forty-eight nulliparous women in active labor participated in this prospective, randomized, double-blinded study. (stanford.edu)

Anesthetic effect, as assessed by probing of pocket depths, has a duration of approximately 20 minutes (individual overall range 14-31 minutes). (drugs.com)
PURPOSE: the aim of this study was to evaluate the use of anesthetic blockage of the auriculotemporal nerve as a treatment for temporomandibular joint disorders. (bvsalud.org)

Ropivacaine is a pures (-) enantiomer and is less cardiotoxic than equivalent concentrations of bupivacaine has recently introduced for its clinical use. (oaji.net)
Conclusion: To conclude, 0.5% ropivacaine was less effective than 0.75% ropivacaine and 0.5% bupivacaine. (oaji.net)
The present study was conducted to assess the role of peri-portal infiltration of ropivacaine in post laparoscopic cholecystectomy pain management. (ijsurgery.com)

Laparoscopic versus open inguinal herniorrhaphy: preliminary results of a randomized controlled trial. (ijsurgery.com)
Quality-of-life differences between values at 3 and 6 months versus baseline increased significantly more in the study group ( P = .05 and .03, respectively), and so did general health perception differences at 6 months ( P = .018). (sogacot.org)
A Perioperative Smoking Cessation Intervention With Varenicline, Counseling, and Fax Referral to a Telephone Quitline Versus a Brief Intervention: A Randomized Controlled Trial. (stopbang.ca)

A single-centre, prospective, double-blinded, randomized controlled trial will be conducted at Hebei General Hospital. (biomedcentral.com)
This study was designed as a prospective randomized trial, and consisted of 70 pregnant women of American Society of Anesthesiologists (ASA) class I-II. (hippokratia.gr)
Comparison of Oropharyngeal Leak Pressure Between the Ambu® AuraGain TM and the LMA® Supreme TM Supraglottic Airways: A Randomized-Controlled Trial. (stopbang.ca)
The current study represents a randomized, blinded, control trial of the effects of three versions of an electronic DST on team performance during multiple simulations of perioperative emergencies. (stanfordchildrens.org)
Yuenyongviwat V, Pornrattanamaneewong C, Chinachoti T, Chareancholvanich K. Periarticular injection with bupivacaine for post- operative pain control in total knee replacement: a prospective randomized double-blind controlled trial. (ijoro.org)
DaGuo, Xue-Wei C, Jin-Wen L, Wen-Wei O, Jian-Ke P, Jun L. Continuous intra-articular infusion anaesthesia for pain control after total knee arthroplasty: Study protocol for a randomised control trial. (ijoro.org)

After lumbar epidural catheter placement, 20 ml bupivacaine (n = 35) or bupivacaine with epinephrine 1:300,000 (n = 35) was administered. (silverchair.com)
The lowest maternal blood pressure was significantly lower in the bupivacaine-epinephrine group (P = 0.03). (silverchair.com)
There were statistically significant reductions in fetal heart rate (P = 0.011) in the bupivacaine-epinephrine group that were not clinically significant. (silverchair.com)
The addition of epidural epinephrine 1:300,000 (66 microg) resulted in a significant 29% reduction in the MLAC of bupivacaine. (silverchair.com)
Group 3 received a postoperative subacromial infusion catheter filled with 0.5% bupivacaine without epinephrine. (unboundmedicine.com)

30 Published studies regarding PRP IAI for knee OA have varying levels of scientific evidence. (sogacot.org)
The purpose of this case series was to assess the efficiency of intra-operative peri-articular cocktail injection in management of pain following total knee arthroplasty. (ijoro.org)
In our study, there was significant improvement of Knee Clinical Score and Knee Functional Score following TKA. (ijoro.org)
Parvataneni HK, Shah VP, Howard H. Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: A prospective randomised study. (ijoro.org)

Chronic pain after surgery is defined by the International Association for the Study of Pain (IASP) as pain that develops after a surgical intervention and is of at least 3-months duration[ 5 ]. (biomedcentral.com)

Subjects were then randomized to either IV or epidural (EPI) fentanyl infusion groups. (stanford.edu)
The MLAC(infusion) of epidural bupivacaine was 0.063% (95% confidence interval, 0.058-0.068) and 0.019% (95% confidence interval, 0.000-0.038) in the IV and EPI groups respectively. (stanford.edu)
The use of continuous bupivacaine subacromial infusion catheters resulted in no detectable pain reduction after arthroscopic rotator cuff repair based on visual analog scale scores and narcotic medication consumption. (unboundmedicine.com)
In the current study, we found that propofol infusion was better regarding early onset and maintenance of OAAS score 3 with no requirement of rescue sedation during the procedure. (jicajournal.in)

Diaphragmatic excursion (via ultrasound) and spirometry were assessed before the block, in the postanesthesia care unit, and at 24 h postblock. (umn.edu)
Prior to placement of interscalene brachial plexus peripheral nerve block (ISPNB), diaphragm function was assessed using ultrasound as normal, no movement, or paradoxical. (druglib.com)
Our study utilized intraoperative ultrasound to verify whether surgeon-administered blocks using only laparoscopic visualization were reliably delivered into the correct plane. (stanfordchildrens.org)
Ultrasound images were reviewed by two blinded anesthesiologists to determine whether the L-TAP block was administered into the desired plane. (stanfordchildrens.org)

One group received intrathecal sufentanil (S) and the other group received the same dose of sufentanil plus supplemental bupivacaine (SB). (longdom.org)

The goal of this randomized, double-blinded, placebo-controlled study was to evaluate the effect of environmental enrichment (EE) on post-operative pain and anxiety in dogs following hemilaminectomy for acute intervertebral disc extrusion (IVDE).MethodsTwenty healthy client-owned dogs. (awionline.org)
Participants are assessed on the first 5 days post-operative, and then at 3-months, 6-months and 12-months. (biomedcentral.com)

Participants and outcome assessors are blind to treatment allocation throughout the study. (biomedcentral.com)

The MLAC of bupivacaine alone was 0.091% wt/vol (95% confidence interval, 0.081-0.102). (silverchair.com)
0.01) in the MLAC of bupivacaine to 0.065% wt/vol (95% confidence interval, 0.047-0.083). (silverchair.com)

[ 2 ] Approximately 71% of those who underwent SNRB with betamethasone and bupivacaine elected not to have surgery (follow-up, 16 months), whereas only 33% of those injected with bupivacaine alone avoided surgery. (medscape.com)

Thus, it did not adequately characterize the safety profile of the study drug when used for femoral nerve block. (medscape.com)

Coadministered epidural fentanyl infusions were more than three times more potent than IV fentanyl infusions, suggesting a predominantly spinal mechanism of opioid action under these study conditions. (stanford.edu)

Seventy pregnant women of American Society of Anesthesiologists (ASA) class I-II were involved in the study, which was completed in a 4-month period. (hippokratia.gr)
The American Society of Anesthesiologists may desire to downplay the results of the JAMA Pediatrics study, but the public deserves a chance to understand what the study accomplished. (theanesthesiaconsultant.com)

Postoperative pain levels were assessed with visual analog scale scores hourly for the first 6 postoperative hours, every 6 hours for the next 2 days, and then every 12 hours for the next 3 days. (unboundmedicine.com)
Pain was assessed using a visual analog scale at 6, 12, 24, and 48 hours after surgery. (podiatryarena.com)

DOI:https://doi.org/10.52587/njmhs.v4i2.40 Objective: The study was planned to measure markers of myocardial injury in experimental model of acute myocardial infarction. (edu.pk)

The primary endpoint for both studies was an area under the curve (AUC) analysis of a numeric rating scale for pain intensity while at rest during the first 72 hours. (medscape.com)
Pain is minimized during the preoperative visit by avoiding unnecessary laboratory studies, especially those that require phlebotomy. (medscape.com)
Visceral pain: a review of experimental studies. (ijsurgery.com)
Lung function and pain control was studied after interscalene peripheral nerve block with 20 milliliters of 0. (druglib.com)
This study assessed the effects of this treatment on pain and function outcomes following meniscectomy. (myorthoevidence.com)
Findings of this study show that the prescription of 16 mg of dexametha- sone (single dose) in the peritoneal cavity may significantly reduce the severity of pain after Laparoscopy in comparison with placebo and may decrease the need for narcotics as pain relief (Registration Number: IRCT201105306640N1). (ijfs.ir)
The study was required to measure pain intensity using tools such as the numerical rating scale or visual analogue scale. (springer.com)

We assessed the incidence and severity of shivering following administration of spinal anaesthesia. (researchbib.com)

They also had a significantly greater percent reduction in forced expiratory volume in 1 s and forced vital capacity compared with the bupivacaine group at 24 h (median decrease of 22% vs. 2%, P = 0.006, and median decrease of 19% vs. 1%, P = 0.049, respectively). (umn.edu)
group BM received 3.5 ml bupivacaine plus 0.5 ml midazolam (5 mg/ml). (ispub.com)

Both were phase 3 multicenter, randomized, double-blind, placebo-controlled studies conducted in the United States and Western Europe. (medscape.com)

Anatomy3

Diseases6

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Psychiatry and Psychology2

Phenomena and Processes12

Health Care7

Clinical trial10

Efficacy23

Brachial Plexus Block2

Patients59

Methods8

Analgesia16

Adjuvant1

Local Anesthetic2

Regional anesthesia2

Liposomal bupivacaine3

Hyperbaric bupivacaine1

ANESTHESIA7

Analgesic6

Concentration of bupivacaine2

0.251

Effect of intrathecal1

Placebo-controlled clinical trials1

Analgesics1

Controlled trials2

Dexmedetomidine6

Effectiveness6

Participated in this prospective1

Anesthetic2

Ropivacaine3

Versus3

Trial6

Epinephrine5

Knee4

Duration1

Infusion4

Ultrasound4

Intrathecal1

Operative2

Allocation1

MLAC2

Underwent1

Femoral nerve1

Infusions1

American Society of Anesth2

Visual analog scale2

Acute1

Pain7

Spinal anaesthesia1

Group2

Phase1